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The map label for this gene is atoC [H]

Identifier: 73540633

GI number: 73540633

Start: 1017889

End: 1019199

Strand: Direct

Name: atoC [H]

Synonym: Reut_A0930

Alternate gene names: 73540633

Gene position: 1017889-1019199 (Clockwise)

Preceding gene: 73540632

Following gene: 73540635

Centisome position: 26.74

GC content: 64.91

Gene sequence:

>1311_bases
ATGAAGCTATATAACCAGGGCGCCCATCCGCCTGCCGCCGCCGGCACCTCCACCGTCTCGTTCGCGGGGCTGATCGAGAA
GCTCGAGATCCTGCGCTCCACGCTGCGCTGGTCGTCGCGGCTCGAGCGCACCGATATCGAGAAGCTGCTCAAGCAGACCA
CCACGCTGCGCGATGAGGTGATGGGGCTGTCGCACAAGGAGCGTTTCGTGCAGGCCGCAACGGGCGGTGAGGCGCCCGTG
CAGGAGGAAATCGAACGCATGCCGCGCGAGCGCCGGCAGGCGCTGCTCGAGCGCAGCTTTATCTTCGAAGGGACGTTCGG
CGATAACCCGAAGCTGCTCGAATCGCTGGAGATTGCCGAAAAGGCGGCGCCTACCGATCTTCCCGTGCTGATCGACGGCG
AAAGCGGCACCGGCAAGGAGCTGATGGCCAAGGTCATCCATGCCAACGGTTCGCGGCAGGAGCGGCCGTTCATCTCGGTC
AACTGCGGCGCTATTCCGGACAGCCTGCTCGAGTCCGAACTGTTCGGCCACAAGAAGGGCGCGTTCACGGGCGCCAGCAA
CGACCGGCGCGGCAAGTTCGAGAGCGCCCACACCGGCACCATCTTCCTCGACGAAATCGGCGAGCTGCCGCTGACGGGGC
AGGTCAAGCTGCTGCGCGTGCTCGAAGCGCACGAGATCCAGCGCGTGGGCTCGGACGAATTGATCGCCGTCGACACCCGA
ATCGTCGCTGCGACCAACAAGGACCTGCGGCGCATGAGCAAGGAAGGAACGTTCCGCGAGGACCTGTTCTACCGGCTCAG
CGTGATCCACGTATCGCTGCCGGCTTTGCGCGAGAGGCGCGACGAGATCCCGTTGCTGGTCTCTTATTTCAGCGACGAAG
CGGCGGGCATGCTCAAGCGGCGCCCGGTCAAGCTTACGCCGAGGCTGCGCGACTTCCTGATGCATTACGAGTATCCGGGC
AACATCCGCGAGCTGCGCAATCTGTTGTACCGGGTGTCGTGCCTGGCCGGTGATACGGCGGATCTTGTCCACCTGCCGGT
GGACATTCGTCCGAAGCCGGCCGCGCTGGCCGTGGTGCCGATCGGGCCGGTTGGTGCGTTGTCAGCGCTGCCGACGTCGC
TGAGCGAAGCCAAGCGCGCTGCCAGCGATGAAGCGGAGCGCGCGTTTCTGGAGCGGGGGCTGCAGGAAGTGGGCGGTACC
GTTGCCGAGCTGGCGCGGCGGTGCGACATGAACCGTTCGCATCTGCAGATGCTGCTGAAGAAGCACGGGATTCATTCGAA
GGACTTTCGGGGGCAGAGGGAGAAGGCGTGA

Upstream 100 bases:

>100_bases
TGCTGTACGAAGGCGCCGTCGTCGAGCAGGGCCGTCACGATGAACTGCTCGACCGCAAGGGCATGTACTACCAGCTGGTG
CAAAAGCAACTGAGCTCAGC

Downstream 100 bases:

>100_bases
GAGCGGTGAGGGACGGGGGGGGGCGCCCGGTTTGGCGAGCCCCCCAACCTTCACTTGCCCTTGTAGTCCGGGAAGAAGAG
CTGTTCCCCTTCGACCTTGT

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKLYNQGAHPPAAAGTSTVSFAGLIEKLEILRSTLRWSSRLERTDIEKLLKQTTTLRDEVMGLSHKERFVQAATGGEAPV
QEEIERMPRERRQALLERSFIFEGTFGDNPKLLESLEIAEKAAPTDLPVLIDGESGTGKELMAKVIHANGSRQERPFISV
NCGAIPDSLLESELFGHKKGAFTGASNDRRGKFESAHTGTIFLDEIGELPLTGQVKLLRVLEAHEIQRVGSDELIAVDTR
IVAATNKDLRRMSKEGTFREDLFYRLSVIHVSLPALRERRDEIPLLVSYFSDEAAGMLKRRPVKLTPRLRDFLMHYEYPG
NIRELRNLLYRVSCLAGDTADLVHLPVDIRPKPAALAVVPIGPVGALSALPTSLSEAKRAASDEAERAFLERGLQEVGGT
VAELARRCDMNRSHLQMLLKKHGIHSKDFRGQREKA

Sequences:

>Translated_436_residues
MKLYNQGAHPPAAAGTSTVSFAGLIEKLEILRSTLRWSSRLERTDIEKLLKQTTTLRDEVMGLSHKERFVQAATGGEAPV
QEEIERMPRERRQALLERSFIFEGTFGDNPKLLESLEIAEKAAPTDLPVLIDGESGTGKELMAKVIHANGSRQERPFISV
NCGAIPDSLLESELFGHKKGAFTGASNDRRGKFESAHTGTIFLDEIGELPLTGQVKLLRVLEAHEIQRVGSDELIAVDTR
IVAATNKDLRRMSKEGTFREDLFYRLSVIHVSLPALRERRDEIPLLVSYFSDEAAGMLKRRPVKLTPRLRDFLMHYEYPG
NIRELRNLLYRVSCLAGDTADLVHLPVDIRPKPAALAVVPIGPVGALSALPTSLSEAKRAASDEAERAFLERGLQEVGGT
VAELARRCDMNRSHLQMLLKKHGIHSKDFRGQREKA
>Mature_436_residues
MKLYNQGAHPPAAAGTSTVSFAGLIEKLEILRSTLRWSSRLERTDIEKLLKQTTTLRDEVMGLSHKERFVQAATGGEAPV
QEEIERMPRERRQALLERSFIFEGTFGDNPKLLESLEIAEKAAPTDLPVLIDGESGTGKELMAKVIHANGSRQERPFISV
NCGAIPDSLLESELFGHKKGAFTGASNDRRGKFESAHTGTIFLDEIGELPLTGQVKLLRVLEAHEIQRVGSDELIAVDTR
IVAATNKDLRRMSKEGTFREDLFYRLSVIHVSLPALRERRDEIPLLVSYFSDEAAGMLKRRPVKLTPRLRDFLMHYEYPG
NIRELRNLLYRVSCLAGDTADLVHLPVDIRPKPAALAVVPIGPVGALSALPTSLSEAKRAASDEAERAFLERGLQEVGGT
VAELARRCDMNRSHLQMLLKKHGIHSKDFRGQREKA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG3604

COG function: function code KT; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=349, Percent_Identity=41.8338108882521, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1790437, Length=314, Percent_Identity=42.6751592356688, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788905, Length=335, Percent_Identity=40.5970149253731, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI87082152, Length=321, Percent_Identity=43.3021806853583, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082117, Length=321, Percent_Identity=42.3676012461059, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1790299, Length=328, Percent_Identity=40.2439024390244, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789233, Length=303, Percent_Identity=42.5742574257426, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI87081872, Length=332, Percent_Identity=41.2650602409639, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789087, Length=326, Percent_Identity=39.8773006134969, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1786524, Length=257, Percent_Identity=43.9688715953307, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI1787583, Length=347, Percent_Identity=35.1585014409222, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789828, Length=260, Percent_Identity=34.6153846153846, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081858, Length=353, Percent_Identity=29.4617563739377, Blast_Score=132, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48523; Mature: 48523

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNQGAHPPAAAGTSTVSFAGLIEKLEILRSTLRWSSRLERTDIEKLLKQTTTLRDEV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLSHKERFVQAATGGEAPVQEEIERMPRERRQALLERSFIFEGTFGDNPKLLESLEIAE
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
KAAPTDLPVLIDGESGTGKELMAKVIHANGSRQERPFISVNCGAIPDSLLESELFGHKKG
HCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
AFTGASNDRRGKFESAHTGTIFLDEIGELPLTGQVKLLRVLEAHEIQRVGSDELIAVDTR
CCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCE
IVAATNKDLRRMSKEGTFREDLFYRLSVIHVSLPALRERRDEIPLLVSYFSDEAAGMLKR
EEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCHHHHHHHHC
RPVKLTPRLRDFLMHYEYPGNIRELRNLLYRVSCLAGDTADLVHLPVDIRPKPAALAVVP
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEE
IGPVGALSALPTSLSEAKRAASDEAERAFLERGLQEVGGTVAELARRCDMNRSHLQMLLK
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
KHGIHSKDFRGQREKA
HCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKLYNQGAHPPAAAGTSTVSFAGLIEKLEILRSTLRWSSRLERTDIEKLLKQTTTLRDEV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MGLSHKERFVQAATGGEAPVQEEIERMPRERRQALLERSFIFEGTFGDNPKLLESLEIAE
HCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHH
KAAPTDLPVLIDGESGTGKELMAKVIHANGSRQERPFISVNCGAIPDSLLESELFGHKKG
HCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCC
AFTGASNDRRGKFESAHTGTIFLDEIGELPLTGQVKLLRVLEAHEIQRVGSDELIAVDTR
CCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCE
IVAATNKDLRRMSKEGTFREDLFYRLSVIHVSLPALRERRDEIPLLVSYFSDEAAGMLKR
EEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCHHHHHHHHC
RPVKLTPRLRDFLMHYEYPGNIRELRNLLYRVSCLAGDTADLVHLPVDIRPKPAALAVVP
CCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEE
IGPVGALSALPTSLSEAKRAASDEAERAFLERGLQEVGGTVAELARRCDMNRSHLQMLLK
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHH
KHGIHSKDFRGQREKA
HCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]