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The map label for this gene is adh [H]

Identifier: 73539603

GI number: 73539603

Start: 2607374

End: 2608477

Strand: Direct

Name: adh [H]

Synonym: Reut_B5783

Alternate gene names: 73539603

Gene position: 2607374-2608477 (Clockwise)

Preceding gene: 73539602

Following gene: 73539604

Centisome position: 95.64

GC content: 64.67

Gene sequence:

>1104_bases
ATGACAAGGAAAGTACTCGCGGCAGTCAAGACTGGTGTCGAGACGACCGAGCTGAGGGAGTTCGACTACCCACTAGTGCA
GCCGGACTCAGGCATCCTCAAGGTCGAGGCTAGCGGCGTTGGCGGCAGCGATCCGGAGCTGTATCGCAAGTCCGAGCACG
CTCCTGTCATCATGGGGCACGAGAATGTCGGCACCATCGTCGAGCTTGGCCCCATTGCGCAGCAACGCTGGGGCGTGAAG
GCCGGCGACCGCGTGGCGCTGCACGAATACCTGCCGTGCTGGCACTGTGAATGGTGCATGAAGGGCGACTTCCGACTGTG
CATGGAGGTGGACTTCTTCAATGTGAAGGACCGGCTCAACACGCTGCGTTTCGGCATGTCGACCTGCACCATTGCACCGC
ACCTGTGGGGTGGCTACGCGCAGTACATGCACTTGCCGCTGAATACGGTCATGCACGTGATCCCGCCCGATATGCCCGCC
GTCCACGCCACCCTCGCGGTGCCGTTCGGCAACGGCGTGCAGTGGGCATGCAATGACGGCGGCGCCGGGCCCGGCAAGAC
AGTGCTGGTATTCGGTCCCGGACAGCAGGGACTGGGTTGCGTGCTGGCGGCCAAGGCCGCAGGGTCCCTGATGGTGATCC
TCGCCGGCATGACCCGCGATCGCAGCCGGCTCGACCTGTCGCTGCGCCTCGGTGCGGACCATGCCATCGACGTGCAGAAC
CAGGATCTCCATGCCGAAGTCATGCGCCTGACCAATGGTCGCGGCGTCGACGTGGTGGTGGATACCACTGGCGATCCGAC
CGGCGAAGTGGCGCAGCTTGCCATTGGCCTGGCTGCCAAGGGCGCGTACCTGAGCCTGAACGGCCTGGCGCAGAGCGTAC
CGATCGGCGAGATCAAGAAGCGCTACCTGACCGTGCGTGCTCCGCGCGGGCGCAGCTACGCGGCGGTGGAACTCGCCTTG
CGCTACATCGGCTCAGGCCGCTATCCGCTCGATGAAGTGTGTTCGCATACCTTCGGGTTGGCACAGACGCACGAGGCGAT
CCTTGCCACTGCCGGTCGCGGCGTGGAGGGCGCCGTCCACGTTACGGTGGATCCTTGGAAGTGA

Upstream 100 bases:

>100_bases
CTGGCGCTAGTGCGCGAATGCCTCCTCGACCATCCGGCAGTGGTTCGCGAGGCCATCCTTGGCGATACCGCGCGCCGTAT
ATTTTGGAAGGAGATTTGAT

Downstream 100 bases:

>100_bases
ACGGCTCGCGCTCCTCTCGAGGTTGAGCGAGCGGAGCGCAAGGCGTCAGACATCACTTCACTTCATTACTTACAGGAGAC
AAAGTCAATGATCGACAGTC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTRKVLAAVKTGVETTELREFDYPLVQPDSGILKVEASGVGGSDPELYRKSEHAPVIMGHENVGTIVELGPIAQQRWGVK
AGDRVALHEYLPCWHCEWCMKGDFRLCMEVDFFNVKDRLNTLRFGMSTCTIAPHLWGGYAQYMHLPLNTVMHVIPPDMPA
VHATLAVPFGNGVQWACNDGGAGPGKTVLVFGPGQQGLGCVLAAKAAGSLMVILAGMTRDRSRLDLSLRLGADHAIDVQN
QDLHAEVMRLTNGRGVDVVVDTTGDPTGEVAQLAIGLAAKGAYLSLNGLAQSVPIGEIKKRYLTVRAPRGRSYAAVELAL
RYIGSGRYPLDEVCSHTFGLAQTHEAILATAGRGVEGAVHVTVDPWK

Sequences:

