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The map label for this gene is pkn1 [H]

Identifier: 73540625

GI number: 73540625

Start: 1005392

End: 1006633

Strand: Reverse

Name: pkn1 [H]

Synonym: Reut_A0922

Alternate gene names: 73540625

Gene position: 1006633-1005392 (Counterclockwise)

Preceding gene: 73540634

Following gene: 73540623

Centisome position: 26.44

GC content: 66.83

Gene sequence:

>1242_bases
ATGTGGCGCAAAGCTCCTGTCGTTCTGATCGCATCCGCGCTGAGTCTCGGCGCGATCCTCGGTGGCATGGCGGTCCCCGC
CACCGCGGGCGAAGCATCGGTTGCGGGCAACAGTGCGCCGCTGCTGCTCGCCGGCATCCTGCCCAAGAACAGCGATGAAC
AATACGAACTGACGTTCTGGGAATCGATCAAGAACAGCAACTACGCCGGCGACTACGAGGCTTATCTCAAGCAATACCCG
AACGGCCGTTTCGCGGCGCTTGCGCGGGCCCGCATGGAACGCCTCGCGGCCGCCAGTGCGCCCGCTGCAAAGACCCCGCC
ACCGGAACGCGCCAAGGCCGCCCAGCCACCCGCTGCCAAACCGGCAACCCCGTCGCCGCAGCGCTCCGCACCGCCGGCTA
CCGCTGCCGCCGGTGCCGTTGCCGGTGCAGGTGCCGCGCCATCAGAAGCGCCGCCTTCGCGTCCGGGCACCACGGCTACC
GGTTCGGTCAGCGTGGGCGGCGAGCGCAAGCCGCCTGTCGAAGCCAAAGGCGAGATTCGCGATTGCCCGGTCTGCCCCGT
GCTGGTGAGCCTGCCAGCCGGCAGCTTCACCATGGGCAGCAATGCGAGCGACCCAGCGGAAAAGCCTTCTCACCACGTTA
CGATCAGCCAGCCGTTTGCGATCGGCCGCTATGAAGTGACCGTCGAACAGTGGAACGCCTGCGTCGACACCGGTGGCTGC
GATCGGATCGCCACCGTCGCGAACAGTGCCAAGAACTCACCCGTGCGCGATGTCAGTTGGGACGACGCGCAGCAGTACGT
GACCTGGCTCAGCAAGACCACCGGCAAGACCTACCGTCTGCCGACCGAAGCGGAATGGGAATACGCGGCGCGGGGCGGCA
CGGCATCGGCCTACTGGTGGGGCGACCAGATGCGCAAGGGCACGGCCAACTGCAAGGACTGCGGCGACCCGTGGAGCCAG
GATGCGCCGGCTAACGTGGGATCGTTCGCGGCCAATCCGTTCGGCCTCTACGACGTCAACGGCAGCGTGTGGGAATGGGT
TCGCGACTGCTGGCACAGCAGCTACAAGAACGCGCCCACCGACGGCCGGAGCTGGGAAGAAGCCAGTTGCGGCGCGCGCG
TGATCCGCGGCGGATCGTGGCGCGAAGGCGCGAGCTACATGGTGTCGTCGACGCGCTTCAAGTACAGTTCGAGCGTGCGG
CAATCGCAGAACGGTTTTCGCGTGGCGCGGGACCTGAAGTAG

Upstream 100 bases:

>100_bases
GCTATCTTGAAGCAAGCCGACGTCGCGGCAACACCACAATGCGCCCCAGGCGCCCACAGCGCGCGCATCGGGCTGGCCGC
AGTTCCAACGGGGTCCGAAA

Downstream 100 bases:

>100_bases
CAACTGCACCTTTCCAACATCACTTCGCGCGCGTGGAGATCTCCACCAGGTCCGCGCTGATGCGGTCCTGACCGTACTTG
TGCGCCATCTGCCCGAGCGG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MWRKAPVVLIASALSLGAILGGMAVPATAGEASVAGNSAPLLLAGILPKNSDEQYELTFWESIKNSNYAGDYEAYLKQYP
NGRFAALARARMERLAAASAPAAKTPPPERAKAAQPPAAKPATPSPQRSAPPATAAAGAVAGAGAAPSEAPPSRPGTTAT
GSVSVGGERKPPVEAKGEIRDCPVCPVLVSLPAGSFTMGSNASDPAEKPSHHVTISQPFAIGRYEVTVEQWNACVDTGGC
DRIATVANSAKNSPVRDVSWDDAQQYVTWLSKTTGKTYRLPTEAEWEYAARGGTASAYWWGDQMRKGTANCKDCGDPWSQ
DAPANVGSFAANPFGLYDVNGSVWEWVRDCWHSSYKNAPTDGRSWEEASCGARVIRGGSWREGASYMVSSTRFKYSSSVR
QSQNGFRVARDLK

