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The map label for this gene is xseA

Identifier: 73540302

GI number: 73540302

Start: 647018

End: 648364

Strand: Direct

Name: xseA

Synonym: Reut_A0596

Alternate gene names: 73540302

Gene position: 647018-648364 (Clockwise)

Preceding gene: 73540294

Following gene: 73540303

Centisome position: 17.0

GC content: 67.85

Gene sequence:

>1347_bases
ATGCCAGCTCGCAATCCGCGCGAAGCGATTCCCGTGGGGGAGCTGAACCATGCGATCGCAACCATGCTGGAGCGGGGCTT
TCCTTTGACGTGGGTGCGCGGAGAAATCTCGAACTTCACCCGCGCGGCCAGTGGTCATTGGTATTTCTCGCTGAAAGACG
CGCGCGCGCAGATTCGCTGTGTGATGTTCCGCGGGCGTAACCAGCATGTCGACTTCACGCCGCGCGAAGGGGAAGCGGTG
GAAGTCCGTGCCGTCGTCACGCTGTACGAGGCGCGTGGCGATCTCCAGCTCGGCGTCGAAGCCATGCGCCGTGCCGGACT
TGGCAATCTTTACGAGGCGTTCCTGCGTTTGAAGGAAAAACTGGCGCAGGCCGGACTGTTCGCGCCCGAGCGCAAGCGCC
CAGTGCCATCTCACCCGCGCTCGATCGGCATCGTCACATCGCTGCAGGCGGCGGCGCTACGCGACGTGCTGACTACGCTG
CGGCGGCGCGCGCCGCACGTGCCGGTGACGGTGTACCCCGTGCCGGTGCAAGGCGCGGGCGCCGCGCAGAAGATTGCCGA
CATGCTGGACCAGGCCAGCGCGCGGCGCGAGTGCGACGTGATCATCCTGTGCCGCGGTGGCGGCAGCATTGAAGACCTGT
GGTCCTTCAACGAAGAAGCGGTAGCGCACGCCATTGCGCGTAGCGCGGTGCCTGTGGTGTCTGGCGTCGGCCACGAAACG
GACTTCACCATTGCAGATTTCGTTGCCGACGTGCGCGCGCCGACACCCACGGGCGCGGCCGAACTGGTCAGTCCCGACCG
CGGGCACTTGCTAGGCCTGACGCGGCGGGCCGGCGATGCGCTGGTACAGTCGATGCGTCGTGAACTGGACCGGCGTGCGC
AGCATCTGGACTGGCTCGCGCGTCGGGTGCGCAGCCCGCTGGCGCAACTGCAGGAGCGGCGTGCGCGCGTCGACAATCTC
GCGCGACACTTGCGTTCGGCCTTGCGTGAAACCGTGGTTGCCCAGCGTCACCGACAGCAATTGCTGGCCATACGCTGGAC
CGCCTGCCGGCCCGATATGGCGGCGGCCAGCGCCGATGTCGCGCGGCTGTCACAGCGCATGCAGGCCGCGGCAACCCGTA
CGCATGAGCGCCAGACGCAGCGCCTGGCGCGCGTAGCCGGTGCGCTGGAGTTGCTGGCGCCGCAGCGTACGCTGGAGCGC
GGCTATGCCGTGCTGCTCGACCAGCGCGGCCGCGCACTGCGTTCGCCCGCGGAACTGCGTGCAGGGAGCGTGGTGGAGGC
CCATCTGGCCGACGGCGTGGCGGACATCGCGATTGCCGGCGTACAGGCCAAACTTGGCGGAATCTAA

Upstream 100 bases:

>100_bases
TCTTGACATACCCGTTATGCTGTGGACATGTCCTATCCCCGCCGCACCGCGGCTACGACCCATGCCAGAGCCGCAGAACT
TTTCGCGTGAAACGCCCTCC

Downstream 100 bases:

>100_bases
GGGTCGGCCGGCATCGCGCGGACAAACTAACATGACCCCAGGGGGCTTTGCGCCGCGGTTTGCGTGGGTCTTGCAAGTCT
CCTACAATCGGCAATTCCTC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MPARNPREAIPVGELNHAIATMLERGFPLTWVRGEISNFTRAASGHWYFSLKDARAQIRCVMFRGRNQHVDFTPREGEAV
EVRAVVTLYEARGDLQLGVEAMRRAGLGNLYEAFLRLKEKLAQAGLFAPERKRPVPSHPRSIGIVTSLQAAALRDVLTTL
RRRAPHVPVTVYPVPVQGAGAAQKIADMLDQASARRECDVIILCRGGGSIEDLWSFNEEAVAHAIARSAVPVVSGVGHET
DFTIADFVADVRAPTPTGAAELVSPDRGHLLGLTRRAGDALVQSMRRELDRRAQHLDWLARRVRSPLAQLQERRARVDNL
ARHLRSALRETVVAQRHRQQLLAIRWTACRPDMAAASADVARLSQRMQAAATRTHERQTQRLARVAGALELLAPQRTLER
GYAVLLDQRGRALRSPAELRAGSVVEAHLADGVADIAIAGVQAKLGGI

