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The map label for this gene is ywrD [H]

Identifier: 73540544

GI number: 73540544

Start: 909712

End: 911337

Strand: Reverse

Name: ywrD [H]

Synonym: Reut_A0841

Alternate gene names: 73540544

Gene position: 911337-909712 (Counterclockwise)

Preceding gene: 73540545

Following gene: 73540543

Centisome position: 23.94

GC content: 65.19

Gene sequence:

>1626_bases
ATGCAGAACTTCAACTGGACCAACCCCTACCCCTCCGTGCGCATCCCGCTGTTCGCGCGCAACGTGGTGTCGACATCGCA
TCCGCTCGCCGCACAGGCCGGCCTGCGCATGCTGCTCAAAGGCGGCAATGCCGTCGACGCGGCGATCGCAGCCGCGGCGA
CGATCACCCTAGTCGAGCCCGTGTCCTGCGGGCTGGGCAGCGATGCCTTCGCCATCCTGTGGGACGGCAAGGAACTGCAC
GGCCTGAACTCCTCCGGCGTGGCGCCGGCCGCGTGGAATCCCGAGTACTTCAAGAACAAGTACGGCACCGATGCCAACGG
GCTGGCGAACCGCCCGGTCCGCGGGTGGGACTCTGTCACCGTCCCCGGCGTGGTAGCGGGCTGGGCCGCGCTCCACGAAC
GTTTCGGCAAGCTGCCGTTCGCCGACCTGATGGAACCGGCGATCGAGATCGCTGAACGTGGCTACGCCGTGCCGCCCGTG
GTCGCGCACAAGTGGGCCGCGGCCGTGCCGGAACTGAAGAACCAGCCGGGCTTTGCCGATACATTCATGCCCAACGGCCG
CGCACCGCTGGTGGGCGAGAAATTCACGCTCAAGGCCGCTGCCGAGACGCTGCGCAAGATCGGCGAGACCGGTGGCCGCG
CCTACTACGAAGGCGAGATTGCCGAGAAAATCGCCGCCTTCAGCAAGCAGAGCGGCGGCGCCATGACGCTGGACGACCTG
CGCAACTACCGGCCCGACTGGGTCAAGCCGATCAGCAAGTCGTATCGTGGCTACGAACTGCACGAAATTCCGCCGAACGG
GCAAGGCATCGCCGCGCTGATCGCGCTGGGCATTCTCAACCAGTTCGACGTTGGCGCGCTGCCCGTGGATTCGGTGGATT
CGCAGCACCTGCAGATCGAAGCCATGAAGCTGGCCTTTGCCGATCTTTACCGCTATGTGGCCGACCCGCGTAGCATGGAA
GTCACGCCTGAGCAGATGCTCGACGACGCCTACCTGAAATCGCGCGCGAAGCTCATCGACATGCAGCGCGCCACGCATTT
CAACTTCGGCATGCCTAAGGTCGGCGGCACCATCTACCTGACGGCCGCGGATGAGAACGGGATGATGATCTCGTTCATCC
AGTCCAACTACATGGGCTTCGGTTCGGGCGTGGTGGTGCCGGACACCGGCATCAGCCTGCAGAACCGCGGCGTGGGCTTC
TCGATGGATCCGAAGTCGGCCAACGTGGTGGCTGGCGGCAAGCGGCCGTTCCACACCATCATCCCGGCCTTCCTGACCAA
AGACGGCCAGCCGGTCATGAGCTTCGGCGTGATGGGCGGCGACATGCAGCCGCAGGGCCATCTGCAGACCGTGGTGCGTA
TGCTCGACTACAAGCAGCAGCCGCAAGCGGCGTGCTGCGCGCCGCGCTGGAAAGTCAACCGCGACTTCACGCTGGACGTG
GAAGGCACCATGGACCCGGCAACGGTCGAGGGCCTGAAGGCACGCGGCCACCAGCTCAAGTCAGTGGACGATCCGTACAT
GGACTTTGGCTCGGGCCAGTTCATCTGGCGTCTGTCGGACGACCCGGAACACGGCTACGTTGCCGCGAGCGACAGTCGAC
GCGACGGACAGGCGGTCGGCTTCTGA

Upstream 100 bases:

>100_bases
GCTGGGGCAAGCTCATCAAGGATCGCAAGATCACGGCAGAATAACGCGATGCCGCAGCCGGCCCGCATCGGGCCGGCTGC
CGGTGACAACGGACAAGACC

Downstream 100 bases:

>100_bases
CCACCATCCTGGCAACAAAAGAAGGGCGCTTCCCGAACGGGCAGCGCCTTTTTTGTTTGCGGCACGTCGGCGCATTCTCA
TAGACTGACTGCCATCGCTC

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQNFNWTNPYPSVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAATITLVEPVSCGLGSDAFAILWDGKELH
GLNSSGVAPAAWNPEYFKNKYGTDANGLANRPVRGWDSVTVPGVVAGWAALHERFGKLPFADLMEPAIEIAERGYAVPPV
VAHKWAAAVPELKNQPGFADTFMPNGRAPLVGEKFTLKAAAETLRKIGETGGRAYYEGEIAEKIAAFSKQSGGAMTLDDL
RNYRPDWVKPISKSYRGYELHEIPPNGQGIAALIALGILNQFDVGALPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDDAYLKSRAKLIDMQRATHFNFGMPKVGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPDTGISLQNRGVGF
SMDPKSANVVAGGKRPFHTIIPAFLTKDGQPVMSFGVMGGDMQPQGHLQTVVRMLDYKQQPQAACCAPRWKVNRDFTLDV
EGTMDPATVEGLKARGHQLKSVDDPYMDFGSGQFIWRLSDDPEHGYVAASDSRRDGQAVGF

Sequences:

>Translated_541_residues
MQNFNWTNPYPSVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAATITLVEPVSCGLGSDAFAILWDGKELH
GLNSSGVAPAAWNPEYFKNKYGTDANGLANRPVRGWDSVTVPGVVAGWAALHERFGKLPFADLMEPAIEIAERGYAVPPV
VAHKWAAAVPELKNQPGFADTFMPNGRAPLVGEKFTLKAAAETLRKIGETGGRAYYEGEIAEKIAAFSKQSGGAMTLDDL
RNYRPDWVKPISKSYRGYELHEIPPNGQGIAALIALGILNQFDVGALPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDDAYLKSRAKLIDMQRATHFNFGMPKVGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPDTGISLQNRGVGF
SMDPKSANVVAGGKRPFHTIIPAFLTKDGQPVMSFGVMGGDMQPQGHLQTVVRMLDYKQQPQAACCAPRWKVNRDFTLDV
EGTMDPATVEGLKARGHQLKSVDDPYMDFGSGQFIWRLSDDPEHGYVAASDSRRDGQAVGF
>Mature_541_residues
MQNFNWTNPYPSVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAATITLVEPVSCGLGSDAFAILWDGKELH
GLNSSGVAPAAWNPEYFKNKYGTDANGLANRPVRGWDSVTVPGVVAGWAALHERFGKLPFADLMEPAIEIAERGYAVPPV
VAHKWAAAVPELKNQPGFADTFMPNGRAPLVGEKFTLKAAAETLRKIGETGGRAYYEGEIAEKIAAFSKQSGGAMTLDDL
RNYRPDWVKPISKSYRGYELHEIPPNGQGIAALIALGILNQFDVGALPVDSVDSQHLQIEAMKLAFADLYRYVADPRSME
VTPEQMLDDAYLKSRAKLIDMQRATHFNFGMPKVGGTIYLTAADENGMMISFIQSNYMGFGSGVVVPDTGISLQNRGVGF
SMDPKSANVVAGGKRPFHTIIPAFLTKDGQPVMSFGVMGGDMQPQGHLQTVVRMLDYKQQPQAACCAPRWKVNRDFTLDV
EGTMDPATVEGLKARGHQLKSVDDPYMDFGSGQFIWRLSDDPEHGYVAASDSRRDGQAVGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=553, Percent_Identity=26.7631103074141, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915090, Length=553, Percent_Identity=26.7631103074141, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915096, Length=553, Percent_Identity=26.7631103074141, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI73915094, Length=553, Percent_Identity=26.7631103074141, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=25.9528130671506, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=25.8992805755396, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI109148539, Length=516, Percent_Identity=27.7131782945736, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI153266885, Length=550, Percent_Identity=24.7272727272727, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI153266901, Length=551, Percent_Identity=24.6823956442831, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI153266907, Length=548, Percent_Identity=24.0875912408759, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1789856, Length=503, Percent_Identity=28.6282306163022, Blast_Score=189, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17506189, Length=533, Percent_Identity=25.328330206379, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17542894, Length=559, Percent_Identity=24.6869409660107, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=525, Percent_Identity=24.7619047619048, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI212646519, Length=525, Percent_Identity=24.7619047619048, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI193208247, Length=506, Percent_Identity=24.703557312253, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193208245, Length=506, Percent_Identity=24.703557312253, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551474, Length=569, Percent_Identity=26.3620386643234, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI161077878, Length=569, Percent_Identity=26.3620386643234, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI161077880, Length=569, Percent_Identity=26.3620386643234, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24642670, Length=569, Percent_Identity=26.3620386643234, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24642666, Length=569, Percent_Identity=26.3620386643234, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI18859893, Length=516, Percent_Identity=26.7441860465116, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859741, Length=562, Percent_Identity=25.2669039145907, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI161077496, Length=544, Percent_Identity=25.9191176470588, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58617; Mature: 58617

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNFNWTNPYPSVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAATITLVEP
CCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
VSCGLGSDAFAILWDGKELHGLNSSGVAPAAWNPEYFKNKYGTDANGLANRPVRGWDSVT
CCCCCCCCEEEEEECCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCC
VPGVVAGWAALHERFGKLPFADLMEPAIEIAERGYAVPPVVAHKWAAAVPELKNQPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCC
TFMPNGRAPLVGEKFTLKAAAETLRKIGETGGRAYYEGEIAEKIAAFSKQSGGAMTLDDL
CCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCEEEHHHH
RNYRPDWVKPISKSYRGYELHEIPPNGQGIAALIALGILNQFDVGALPVDSVDSQHLQIE
HCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
AMKLAFADLYRYVADPRSMEVTPEQMLDDAYLKSRAKLIDMQRATHFNFGMPKVGGTIYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
TAADENGMMISFIQSNYMGFGSGVVVPDTGISLQNRGVGFSMDPKSANVVAGGKRPFHTI
EEECCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHH
IPAFLTKDGQPVMSFGVMGGDMQPQGHLQTVVRMLDYKQQPQAACCAPRWKVNRDFTLDV
HHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEE
EGTMDPATVEGLKARGHQLKSVDDPYMDFGSGQFIWRLSDDPEHGYVAASDSRRDGQAVG
CCCCCCHHHHHHHHCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCC
F
C
>Mature Secondary Structure
MQNFNWTNPYPSVRIPLFARNVVSTSHPLAAQAGLRMLLKGGNAVDAAIAAAATITLVEP
CCCCCCCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECC
VSCGLGSDAFAILWDGKELHGLNSSGVAPAAWNPEYFKNKYGTDANGLANRPVRGWDSVT
CCCCCCCCEEEEEECCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCC
VPGVVAGWAALHERFGKLPFADLMEPAIEIAERGYAVPPVVAHKWAAAVPELKNQPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCC
TFMPNGRAPLVGEKFTLKAAAETLRKIGETGGRAYYEGEIAEKIAAFSKQSGGAMTLDDL
CCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHCCCCCEEEHHHH
RNYRPDWVKPISKSYRGYELHEIPPNGQGIAALIALGILNQFDVGALPVDSVDSQHLQIE
HCCCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
AMKLAFADLYRYVADPRSMEVTPEQMLDDAYLKSRAKLIDMQRATHFNFGMPKVGGTIYL
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
TAADENGMMISFIQSNYMGFGSGVVVPDTGISLQNRGVGFSMDPKSANVVAGGKRPFHTI
EEECCCCCEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHH
IPAFLTKDGQPVMSFGVMGGDMQPQGHLQTVVRMLDYKQQPQAACCAPRWKVNRDFTLDV
HHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCEEEEE
EGTMDPATVEGLKARGHQLKSVDDPYMDFGSGQFIWRLSDDPEHGYVAASDSRRDGQAVG
CCCCCCHHHHHHHHCCCCCCCCCCCHHCCCCCEEEEEECCCCCCCEEEECCCCCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]