>Translated_367_residues
MTRKVLAAVKTGVETTELREFDYPLVQPDSGILKVEASGVGGSDPELYRKSEHAPVIMGHENVGTIVELGPIAQQRWGVK
AGDRVALHEYLPCWHCEWCMKGDFRLCMEVDFFNVKDRLNTLRFGMSTCTIAPHLWGGYAQYMHLPLNTVMHVIPPDMPA
VHATLAVPFGNGVQWACNDGGAGPGKTVLVFGPGQQGLGCVLAAKAAGSLMVILAGMTRDRSRLDLSLRLGADHAIDVQN
QDLHAEVMRLTNGRGVDVVVDTTGDPTGEVAQLAIGLAAKGAYLSLNGLAQSVPIGEIKKRYLTVRAPRGRSYAAVELAL
RYIGSGRYPLDEVCSHTFGLAQTHEAILATAGRGVEGAVHVTVDPWK
>Mature_366_residues
TRKVLAAVKTGVETTELREFDYPLVQPDSGILKVEASGVGGSDPELYRKSEHAPVIMGHENVGTIVELGPIAQQRWGVKA
GDRVALHEYLPCWHCEWCMKGDFRLCMEVDFFNVKDRLNTLRFGMSTCTIAPHLWGGYAQYMHLPLNTVMHVIPPDMPAV
HATLAVPFGNGVQWACNDGGAGPGKTVLVFGPGQQGLGCVLAAKAAGSLMVILAGMTRDRSRLDLSLRLGADHAIDVQNQ
DLHAEVMRLTNGRGVDVVVDTTGDPTGEVAQLAIGLAAKGAYLSLNGLAQSVPIGEIKKRYLTVRAPRGRSYAAVELALR
YIGSGRYPLDEVCSHTFGLAQTHEAILATAGRGVEGAVHVTVDPWK

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501929, Length=328, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI34577061, Length=217, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4501933, Length=241, Percent_Identity=27.8008298755187, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788073, Length=350, Percent_Identity=24.5714285714286, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790045, Length=316, Percent_Identity=24.3670886075949, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788407, Length=283, Percent_Identity=26.5017667844523, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788075, Length=376, Percent_Identity=22.8723404255319, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI226510992, Length=343, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787863, Length=325, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=250, Percent_Identity=25.2, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=363, Percent_Identity=27.8236914600551, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=360, Percent_Identity=24.4444444444444, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=333, Percent_Identity=23.7237237237237, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=333, Percent_Identity=23.7237237237237, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17737897, Length=375, Percent_Identity=25.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137530, Length=385, Percent_Identity=26.4935064935065, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39470; Mature: 39339

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKVLAAVKTGVETTELREFDYPLVQPDSGILKVEASGVGGSDPELYRKSEHAPVIMGH
CCHHHHHHHHCCCCHHHHHHCCCCEECCCCCEEEEEECCCCCCCHHHHHCCCCCCEEEEC
ENVGTIVELGPIAQQRWGVKAGDRVALHEYLPCWHCEWCMKGDFRLCMEVDFFNVKDRLN
CCCCCEEEECCCHHHHCCCCCCCEEEHHHCCCCEEEHHEECCCEEEEEEEEEECHHHHHH
TLRFGMSTCTIAPHLWGGYAQYMHLPLNTVMHVIPPDMPAVHATLAVPFGNGVQWACNDG
HHHHCCHHEEECCHHCCCHHHHEECCHHHHHEECCCCCCCEEEEEEEECCCCEEEEECCC
GAGPGKTVLVFGPGQQGLGCVLAAKAAGSLMVILAGMTRDRSRLDLSLRLGADHAIDVQN
CCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCEEEECCC
QDLHAEVMRLTNGRGVDVVVDTTGDPTGEVAQLAIGLAAKGAYLSLNGLAQSVPIGEIKK
CCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHCE
RYLTVRAPRGRSYAAVELALRYIGSGRYPLDEVCSHTFGLAQTHEAILATAGRGVEGAVH
EEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEE
VTVDPWK
EEECCCC
>Mature Secondary Structure 
TRKVLAAVKTGVETTELREFDYPLVQPDSGILKVEASGVGGSDPELYRKSEHAPVIMGH
CHHHHHHHHCCCCHHHHHHCCCCEECCCCCEEEEEECCCCCCCHHHHHCCCCCCEEEEC
ENVGTIVELGPIAQQRWGVKAGDRVALHEYLPCWHCEWCMKGDFRLCMEVDFFNVKDRLN
CCCCCEEEECCCHHHHCCCCCCCEEEHHHCCCCEEEHHEECCCEEEEEEEEEECHHHHHH
TLRFGMSTCTIAPHLWGGYAQYMHLPLNTVMHVIPPDMPAVHATLAVPFGNGVQWACNDG
HHHHCCHHEEECCHHCCCHHHHEECCHHHHHEECCCCCCCEEEEEEEECCCCEEEEECCC
GAGPGKTVLVFGPGQQGLGCVLAAKAAGSLMVILAGMTRDRSRLDLSLRLGADHAIDVQN
CCCCCCEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCEEEECCC
QDLHAEVMRLTNGRGVDVVVDTTGDPTGEVAQLAIGLAAKGAYLSLNGLAQSVPIGEIKK
CCHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHCE
RYLTVRAPRGRSYAAVELALRYIGSGRYPLDEVCSHTFGLAQTHEAILATAGRGVEGAVH
EEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEE
VTVDPWK
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]