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The map label for this gene is vicR [H]

Identifier: 71910248

GI number: 71910248

Start: 428312

End: 429022

Strand: Direct

Name: vicR [H]

Synonym: M5005_Spy_0435

Alternate gene names: 71910248

Gene position: 428312-429022 (Clockwise)

Preceding gene: 71910247

Following gene: 71910249

Centisome position: 23.3

GC content: 39.94

Gene sequence:

>711_bases
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTGACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGGCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGCCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Upstream 100 bases:

>100_bases
AGGTAGAAATAATTTAGAAAAATATAGTTTTGTGATTTTTTATTAACCACAAAAATCACAAATTGTAATATCAATTACAA
GAACTTTCTGAGGTATAGAC

Downstream 100 bases:

>100_bases
AGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTTTATCCATC
TTGCGGTGCGTGATTACCGA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Sequences:

>Translated_236_residues
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
>Mature_236_residues
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=40.5982905982906, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=39.2070484581498, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=36.2068965517241, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=39.6551724137931, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=35.9649122807018, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=38.695652173913, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=36.9565217391304, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786784, Length=235, Percent_Identity=35.7446808510638, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1790860, Length=237, Percent_Identity=32.4894514767932, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=32.0675105485232, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=31.8965517241379, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=32.4675324675325, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=33.3333333333333, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1787375, Length=229, Percent_Identity=31.0043668122271, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=34.8623853211009, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788905, Length=100, Percent_Identity=38, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790437, Length=139, Percent_Identity=31.6546762589928, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=31.3725490196078, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27084; Mature: 27084

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDG
CCEEEEEECCCCHHHHHEECCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEECCCCCC
LEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTE
HHHHHHHHHHCCCCEEEEECCCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
TIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVELTHREFELLHHLANHMGQVM
HHHHHHHHCCCCCCCCEEEECCEEECCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
TREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCC
>Mature Secondary Structure
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDG
CCEEEEEECCCCHHHHHEECCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEECCCCCC
LEVAKEIRKTSHVPIIMLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTE
HHHHHHHHHHCCCCEEEEECCCCCCHHEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
TIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVELTHREFELLHHLANHMGQVM
HHHHHHHHCCCCCCCCEEEECCEEECCHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHH
TREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD
HHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]