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The map label for this gene is glmS [H]

Identifier: 71910799

GI number: 71910799

Start: 972010

End: 973824

Strand: Reverse

Name: glmS [H]

Synonym: M5005_Spy_0986

Alternate gene names: 71910799

Gene position: 973824-972010 (Counterclockwise)

Preceding gene: 71910800

Following gene: 71910798

Centisome position: 52.97

GC content: 41.43

Gene sequence:

>1815_bases
ATGTGTGGAATTGTTGGAGTTGTTGGAAATCGCAATGCAACGGATATTTTAATGCAAGGCCTTGAAAAGCTTGAATACCG
GGGTTATGATTCAGCAGGAATTTTTGTGGCTAATGCCAATCAAACAAACTTGATTAAATCAGTGGGGCGGATTGCTGATT
TGCGTGCCAAGATTGGCATTGATGTTGCTGGTTCAACAGGGATTGGTCACACCCGTTGGGCAACGCATGGCCAATCAACA
GAGGATAATGCCCATCCTCACACGTCACAAACTGGACGTTTTGTACTTGTTCATAATGGTGTGATTGAAAATTACCTTCA
CATTAAAACAGAGTTCCTAGCTGGACATGATTTTAAGGGGCAGACAGATACTGAGATTGCAGTACACTTGATTGGAAAAT
TTGTGGAAGAAGACAAGTTGTCAGTACTGGAAGCTTTTAAAAAATCTTTAAGCATTATTGAAGGTTCCTACGCCTTTGCA
TTAATGGATAGCCAAGCAACTGATACTATTTATGTGGCTAAAAACAAGTCTCCATTGTTGATTGGACTTGGTGAAGGTTA
CAACATGGTTTGTTCAGATGCCATGGCCATGATTCGTGAAACCAGTGAATTTATGGAAATTCATGATAAGGAGCTAGTTA
TTTTAACCAAAGATAAGGTAACTGTTACAGACTACGATGGTAAAGAGCTGATACGAGATTCCTACACTGCTGAATTAGAC
TTATCTGATATTGGCAAAGGGACTTATCCTTTCTATATGCTGAAAGAAATTGATGAGCAACCAACCGTAATGCGTCAATT
AATTTCAACTTATGCAGATGAAACTGGTAACGTACAGGTTGATCCGGCTATCATTACCTCTATCCAAGAGGCTGACCGTC
TTTATATTTTAGCGGCAGGGACTTCCTACCATGCTGGTTTTGCAACAAAAAATATGCTTGAGCAATTGACAGATACACCA
GTTGAGTTGGGCGTGGCTTCTGAGTGGGGTTACCACATGCCTCTGCTTAGCAAGAAACCAATGTTTATTCTACTAAGCCA
ATCAGGAGAAACCGCAGATAGTCGTCAAGTTTTAGTAAAGGCAAATGCTATGGGCATTCCGAGTTTGACAGTAACTAACG
TTCCAGGATCAACCTTATCACGTGAAGCAACATACACCATGTTGATTCATGCTGGACCTGAAATTGCTGTTGCGTCTACA
AAAGCTTACACTGCACAAATTGCTGCCCTTGCCTTTTTGGCTAAGGCAGTTGGTGAGGCAAATGGTAAGCAAGAAGCTCT
TGACTTTAACTTGGTACATGAGTTGTCATTGGTTGCCCAATCTATTGAGGCGACTTTGTCTGAAAAAGATCTCGCGGCAG
AAAAGGTTCAAGCTTTGCTAGCTACTACTCGTAATGCTTTTTACATCGGGCGTGGCAATGATTATTACGTTGCGATGGAA
GCTGCTTTGAAATTAAAAGAGATTTCTTATATTCAATGCGAAGGCTTTGCGGCTGGTGAATTGAAACATGGAACCATTTC
ATTAATTGAGGAGGACACGCCAGTAATCGCTTTAATATCGTCTAGTCAGTTGGTTGCCTCTCATACGCGTGGTAATATTC
AAGAAGTTGCTGCCCGTGGGGCTCATGTTTTAACAGTTGTGGAAGAAGGGCTTGACCGTGAGGGAGATGACATTATTGTC
AATAAGGTTCATCCTTTCCTAGCCCCGATTGCTATGGTCATTCCAACTCAACTGATTGCTTACTACGCTTCATTACAACG
TGGACTTGATGTTGATAAGCCACGTAATTTGGCTAAAGCTGTAACAGTAGAATAA

Upstream 100 bases:

>100_bases
TACTGTAAACATAATGTTTTTATCGGTATAATTAGACTATACCAATTATTGAAATTATGAGAGAAAGTAGCAAGTTAACG
AACTTGTTAAGGTAATTAAG

Downstream 100 bases:

>100_bases
ATGATTATAATGGATAAGGCAACCATCTGTTAGGTGGTTGCTTTTTGTTTTTAGGAGAATAGCAGAGCTTAGAAAATGGC
CTTGAGAAAAGCTATACAAG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKSLSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLAAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE

Sequences:

>Translated_604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKSLSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLAAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE
>Mature_604_residues
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGIDVAGSTGIGHTRWATHGQST
EDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKGQTDTEIAVHLIGKFVEEDKLSVLEAFKKSLSIIEGSYAFA
LMDSQATDTIYVAKNKSPLLIGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAGTSYHAGFATKNMLEQLTDTP
VELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVKANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVAST
KAYTAQIAALAFLAKAVGEANGKQEALDFNLVHELSLVAQSIEATLSEKDLAAEKVQALLATTRNAFYIGRGNDYYVAME
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARGAHVLTVVEEGLDREGDDIIV
NKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=697, Percent_Identity=32.9985652797704, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI4826742, Length=697, Percent_Identity=32.1377331420373, Blast_Score=293, Evalue=4e-79,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=38.4116693679092, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=28.3236994219653, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=31.2354312354312, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17532899, Length=433, Percent_Identity=33.0254041570439, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17532897, Length=433, Percent_Identity=33.0254041570439, Blast_Score=205, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6322745, Length=476, Percent_Identity=31.3025210084034, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323731, Length=413, Percent_Identity=27.3607748184019, Blast_Score=147, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=34.1463414634146, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=30.2898550724638, Blast_Score=298, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65565; Mature: 65565

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCE
DVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKG
EECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCC
QTDTEIAVHLIGKFVEEDKLSVLEAFKKSLSIIEGSYAFALMDSQATDTIYVAKNKSPLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
IGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEE
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAG
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVK
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEA
ECCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCC
NGKQEALDFNLVHELSLVAQSIEATLSEKDLAAEKVQALLATTRNAFYIGRGNDYYVAME
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARG
EHHHHHHCCEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCC
AHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKA
CEEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHE
VTVE
EECC
>Mature Secondary Structure
MCGIVGVVGNRNATDILMQGLEKLEYRGYDSAGIFVANANQTNLIKSVGRIADLRAKIGI
CCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCE
DVAGSTGIGHTRWATHGQSTEDNAHPHTSQTGRFVLVHNGVIENYLHIKTEFLAGHDFKG
EECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHEEEEEECCCCCCC
QTDTEIAVHLIGKFVEEDKLSVLEAFKKSLSIIEGSYAFALMDSQATDTIYVAKNKSPLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEE
IGLGEGYNMVCSDAMAMIRETSEFMEIHDKELVILTKDKVTVTDYDGKELIRDSYTAELD
EECCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCEEEEECCCCHHHHHCCCCEEEE
LSDIGKGTYPFYMLKEIDEQPTVMRQLISTYADETGNVQVDPAIITSIQEADRLYILAAG
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEEC
TSYHAGFATKNMLEQLTDTPVELGVASEWGYHMPLLSKKPMFILLSQSGETADSRQVLVK
CCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEE
ANAMGIPSLTVTNVPGSTLSREATYTMLIHAGPEIAVASTKAYTAQIAALAFLAKAVGEA
ECCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCC
NGKQEALDFNLVHELSLVAQSIEATLSEKDLAAEKVQALLATTRNAFYIGRGNDYYVAME
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEE
AALKLKEISYIQCEGFAAGELKHGTISLIEEDTPVIALISSSQLVASHTRGNIQEVAARG
EHHHHHHCCEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEHHCCCCHHHHHHCC
AHVLTVVEEGLDREGDDIIVNKVHPFLAPIAMVIPTQLIAYYASLQRGLDVDKPRNLAKA
CEEEEEEHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHE
VTVE
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]