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The map label for this gene is ldh [H]

Identifier: 73539636

GI number: 73539636

Start: 2642083

End: 2643180

Strand: Direct

Name: ldh [H]

Synonym: Reut_B5816

Alternate gene names: 73539636

Gene position: 2642083-2643180 (Clockwise)

Preceding gene: 73539635

Following gene: 73539639

Centisome position: 96.92

GC content: 66.94

Gene sequence:

>1098_bases
ATGGAGAAGAAGTTGAACGACTGTACCCACGCAGCGGCCGCTGTCCGCCTGTTCGGCACCGGCGAAGGCCTGTCTCACGA
GCGCGTGACGCTCGCCACCGATCCGGAATCCGGCCTGCAGGCCATCATCGCGATCTACAACACCAGACTCGGTCCTGCCT
TCGGCGGCTGCCGGTACTGGACCTATGCAGCCGAGACCGAGGCGCTGTCCGACGCCCTGCGCCTGTCGCAGGGCATGGCC
TACAAGAACGCCCTCGCCGGGCTCCCGTTCGGCGGCGGCAAGGCGGTGATCCTGCGCTCGCCTGCGCAGACAGACCGCGA
ACAACTCTTCCGCGCTTTCGGCCGCATGGTCGAGTCACTGCGCGGCAGCTATATCACGGCTGAAGATGTGGGTACGACGG
TGGACGACATGCGCGCTGTCCAGGCCGAGACCCGCTATGTCAGCGGCATGCCGCGCGACGGCGGATTCGGTGGCAACCCT
TCGCCGTGGACGGCTTACGGCGTGTTCGTCGGTATTCAAGCGGCGGCGCAGTACCGCCTGGACCGCAAGTCGCTCACCGG
CCTGTCTGTGGCGGTTCAGGGTCTGGGGTCGGTAGGCTGGGAACTCTGCCGCCGCCTCCATGAAGCGGGCGCCATCCTGA
CCGTGGCCGATATCGACGCAGGGCGCACGACGCGGGCGCAACAGCAATTTGGCGCACGCGTCGTATCGCCGGAAGCCATT
ACGGCAGTGGATGCCGACATATTCGCGCCCTGCGCGCTGGGTGCCGTCATCACCGCGGCCGTGGCCGAAAACTGCCGCTT
CCAGATCATCGCCGGCGGCGCAAACAACCAACTTGCCTCGCTGGCCGAGGGCGACACCCTGCATCAGCGCGGCGTCTTCT
ATGCGCCCGATTTCTTGATCAATGCCGGCGGCATCGTAAGTTGCGCGCGGGAGTACCTCGGTGGCGTCGACGATTCCGCC
CTGCGCGACGAAGTCGCTGGTATCCGCGATCGTGTACTCGGACTGGCGCAGCGCGTGGAGTCGACGCGCCAGGCGCCCGC
ACGCGCGGCAGTGACATGGGCGCACGAGGTGTTGTCGCGCGGCATCGCGCCGAACTGA

Upstream 100 bases:

>100_bases
CGGACGCGATGGGGCTCCGCGCCCTGTCAAAGCCGCACCGCACTGCGACCCAGGCGGTGTGCCAAGGAAGGCAGAGCTAC
AGCTTTGCATTCCCCACGTC

Downstream 100 bases:

>100_bases
GCGGTCACCCCCACACGGAGAAAGCTAGCGCTGTTTGATCTCAGCGAGGAGCCTTCGCGCCGTACCTATATCGGCGAGGT
TGCCGCCCTCCATGATGCTG

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MEKKLNDCTHAAAAVRLFGTGEGLSHERVTLATDPESGLQAIIAIYNTRLGPAFGGCRYWTYAAETEALSDALRLSQGMA
YKNALAGLPFGGGKAVILRSPAQTDREQLFRAFGRMVESLRGSYITAEDVGTTVDDMRAVQAETRYVSGMPRDGGFGGNP
SPWTAYGVFVGIQAAAQYRLDRKSLTGLSVAVQGLGSVGWELCRRLHEAGAILTVADIDAGRTTRAQQQFGARVVSPEAI
TAVDADIFAPCALGAVITAAVAENCRFQIIAGGANNQLASLAEGDTLHQRGVFYAPDFLINAGGIVSCAREYLGGVDDSA
LRDEVAGIRDRVLGLAQRVESTRQAPARAAVTWAHEVLSRGIAPN

