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The map label for this gene is ilvR [H]

Identifier: 73540346

GI number: 73540346

Start: 687937

End: 688893

Strand: Direct

Name: ilvR [H]

Synonym: Reut_A0640

Alternate gene names: 73540346

Gene position: 687937-688893 (Clockwise)

Preceding gene: 73540343

Following gene: 73540347

Centisome position: 18.07

GC content: 67.08

Gene sequence:

>957_bases
TTGGACCTGCGCCAGCTGCGGTACTTCGTCACGGTGGCGGAAGAGCTGCATTTCGGAAGGGCGGCCACGCGGCTAGCCAT
GACGCAGCCGCCGCTTTCCCAGCAGATTCAGTCGCTGGAAGAGGAAATCGGCGTGCAGTTGTTCGTGCGCACGCGCCGTT
CGGTGATGATGACGCCGGCCGGGCAGCAATGGCTGCCCGAGGTTCGCCGCGTGCTCGCTGACGCTGCGGCGTTGCCGGGG
CTTGCCCAGAGGCTGGCACGCGGGGAGATCGGCTCGCTCGTGCTGGCCTTCGTCAGCACCGCCGATTACGGCATCCTGCC
CGACCTTCTGCGGCGGTTTCGCGCGCAGCATCCGGAGGTCCAGCTTCAGTTGCGTGAAGCCACCAGCGATGTCCAGCTCG
AAGCATTGAGCGAAGGCAGCATCGACGCGGGGCTGGTGATTCGCCCCCAGTTGCCGGCGATGCCGCATGGCCTGTCCTAC
CTGCCGCTGGTGCGCGAACCGCTGGTGCTGGCCGTGCCGGACGGCTGGCGGCCCGCGCATGGCAGCATGCCGGCGGATGG
CAAAGTTTCGCTGCGCGATGCCGCGCGCGAACCGCTGATCATTTTCCCGCGTCGAAGCGCGCCGGTTTTTTATGACATCA
TTACAGGCTACTATGCGCGCGACGGCTTGTCGCCAGTGATCGCGCAGGAAGCCATCCAGATGCAGACCATCGTGAGCCTG
GTGTCTGCGGGCATGGGGGTGGCGCTGGTGCCGGCCTCGCTCTGCAACCTTCGCCGTACCGGCGTGTCGTACCTCGCGTT
ACGCGAGGCAGGGCCGCAGATCGAGACCGGGCTGCTCTGGCGCGAAGGCGCTGCCGGCGTCGCGCCGGCACTGCGTTCAC
TGATCGACATCGCGAGCGGGCTGTCCTCGGCGGAATCTGCGCAACCCTCAGTCTCCGCGGCGGCCGGGCCTTTTTAA

Upstream 100 bases:

>100_bases
CTGAGGCTCGGGGGTTTGTGCAAAGAATGCGACTTGCGTTTTGGAGTGTCAAATATATTATTTGACCTTTATTGAGTCGA
AAAACATATCAGGAGCGCTT

Downstream 100 bases:

>100_bases
CTTCCACCCACCTCACCATGCTGATTCATCCCCAATTCGATCCCGTCGCCATCCATATCGGCCCGCTTGCCATCCGCTGG
TACGGGCTGATGTACCTGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MDLRQLRYFVTVAEELHFGRAATRLAMTQPPLSQQIQSLEEEIGVQLFVRTRRSVMMTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEIGSLVLAFVSTADYGILPDLLRRFRAQHPEVQLQLREATSDVQLEALSEGSIDAGLVIRPQLPAMPHGLSY
LPLVREPLVLAVPDGWRPAHGSMPADGKVSLRDAAREPLIIFPRRSAPVFYDIITGYYARDGLSPVIAQEAIQMQTIVSL
VSAGMGVALVPASLCNLRRTGVSYLALREAGPQIETGLLWREGAAGVAPALRSLIDIASGLSSAESAQPSVSAAAGPF

Sequences:

>Translated_318_residues
MDLRQLRYFVTVAEELHFGRAATRLAMTQPPLSQQIQSLEEEIGVQLFVRTRRSVMMTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEIGSLVLAFVSTADYGILPDLLRRFRAQHPEVQLQLREATSDVQLEALSEGSIDAGLVIRPQLPAMPHGLSY
LPLVREPLVLAVPDGWRPAHGSMPADGKVSLRDAAREPLIIFPRRSAPVFYDIITGYYARDGLSPVIAQEAIQMQTIVSL
VSAGMGVALVPASLCNLRRTGVSYLALREAGPQIETGLLWREGAAGVAPALRSLIDIASGLSSAESAQPSVSAAAGPF
>Mature_318_residues
MDLRQLRYFVTVAEELHFGRAATRLAMTQPPLSQQIQSLEEEIGVQLFVRTRRSVMMTPAGQQWLPEVRRVLADAAALPG
LAQRLARGEIGSLVLAFVSTADYGILPDLLRRFRAQHPEVQLQLREATSDVQLEALSEGSIDAGLVIRPQLPAMPHGLSY
LPLVREPLVLAVPDGWRPAHGSMPADGKVSLRDAAREPLIIFPRRSAPVFYDIITGYYARDGLSPVIAQEAIQMQTIVSL
VSAGMGVALVPASLCNLRRTGVSYLALREAGPQIETGLLWREGAAGVAPALRSLIDIASGLSSAESAQPSVSAAAGPF

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=281, Percent_Identity=40.5693950177936, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI2367136, Length=274, Percent_Identity=35.7664233576642, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788887, Length=298, Percent_Identity=31.8791946308725, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790399, Length=304, Percent_Identity=28.9473684210526, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI157672245, Length=296, Percent_Identity=29.0540540540541, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790208, Length=259, Percent_Identity=32.046332046332, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787806, Length=289, Percent_Identity=25.9515570934256, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081904, Length=207, Percent_Identity=34.2995169082126, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788748, Length=258, Percent_Identity=29.0697674418605, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693105, Length=171, Percent_Identity=30.4093567251462, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787530, Length=258, Percent_Identity=28.6821705426357, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788297, Length=260, Percent_Identity=28.0769230769231, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787589, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787601, Length=194, Percent_Identity=28.3505154639175, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=260, Percent_Identity=27.6923076923077, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=315, Percent_Identity=26.3492063492064, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693193, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=252, Percent_Identity=26.984126984127, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI48994962, Length=157, Percent_Identity=31.2101910828025, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1789506, Length=237, Percent_Identity=22.3628691983122, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34282; Mature: 34282

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRQLRYFVTVAEELHFGRAATRLAMTQPPLSQQIQSLEEEIGVQLFVRTRRSVMMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHEEECCHHEEECCC
GQQWLPEVRRVLADAAALPGLAQRLARGEIGSLVLAFVSTADYGILPDLLRRFRAQHPEV
CHHHHHHHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
QLQLREATSDVQLEALSEGSIDAGLVIRPQLPAMPHGLSYLPLVREPLVLAVPDGWRPAH
EEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCC
GSMPADGKVSLRDAAREPLIIFPRRSAPVFYDIITGYYARDGLSPVIAQEAIQMQTIVSL
CCCCCCCCEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VSAGMGVALVPASLCNLRRTGVSYLALREAGPQIETGLLWREGAAGVAPALRSLIDIASG
HHCCCCHHHHHHHHHHHHHHCHHHEEHHHCCCCCHHCCEECCCCCCHHHHHHHHHHHHHC
LSSAESAQPSVSAAAGPF
CCCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDLRQLRYFVTVAEELHFGRAATRLAMTQPPLSQQIQSLEEEIGVQLFVRTRRSVMMTPA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHEEECCHHEEECCC
GQQWLPEVRRVLADAAALPGLAQRLARGEIGSLVLAFVSTADYGILPDLLRRFRAQHPEV
CHHHHHHHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
QLQLREATSDVQLEALSEGSIDAGLVIRPQLPAMPHGLSYLPLVREPLVLAVPDGWRPAH
EEEEECCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCCCCHHHHCCEEEECCCCCCCCC
GSMPADGKVSLRDAAREPLIIFPRRSAPVFYDIITGYYARDGLSPVIAQEAIQMQTIVSL
CCCCCCCCEEHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VSAGMGVALVPASLCNLRRTGVSYLALREAGPQIETGLLWREGAAGVAPALRSLIDIASG
HHCCCCHHHHHHHHHHHHHHCHHHEEHHHCCCCCHHCCEECCCCCCHHHHHHHHHHHHHC
LSSAESAQPSVSAAAGPF
CCCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]