Sequences:

>Translated_413_residues
MWRKAPVVLIASALSLGAILGGMAVPATAGEASVAGNSAPLLLAGILPKNSDEQYELTFWESIKNSNYAGDYEAYLKQYP
NGRFAALARARMERLAAASAPAAKTPPPERAKAAQPPAAKPATPSPQRSAPPATAAAGAVAGAGAAPSEAPPSRPGTTAT
GSVSVGGERKPPVEAKGEIRDCPVCPVLVSLPAGSFTMGSNASDPAEKPSHHVTISQPFAIGRYEVTVEQWNACVDTGGC
DRIATVANSAKNSPVRDVSWDDAQQYVTWLSKTTGKTYRLPTEAEWEYAARGGTASAYWWGDQMRKGTANCKDCGDPWSQ
DAPANVGSFAANPFGLYDVNGSVWEWVRDCWHSSYKNAPTDGRSWEEASCGARVIRGGSWREGASYMVSSTRFKYSSSVR
QSQNGFRVARDLK
>Mature_413_residues
MWRKAPVVLIASALSLGAILGGMAVPATAGEASVAGNSAPLLLAGILPKNSDEQYELTFWESIKNSNYAGDYEAYLKQYP
NGRFAALARARMERLAAASAPAAKTPPPERAKAAQPPAAKPATPSPQRSAPPATAAAGAVAGAGAAPSEAPPSRPGTTAT
GSVSVGGERKPPVEAKGEIRDCPVCPVLVSLPAGSFTMGSNASDPAEKPSHHVTISQPFAIGRYEVTVEQWNACVDTGGC
DRIATVANSAKNSPVRDVSWDDAQQYVTWLSKTTGKTYRLPTEAEWEYAARGGTASAYWWGDQMRKGTANCKDCGDPWSQ
DAPANVGSFAANPFGLYDVNGSVWEWVRDCWHSSYKNAPTDGRSWEEASCGARVIRGGSWREGASYMVSSTRFKYSSSVR
QSQNGFRVARDLK

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI257470975, Length=334, Percent_Identity=29.3413173652695, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI38202250, Length=359, Percent_Identity=27.2980501392758, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194248087, Length=270, Percent_Identity=29.6296296296296, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI257470977, Length=283, Percent_Identity=27.208480565371, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI194248088, Length=285, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI226437577, Length=172, Percent_Identity=34.8837209302326, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 43726; Mature: 43726

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRKAPVVLIASALSLGAILGGMAVPATAGEASVAGNSAPLLLAGILPKNSDEQYELTFW
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEH
ESIKNSNYAGDYEAYLKQYPNGRFAALARARMERLAAASAPAAKTPPPERAKAAQPPAAK
HHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCC
PATPSPQRSAPPATAAAGAVAGAGAAPSEAPPSRPGTTATGSVSVGGERKPPVEAKGEIR
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
DCPVCPVLVSLPAGSFTMGSNASDPAEKPSHHVTISQPFAIGRYEVTVEQWNACVDTGGC
CCCCCCEEEECCCCCEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEHHHHHHHHCCCCC
DRIATVANSAKNSPVRDVSWDDAQQYVTWLSKTTGKTYRLPTEAEWEYAARGGTASAYWW
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCEEEEC
GDQMRKGTANCKDCGDPWSQDAPANVGSFAANPFGLYDVNGSVWEWVRDCWHSSYKNAPT
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCC
DGRSWEEASCGARVIRGGSWREGASYMVSSTRFKYSSSVRQSQNGFRVARDLK
CCCCCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MWRKAPVVLIASALSLGAILGGMAVPATAGEASVAGNSAPLLLAGILPKNSDEQYELTFW
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEH
ESIKNSNYAGDYEAYLKQYPNGRFAALARARMERLAAASAPAAKTPPPERAKAAQPPAAK
HHHCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCC
PATPSPQRSAPPATAAAGAVAGAGAAPSEAPPSRPGTTATGSVSVGGERKPPVEAKGEIR
CCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCC
DCPVCPVLVSLPAGSFTMGSNASDPAEKPSHHVTISQPFAIGRYEVTVEQWNACVDTGGC
CCCCCCEEEECCCCCEECCCCCCCCCCCCCCEEEECCCCCCCEEEEEHHHHHHHHCCCCC
DRIATVANSAKNSPVRDVSWDDAQQYVTWLSKTTGKTYRLPTEAEWEYAARGGTASAYWW
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCEEEEC
GDQMRKGTANCKDCGDPWSQDAPANVGSFAANPFGLYDVNGSVWEWVRDCWHSSYKNAPT
CHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCC
DGRSWEEASCGARVIRGGSWREGASYMVSSTRFKYSSSVRQSQNGFRVARDLK
CCCCCCHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]