Sequences:

>Translated_365_residues
MEKKLNDCTHAAAAVRLFGTGEGLSHERVTLATDPESGLQAIIAIYNTRLGPAFGGCRYWTYAAETEALSDALRLSQGMA
YKNALAGLPFGGGKAVILRSPAQTDREQLFRAFGRMVESLRGSYITAEDVGTTVDDMRAVQAETRYVSGMPRDGGFGGNP
SPWTAYGVFVGIQAAAQYRLDRKSLTGLSVAVQGLGSVGWELCRRLHEAGAILTVADIDAGRTTRAQQQFGARVVSPEAI
TAVDADIFAPCALGAVITAAVAENCRFQIIAGGANNQLASLAEGDTLHQRGVFYAPDFLINAGGIVSCAREYLGGVDDSA
LRDEVAGIRDRVLGLAQRVESTRQAPARAAVTWAHEVLSRGIAPN
>Mature_365_residues
MEKKLNDCTHAAAAVRLFGTGEGLSHERVTLATDPESGLQAIIAIYNTRLGPAFGGCRYWTYAAETEALSDALRLSQGMA
YKNALAGLPFGGGKAVILRSPAQTDREQLFRAFGRMVESLRGSYITAEDVGTTVDDMRAVQAETRYVSGMPRDGGFGGNP
SPWTAYGVFVGIQAAAQYRLDRKSLTGLSVAVQGLGSVGWELCRRLHEAGAILTVADIDAGRTTRAQQQFGARVVSPEAI
TAVDADIFAPCALGAVITAAVAENCRFQIIAGGANNQLASLAEGDTLHQRGVFYAPDFLINAGGIVSCAREYLGGVDDSA
LRDEVAGIRDRVLGLAQRVESTRQAPARAAVTWAHEVLSRGIAPN

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids. Catalyzes the reversible deamination of these branched-chain L-amino acids to their oxo analogs [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=310, Percent_Identity=27.4193548387097, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4885281, Length=310, Percent_Identity=26.7741935483871, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24649283, Length=308, Percent_Identity=25.6493506493506, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549226, Length=320, Percent_Identity=27.5, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553475, Length=320, Percent_Identity=27.5, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 38621; Mature: 38621

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKLNDCTHAAAAVRLFGTGEGLSHERVTLATDPESGLQAIIAIYNTRLGPAFGGCRYW
CCCCHHHHHHHHHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEE
TYAAETEALSDALRLSQGMAYKNALAGLPFGGGKAVILRSPAQTDREQLFRAFGRMVESL
EEHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RGSYITAEDVGTTVDDMRAVQAETRYVSGMPRDGGFGGNPSPWTAYGVFVGIQAAAQYRL
CCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DRKSLTGLSVAVQGLGSVGWELCRRLHEAGAILTVADIDAGRTTRAQQQFGARVVSPEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEECCCHHH
TAVDADIFAPCALGAVITAAVAENCRFQIIAGGANNQLASLAEGDTLHQRGVFYAPDFLI
HHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHCCCEECCHHHC
NAGGIVSCAREYLGGVDDSALRDEVAGIRDRVLGLAQRVESTRQAPARAAVTWAHEVLSR
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GIAPN
CCCCC
>Mature Secondary Structure
MEKKLNDCTHAAAAVRLFGTGEGLSHERVTLATDPESGLQAIIAIYNTRLGPAFGGCRYW
CCCCHHHHHHHHHHHEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEEE
TYAAETEALSDALRLSQGMAYKNALAGLPFGGGKAVILRSPAQTDREQLFRAFGRMVESL
EEHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
RGSYITAEDVGTTVDDMRAVQAETRYVSGMPRDGGFGGNPSPWTAYGVFVGIQAAAQYRL
CCCEEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
DRKSLTGLSVAVQGLGSVGWELCRRLHEAGAILTVADIDAGRTTRAQQQFGARVVSPEAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEECCCHHH
TAVDADIFAPCALGAVITAAVAENCRFQIIAGGANNQLASLAEGDTLHQRGVFYAPDFLI
HHHCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCHHHCCCEECCHHHC
NAGGIVSCAREYLGGVDDSALRDEVAGIRDRVLGLAQRVESTRQAPARAAVTWAHEVLSR
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHC
GIAPN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020469 [H]