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The map label for this gene is cysM [C]

Identifier: 73537519

GI number: 73537519

Start: 266577

End: 267620

Strand: Reverse

Name: cysM [C]

Synonym: Reut_B3684

Alternate gene names: 73537519

Gene position: 267620-266577 (Counterclockwise)

Preceding gene: 73537520

Following gene: 73537518

Centisome position: 9.82

GC content: 65.13

Gene sequence:

>1044_bases
ATGATCCTGTGGAAAGTGTCAGACCTGATCGGCAACACACCGATGCTGGGCATCCCCGTCCCCGACAAGGACTCGGTGCT
GTTGCTGAAGGTGGAGAAGAACAACCCGGGCGGCAGCATGAAGGATCGCATGGCCCGCAATATGGTATTGGCTGCGCTGA
AGTCCGGGCGGCTGCAACCGAACGGCGTGATTGTCGAATCGTCGTCCGGCAACACCGGCATCGGGCTGGCGCTGGCCGCG
ATTGAATTCGGCTTGCGCTTCATTGCCGTGGTTGACCACCACGCGGCGCCGGACAAGATCGCCGTCATGCGCGCGCTGGG
CGCCGAGATTCGCTACGTAGAAGGCAATTTCCAAGAAAACGAAGTCGCCGTGGTGGAGCGCCAGCGCCTCGCTGCTGAGA
TCGCCAGTCAGACGCCCGGCGCCGTATTCATGAACCAGTCGGACAATGCGGCCAATGCCGGCGGCTACCTCGAATTCGTC
CGAGAGACCTTTGCCCAGGCGCGCGAAGTCAATGCGTTCGTGGGTTGCGTCGGCACCGGCGGCTCGATGACCGGCATCGC
CCGCGGCGTGAAGCAGTTCAATCCCGACGCTGTAACCATTGCGGTCGAGCCGTCCGGATCGATCGTGTTCGGCATGCCTG
GCCACCCCTACTACCAGTCGGGCACGGGCACGCCGCAGGGTGACACGGTCGGGCTCGTGCTCGACTACAGCTGCATCGAC
ATGGGCGTACAGGTCACCGATGCGCAGGCCTTCGAGACCGCGCGCTACGTGGCCCGCCAGACCGGGCTGCTGGTGGGCGG
CTCCACCGGTGGCGCCATCTACAAGGCACTGGAGGCCATCCATGACAGCCAAATACGCGGCAACGTCGTCGTCCCCGTGG
CCGACGGCGGCGAGAAGTACCTGCACACCGTCTTCGACGAGGACTGGCTGCGGGCGCGCAACCTGCTCGCGCCGCAGGTA
TGGCAGCGCCTGGACGCATGGCTTGGCAAGGCCACGTGCCGCGACGAGGTCGCGCCCGACGTCCTGCGCCTGAATGCCGC
ATGA

Upstream 100 bases:

>100_bases
AAACGAGTTTCACCGCCACCCCATGCCACGCCGCGTGGCCGCGCAGTGCGGTGACGCGGGCCGCGTTTCCTTTTCCCTTG
ACCAATGAACGGAGCTCCCG

Downstream 100 bases:

>100_bases
GCGCGCCACCGCTGTGCGTGACAGTCTGCGGCGGCGGCCGCACCGGACACCTGAACGCCATCCTGTTCGCGCAACGGCCC
GGTGTGCGCGTGAAGCTGCT

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MILWKVSDLIGNTPMLGIPVPDKDSVLLLKVEKNNPGGSMKDRMARNMVLAALKSGRLQPNGVIVESSSGNTGIGLALAA
IEFGLRFIAVVDHHAAPDKIAVMRALGAEIRYVEGNFQENEVAVVERQRLAAEIASQTPGAVFMNQSDNAANAGGYLEFV
RETFAQAREVNAFVGCVGTGGSMTGIARGVKQFNPDAVTIAVEPSGSIVFGMPGHPYYQSGTGTPQGDTVGLVLDYSCID
MGVQVTDAQAFETARYVARQTGLLVGGSTGGAIYKALEAIHDSQIRGNVVVPVADGGEKYLHTVFDEDWLRARNLLAPQV
WQRLDAWLGKATCRDEVAPDVLRLNAA

Sequences:

>Translated_347_residues
MILWKVSDLIGNTPMLGIPVPDKDSVLLLKVEKNNPGGSMKDRMARNMVLAALKSGRLQPNGVIVESSSGNTGIGLALAA
IEFGLRFIAVVDHHAAPDKIAVMRALGAEIRYVEGNFQENEVAVVERQRLAAEIASQTPGAVFMNQSDNAANAGGYLEFV
RETFAQAREVNAFVGCVGTGGSMTGIARGVKQFNPDAVTIAVEPSGSIVFGMPGHPYYQSGTGTPQGDTVGLVLDYSCID
MGVQVTDAQAFETARYVARQTGLLVGGSTGGAIYKALEAIHDSQIRGNVVVPVADGGEKYLHTVFDEDWLRARNLLAPQV
WQRLDAWLGKATCRDEVAPDVLRLNAA
>Mature_347_residues
MILWKVSDLIGNTPMLGIPVPDKDSVLLLKVEKNNPGGSMKDRMARNMVLAALKSGRLQPNGVIVESSSGNTGIGLALAA
IEFGLRFIAVVDHHAAPDKIAVMRALGAEIRYVEGNFQENEVAVVERQRLAAEIASQTPGAVFMNQSDNAANAGGYLEFV
RETFAQAREVNAFVGCVGTGGSMTGIARGVKQFNPDAVTIAVEPSGSIVFGMPGHPYYQSGTGTPQGDTVGLVLDYSCID
MGVQVTDAQAFETARYVARQTGLLVGGSTGGAIYKALEAIHDSQIRGNVVVPVADGGEKYLHTVFDEDWLRARNLLAPQV
WQRLDAWLGKATCRDEVAPDVLRLNAA

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=337, Percent_Identity=34.1246290801187, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI295821200, Length=337, Percent_Identity=34.1246290801187, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4557415, Length=337, Percent_Identity=34.1246290801187, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=31.6993464052288, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=31.0344827586207, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17534315, Length=335, Percent_Identity=33.7313432835821, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI25147552, Length=334, Percent_Identity=33.2335329341317, Blast_Score=127, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=30.1639344262295, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=29.073482428115, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32566674, Length=304, Percent_Identity=29.2763157894737, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996324, Length=352, Percent_Identity=27.8409090909091, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115535073, Length=329, Percent_Identity=30.0911854103343, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561720, Length=306, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=347, Percent_Identity=32.8530259365994, Blast_Score=151, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=27.7945619335347, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643623, Length=327, Percent_Identity=31.4984709480122, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI20129101, Length=327, Percent_Identity=31.4984709480122, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36941; Mature: 36941

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILWKVSDLIGNTPMLGIPVPDKDSVLLLKVEKNNPGGSMKDRMARNMVLAALKSGRLQP
CEEEEEHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
NGVIVESSSGNTGIGLALAAIEFGLRFIAVVDHHAAPDKIAVMRALGAEIRYVEGNFQEN
CCEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCC
EVAVVERQRLAAEIASQTPGAVFMNQSDNAANAGGYLEFVRETFAQAREVNAFVGCVGTG
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECC
GSMTGIARGVKQFNPDAVTIAVEPSGSIVFGMPGHPYYQSGTGTPQGDTVGLVLDYSCID
CCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEHHHH
MGVQVTDAQAFETARYVARQTGLLVGGSTGGAIYKALEAIHDSQIRGNVVVPVADGGEKY
CCEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHH
LHTVFDEDWLRARNLLAPQVWQRLDAWLGKATCRDEVAPDVLRLNAA
HHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCEEECCC
>Mature Secondary Structure
MILWKVSDLIGNTPMLGIPVPDKDSVLLLKVEKNNPGGSMKDRMARNMVLAALKSGRLQP
CEEEEEHHHHCCCCEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
NGVIVESSSGNTGIGLALAAIEFGLRFIAVVDHHAAPDKIAVMRALGAEIRYVEGNFQEN
CCEEEECCCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHCCEEEEEECCCCCC
EVAVVERQRLAAEIASQTPGAVFMNQSDNAANAGGYLEFVRETFAQAREVNAFVGCVGTG
CCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECC
GSMTGIARGVKQFNPDAVTIAVEPSGSIVFGMPGHPYYQSGTGTPQGDTVGLVLDYSCID
CCHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEEEHHHH
MGVQVTDAQAFETARYVARQTGLLVGGSTGGAIYKALEAIHDSQIRGNVVVPVADGGEKY
CCEEEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHH
LHTVFDEDWLRARNLLAPQVWQRLDAWLGKATCRDEVAPDVLRLNAA
HHHHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]