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The map label for this gene is hsaA [H]

Identifier: 73539599

GI number: 73539599

Start: 2603704

End: 2604921

Strand: Direct

Name: hsaA [H]

Synonym: Reut_B5779

Alternate gene names: 73539599

Gene position: 2603704-2604921 (Clockwise)

Preceding gene: 73539598

Following gene: 73539600

Centisome position: 95.51

GC content: 66.17

Gene sequence:

>1218_bases
GTGAGCACATCCCCCTTGGCAACCGCTTCCGGTAGCCTCCCCGTACTGGCCAGCCACGATGCCGCGATTGCCGCGGCGCG
TGCGCTGCACGACAAGATCCGCGCGCGCGCCGACCGTACCGAAAGCGAGCGCATCGTATCTGCCGAGACCATCCGCGAGC
TGATGGAAGCCGGCCTGTTCGGCGTCGTGACGCCGCGCATGTTTGGCGGTTCGGAGCTGGGCTTCGCGACGCTGGTCGAC
GTGACTGCCGAGATCGCCTCCGCGTGCGGCTCGACCGGCTGGGTCTATGGTGTCCTGGCCGGCCATAGCTGGATGCTGAA
CCTGTTCCCGCTGCAGGCGCAGCGCGAAGTGATGAGCGCCGACCGCGTGCTGACCGCGACCGTGTTCCGTCTCGGCGGCA
CCGTCACGGAAGTGGACGGCGGTTATCGGCTGGTCAACGGCGACGGCCGCTTCTGTTCCGGCATCGACCATGTCCAATGG
GTCATTGTCGGCAATGCGGTGCAGCGTGAGGGCCAACCGCCGGAGCCGCGCTTCTTCGTGGTGCCGCGCGAGGATATCGA
GATCGTTGACGATTGGTTCACGGCAGGCATGCGCGGCACCGGTAGCCGCTCGATCCGAATCGCCGATACGTTCATCCCGG
CGCATCGCTCGGTATCGGTGAAGGACATGATGTCGGGCATGGCCGATGAAACCGGATCGGTGCGCGCACCGATCTACCGG
ATGCCGTTCCAGAACGTCACGCCGTTTTCGCTCGTGGGCGCGCCACTAGGCATGGCCCGTGCGGCGGTGCGGTCATTCTC
CGACGGGCTGGCGGCGCGCCTGGCCACGTTCAGCAGTGAACAGGCAGCCGAGCAATCGGCCACGTTCGCACGGGTGGCGG
AATCGGTGGCCGAGATCGACGCGGCGCTGGCCGTGGTGCGCGAGGATGCGCGACGTGTAGACAGTGCGGACGATCCGCGC
TCGATCAGCGACCTGGACTGGGCACGCATTCCACGCGATTGGGCCTATGCCGCGCAGAAGGCGCGCTACGCGGTAAACGC
GCTGTTCGAAGCAGCCGGCGGGTCCGGTATCTACAACAGTTCCGAGTTGCAGAGAATCTGGCGCGACGTAAATTCCGCCG
CCCAGCACTTCGCCTTTACGTGGGACAGCGCCATGACCAGCTACGGACGTGCGGTCATTGGCCTGCAGCCCTCGAAATTC
GGCCCGAAGGGCCGGTAA

Upstream 100 bases:

>100_bases
GCCGCCCCGGCCGAACCATTCAGAAACGACGAACCATGCCTCGCCGCGGCGTCACCGGCGCGCGGCGCGGAGGCGTACGT
CCTCACAAAGGAGACAAGAC

Downstream 100 bases:

>100_bases
CGGCGCGCCGAGTGGAAAGCCCCATGCATGCCGATGAACTGACTTCCATCGACGACTACTCGGCCGCCACGCTGTCGTCG
ATCTGCGAGCGGATGGCGGT

Product: hypothetical protein

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSTSPLATASGSLPVLASHDAAIAAARALHDKIRARADRTESERIVSAETIRELMEAGLFGVVTPRMFGGSELGFATLVD
VTAEIASACGSTGWVYGVLAGHSWMLNLFPLQAQREVMSADRVLTATVFRLGGTVTEVDGGYRLVNGDGRFCSGIDHVQW
VIVGNAVQREGQPPEPRFFVVPREDIEIVDDWFTAGMRGTGSRSIRIADTFIPAHRSVSVKDMMSGMADETGSVRAPIYR
MPFQNVTPFSLVGAPLGMARAAVRSFSDGLAARLATFSSEQAAEQSATFARVAESVAEIDAALAVVREDARRVDSADDPR
SISDLDWARIPRDWAYAAQKARYAVNALFEAAGGSGIYNSSELQRIWRDVNSAAQHFAFTWDSAMTSYGRAVIGLQPSKF
GPKGR

Sequences:

>Translated_405_residues
MSTSPLATASGSLPVLASHDAAIAAARALHDKIRARADRTESERIVSAETIRELMEAGLFGVVTPRMFGGSELGFATLVD
VTAEIASACGSTGWVYGVLAGHSWMLNLFPLQAQREVMSADRVLTATVFRLGGTVTEVDGGYRLVNGDGRFCSGIDHVQW
VIVGNAVQREGQPPEPRFFVVPREDIEIVDDWFTAGMRGTGSRSIRIADTFIPAHRSVSVKDMMSGMADETGSVRAPIYR
MPFQNVTPFSLVGAPLGMARAAVRSFSDGLAARLATFSSEQAAEQSATFARVAESVAEIDAALAVVREDARRVDSADDPR
SISDLDWARIPRDWAYAAQKARYAVNALFEAAGGSGIYNSSELQRIWRDVNSAAQHFAFTWDSAMTSYGRAVIGLQPSKF
GPKGR
>Mature_404_residues
STSPLATASGSLPVLASHDAAIAAARALHDKIRARADRTESERIVSAETIRELMEAGLFGVVTPRMFGGSELGFATLVDV
TAEIASACGSTGWVYGVLAGHSWMLNLFPLQAQREVMSADRVLTATVFRLGGTVTEVDGGYRLVNGDGRFCSGIDHVQWV
IVGNAVQREGQPPEPRFFVVPREDIEIVDDWFTAGMRGTGSRSIRIADTFIPAHRSVSVKDMMSGMADETGSVRAPIYRM
PFQNVTPFSLVGAPLGMARAAVRSFSDGLAARLATFSSEQAAEQSATFARVAESVAEIDAALAVVREDARRVDSADDPRS
ISDLDWARIPRDWAYAAQKARYAVNALFEAAGGSGIYNSSELQRIWRDVNSAAQHFAFTWDSAMTSYGRAVIGLQPSKFG
PKGR

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43617; Mature: 43485

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPLATASGSLPVLASHDAAIAAARALHDKIRARADRTESERIVSAETIRELMEAGLF
CCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GVVTPRMFGGSELGFATLVDVTAEIASACGSTGWVYGVLAGHSWMLNLFPLQAQREVMSA
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHCCCEEEEEECCHHHHHHHHH
DRVLTATVFRLGGTVTEVDGGYRLVNGDGRFCSGIDHVQWVIVGNAVQREGQPPEPRFFV
HHHHHHHHHHHCCEEEEECCCEEEECCCCCEECCCCCEEEEEECCHHHCCCCCCCCCEEE
VPREDIEIVDDWFTAGMRGTGSRSIRIADTFIPAHRSVSVKDMMSGMADETGSVRAPIYR
ECCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEE
MPFQNVTPFSLVGAPLGMARAAVRSFSDGLAARLATFSSEQAAEQSATFARVAESVAEID
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
AALAVVREDARRVDSADDPRSISDLDWARIPRDWAYAAQKARYAVNALFEAAGGSGIYNS
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SELQRIWRDVNSAAQHFAFTWDSAMTSYGRAVIGLQPSKFGPKGR
HHHHHHHHHHHHHHHHHEEEHHHHHHHHCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
STSPLATASGSLPVLASHDAAIAAARALHDKIRARADRTESERIVSAETIRELMEAGLF
CCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GVVTPRMFGGSELGFATLVDVTAEIASACGSTGWVYGVLAGHSWMLNLFPLQAQREVMSA
EEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHCCCEEEEEECCHHHHHHHHH
DRVLTATVFRLGGTVTEVDGGYRLVNGDGRFCSGIDHVQWVIVGNAVQREGQPPEPRFFV
HHHHHHHHHHHCCEEEEECCCEEEECCCCCEECCCCCEEEEEECCHHHCCCCCCCCCEEE
VPREDIEIVDDWFTAGMRGTGSRSIRIADTFIPAHRSVSVKDMMSGMADETGSVRAPIYR
ECCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCCCEEE
MPFQNVTPFSLVGAPLGMARAAVRSFSDGLAARLATFSSEQAAEQSATFARVAESVAEID
CCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
AALAVVREDARRVDSADDPRSISDLDWARIPRDWAYAAQKARYAVNALFEAAGGSGIYNS
HHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
SELQRIWRDVNSAAQHFAFTWDSAMTSYGRAVIGLQPSKFGPKGR
HHHHHHHHHHHHHHHHHEEEHHHHHHHHCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]