Sequences:

>Translated_448_residues
MPARNPREAIPVGELNHAIATMLERGFPLTWVRGEISNFTRAASGHWYFSLKDARAQIRCVMFRGRNQHVDFTPREGEAV
EVRAVVTLYEARGDLQLGVEAMRRAGLGNLYEAFLRLKEKLAQAGLFAPERKRPVPSHPRSIGIVTSLQAAALRDVLTTL
RRRAPHVPVTVYPVPVQGAGAAQKIADMLDQASARRECDVIILCRGGGSIEDLWSFNEEAVAHAIARSAVPVVSGVGHET
DFTIADFVADVRAPTPTGAAELVSPDRGHLLGLTRRAGDALVQSMRRELDRRAQHLDWLARRVRSPLAQLQERRARVDNL
ARHLRSALRETVVAQRHRQQLLAIRWTACRPDMAAASADVARLSQRMQAAATRTHERQTQRLARVAGALELLAPQRTLER
GYAVLLDQRGRALRSPAELRAGSVVEAHLADGVADIAIAGVQAKLGGI
>Mature_447_residues
PARNPREAIPVGELNHAIATMLERGFPLTWVRGEISNFTRAASGHWYFSLKDARAQIRCVMFRGRNQHVDFTPREGEAVE
VRAVVTLYEARGDLQLGVEAMRRAGLGNLYEAFLRLKEKLAQAGLFAPERKRPVPSHPRSIGIVTSLQAAALRDVLTTLR
RRAPHVPVTVYPVPVQGAGAAQKIADMLDQASARRECDVIILCRGGGSIEDLWSFNEEAVAHAIARSAVPVVSGVGHETD
FTIADFVADVRAPTPTGAAELVSPDRGHLLGLTRRAGDALVQSMRRELDRRAQHLDWLARRVRSPLAQLQERRARVDNLA
RHLRSALRETVVAQRHRQQLLAIRWTACRPDMAAASADVARLSQRMQAAATRTHERQTQRLARVAGALELLAPQRTLERG
YAVLLDQRGRALRSPAELRAGSVVEAHLADGVADIAIAGVQAKLGGI

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=454, Percent_Identity=40.5286343612335, Blast_Score=318, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CUPPJ (Q475F5)

Other databases:

- EMBL:   CP000090
- RefSeq:   YP_294822.1
- GeneID:   3610780
- GenomeReviews:   CP000090_GR
- KEGG:   reu:Reut_A0596
- NMPDR:   fig|264198.3.peg.1108
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   REUT264198:REUT_A0596-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 49214; Mature: 49083

Theoretical pI: Translated: 11.32; Mature: 11.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARNPREAIPVGELNHAIATMLERGFPLTWVRGEISNFTRAASGHWYFSLKDARAQIRC
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCEEEEEECCCCEEEE
VMFRGRNQHVDFTPREGEAVEVRAVVTLYEARGDLQLGVEAMRRAGLGNLYEAFLRLKEK
EEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
LAQAGLFAPERKRPVPSHPRSIGIVTSLQAAALRDVLTTLRRRAPHVPVTVYPVPVQGAG
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
AAQKIADMLDQASARRECDVIILCRGGGSIEDLWSFNEEAVAHAIARSAVPVVSGVGHET
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
DFTIADFVADVRAPTPTGAAELVSPDRGHLLGLTRRAGDALVQSMRRELDRRAQHLDWLA
CCHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVRSPLAQLQERRARVDNLARHLRSALRETVVAQRHRQQLLAIRWTACRPDMAAASADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ARLSQRMQAAATRTHERQTQRLARVAGALELLAPQRTLERGYAVLLDQRGRALRSPAELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCHHCCHHHHC
AGSVVEAHLADGVADIAIAGVQAKLGGI
CCCHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PARNPREAIPVGELNHAIATMLERGFPLTWVRGEISNFTRAASGHWYFSLKDARAQIRC
CCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCEEEEEECCCCEEEE
VMFRGRNQHVDFTPREGEAVEVRAVVTLYEARGDLQLGVEAMRRAGLGNLYEAFLRLKEK
EEEECCCCCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
LAQAGLFAPERKRPVPSHPRSIGIVTSLQAAALRDVLTTLRRRAPHVPVTVYPVPVQGAG
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
AAQKIADMLDQASARRECDVIILCRGGGSIEDLWSFNEEAVAHAIARSAVPVVSGVGHET
HHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCC
DFTIADFVADVRAPTPTGAAELVSPDRGHLLGLTRRAGDALVQSMRRELDRRAQHLDWLA
CCHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRVRSPLAQLQERRARVDNLARHLRSALRETVVAQRHRQQLLAIRWTACRPDMAAASADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ARLSQRMQAAATRTHERQTQRLARVAGALELLAPQRTLERGYAVLLDQRGRALRSPAELR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCHHCCHHHHC
AGSVVEAHLADGVADIAIAGVQAKLGGI
CCCHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA