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The map label for this gene is mmsB [H]

Identifier: 73538089

GI number: 73538089

Start: 916755

End: 917648

Strand: Direct

Name: mmsB [H]

Synonym: Reut_B4259

Alternate gene names: 73538089

Gene position: 916755-917648 (Clockwise)

Preceding gene: 73538088

Following gene: 73538090

Centisome position: 33.63

GC content: 68.34

Gene sequence:

>894_bases
ATGCATATCGCCTTTATCGGCCTAGGCAACATGGGCGCCCCGATGGCGCGCAACCTGCTCAAGTCCGGTCACACGCTCAC
CGTCTTCGATCTCAATGCCACCGCCGTGGCATCGCTGTGCGCCGAAGGCGCAGCCTCGGCCGATTCCGCACGCAAGGCGG
TGGCCGAGGCCGACTTCGTCATGACGATGCTGCCCGCCGCCGCGCATGTCCGGACGGCGTATCTCGGTGACGAGGGCGTG
CTGGCGGGCGTGCGCGCCGGTGTGCCGCTGGTGGACTCGAGCACGATCGACCCGGCTACCGTGCGCGAACTGGCCGCCGC
CGCTGCGGCGCACGGCAACCCGCTGGCCGATGCGCCAGTGTCCGGCGGCACCGGCGGTGCGCAGGCCGGGACGCTGACCT
TCATGGTCGGCGCCACGCCGGATTTGTTCGAGCAGGTCAAGCCCGTGCTGGCCAATATGGGCCGCAACCTGGTCCATTGC
GGCGACACCGGCACCGGCCAGGTCGCCAAGATCTGTAACAACCTGATCCTCGGCATCTCGATGATCGGCGTGTCCGAGGC
CATGGCGCTCGGTGTGAGGCTCGGCATCGATGCCAATGTGCTCGCGGGCATCGTCAATACGTCGACGGGGCGATGCTGGT
CCTCCGACACCTACAACCCCCACCCCGGCGTGATCGAGACCGCGCCGTCGTCGCGCGGCTATACGGGTGGCTTCGGCGCC
GACCTGATGCTCAAGGACCTGGGCCTCGCCGCCGACGCCGCACGCAGCGTGAAGCAGCCGCTGTTCCTGGGCGCGCTGGC
GCAGCAGATCTATCAGGCGATGAGTCAGGCCGGCGATGGCCAGCTCGATTTCTCCGGCGTGATCCGGCAATACCAGCCCA
AGTCCGGGGCCTGA

Upstream 100 bases:

>100_bases
GGTTCGACGATGCCACGGTGAATGACGGCGTGAACACCACCATCAGCCTGAAGTAAGACCCCATAGGCAACCAATAAGCA
CCATATCCAGGAGACCCGAC

Downstream 100 bases:

>100_bases
CGGAGGCGACTGATGATTGAATTTTCCTTGGACGGGCATATCGCCCGTCTCACGCTGAGCCGCCCGCCCGCCAATGCATT
CACCGCAGAGGGCCTGCAGC

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MHIAFIGLGNMGAPMARNLLKSGHTLTVFDLNATAVASLCAEGAASADSARKAVAEADFVMTMLPAAAHVRTAYLGDEGV
LAGVRAGVPLVDSSTIDPATVRELAAAAAAHGNPLADAPVSGGTGGAQAGTLTFMVGATPDLFEQVKPVLANMGRNLVHC
GDTGTGQVAKICNNLILGISMIGVSEAMALGVRLGIDANVLAGIVNTSTGRCWSSDTYNPHPGVIETAPSSRGYTGGFGA
DLMLKDLGLAADAARSVKQPLFLGALAQQIYQAMSQAGDGQLDFSGVIRQYQPKSGA

Sequences:

>Translated_297_residues
MHIAFIGLGNMGAPMARNLLKSGHTLTVFDLNATAVASLCAEGAASADSARKAVAEADFVMTMLPAAAHVRTAYLGDEGV
LAGVRAGVPLVDSSTIDPATVRELAAAAAAHGNPLADAPVSGGTGGAQAGTLTFMVGATPDLFEQVKPVLANMGRNLVHC
GDTGTGQVAKICNNLILGISMIGVSEAMALGVRLGIDANVLAGIVNTSTGRCWSSDTYNPHPGVIETAPSSRGYTGGFGA
DLMLKDLGLAADAARSVKQPLFLGALAQQIYQAMSQAGDGQLDFSGVIRQYQPKSGA
>Mature_297_residues
MHIAFIGLGNMGAPMARNLLKSGHTLTVFDLNATAVASLCAEGAASADSARKAVAEADFVMTMLPAAAHVRTAYLGDEGV
LAGVRAGVPLVDSSTIDPATVRELAAAAAAHGNPLADAPVSGGTGGAQAGTLTFMVGATPDLFEQVKPVLANMGRNLVHC
GDTGTGQVAKICNNLILGISMIGVSEAMALGVRLGIDANVLAGIVNTSTGRCWSSDTYNPHPGVIETAPSSRGYTGGFGA
DLMLKDLGLAADAARSVKQPLFLGALAQQIYQAMSQAGDGQLDFSGVIRQYQPKSGA

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=51.5679442508711, Blast_Score=298, Evalue=3e-81,
Organism=Homo sapiens, GI40556376, Length=293, Percent_Identity=28.6689419795222, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=35.2739726027397, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1790315, Length=296, Percent_Identity=35.472972972973, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1786719, Length=292, Percent_Identity=32.5342465753425, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789092, Length=294, Percent_Identity=32.312925170068, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17557316, Length=294, Percent_Identity=48.9795918367347, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24655230, Length=286, Percent_Identity=51.0489510489511, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI19922568, Length=286, Percent_Identity=51.0489510489511, Blast_Score=281, Evalue=3e-76,
Organism=Drosophila melanogaster, GI28574115, Length=294, Percent_Identity=22.4489795918367, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24655240, Length=63, Percent_Identity=50.7936507936508, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30065; Mature: 30065

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIAFIGLGNMGAPMARNLLKSGHTLTVFDLNATAVASLCAEGAASADSARKAVAEADFV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MTMLPAAAHVRTAYLGDEGVLAGVRAGVPLVDSSTIDPATVRELAAAAAAHGNPLADAPV
HHHHHHHHHHHHEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SGGTGGAQAGTLTFMVGATPDLFEQVKPVLANMGRNLVHCGDTGTGQVAKICNNLILGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MIGVSEAMALGVRLGIDANVLAGIVNTSTGRCWSSDTYNPHPGVIETAPSSRGYTGGFGA
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCH
DLMLKDLGLAADAARSVKQPLFLGALAQQIYQAMSQAGDGQLDFSGVIRQYQPKSGA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MHIAFIGLGNMGAPMARNLLKSGHTLTVFDLNATAVASLCAEGAASADSARKAVAEADFV
CEEEEEECCCCCCHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
MTMLPAAAHVRTAYLGDEGVLAGVRAGVPLVDSSTIDPATVRELAAAAAAHGNPLADAPV
HHHHHHHHHHHHEEECCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
SGGTGGAQAGTLTFMVGATPDLFEQVKPVLANMGRNLVHCGDTGTGQVAKICNNLILGIS
CCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHH
MIGVSEAMALGVRLGIDANVLAGIVNTSTGRCWSSDTYNPHPGVIETAPSSRGYTGGFGA
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCH
DLMLKDLGLAADAARSVKQPLFLGALAQQIYQAMSQAGDGQLDFSGVIRQYQPKSGA
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]