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The map label for this gene is aroE [H]

Identifier: 71910254

GI number: 71910254

Start: 437234

End: 438106

Strand: Direct

Name: aroE [H]

Synonym: M5005_Spy_0441

Alternate gene names: 71910254

Gene position: 437234-438106 (Clockwise)

Preceding gene: 71910252

Following gene: 71910255

Centisome position: 23.78

GC content: 27.72

Gene sequence:

>873_bases
ATGTATTCTGCATTGCTTGGTAATCCAGTTGAACATTCTATATCAGATGAATTATTTGAATATCTAAATCACAACATAGG
AGTTCTGGATGAATATAAACATAAAAAAATTTTGGTAGACTCAGTGTGTTTAGAAGATAAAATCAAACATCTGATAAATG
ATCCAAAATGTATTGGATTAAATATAACTTTACCTTATAAAAGAGAGGTAATGAGGTATATTGACAATTTAGACAGAGTA
GCAGAGATAACTGGATCTGTTAACAATATTTATAAATCTGGAAATATAATTACAGGAACTAATACTGATTGGAAAGGTAT
TTATAATACATTAGTTTTCTTTAATATTAGCCATATAACAAAATGTTGTGTTTTAGGTACTGGCGGTACTGCTAGAGCTG
CTATTTTCACTTTACAAAAACTACAAATCTCACCAACAGTTGTATACAGGGAGCCAATTAGTGAGAATACAAGAAGTTTG
ATAAAGAGTTTCCCTGATTTAAAGTATATTACATATAAGGAATTGGCTGATCAACAAATTTTAAATGATATGGAAATCAT
AATAAATACTACACCAGTTGGTATGATAAATTATGAAGAAAGTTTACCTATAAATTTTGATCATTTGGACAATGTTAATT
ATAAAGATAAATACTTTATGGATGTAGTTTTCAATCCTTTACATACGAAACTTCATGAATATTTTGGTAAAAAAGGAGCA
AAAATAATTGATGGTTTATGGGTTTTGATTTTTCAGGGAATTGAAGCATTTTCATTGTGGAGTGATAAAATTAATGATGG
TAAATATTTTTTTTCAAAAGATGATGTTGTCCTAATTCATACATTTCTAGAAGGGAAGATAAAAGGAAAATGA

Upstream 100 bases:

>100_bases
TCTTTAGAGTATCTAAAGACTTATAGGTAATGGTTAGCTCTGTGTAATGCTTGTACTTTATGTTAGTAGTAAACTAATTA
AACGTAGGAGGATGAAATTT

Downstream 100 bases:

>100_bases
CTTTTCACATTACAGTAAATCTTGATGAAATATCAGACAAACTAGATGATTCATTGAAATTTTTAAATAGATTATCAATT
AAAAGTTGTGAATTACGAAT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRV
AEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSL
IKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGA
KIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Sequences:

>Translated_290_residues
MYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRV
AEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSL
IKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGA
KIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK
>Mature_290_residues
MYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGLNITLPYKREVMRYIDNLDRV
AEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHITKCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSL
IKSFPDLKYITYKELADQQILNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGA
KIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=280, Percent_Identity=27.8571428571429, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789675, Length=274, Percent_Identity=24.0875912408759, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320332, Length=168, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 33244; Mature: 33244

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
NITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHIT
EEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHHEEHHHHH
KCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQI
EEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHH
LNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGA
HCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK
HHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCEECCC
>Mature Secondary Structure
MYSALLGNPVEHSISDELFEYLNHNIGVLDEYKHKKILVDSVCLEDKIKHLINDPKCIGL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEE
NITLPYKREVMRYIDNLDRVAEITGSVNNIYKSGNIITGTNTDWKGIYNTLVFFNISHIT
EEECCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCCCCHHHHHHHHHHEEHHHHH
KCCVLGTGGTARAAIFTLQKLQISPTVVYREPISENTRSLIKSFPDLKYITYKELADQQI
EEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHH
LNDMEIIINTTPVGMINYEESLPINFDHLDNVNYKDKYFMDVVFNPLHTKLHEYFGKKGA
HCCEEEEEECCCCEEEECCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
KIIDGLWVLIFQGIEAFSLWSDKINDGKYFFSKDDVVLIHTFLEGKIKGK
HHHHHHHHHHHHCHHHHHHHHCCCCCCEEEECCCCEEEEEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]