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The map label for this gene is gabP [H]

Identifier: 73537588

GI number: 73537588

Start: 349615

End: 351051

Strand: Reverse

Name: gabP [H]

Synonym: Reut_B3753

Alternate gene names: 73537588

Gene position: 351051-349615 (Counterclockwise)

Preceding gene: 73537592

Following gene: 73537587

Centisome position: 12.88

GC content: 64.23

Gene sequence:

>1437_bases
ATGACCCAAACACCGCAGCCCTCCTCAGGGCTATCGCACGGCCTCAAGCAGCGGCACATGACCATGATCGCCCTGGGTGG
CGTCATCGGCGCCGGCCTCTTTGTCGGCAGTGGCGTCGTCATCAAATCCGCCGGGCCCGCCGCGGTCCTTTCCTTCCTGA
TCACCGGCCTCCTTGTCGTGCTGGTAATGCGCATGCTCGGTGAACTGGCCTGCGCCATGCCCGGCGGCGGCTCGTTCTAT
GAGTATGCCCGCGAGGCCTGGAGCGACCGCCCCGCAGTCGGCAATCTGGCCAGCTTCCTGACCGGGTGGATGTACTGGTA
CTTCTGGGTCATCGTTGTGGCGCTCGAAGCCGTGGCAGGGGCTGACCTGGTGCGCTACTGGCTGCCGGACGTGCCGAACT
GGACCATCAGCCTGGTGCTGCTGGTCATGCTCACGCTGACCAACCTGATCTCGGTAAAGTCATTCGGCGAGTTCGAGTTC
TGGTTCGCGTCCATCAAGGTCGCGGCGATCATGGTGTTCCTGTTCGTGGCCGGCGTGTACGTGCTTGGCCTCGCGCCCGG
CGCCCATGGCATGAACGTGGCCAACCTGACCGCGAACGGCGGCTTCATGCCGAACGGCATCGTGCCCGTGCTGACCGGCG
CGGTGGCGGCGACAGGCTTCTACTTCGGCGCCGAGATCGTCACCATCGCCGCGGCCGAAACCGCCGAGCCGCAGAAAGCG
GTGGCCCGTGCCACGAACTCGGTCATCACGCGCGTACTCGTGTTCTACGTGGGTTCGGTGCTGCTGGTGGTTTGCCTGGT
GCCGTGGAACGCCACTGGCATCGCCACGCCGTACGTCAGCGCGCTCAACGTCATGGGGATTCCGGCAGCCGCGCAGATCA
TGAACGCGATCGTGCTGACCGCCGTGCTGTCGGCGCTGAACTCCGGCCTGTATGCCTCGTCGCGCATGCTGTTCGCGCTC
ACGAAGCGCGGCGACGCACCGCGTTCCCTCGCCCGCGTCAGCCGCAACGGCGTGCCGACGCGCGCGATCCTCGTCGCCAC
ACTGTTTGGCTACGGCGCGGTAGTGATGTCGTATGTATCGCCGGACAAGGTCTTTGCATTCCTGGTGAACTCGTATGGCA
CGGTGGCCATCTTCGTGTACATCCTGATCGCGGTGTCTCAGTTGCGGTTGCGTGCGCGGCTTGAGCGCGAAGCGCCTCAC
CTGCTCAAGGTGCGGATGTGGTGCTATCCGTATCTGACGTGGCTGGCGATTTTCGGGATGCTGGCGATTGTAGTGGCGAT
GGCGTTTATTCCGGATCAGCGGACGCCGCTGGCCCTGGGCGTGGCTAGCCTTGGACTGTTGGTATCGGCCTATATCGTGC
GGCATCTGTTTCGGCGTGGCGTCCAACAGGTCGTGCCCCTAGCGGAGATGCCTCGGCCGGATTTGCATGAATATTGA

Upstream 100 bases:

>100_bases
ACCACGGCACAGGCCTGCAACCAAGCGCAGGGCCGACTATTACAGAGAAAGACGCCGTGGCGGCTGACAGTACAGCAGTC
AGCAGTACAGGAGACACAAC

Downstream 100 bases:

>100_bases
TTGAGGATGGGAAAGGGTGTGGAGATGGGGTAACCTGTCTTCCGCCCCCTCAAGACAGCCGCCCTATGACCTCCAAGCTG
ACGCCCCCCATGTGGGACCA

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTQTPQPSSGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGELACAMPGGGSFY
EYAREAWSDRPAVGNLASFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWTISLVLLVMLTLTNLISVKSFGEFEF
WFASIKVAAIMVFLFVAGVYVLGLAPGAHGMNVANLTANGGFMPNGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
VARATNSVITRVLVFYVGSVLLVVCLVPWNATGIATPYVSALNVMGIPAAAQIMNAIVLTAVLSALNSGLYASSRMLFAL
TKRGDAPRSLARVSRNGVPTRAILVATLFGYGAVVMSYVSPDKVFAFLVNSYGTVAIFVYILIAVSQLRLRARLEREAPH
LLKVRMWCYPYLTWLAIFGMLAIVVAMAFIPDQRTPLALGVASLGLLVSAYIVRHLFRRGVQQVVPLAEMPRPDLHEY

Sequences:

>Translated_478_residues
MTQTPQPSSGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGELACAMPGGGSFY
EYAREAWSDRPAVGNLASFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWTISLVLLVMLTLTNLISVKSFGEFEF
WFASIKVAAIMVFLFVAGVYVLGLAPGAHGMNVANLTANGGFMPNGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
VARATNSVITRVLVFYVGSVLLVVCLVPWNATGIATPYVSALNVMGIPAAAQIMNAIVLTAVLSALNSGLYASSRMLFAL
TKRGDAPRSLARVSRNGVPTRAILVATLFGYGAVVMSYVSPDKVFAFLVNSYGTVAIFVYILIAVSQLRLRARLEREAPH
LLKVRMWCYPYLTWLAIFGMLAIVVAMAFIPDQRTPLALGVASLGLLVSAYIVRHLFRRGVQQVVPLAEMPRPDLHEY
>Mature_477_residues
TQTPQPSSGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGELACAMPGGGSFYE
YAREAWSDRPAVGNLASFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWTISLVLLVMLTLTNLISVKSFGEFEFW
FASIKVAAIMVFLFVAGVYVLGLAPGAHGMNVANLTANGGFMPNGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKAV
ARATNSVITRVLVFYVGSVLLVVCLVPWNATGIATPYVSALNVMGIPAAAQIMNAIVLTAVLSALNSGLYASSRMLFALT
KRGDAPRSLARVSRNGVPTRAILVATLFGYGAVVMSYVSPDKVFAFLVNSYGTVAIFVYILIAVSQLRLRARLEREAPHL
LKVRMWCYPYLTWLAIFGMLAIVVAMAFIPDQRTPLALGVASLGLLVSAYIVRHLFRRGVQQVVPLAEMPRPDLHEY

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=24.9417249417249, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258614003, Length=430, Percent_Identity=23.7209302325581, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI258614005, Length=430, Percent_Identity=23.7209302325581, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789017, Length=470, Percent_Identity=44.6808510638298, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1786302, Length=433, Percent_Identity=37.4133949191686, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI87081708, Length=474, Percent_Identity=36.9198312236287, Blast_Score=278, Evalue=6e-76,
Organism=Escherichia coli, GI1786789, Length=434, Percent_Identity=35.2534562211982, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1790653, Length=444, Percent_Identity=34.6846846846847, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI48994972, Length=454, Percent_Identity=35.4625550660793, Blast_Score=261, Evalue=1e-70,
Organism=Escherichia coli, GI87081915, Length=429, Percent_Identity=38.2284382284382, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1788480, Length=401, Percent_Identity=38.1546134663342, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1786602, Length=460, Percent_Identity=35.2173913043478, Blast_Score=255, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI17532491, Length=373, Percent_Identity=22.5201072386059, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17531343, Length=423, Percent_Identity=24.3498817966903, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=402, Percent_Identity=36.318407960199, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6324061, Length=476, Percent_Identity=31.5126050420168, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324059, Length=450, Percent_Identity=33.5555555555556, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=449, Percent_Identity=30.0668151447661, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6322892, Length=494, Percent_Identity=29.7570850202429, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320717, Length=419, Percent_Identity=29.3556085918854, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321053, Length=397, Percent_Identity=31.4861460957179, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=406, Percent_Identity=32.7586206896552, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324553, Length=408, Percent_Identity=31.3725490196078, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=415, Percent_Identity=28.1927710843373, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=29.7560975609756, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=498, Percent_Identity=27.5100401606426, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=29.7229219143577, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320251, Length=421, Percent_Identity=25.8907363420428, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=423, Percent_Identity=27.4231678486998, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=30.3030303030303, Blast_Score=139, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319608, Length=440, Percent_Identity=24.3181818181818, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=511, Percent_Identity=23.2876712328767, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51246; Mature: 51114

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTPQPSSGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LVMRMLGELACAMPGGGSFYEYAREAWSDRPAVGNLASFLTGWMYWYFWVIVVALEAVAG
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLVRYWLPDVPNWTISLVLLVMLTLTNLISVKSFGEFEFWFASIKVAAIMVFLFVAGVY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLGLAPGAHGMNVANLTANGGFMPNGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
VARATNSVITRVLVFYVGSVLLVVCLVPWNATGIATPYVSALNVMGIPAAAQIMNAIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AVLSALNSGLYASSRMLFALTKRGDAPRSLARVSRNGVPTRAILVATLFGYGAVVMSYVS
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PDKVFAFLVNSYGTVAIFVYILIAVSQLRLRARLEREAPHLLKVRMWCYPYLTWLAIFGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAIVVAMAFIPDQRTPLALGVASLGLLVSAYIVRHLFRRGVQQVVPLAEMPRPDLHEY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure 
TQTPQPSSGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LVMRMLGELACAMPGGGSFYEYAREAWSDRPAVGNLASFLTGWMYWYFWVIVVALEAVAG
HHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLVRYWLPDVPNWTISLVLLVMLTLTNLISVKSFGEFEFWFASIKVAAIMVFLFVAGVY
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLGLAPGAHGMNVANLTANGGFMPNGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
VARATNSVITRVLVFYVGSVLLVVCLVPWNATGIATPYVSALNVMGIPAAAQIMNAIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AVLSALNSGLYASSRMLFALTKRGDAPRSLARVSRNGVPTRAILVATLFGYGAVVMSYVS
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PDKVFAFLVNSYGTVAIFVYILIAVSQLRLRARLEREAPHLLKVRMWCYPYLTWLAIFGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
LAIVVAMAFIPDQRTPLALGVASLGLLVSAYIVRHLFRRGVQQVVPLAEMPRPDLHEY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]