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The map label for this gene is pyrC [H]

Identifier: 71910522

GI number: 71910522

Start: 711270

End: 712538

Strand: Direct

Name: pyrC [H]

Synonym: M5005_Spy_0709

Alternate gene names: 71910522

Gene position: 711270-712538 (Clockwise)

Preceding gene: 71910521

Following gene: 71910524

Centisome position: 38.69

GC content: 41.13

Gene sequence:

>1269_bases
ATGATACTCATCAAAAATGGACGCGTTATGGACCCGAAATCGCAGAGAGATCAAGTGGCAGATGTCTTGATTGATGGTAA
ACAGATTGTAAAGATAGCTTCAGCTATTGAATGCCAAGAAGCTCAAGTGATTGATGCTAGTGGTCTTATTGTTGCCCCGG
GTTTGGTCGATATTCATGTGCATTTTAGAGAACCCGGTCAAACGCACAAAGAAGATATTCACACGGGAGCCTTGGCAGCA
GCAGCAGGTGGTGTGACTACGGTTGTCATGATGGCTAATACCAATCCTGTCATTTCAGATGTCGAAACTTTACAGGAAGT
GCTAGCTAGCGCAGCTAAAGAAAAGATTCATATTTACACCAATGCCAGTGTCACCCAAGCCTTTAATGGAAAAGACGTGA
CTGATTTTAAAGCTTTGTTGGAAGCAGGAGCAGTAAGCTTTTCAGATGATGGTATTCCCTTAGAAAGTTCTAAAGTTTTA
AAAGAAGCCTTTGATTTGGCTAATGCCAACCAAACTTTCATTTCTTTGCATGAGGAAGATCCTCAGTTAAATGGGGTTCT
TGGTTTTAATGAAGGTATTGCTGAGGAGCATTTTCATTTTTGTGGGGCAACTGGTGTAGCAGAATATAGTATGATTGCAA
GAGATGTCATGATTGCTTATGACAGGCAAGCTCATGTTCATATCCAACATTTATCTAAAGCAGAATCGGTTCAAGTAGTG
GCTTTTGCTCAGCAGTTGGGTGCTAAGGTAACTGCTGAAGTGTCCCCACAACATTTTTCAACAACTGAAGATCTCTTATT
GATCGCAGGTACCAGCGCCAAGATGAATCCTCCCCTTCGTACACAAAGAGATCGCTTAGCTGTCATAGAAGGCTTGAAAT
CGGGTGTTATCACAGTCATTGCCACTGATCATGCTCCTCATCACAAGGATGAAAAAGCTGTGGATGATATGACTAAAGCC
CCATCTGGTATGACAGGACTTGAAACTTCTTTGTCATTAGGTTTGACGCATTTGGTTGAACCAGGTCATCTTACACTTAT
GTCACTATTAGAAAAAATGACGCTTAATCCAGCTTTGCTTTATGGTTTTGATGCGGGTTATTTGGCAGAAAATGGTCCAG
CAGATTTGGTTATTTTTGCAGACAAGCAAGAACGTCTGATCACTGAGAATTTTGCTTCTAAAGCTAGTAATTCCCCATTT
ATTGGTAACAAACTCAAAGGTGTCGTGAAATACACTATTGCAGACGGAGAGGTTGTTTACCCTAATTAA

Upstream 100 bases:

>100_bases
GACATTTTGATACCTTTAATAAGTGAAATGAGTGCAGTAGATTTTTCCTATTAAAGAACGTAAGGTCTTATGGTTAAAAC
AGATAAATAAAGGAGAAAAC

Downstream 100 bases:

>100_bases
CAAATGAGTTAAAACAAAAAAGCTTGACTTTCAGAGAAAGTCAGGCTTTTAGTAAATTTATTTTTTAGGCACTTGTTTGC
TTAAATTTAGCCCCCAAGGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Sequences:

>Translated_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN
>Mature_422_residues
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHVHFREPGQTHKEDIHTGALAA
AAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYTNASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVL
KEAFDLANANQTFISLHEEDPQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVIATDHAPHHKDEKAVDDMTKA
PSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALLYGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPF
IGNKLKGVVKYTIADGEVVYPN

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=391, Percent_Identity=31.9693094629156, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI4503051, Length=453, Percent_Identity=22.7373068432671, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI62422571, Length=453, Percent_Identity=22.7373068432671, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=29.2906178489703, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=27.2321428571429, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI193204318, Length=402, Percent_Identity=32.5870646766169, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI86575075, Length=452, Percent_Identity=24.7787610619469, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=398, Percent_Identity=26.6331658291457, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24642586, Length=380, Percent_Identity=30.7894736842105, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859883, Length=409, Percent_Identity=26.8948655256724, Blast_Score=99, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45261; Mature: 45261

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC
>Mature Secondary Structure
MILIKNGRVMDPKSQRDQVADVLIDGKQIVKIASAIECQEAQVIDASGLIVAPGLVDIHV
CEEECCCEEECCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCEEECCEEEEEE
HFREPGQTHKEDIHTGALAAAAGGVTTVVMMANTNPVISDVETLQEVLASAAKEKIHIYT
EECCCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCEEEEEE
NASVTQAFNGKDVTDFKALLEAGAVSFSDDGIPLESSKVLKEAFDLANANQTFISLHEED
CCCEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
PQLNGVLGFNEGIAEEHFHFCGATGVAEYSMIARDVMIAYDRQAHVHIQHLSKAESVQVV
CCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHEECCCCEEEHHHHCCCCCCHHH
AFAQQLGAKVTAEVSPQHFSTTEDLLLIAGTSAKMNPPLRTQRDRLAVIEGLKSGVITVI
HHHHHHCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEEE
ATDHAPHHKDEKAVDDMTKAPSGMTGLETSLSLGLTHLVEPGHLTLMSLLEKMTLNPALL
EECCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHCCCCEEE
YGFDAGYLAENGPADLVIFADKQERLITENFASKASNSPFIGNKLKGVVKYTIADGEVVY
EECCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCEEEC
PN
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]