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The map label for this gene is tdcB [H]

Identifier: 73538177

GI number: 73538177

Start: 1007302

End: 1008270

Strand: Direct

Name: tdcB [H]

Synonym: Reut_B4347

Alternate gene names: 73538177

Gene position: 1007302-1008270 (Clockwise)

Preceding gene: 73538172

Following gene: 73538180

Centisome position: 36.95

GC content: 63.57

Gene sequence:

>969_bases
ATGACCGAACTGAAGCTACCAACGTACGCAGACGTCCAGGAAGCCGCGAAGCGCCTTGATGGCGTTGCCAACCGCACGCC
GGTCAATACGTCGCGCACGCTCAATGACATGCTCGGCGCCGAAGTCTTCTTCAAATGCGAGAATTTCCAGCGCATGGGAG
CGTTCAAGTTCCGCGGCGCGTACAACGCGCTGGCGAAGTTCAGCCCCGCGCAACGCCGAGCGGGTGTGGTGGCGTTCTCG
TCGGGCAACCATGCGCAGGGCATCGCGCTGTCGGCAAAGCTGCTTGGCATTCCCGCCACCATCGTGATGCCGCACGACGC
ACCGGCGGCCAAGGTCGCGGCCACCAAAGGCTACGGCGCCAATGTCGTGATCTACGACCGCTACACCGAGGACCGCGAAG
CCATCGGGCGCCGCCTGGCCGACGAACACGGCTTCACGCTGATTCCGCCCTATGACCATCCGGACGTCCTGTCCGGCCAG
GGCACGGCAGCAAAGGAACTGTTCGAGGCGGTCGGCGCACTGGACGTCGTGCTGACGCCGCTCGGCGGCGGTGGATTGCT
ATCCGGCACCGCACTGACCACACGCGCGCTGTCGCCGCAATGCAAGCTCTTTGGCGTCGAACCTGAAGCCGGCAACGATG
GACAGCAGTCGTTCCGCAGCGGCGCCATCGTGCACATCGATACCCCGAAGACCATTGCGGACGGCGCCCAGACGCAGCAT
CTCGGGCAGTACACGTTCAGCATCATCAAGCGGGACGTCGACGATATCCTGACGGCGTCCGATGCCCAACTGGTGGAAGC
GATGAAGTTCTACGCCACACGCATGAAGATGATCGTCGAGCCCACGGGCTGCCTAGGCCTGGCCGCCGCCATGCATATGA
AGGATGCGCTGAAGGGCAAGCGCATCGGCATCATCATCAGCGGCGGCAATATCGACCTGGAGCGGTTCTGCGAACTGGTG
TCGGCGTAA

Upstream 100 bases:

>100_bases
TGCCTCGCAAACGCCGCTTGCGCGCCCATGGCGCTGCAATTCAGCGCATCTCCGACAGGCCTGTAGGATATCGGTCTCAT
CCCACGCAACAGGACAGCCG

Downstream 100 bases:

>100_bases
ATGCAGGCGGCCTGCCCAAGAGCCGCCTGTGCGCGGATCTGCCAGATGGTCGGAACACCGGCCGCCAGCGTGACGCGCTC
ATCGCGCAGCAGGTCATAGA

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTELKLPTYADVQEAAKRLDGVANRTPVNTSRTLNDMLGAEVFFKCENFQRMGAFKFRGAYNALAKFSPAQRRAGVVAFS
SGNHAQGIALSAKLLGIPATIVMPHDAPAAKVAATKGYGANVVIYDRYTEDREAIGRRLADEHGFTLIPPYDHPDVLSGQ
GTAAKELFEAVGALDVVLTPLGGGGLLSGTALTTRALSPQCKLFGVEPEAGNDGQQSFRSGAIVHIDTPKTIADGAQTQH
LGQYTFSIIKRDVDDILTASDAQLVEAMKFYATRMKMIVEPTGCLGLAAAMHMKDALKGKRIGIIISGGNIDLERFCELV
SA

Sequences:

>Translated_322_residues
MTELKLPTYADVQEAAKRLDGVANRTPVNTSRTLNDMLGAEVFFKCENFQRMGAFKFRGAYNALAKFSPAQRRAGVVAFS
SGNHAQGIALSAKLLGIPATIVMPHDAPAAKVAATKGYGANVVIYDRYTEDREAIGRRLADEHGFTLIPPYDHPDVLSGQ
GTAAKELFEAVGALDVVLTPLGGGGLLSGTALTTRALSPQCKLFGVEPEAGNDGQQSFRSGAIVHIDTPKTIADGAQTQH
LGQYTFSIIKRDVDDILTASDAQLVEAMKFYATRMKMIVEPTGCLGLAAAMHMKDALKGKRIGIIISGGNIDLERFCELV
SA
>Mature_321_residues
TELKLPTYADVQEAAKRLDGVANRTPVNTSRTLNDMLGAEVFFKCENFQRMGAFKFRGAYNALAKFSPAQRRAGVVAFSS
GNHAQGIALSAKLLGIPATIVMPHDAPAAKVAATKGYGANVVIYDRYTEDREAIGRRLADEHGFTLIPPYDHPDVLSGQG
TAAKELFEAVGALDVVLTPLGGGGLLSGTALTTRALSPQCKLFGVEPEAGNDGQQSFRSGAIVHIDTPKTIADGAQTQHL
GQYTFSIIKRDVDDILTASDAQLVEAMKFYATRMKMIVEPTGCLGLAAAMHMKDALKGKRIGIIISGGNIDLERFCELVS
A

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=39.6166134185303, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI19923959, Length=145, Percent_Identity=34.4827586206897, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI33469958, Length=148, Percent_Identity=33.1081081081081, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=39.2282958199357, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1790207, Length=308, Percent_Identity=35.0649350649351, Blast_Score=165, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17508781, Length=309, Percent_Identity=32.3624595469256, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=305, Percent_Identity=33.1147540983607, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=309, Percent_Identity=33.6569579288026, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=69.3037974683544, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320930, Length=305, Percent_Identity=35.0819672131148, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=292, Percent_Identity=23.6301369863014, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355833, Length=311, Percent_Identity=33.4405144694534, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645328, Length=216, Percent_Identity=30.5555555555556, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34345; Mature: 34214

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELKLPTYADVQEAAKRLDGVANRTPVNTSRTLNDMLGAEVFFKCENFQRMGAFKFRGA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHEEEEECCHHHCCCEEECCH
YNALAKFSPAQRRAGVVAFSSGNHAQGIALSAKLLGIPATIVMPHDAPAAKVAATKGYGA
HHHHHHCCCHHHHCCEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCHHEEECCCCCC
NVVIYDRYTEDREAIGRRLADEHGFTLIPPYDHPDVLSGQGTAAKELFEAVGALDVVLTP
EEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEC
LGGGGLLSGTALTTRALSPQCKLFGVEPEAGNDGQQSFRSGAIVHIDTPKTIADGAQTQH
CCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCHHHHHHCCCEEEECCCCHHHCCCHHHH
LGQYTFSIIKRDVDDILTASDAQLVEAMKFYATRMKMIVEPTGCLGLAAAMHMKDALKGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCC
RIGIIISGGNIDLERFCELVSA
EEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TELKLPTYADVQEAAKRLDGVANRTPVNTSRTLNDMLGAEVFFKCENFQRMGAFKFRGA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCHHEEEEECCHHHCCCEEECCH
YNALAKFSPAQRRAGVVAFSSGNHAQGIALSAKLLGIPATIVMPHDAPAAKVAATKGYGA
HHHHHHCCCHHHHCCEEEECCCCCCCCEEEEEEEECCCEEEEECCCCCCHHEEECCCCCC
NVVIYDRYTEDREAIGRRLADEHGFTLIPPYDHPDVLSGQGTAAKELFEAVGALDVVLTP
EEEEEECCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEC
LGGGGLLSGTALTTRALSPQCKLFGVEPEAGNDGQQSFRSGAIVHIDTPKTIADGAQTQH
CCCCCCCCCCHHHHHCCCCCCEEEECCCCCCCCHHHHHHCCCEEEECCCCHHHCCCHHHH
LGQYTFSIIKRDVDDILTASDAQLVEAMKFYATRMKMIVEPTGCLGLAAAMHMKDALKGK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCC
RIGIIISGGNIDLERFCELVSA
EEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA