Click here to switch to the map view.

The map label for this gene is ald [H]

Identifier: 73539698

GI number: 73539698

Start: 2720050

End: 2721168

Strand: Direct

Name: ald [H]

Synonym: Reut_B5878

Alternate gene names: 73539698

Gene position: 2720050-2721168 (Clockwise)

Preceding gene: 73539697

Following gene: NA

Centisome position: 99.78

GC content: 66.67

Gene sequence:

>1119_bases
ATGAGGATCGGAGTACCGAAGGAAATCAAGAATCATGAGTATCGCGTCGGCCTGACGCCATCGTCTGTGCGCGAGATGAC
GGCACACGGCCACCACGTGCTCGTACAGACGACGGCTGGCGCCGGCATCGGCGCAAGCGATGCCGATTACCGCAAGGCCG
GCGCCACCATCGTCGACACGGCGCAGGAGATCTTCGCCAAGGCGGAAATGATCGTGAAGGTCAAGGAGCCGCAGGCCAAC
GAGCGCGCCATGCTGCGCGAGGGGCAGATTCTCTATACCTACCTGCACCTGGCGCCGGATCCGGACCAGTGCGCTGACCT
CGTCCGCAGCGGCGCGGTGTGCATCGCCTACGAGACCGTCACCCAGGCGGGCGGCGGGCTGCCGCTGCTGGCGCCCATGT
CTGAGGTCGCGGGCCGCATGTCGGTGCAGGCCGGAGCGCACTGCCTGGAGAAGGCGCGCGGCGGCATGGGCGTGCTGCTG
GGCGGCGTGGCGGGCGTGGAGCCGGCCAAGATCGTGATCCTCGGTGGCGGCGTGGTGGGCAGCAACGCGGCGCAGATCGC
CGTGGGCACCGGCGCCCACGTAGTGGTGATCGACCGCAATATCGACGTGCTGCGCCGCATGGACCGTCTGCTCGGCGCCC
GTGTGACGACGGTCTACTCCAACCAGGACAACGTCGAACGCCACGTGCTGTCGGCCGATCTCGTCATCGGCGGCGTGCTG
ATTCCTGGCGCGGCCGCGCCCAAGCTGGTCACGGCCGGCATGGTGGACGCGATGAAGCCGGGGTCGGTCATCGTGGATGT
GGCGATCGACCAGGGCGGCTGCTGCGAGACGGCAAAGGCGACGACACATGCGGAACCGACCTATCTGGTCGGCCAGGTGC
TGCACTACTGCGTCGCGAATATGCCCGGCGCGGTGCCGCGTACCTCGACCTACGCACTCAACAACGCCACGCTGCCATTC
GCGCTGCAGATCGCGGACAAAGGCTGGAAGGCGGCATTGGCGGACAACCCGCATCTTGCCAACGGCCTGAACGTGGCGTT
CGGCAAGGTGACATGCAAGGAGGTCGCGCACGATCTTGGCTATGAATGCCACGATGCTGCGAAACTGCTGGCGCATTGA

Upstream 100 bases:

>100_bases
GCAATGAAGAGCTTCTGCAATACCAAGACCTACTCGCTGCCCTGGTAAGACAGCAGCGCCACCGTACCGGATTTGCATAC
CATTCAAACAGGAGACAGCA

Downstream 100 bases:

>100_bases
GTGGGTGGCGAACGAATCGGTCCCTGTGAGGAGATCGCGTCCCGCCATGTCCGGCGGGACGGTTCGCCACGCGCGCATTA
GCGCGCGAACTGGCTCAGCA

Product: L-alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRIGVPKEIKNHEYRVGLTPSSVREMTAHGHHVLVQTTAGAGIGASDADYRKAGATIVDTAQEIFAKAEMIVKVKEPQAN
ERAMLREGQILYTYLHLAPDPDQCADLVRSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAGAHCLEKARGGMGVLL
GGVAGVEPAKIVILGGGVVGSNAAQIAVGTGAHVVVIDRNIDVLRRMDRLLGARVTTVYSNQDNVERHVLSADLVIGGVL
IPGAAAPKLVTAGMVDAMKPGSVIVDVAIDQGGCCETAKATTHAEPTYLVGQVLHYCVANMPGAVPRTSTYALNNATLPF
ALQIADKGWKAALADNPHLANGLNVAFGKVTCKEVAHDLGYECHDAAKLLAH

Sequences:

>Translated_372_residues
MRIGVPKEIKNHEYRVGLTPSSVREMTAHGHHVLVQTTAGAGIGASDADYRKAGATIVDTAQEIFAKAEMIVKVKEPQAN
ERAMLREGQILYTYLHLAPDPDQCADLVRSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAGAHCLEKARGGMGVLL
GGVAGVEPAKIVILGGGVVGSNAAQIAVGTGAHVVVIDRNIDVLRRMDRLLGARVTTVYSNQDNVERHVLSADLVIGGVL
IPGAAAPKLVTAGMVDAMKPGSVIVDVAIDQGGCCETAKATTHAEPTYLVGQVLHYCVANMPGAVPRTSTYALNNATLPF
ALQIADKGWKAALADNPHLANGLNVAFGKVTCKEVAHDLGYECHDAAKLLAH
>Mature_372_residues
MRIGVPKEIKNHEYRVGLTPSSVREMTAHGHHVLVQTTAGAGIGASDADYRKAGATIVDTAQEIFAKAEMIVKVKEPQAN
ERAMLREGQILYTYLHLAPDPDQCADLVRSGAVCIAYETVTQAGGGLPLLAPMSEVAGRMSVQAGAHCLEKARGGMGVLL
GGVAGVEPAKIVILGGGVVGSNAAQIAVGTGAHVVVIDRNIDVLRRMDRLLGARVTTVYSNQDNVERHVLSADLVIGGVL
IPGAAAPKLVTAGMVDAMKPGSVIVDVAIDQGGCCETAKATTHAEPTYLVGQVLHYCVANMPGAVPRTSTYALNNATLPF
ALQIADKGWKAALADNPHLANGLNVAFGKVTCKEVAHDLGYECHDAAKLLAH

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=29.971181556196, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=29.971181556196, Blast_Score=118, Evalue=8e-27,
Organism=Escherichia coli, GI1787887, Length=299, Percent_Identity=30.4347826086957, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550456, Length=353, Percent_Identity=28.8951841359773, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38766; Mature: 38766

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVPKEIKNHEYRVGLTPSSVREMTAHGHHVLVQTTAGAGIGASDADYRKAGATIVDT
CCCCCCCHHCCCCEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCCCHHHHH
AQEIFAKAEMIVKVKEPQANERAMLREGQILYTYLHLAPDPDQCADLVRSGAVCIAYETV
HHHHHHHHEEEEEECCCCCCCHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCEEEEEEHH
TQAGGGLPLLAPMSEVAGRMSVQAGAHCLEKARGGMGVLLGGVAGVEPAKIVILGGGVVG
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEECCEEC
SNAAQIAVGTGAHVVVIDRNIDVLRRMDRLLGARVTTVYSNQDNVERHVLSADLVIGGVL
CCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHEEEEEE
IPGAAAPKLVTAGMVDAMKPGSVIVDVAIDQGGCCETAKATTHAEPTYLVGQVLHYCVAN
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MPGAVPRTSTYALNNATLPFALQIADKGWKAALADNPHLANGLNVAFGKVTCKEVAHDLG
CCCCCCCCCEEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHCC
YECHDAAKLLAH
CCHHHHHHHHCC
>Mature Secondary Structure
MRIGVPKEIKNHEYRVGLTPSSVREMTAHGHHVLVQTTAGAGIGASDADYRKAGATIVDT
CCCCCCCHHCCCCEEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHCCCHHHHH
AQEIFAKAEMIVKVKEPQANERAMLREGQILYTYLHLAPDPDQCADLVRSGAVCIAYETV
HHHHHHHHEEEEEECCCCCCCHHHHHCCCEEEEEEEECCCHHHHHHHHHCCCEEEEEEHH
TQAGGGLPLLAPMSEVAGRMSVQAGAHCLEKARGGMGVLLGGVAGVEPAKIVILGGGVVG
HHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEEEECCEEC
SNAAQIAVGTGAHVVVIDRNIDVLRRMDRLLGARVTTVYSNQDNVERHVLSADLVIGGVL
CCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHEEEEEE
IPGAAAPKLVTAGMVDAMKPGSVIVDVAIDQGGCCETAKATTHAEPTYLVGQVLHYCVAN
CCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHC
MPGAVPRTSTYALNNATLPFALQIADKGWKAALADNPHLANGLNVAFGKVTCKEVAHDLG
CCCCCCCCCEEEECCCCCEEEEEEECCCCEEEECCCCCCCCCCEEEECCHHHHHHHHHCC
YECHDAAKLLAH
CCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]