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The map label for this gene is upp [H]

Identifier: 73537820

GI number: 73537820

Start: 625709

End: 626392

Strand: Direct

Name: upp [H]

Synonym: Reut_B3987

Alternate gene names: 73537820

Gene position: 625709-626392 (Clockwise)

Preceding gene: 73537819

Following gene: 73537821

Centisome position: 22.95

GC content: 65.64

Gene sequence:

>684_bases
ATGAACGACATGTCTGCCGTCCCCGTGGCTCCGGCCGAAGCCGCCAACGCACCGGCCGCCTCCGTGCTGGTGGTCGATCA
CCCGCTGGTCCAGCACAAGGTCACGCTGGCGCGCAGCGAGGAGACCACGACCGACAATTTTCGCCGGCTCGTGCGCGAGA
TCAGCCAACTGCTGACTTACGAAGCGACGCGCGATTTGCCGATGGAAACCATTGCCATCAAGACGCCGATCGCGCCGACG
CAATCGCCGGTGCTGGCGGGCAAGAAGCTCTGCCTGGTGTCGATCCTGCGGGCGGGCAACGGCTTCCTCGACGGGATGCT
GGAGCTTTTGCCGGCCGCGCGCGTGGGCCATATCGGCCTGTACCGGGATCCGGAAACGCTGGAACCGGTCGAGTACTACT
TCAAGATGCCCGAGGACATCCAGGAACGGATCGTGATCGTGGTGGACCCCATGCTGGCCACCGGCAACTCCGCCATTGCC
GCGCTCAACCGCCTCAAGGAAAGCGGTGTGAGCATGCTGAAATACGTCTGCCTGATTGCGTCGCGCCCGGGCCTGAAGGC
GCTGCAGGCCGCGCATCCGGACGTTGCGATCGTCACGGCGGCCATCGACGAGGAGCTGAACGAGCACGGCTACATCGTGC
CCGGGCTCGGCGATGCCGGGGACCGCCTCTACGGCACACGGTGA

Upstream 100 bases:

>100_bases
TTTTGAGCGCCACAGCCGCGCAGCAACGCTTGCCCGCCGGATCCATCCGGCGGTGCAATCCCTGATTCCCTCGCCAGTCC
GATTGCATAGGAGCGTCACC

Downstream 100 bases:

>100_bases
TGGACGGCCCCGCGGTTGCCGCGGCGCGCCGCCTGCCGCTGGCGCGCGACGCCAGCGTCGGGCGCATCCGGCAGGAGAAC
GAGGCCATGATCCTGCGCGC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNDMSAVPVAPAEAANAPAASVLVVDHPLVQHKVTLARSEETTTDNFRRLVREISQLLTYEATRDLPMETIAIKTPIAPT
QSPVLAGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGLYRDPETLEPVEYYFKMPEDIQERIVIVVDPMLATGNSAIA
ALNRLKESGVSMLKYVCLIASRPGLKALQAAHPDVAIVTAAIDEELNEHGYIVPGLGDAGDRLYGTR

Sequences:

>Translated_227_residues
MNDMSAVPVAPAEAANAPAASVLVVDHPLVQHKVTLARSEETTTDNFRRLVREISQLLTYEATRDLPMETIAIKTPIAPT
QSPVLAGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGLYRDPETLEPVEYYFKMPEDIQERIVIVVDPMLATGNSAIA
ALNRLKESGVSMLKYVCLIASRPGLKALQAAHPDVAIVTAAIDEELNEHGYIVPGLGDAGDRLYGTR
>Mature_227_residues
MNDMSAVPVAPAEAANAPAASVLVVDHPLVQHKVTLARSEETTTDNFRRLVREISQLLTYEATRDLPMETIAIKTPIAPT
QSPVLAGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGLYRDPETLEPVEYYFKMPEDIQERIVIVVDPMLATGNSAIA
ALNRLKESGVSMLKYVCLIASRPGLKALQAAHPDVAIVTAAIDEELNEHGYIVPGLGDAGDRLYGTR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.1881188118812, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.1881188118812, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=50.2415458937198, Blast_Score=223, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=211, Percent_Identity=26.5402843601896, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=211, Percent_Identity=26.5402843601896, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=41.1458333333333, Blast_Score=136, Evalue=2e-33,
Organism=Drosophila melanogaster, GI45550449, Length=216, Percent_Identity=31.0185185185185, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573516, Length=216, Percent_Identity=31.0185185185185, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573514, Length=216, Percent_Identity=31.0185185185185, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573512, Length=216, Percent_Identity=31.0185185185185, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21358379, Length=202, Percent_Identity=27.2277227722772, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 24505; Mature: 24505

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDMSAVPVAPAEAANAPAASVLVVDHPLVQHKVTLARSEETTTDNFRRLVREISQLLTY
CCCCCCCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
EATRDLPMETIAIKTPIAPTQSPVLAGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YRDPETLEPVEYYFKMPEDIQERIVIVVDPMLATGNSAIAALNRLKESGVSMLKYVCLIA
CCCCCCCCHHHHHHCCCHHHHCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SRPGLKALQAAHPDVAIVTAAIDEELNEHGYIVPGLGDAGDRLYGTR
CCCCHHHHHHCCCCEEEEEHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MNDMSAVPVAPAEAANAPAASVLVVDHPLVQHKVTLARSEETTTDNFRRLVREISQLLTY
CCCCCCCCCCCHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
EATRDLPMETIAIKTPIAPTQSPVLAGKKLCLVSILRAGNGFLDGMLELLPAARVGHIGL
HHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
YRDPETLEPVEYYFKMPEDIQERIVIVVDPMLATGNSAIAALNRLKESGVSMLKYVCLIA
CCCCCCCCHHHHHHCCCHHHHCCEEEEECCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHC
SRPGLKALQAAHPDVAIVTAAIDEELNEHGYIVPGLGDAGDRLYGTR
CCCCHHHHHHCCCCEEEEEHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA