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The map label for this gene is tpiA [H]

Identifier: 73540662

GI number: 73540662

Start: 1047775

End: 1048512

Strand: Direct

Name: tpiA [H]

Synonym: Reut_A0959

Alternate gene names: 73540662

Gene position: 1047775-1048512 (Clockwise)

Preceding gene: 73540661

Following gene: 73540663

Centisome position: 27.53

GC content: 63.69

Gene sequence:

>738_bases
GTGAGACAAAAGCTCGTCATCGGCAACTGGAAGATGCACGGCAGCCTGGCAGCCAACGCTGCGCTGCTGGAAGGTATCAA
GGCTGCACCTGCGCGCGCGCGGTTGGCAGTCTGCGCGCCTTTCCCTTATCTTGCACAGTGCCAGGCGTTGCTGAATGGCT
CGCAGGTAGCCTGGGGCGCACAAGATGTGTCCGCCGAGGCCCGTGGCGCGTTCACCGGCGAGGTGGCCGCGTCGATGCTG
GGTGAGTTCGGCTGCACGTACGCGCTGGTCGGACACTCGGAGCGCCGCACGTACCATGGGGAATCCGATGCCGTGGTAGC
TGCCAAAGCGCTGCGCGCGCTGGAATTCGGCATCATTCCGGTGATTTGCGTCGGTGAAACGCTCGCCCAGCGCGAGGCCG
GTGAAACCGAAGTTGTCGTCGGTCGTCAATTGCAGGCCGCTCTCGACGCGCTGTCGGTGGAGCAACTGGGTCGTGTGGTG
CTGGCCTACGAACCGGTGTGGGCCATCGGTACTGGCAAGACCGCAAGCAGCGAGCAGGCGCAGGCCGTGCATGCGTTCTT
GCGTGCAGAGGTGCGCGAGCGCGACGCCGGTGTGGCTGACCGTATGGCGATTTTGTACGGTGGCAGTGTCAAGCCGGACA
ATGCGGCCGAATTGTTTTCCATGTCCGATATCGACGGGGGCCTGATTGGGGGTGCCTCGCTGAAGTCGGAAGATTTTCTC
GCGATCGGCAACGCCTGA

Upstream 100 bases:

>100_bases
TAATTGCACGAAAAAGTTGCTACCGCGGCCAAGCCGGCCGCGGTAGCGCCGGTCCCCCGCCGCAAGCTACAATAACGGGT
TTGATTTGGGAGGGGACCTC

Downstream 100 bases:

>100_bases
ATGCCCGTCGTGCCAGACATCCGATCAGGCAAGTAACGCTAACTTTATCCAAATGGCAATTTTCAAGACTTTGTTGGTGC
TGGTGCAGGTGTTGTCGGCG

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MRQKLVIGNWKMHGSLAANAALLEGIKAAPARARLAVCAPFPYLAQCQALLNGSQVAWGAQDVSAEARGAFTGEVAASML
GEFGCTYALVGHSERRTYHGESDAVVAAKALRALEFGIIPVICVGETLAQREAGETEVVVGRQLQAALDALSVEQLGRVV
LAYEPVWAIGTGKTASSEQAQAVHAFLRAEVRERDAGVADRMAILYGGSVKPDNAAELFSMSDIDGGLIGGASLKSEDFL
AIGNA

Sequences:

>Translated_245_residues
MRQKLVIGNWKMHGSLAANAALLEGIKAAPARARLAVCAPFPYLAQCQALLNGSQVAWGAQDVSAEARGAFTGEVAASML
GEFGCTYALVGHSERRTYHGESDAVVAAKALRALEFGIIPVICVGETLAQREAGETEVVVGRQLQAALDALSVEQLGRVV
LAYEPVWAIGTGKTASSEQAQAVHAFLRAEVRERDAGVADRMAILYGGSVKPDNAAELFSMSDIDGGLIGGASLKSEDFL
AIGNA
>Mature_245_residues
MRQKLVIGNWKMHGSLAANAALLEGIKAAPARARLAVCAPFPYLAQCQALLNGSQVAWGAQDVSAEARGAFTGEVAASML
GEFGCTYALVGHSERRTYHGESDAVVAAKALRALEFGIIPVICVGETLAQREAGETEVVVGRQLQAALDALSVEQLGRVV
LAYEPVWAIGTGKTASSEQAQAVHAFLRAEVRERDAGVADRMAILYGGSVKPDNAAELFSMSDIDGGLIGGASLKSEDFL
AIGNA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=247, Percent_Identity=43.3198380566802, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI226529917, Length=247, Percent_Identity=43.3198380566802, Blast_Score=174, Evalue=7e-44,
Organism=Escherichia coli, GI1790353, Length=245, Percent_Identity=47.3469387755102, Blast_Score=222, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17536593, Length=249, Percent_Identity=49.3975903614458, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6320255, Length=247, Percent_Identity=40.8906882591093, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=44.5344129554656, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=44.5344129554656, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=44.5344129554656, Blast_Score=181, Evalue=3e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25584; Mature: 25584

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQKLVIGNWKMHGSLAANAALLEGIKAAPARARLAVCAPFPYLAQCQALLNGSQVAWGA
CCCCEEEECEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEECC
QDVSAEARGAFTGEVAASMLGEFGCTYALVGHSERRTYHGESDAVVAAKALRALEFGIIP
HHCCHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
VICVGETLAQREAGETEVVVGRQLQAALDALSVEQLGRVVLAYEPVWAIGTGKTASSEQA
EEECCHHHHHHCCCCCEEEEHHHHHHHHHHHCHHHHCCEEEEECCEEEEECCCCCCHHHH
QAVHAFLRAEVRERDAGVADRMAILYGGSVKPDNAAELFSMSDIDGGLIGGASLKSEDFL
HHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCHHHHEECCCCCCCEECCCCCCCCCEE
AIGNA
EECCC
>Mature Secondary Structure
MRQKLVIGNWKMHGSLAANAALLEGIKAAPARARLAVCAPFPYLAQCQALLNGSQVAWGA
CCCCEEEECEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCCEEEECC
QDVSAEARGAFTGEVAASMLGEFGCTYALVGHSERRTYHGESDAVVAAKALRALEFGIIP
HHCCHHHCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
VICVGETLAQREAGETEVVVGRQLQAALDALSVEQLGRVVLAYEPVWAIGTGKTASSEQA
EEECCHHHHHHCCCCCEEEEHHHHHHHHHHHCHHHHCCEEEEECCEEEEECCCCCCHHHH
QAVHAFLRAEVRERDAGVADRMAILYGGSVKPDNAAELFSMSDIDGGLIGGASLKSEDFL
HHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCHHHHEECCCCCCCEECCCCCCCCCEE
AIGNA
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA