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The map label for this gene is covR [H]

Identifier: 71910096

GI number: 71910096

Start: 292430

End: 293116

Strand: Direct

Name: covR [H]

Synonym: M5005_Spy_0282

Alternate gene names: 71910096

Gene position: 292430-293116 (Clockwise)

Preceding gene: 71910095

Following gene: 71910097

Centisome position: 15.91

GC content: 38.43

Gene sequence:

>687_bases
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Upstream 100 bases:

>100_bases
ATTTGACCATTAGAACTGAAATAGTCTAGGATATGAGATGAATTTCATAGTTTTCTTTCTGGGAGAAAAAGATAGATTAA
GAGGATAAGGGTTGGTATAA

Downstream 100 bases:

>100_bases
GTCATATGGAAAATCAGAAACAAAAACAGAAGAAATATAAAAATTCGTTACCAAAACGACTATCTAATATCTTTTTTGTT
CTTTTTTCTGCATTTTCTCT

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Sequences:

>Translated_228_residues
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK
>Mature_227_residues
TKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMTA
RDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREYD
LLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Specific function: Member of the two-component regulatory system ArlS/ArlR [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=42.2727272727273, Blast_Score=170, Evalue=8e-44,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=39.3805309734513, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=40.8071748878924, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=37.8854625550661, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=34.841628959276, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=32.7433628318584, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=33.7777777777778, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=36.2445414847162, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=31.8385650224215, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=31.390134529148, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=34.3478260869565, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.0396475770925, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=31.7391304347826, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=29.3859649122807, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=32.520325203252, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=30.8943089430894, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=27.9411764705882, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26619; Mature: 26488

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMD
CCCEEEEEECCCHHHHHHHEEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEEHHCCCCC
GFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQ
CHHHHHHHHCCCEEEEEEEECHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHH
DIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREYDLLNILMTNMNRVMTREELL
CCCHHHCCCCCCCHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
SNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECC
>Mature Secondary Structure 
TKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMD
CCEEEEEECCCHHHHHHHEEEECCCEEEEEEECCCCCHHHHHHHHHHHHEEEHHCCCCC
GFEVTRRLQTEKTTYIMMMTARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQ
CHHHHHHHHCCCEEEEEEEECHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHHH
DIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREYDLLNILMTNMNRVMTREELL
CCCHHHCCCCCCCHHHEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
SNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA