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The map label for this gene is hasA [H]

Identifier: 71911664

GI number: 71911664

Start: 1818708

End: 1819967

Strand: Direct

Name: hasA [H]

Synonym: M5005_Spy_1851

Alternate gene names: 71911664

Gene position: 1818708-1819967 (Clockwise)

Preceding gene: 71911655

Following gene: 71911665

Centisome position: 98.92

GC content: 32.54

Gene sequence:

>1260_bases
GTGCCTATTTTTAAAAAAACTTTAATTATTTTATCCTTTATTTTTTTGATATCTATCTTGATTTATCTAAATATGTATCT
ATTTGGAACATCAACTGTAGGAATTTATGGAGTAATATTAATAACCTATCTAGTTATTAAACTTGGATTATCTTTCCTTT
ATGAGCCATTTAAAGGAAAGCCACATGACTATAAAGTTGCTGCTGTAATTCCTTCTTATAATGAAGATGCCGAGTCATTA
TTAGAAACTCTTAAAAGTGTGTTAGCACAGACCTATCCGTTATCAGAAATTTATATTGTTGATGATGGGAGTTCAAACAC
AGATGCAATACAATTAATTGAAGAGTATGTAAATAGAGAAGTGGATATTTGTCGAAACGTTATCGTTCACCGTTCCCTTG
TCAATAAAGGAAAACGCCATGCTCAAGCGTGGGCATTTGAAAGATCTGACGCTGACGTTTTTTTAACCGTAGATTCAGAT
ACTTATATCTATCCAAATGCCTTAGAAGAACTCCTAAAAAGCTTCAATGATGAGACAGTTTATGCTGCAACAGGACATTT
GAATGCTAGAAACAGACAAACTAATCTATTAACGCGACTTACAGATATCCGTTACGATAATGCCTTTGGGGTGGAGCGTG
CTGCTCAATCATTAACAGGTAATATTTTAGTTTGCTCAGGACCATTGAGTATTTATCGACGTGAAGTGATTATTCCTAAC
TTAGAGCGCTATAAAAATCAAACATTCCTAGGTTTACCTGTTAGCATTGGGGATGATCGATGTTTAACAAATTATGCTAT
TGATTTAGGACGCACTGTCTACCAATCAACAGCTAGATGTGATACTGATGTACCTTTCCAATTAAAAAGTTATTTAAAGC
AACAAAATCGATGGAATAAATCTTTTTTTAGAGAATCTATTATTTCTGTTAAAAAAATTCTTTCTAATCCCATCGTTGCC
TTATGGACTATTTTCGAAGTCGTTATGTTTATGATGTTGATTGTCGCAATTGGGAATCTTTTGTTTAATCAAGCTATTCA
ATTAGACCTTATTAAACTTTTTGCCTTTTTATCCATCATCTTTATCGTTGCTTTATGTCGTAATGTTCATTATATGATCA
AACATCCTGCTAGTTTTTTGTTATCTCCTCTGTATGGAATATTACACTTGTTTGTCTTACAGCCCCTAAAACTTTATTCT
TTATGCACCATTAAAAATACGGAATGGGGAACACGTAAAAAGGTCACTATTTTTAAATAA

Upstream 100 bases:

>100_bases
TTAAAAATATTTCTATGACTAGTTGACATTACCCCTTATTTATATTAGAATATCGAGGTCCCTGTCTTTCAAGGAAATTA
AAAAAGAAAGAGGTGTAATT

Downstream 100 bases:

>100_bases
TATGTGCATCGAGTAGTTAGAGAAGGAGTAATTTTATGAAAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTA
GGAGTTCTTTTATCACTTCA

Product: hyaluronan synthase

Products: NA

Alternate protein names: Hyaluronate synthase; Hyaluronic acid synthase; HA synthase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPIFKKTLIILSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESL
LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD
TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVA
LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYS
LCTIKNTEWGTRKKVTIFK

Sequences:

>Translated_419_residues
MPIFKKTLIILSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESL
LETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSD
TYIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVA
LWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYS
LCTIKNTEWGTRKKVTIFK
>Mature_418_residues
PIFKKTLIILSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGKPHDYKVAAVIPSYNEDAESLL
ETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNREVDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDT
YIYPNALEELLKSFNDETVYAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPNL
ERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNKSFFRESIISVKKILSNPIVAL
WTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSIIFIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSL
CTIKNTEWGTRKKVTIFK

Specific function: Glycosaminoglycan synthesis. The hyaluronic acid capsule is involved in the pathogenicity of group A Streptococci; it may be the major virulence determinant [H]

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nodC/HAS family [H]

Homologues:

Organism=Homo sapiens, GI4885391, Length=434, Percent_Identity=28.110599078341, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI20302153, Length=437, Percent_Identity=28.1464530892449, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI167466171, Length=452, Percent_Identity=27.4336283185841, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1787259, Length=261, Percent_Identity=22.9885057471264, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: =2.4.1.212 [H]

Molecular weight: Translated: 47929; Mature: 47797

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIFKKTLIILSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH
VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE
YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK
HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
SFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEC
>Mature Secondary Structure 
PIFKKTLIILSFIFLISILIYLNMYLFGTSTVGIYGVILITYLVIKLGLSFLYEPFKGK
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PHDYKVAAVIPSYNEDAESLLETLKSVLAQTYPLSEIYIVDDGSSNTDAIQLIEEYVNRE
CCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCH
VDICRNVIVHRSLVNKGKRHAQAWAFERSDADVFLTVDSDTYIYPNALEELLKSFNDETV
HHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCEECHHHHHHHHHHCCCCEE
YAATGHLNARNRQTNLLTRLTDIRYDNAFGVERAAQSLTGNILVCSGPLSIYRREVIIPN
EEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHCCCC
LERYKNQTFLGLPVSIGDDRCLTNYAIDLGRTVYQSTARCDTDVPFQLKSYLKQQNRWNK
HHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCH
SFFRESIISVKKILSNPIVALWTIFEVVMFMMLIVAIGNLLFNQAIQLDLIKLFAFLSII
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVALCRNVHYMIKHPASFLLSPLYGILHLFVLQPLKLYSLCTIKNTEWGTRKKVTIFK
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]