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The map label for this gene is ytnA [H]

Identifier: 73538719

GI number: 73538719

Start: 1617208

End: 1618587

Strand: Direct

Name: ytnA [H]

Synonym: Reut_B4894

Alternate gene names: 73538719

Gene position: 1617208-1618587 (Clockwise)

Preceding gene: 73538718

Following gene: 73538720

Centisome position: 59.32

GC content: 64.42

Gene sequence:

>1380_bases
ATGAGTGCAAATTCGGAACATTTGCAGCGCGGGCTTGGCGAACGCCATATCCGCCTGATGGCACTGGGATCGGCCATCGG
CGTAGGGCTGTTCCTCGGCTCGGCCAATGCCATCAGGATGGCGGGGCCCGCCATCATGCTGGCCTACCTGATCGGCGGCG
CGATGATCTTCCTGATCATGCGAGCGCTGGGCGAAATGGCCGTCCACAACCCGGTGGCAGGTTCATTCTGCCGCTACGCG
CAAGACCATATGGGCCCGCTGGCCGGCTACCTGACCGGCTGGAACTACTGGTTCCTGTGGCTCGTGACCTGCGTGGCGGA
GATCACGGCCGTGGCGATCTACATGGGCGTCTGGTTCCCCGACGTGCCGCGCTGGATCTGGGCGCTTGCCGCACTGGCCA
CGATGGGCTCGGTCAACCTGCTGACGGTCAAGGCCTACGGCGAGTTCGAGTTCTGGTTCGCCATGATCAAGATCGTGACC
ATCGTGCTGATGCTGTTTGGCGGCGGCGCAATGATCGTGTTCGGGCTCGGCAACGGCGGCATCGCCACGGGTATCAGCAA
CCTGTGGGCGCACGGCGGCTTCATGCCGAACGGCGCCAGCGGCGTGCTGATGTCGCTGCAGATGGTGATGTTCGCGTACC
TCGGCGTCGAGATGATCGGCCTGACCGCCGGCGAGGCGAAGAACCCGCGCAAGTCGATTCCGGACGCGATCAATTCTGTG
TTCTGGCGCATCCTGATCTTCTACGTCGGCGCGCTGTTCGTGATCTTGTCGCTCTACCCCTGGAACGAGATTGGCGCGCA
GGGCAGCCCATTCGTGATGACGTTCGAGCGCCTGGGCATCAAGACCGCTGCCGGCATCATCAACTTCGTGGTTCTGACCG
CAGCGCTGTCGTCGTGCAACGGCGGCATCTTCAGCACGGGCCGCATGCTGTACAACCTGGCCCAGCAAGGGCAGGCGCCG
GCGGCATTCGCCAGGGTCGACCGCAACGGCGTGCCGCGCCGCGCGCTGCTGGTCTCGATCGGCGCGCTGCTGTGCGGCGT
GCTGCTGAACTACCTCGTGCCCGAAAAGGTGTTCGTGTGGGTCACGTCGATCTCGACCTTTGGCGCGATCTGGACGTGGG
CCATTATCCTCGTCACGCAGATGCAGTTCCGCAAGAACCTCTCGCCCGCTGAGCGCGACAAGCTGGCGTTCCGCATGCCG
TTCTGGCCGTATGGCTCGTGGATCGCGCTGGCCTTCCTGGCGCTGGTCATTGCGCTGATGGCTTATTTCCCGGACACGCG
CATCGCCCTGTACGTCGGCCCGGCCTGGCTGGTGCTGCTGACGGTGCTGTACTACCGCCTGGGCATGCAGGCTCGCGGCC
CGGTCACTTACCAGGCCTGA

Upstream 100 bases:

>100_bases
ACCTGGCCGCGCTCGCGTTCTGGCCGGAACGGCAAGGCTCACTGCGCCGCATCGCCCCACAAGGGCGCCGCGGCCTTCTG
ATGAACGGAGACAACGACAC

Downstream 100 bases:

>100_bases
ACGGCATTCACGGCGGGTGCGCCAGCGGACGCCCGCCGCTACAATGGCCCCCGGGCAATCCATTGCCAGGGGGCCAGATG
TCCGAACTGTACGCCGCGCC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSANSEHLQRGLGERHIRLMALGSAIGVGLFLGSANAIRMAGPAIMLAYLIGGAMIFLIMRALGEMAVHNPVAGSFCRYA
QDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGVWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFAMIKIVT
IVLMLFGGGAMIVFGLGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEAKNPRKSIPDAINSV
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAP
AAFARVDRNGVPRRALLVSIGALLCGVLLNYLVPEKVFVWVTSISTFGAIWTWAIILVTQMQFRKNLSPAERDKLAFRMP
FWPYGSWIALAFLALVIALMAYFPDTRIALYVGPAWLVLLTVLYYRLGMQARGPVTYQA

Sequences:

>Translated_459_residues
MSANSEHLQRGLGERHIRLMALGSAIGVGLFLGSANAIRMAGPAIMLAYLIGGAMIFLIMRALGEMAVHNPVAGSFCRYA
QDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGVWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFAMIKIVT
IVLMLFGGGAMIVFGLGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEAKNPRKSIPDAINSV
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAP
AAFARVDRNGVPRRALLVSIGALLCGVLLNYLVPEKVFVWVTSISTFGAIWTWAIILVTQMQFRKNLSPAERDKLAFRMP
FWPYGSWIALAFLALVIALMAYFPDTRIALYVGPAWLVLLTVLYYRLGMQARGPVTYQA
>Mature_458_residues
SANSEHLQRGLGERHIRLMALGSAIGVGLFLGSANAIRMAGPAIMLAYLIGGAMIFLIMRALGEMAVHNPVAGSFCRYAQ
DHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGVWFPDVPRWIWALAALATMGSVNLLTVKAYGEFEFWFAMIKIVTI
VLMLFGGGAMIVFGLGNGGIATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEAKNPRKSIPDAINSVF
WRILIFYVGALFVILSLYPWNEIGAQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCNGGIFSTGRMLYNLAQQGQAPA
AFARVDRNGVPRRALLVSIGALLCGVLLNYLVPEKVFVWVTSISTFGAIWTWAIILVTQMQFRKNLSPAERDKLAFRMPF
WPYGSWIALAFLALVIALMAYFPDTRIALYVGPAWLVLLTVLYYRLGMQARGPVTYQA

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=316, Percent_Identity=25.3164556962025, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4507047, Length=446, Percent_Identity=25.3363228699552, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI258614003, Length=441, Percent_Identity=22.4489795918367, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI258645169, Length=441, Percent_Identity=23.3560090702948, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI258614005, Length=441, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI114326544, Length=428, Percent_Identity=21.4953271028037, Blast_Score=65, Evalue=9e-11,
Organism=Homo sapiens, GI114326550, Length=428, Percent_Identity=21.4953271028037, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1786602, Length=439, Percent_Identity=56.2642369020501, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=50.1098901098901, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1786302, Length=443, Percent_Identity=45.823927765237, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1786789, Length=439, Percent_Identity=45.5580865603645, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1790653, Length=439, Percent_Identity=43.9635535307517, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI87081915, Length=445, Percent_Identity=42.247191011236, Blast_Score=348, Evalue=5e-97,
Organism=Escherichia coli, GI87081708, Length=450, Percent_Identity=37.7777777777778, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI1789017, Length=428, Percent_Identity=37.8504672897196, Blast_Score=306, Evalue=2e-84,
Organism=Escherichia coli, GI1788480, Length=442, Percent_Identity=36.1990950226244, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87081869, Length=192, Percent_Identity=26.0416666666667, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI2367353, Length=383, Percent_Identity=25.8485639686684, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790575, Length=280, Percent_Identity=26.0714285714286, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=23.859649122807, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=422, Percent_Identity=24.4075829383886, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17540018, Length=364, Percent_Identity=21.7032967032967, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=461, Percent_Identity=31.6702819956616, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=32.2799097065463, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324924, Length=457, Percent_Identity=32.8227571115974, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=434, Percent_Identity=33.1797235023041, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6324990, Length=448, Percent_Identity=30.8035714285714, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6321629, Length=438, Percent_Identity=30.5936073059361, Blast_Score=190, Evalue=4e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=437, Percent_Identity=31.1212814645309, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319824, Length=439, Percent_Identity=29.8405466970387, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=441, Percent_Identity=29.0249433106576, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=416, Percent_Identity=32.6923076923077, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6319543, Length=423, Percent_Identity=28.3687943262411, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320251, Length=441, Percent_Identity=27.891156462585, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=429, Percent_Identity=29.3706293706294, Blast_Score=166, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=423, Percent_Identity=27.1867612293144, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6319608, Length=439, Percent_Identity=27.5626423690205, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=422, Percent_Identity=29.1469194312796, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324981, Length=427, Percent_Identity=26.463700234192, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=507, Percent_Identity=25.2465483234714, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24667468, Length=416, Percent_Identity=25, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI221512776, Length=342, Percent_Identity=21.6374269005848, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24666159, Length=342, Percent_Identity=21.6374269005848, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI161077963, Length=383, Percent_Identity=23.7597911227154, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281366235, Length=343, Percent_Identity=23.6151603498542, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI116007820, Length=343, Percent_Identity=23.6151603498542, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50082; Mature: 49951

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANSEHLQRGLGERHIRLMALGSAIGVGLFLGSANAIRMAGPAIMLAYLIGGAMIFLIM
CCCCHHHHHHCCCHHHHHHEEHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RALGEMAVHNPVAGSFCRYAQDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGVWFP
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPRWIWALAALATMGSVNLLTVKAYGEFEFWFAMIKIVTIVLMLFGGGAMIVFGLGNGG
CHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
IATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEAKNPRKSIPDAINSV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHH
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHCC
GGIFSTGRMLYNLAQQGQAPAAFARVDRNGVPRRALLVSIGALLCGVLLNYLVPEKVFVW
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VTSISTFGAIWTWAIILVTQMQFRKNLSPAERDKLAFRMPFWPYGSWIALAFLALVIALM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHH
AYFPDTRIALYVGPAWLVLLTVLYYRLGMQARGPVTYQA
HHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SANSEHLQRGLGERHIRLMALGSAIGVGLFLGSANAIRMAGPAIMLAYLIGGAMIFLIM
CCCHHHHHHCCCHHHHHHEEHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHH
RALGEMAVHNPVAGSFCRYAQDHMGPLAGYLTGWNYWFLWLVTCVAEITAVAIYMGVWFP
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DVPRWIWALAALATMGSVNLLTVKAYGEFEFWFAMIKIVTIVLMLFGGGAMIVFGLGNGG
CHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
IATGISNLWAHGGFMPNGASGVLMSLQMVMFAYLGVEMIGLTAGEAKNPRKSIPDAINSV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHH
FWRILIFYVGALFVILSLYPWNEIGAQGSPFVMTFERLGIKTAAGIINFVVLTAALSSCN
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHCC
GGIFSTGRMLYNLAQQGQAPAAFARVDRNGVPRRALLVSIGALLCGVLLNYLVPEKVFVW
CCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VTSISTFGAIWTWAIILVTQMQFRKNLSPAERDKLAFRMPFWPYGSWIALAFLALVIALM
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHH
AYFPDTRIALYVGPAWLVLLTVLYYRLGMQARGPVTYQA
HHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]