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The map label for this gene is hemN [H]

Identifier: 71910578

GI number: 71910578

Start: 769506

End: 770702

Strand: Direct

Name: hemN [H]

Synonym: M5005_Spy_0765

Alternate gene names: 71910578

Gene position: 769506-770702 (Clockwise)

Preceding gene: 71910577

Following gene: 71910579

Centisome position: 41.85

GC content: 38.1

Gene sequence:

>1197_bases
ATGAAGAATCAAGGGAAATGGTTTATTCATAGAAACATTTTATCATCAAAGTGGTATAATAAGACCATGTCAAAAAAACC
TACTTCAGCCTATGTGCACATTCCTTTTTGCACACAAATTTGTTATTATTGCGATTTTTCAAAAGTCTTTATCCAAAATC
AACCTGTTGATGCTTATTTGAAAGCCTTGATTCAAGAATTTGACTCTTATGGCATTCGAGACCTAAAAACCCTTTATATT
GGAGGAGGTACGCCTACAGCTATCACTGCTAAACAGTTGGAGTATCTCCTAAATCACCTTGAACGAAACCTCAATTTAGA
TGATCTTGAAGAATTCACAATTGAGGCAAATCCTGGTGATTTGACGCCAGAAAAAATTGCGGTGCTTCAGAGGTCAGCTG
TCAATCGGATTTCCTTGGGGGTGCAGACTTTTAATAACAAGCAATTAAAGCAGATTGGCCGTAGCCATAATGAAGAACAA
ATTTATAGCACCATTGCCAATTTAAAAACTGCAGGCTTTCACAATATTTCCATTGATTTAATTTATGCCTTGCCAGGTCA
AACCTTAGATCAAGTCAAGGAAAATGTTGCTAAAGCTTTGGCACTTGATATTCCCCACCTTAGTCTTTATAGCCTTATTT
TGGAACATCACACTGTTTTTATGAACAAAATGCGACGTGGTAAACTTAACTTACCAACGGAAGACTTGGAAGCGGAAATG
TTTGAGTACATTATTTCAGAAATGGAAGCTAATGGTTTTGAGCATTATGAAATTTCCAATTTTACCAAACCAGGTTTTGA
AAGTCGCCATAACTTGATGTATTGGGATAATGTGGAGTATTTTGGATGTGGTGCAGGGGCTTCAGGTTACCTTAATGGCA
TTCGTTATCAGAATCGGGTGCCCATCCAGCATTATCTTAAAGCGGTTGAAGCAGGGAATGCTAGACTAAATGAAGAAGTG
CTGCGCAAAGAGGAAATGATGGAAGAGGAACTCTTTTTGGGCTTACGTAAAAAGACAGGAGTCTCCATCCAGCGGTTCCA
AGAAAAATTTGGTATGTCTTTTGAGGAGCGTTATGGAAATATTGTTAGGGAGCTTCAAAACCAAGGACTGCTTGTCAAAG
ATGACGCCTTTGTCAGAATGACTAAAAAGGGTCTTTTCTTAGGTGATTCTGTTGCTGAGCGGTTTATATTAGATTAG

Upstream 100 bases:

>100_bases
TTTACCAAGAACAAGGGTTTGTTTTGCTAGCTAAGGGTTGCAAGCCAGGAAACGAAAATGATTCTGACGTTTGTCAGCTC
GTAAAATACTTTTCCAAGCC

Downstream 100 bases:

>100_bases
GAGAGTATTATGGGATTAAGTTATCAGGAGGAGTTGACACTTCCTTTTGAATTATGTGATGTCAAATCAGATATAAAATT
GCCCCTTTTATTAGACTATT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKNQGKWFIHRNILSSKWYNKTMSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLKALIQEFDSYGIRDLKTLYI
GGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQ
IYSTIANLKTAGFHNISIDLIYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEV
LRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMSFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD

Sequences:

>Translated_398_residues
MKNQGKWFIHRNILSSKWYNKTMSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLKALIQEFDSYGIRDLKTLYI
GGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQ
IYSTIANLKTAGFHNISIDLIYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEV
LRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMSFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD
>Mature_398_residues
MKNQGKWFIHRNILSSKWYNKTMSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYLKALIQEFDSYGIRDLKTLYI
GGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGDLTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQ
IYSTIANLKTAGFHNISIDLIYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRVPIQHYLKAVEAGNARLNEEV
LRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMSFEERYGNIVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=280, Percent_Identity=31.4285714285714, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1789325, Length=268, Percent_Identity=36.1940298507463, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082341, Length=384, Percent_Identity=25, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 45874; Mature: 45874

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQGKWFIHRNILSSKWYNKTMSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYL
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCHHHHCCCCCHHHHH
KALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGD
HHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCC
LTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKTAGFHNISIDL
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
IYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRV
HHHHHHHHHCCCCCCEECCCCCCCCCCCCCCEEEECCCCEEECCCCCCHHHHCCCCCCCC
PIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMSFEERYGN
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
IVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD
HHHHHHHCCEEEECCHHEEEHHCCCEECHHHHHHHCCC
>Mature Secondary Structure
MKNQGKWFIHRNILSSKWYNKTMSKKPTSAYVHIPFCTQICYYCDFSKVFIQNQPVDAYL
CCCCCCEEEEHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHCCHHHHCCCCCHHHHH
KALIQEFDSYGIRDLKTLYIGGGTPTAITAKQLEYLLNHLERNLNLDDLEEFTIEANPGD
HHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHEEEECCCCC
LTPEKIAVLQRSAVNRISLGVQTFNNKQLKQIGRSHNEEQIYSTIANLKTAGFHNISIDL
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
IYALPGQTLDQVKENVAKALALDIPHLSLYSLILEHHTVFMNKMRRGKLNLPTEDLEAEM
EEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FEYIISEMEANGFEHYEISNFTKPGFESRHNLMYWDNVEYFGCGAGASGYLNGIRYQNRV
HHHHHHHHHCCCCCCEECCCCCCCCCCCCCCEEEECCCCEEECCCCCCHHHHCCCCCCCC
PIQHYLKAVEAGNARLNEEVLRKEEMMEEELFLGLRKKTGVSIQRFQEKFGMSFEERYGN
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHH
IVRELQNQGLLVKDDAFVRMTKKGLFLGDSVAERFILD
HHHHHHHCCEEEECCHHEEEHHCCCEECHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]