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The map label for this gene is hlyX [C]

Identifier: 71910131

GI number: 71910131

Start: 323139

End: 324473

Strand: Direct

Name: hlyX [C]

Synonym: M5005_Spy_0317

Alternate gene names: 71910131

Gene position: 323139-324473 (Clockwise)

Preceding gene: 71910130

Following gene: 71910132

Centisome position: 17.58

GC content: 38.73

Gene sequence:

>1335_bases
ATGGAAGACCCTGTGAGTCAGCCCTTAGTGATTCAATTTTTATTGTTAGTTGTTTTAACCTTGTTAAATGCTTTTTTTTC
AGCCAGTGAAATGGCCTTAGTTTCTCTCAATCGTTCTCGGGTGGAACAAAAAGCAGCAGACGGTGATAAAAAATACGCTC
GTTTGTTGCGGGTTTTAGAGGAACCTAATCATTTTTTATCAACGATTCAAGTTGGGATTACCTTTATTAGTTTACTATCA
GGAGCAAGTTTATCAGCTTCTTTGGGTAAGGTGATCTCAGGTTGGCTAGGTAATTCAGCGACCGCAAGGACAGCTGGTAC
TATCATCTCCTTGGTTTTCTTGACTTATGTCTCTATTGTTTTAGGAGAATTGTATCCAAAACGGATTGCCATGAACCTCA
AAGACAAGTTGGCGATTGTTTCAGCCCCTATTATCATTGGGTTAGGGAGACTGGTTAGTCCCTTTGTATGGCTCTTATCA
GCTTCTACTAATTTACTGAGCCGACTTACCCCTATGACCTTTGATGATGCAGATGAGCAAATGACACGTGATGAAATCGA
GTATATGTTATCAAAAAGTGAGGCGACCCTTGATGCTGAAGAAATTGAGATGTTGCAAGGAGTTTTCTCACTTGATGAAA
TGATGGCGCGTGAAGTCATGGTCCCAAGGACCGATGCTTTCATGATTGACATTAACGATGATCCGCTTGAAAATATTCAG
GAAATCTTAAAACAAAGTTTTTCACGCATTCCTGTTTATGATGTGGATAAAGATAAAATTATCGGTCTCATCCACACTAA
GCGTCTCTTGGAGTCAGGTTTCCGCCAGGGATTTGATCAGATTAACATGCGAAAAATGTTACAAGAACCTCTTTTTGTTC
CCGAAACCATTTTTGTAGATGATCTCTTACGCCAGCTGCGCAATACCCAAAATCAGATGGCTATTTTGCTAGATGAATAT
GGTGGTGTGGCAGGACTTGTGACTTTGGAAGACTTGCTTGAAGAAATCGTCGGTGAAATCGATGATGAAACCGATAAAGC
AGAACAATTTGTTCATGAGATTGGAGACAATACCTATATTGTTGTTGGTACTATGACTTTAAATGAGTTTAATGACTATT
TTGATACCGAACTAGAATCAGATGATGTAGATACCATTGCTGGTTTTTATTTGACAGGTATCGGAACCATTCCAAGCCAG
GAGCAAAAAGAAGCCTACGAAATAGATAACAAAGACAAACATTTAGTTCTAATCAACGATAAAGTCAAAGATGGCCGTAT
TACGAAATTAAAATTAATCCTGTCTAATATAGAACAGATTATTGAGGAAGACTAG

Upstream 100 bases:

>100_bases
CTGCGATTATTTCGGTGGAAAAAGAAGAAATCCCATAGGCTTTGGCTATAAATGTGATATAATGAAGTCACTATATTATT
TTTTTAGGAGTTACATTAAC

Downstream 100 bases:

>100_bases
GCTCCATGCCTAGTCTTTTTGATGAAAAGTGTTATAATGAAAATGTAAAAACGTTTACAAGTAATGAAGGAGATGCAATG
ACTGAGAAAGATTATGGACA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLSTIQVGITFISLLS
GASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLS
ASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAFMIDINDDPLENIQ
EILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLRNTQNQMAILLDEY
GGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQ
EQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED

Sequences:

>Translated_444_residues
MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLSTIQVGITFISLLS
GASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLS
ASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAFMIDINDDPLENIQ
EILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLRNTQNQMAILLDEY
GGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQ
EQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED
>Mature_444_residues
MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLEEPNHFLSTIQVGITFISLLS
GASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIVLGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLS
ASTNLLSRLTPMTFDDADEQMTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAFMIDINDDPLENIQ
EILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVDDLLRQLRNTQNQMAILLDEY
GGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYIVVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQ
EQKEAYEIDNKDKHLVLINDKVKDGRITKLKLILSNIEQIIEED

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=382, Percent_Identity=32.9842931937173, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI40068055, Length=365, Percent_Identity=25.2054794520548, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40068053, Length=365, Percent_Identity=25.2054794520548, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI94681046, Length=367, Percent_Identity=26.4305177111717, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693175, Length=382, Percent_Identity=29.5811518324607, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790664, Length=399, Percent_Identity=24.5614035087719, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1786879, Length=225, Percent_Identity=32.4444444444444, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87082033, Length=246, Percent_Identity=28.4552845528455, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788119, Length=225, Percent_Identity=31.1111111111111, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324512, Length=353, Percent_Identity=21.8130311614731, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 49844; Mature: 49844

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHH
EPNHFLSTIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIV
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLSASTNLLSRLTPMTFDDADEQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
MTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAFMIDINDDPLENIQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
EILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVD
HHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHH
DLLRQLRNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYI
HHHHHHHCCHHHEEEEEHHCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEE
VVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQEQKEAYEIDNKDKHLVLIND
EEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEC
KVKDGRITKLKLILSNIEQIIEED
CCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEDPVSQPLVIQFLLLVVLTLLNAFFSASEMALVSLNRSRVEQKAADGDKKYARLLRVLE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHH
EPNHFLSTIQVGITFISLLSGASLSASLGKVISGWLGNSATARTAGTIISLVFLTYVSIV
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LGELYPKRIAMNLKDKLAIVSAPIIIGLGRLVSPFVWLLSASTNLLSRLTPMTFDDADEQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
MTRDEIEYMLSKSEATLDAEEIEMLQGVFSLDEMMAREVMVPRTDAFMIDINDDPLENIQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHH
EILKQSFSRIPVYDVDKDKIIGLIHTKRLLESGFRQGFDQINMRKMLQEPLFVPETIFVD
HHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHH
DLLRQLRNTQNQMAILLDEYGGVAGLVTLEDLLEEIVGEIDDETDKAEQFVHEIGDNTYI
HHHHHHHCCHHHEEEEEHHCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEE
VVGTMTLNEFNDYFDTELESDDVDTIAGFYLTGIGTIPSQEQKEAYEIDNKDKHLVLIND
EEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEC
KVKDGRITKLKLILSNIEQIIEED
CCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]