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The map label for this gene is tadA

Identifier: 71909993

GI number: 71909993

Start: 188377

End: 188892

Strand: Direct

Name: tadA

Synonym: M5005_Spy_0179

Alternate gene names: 71909993

Gene position: 188377-188892 (Clockwise)

Preceding gene: 71909992

Following gene: 71909995

Centisome position: 10.25

GC content: 44.77

Gene sequence:

>516_bases
ATGCCATATAGTTTAGAAGAGCAAACTTATTTCATGCAAGAGGCTTTAAAAGAAGCCGAAAAATCCTTACAGAAAGCTGA
AATCCCCATTGGCTGTGTCATTGTCAAGGATGGTGAGATTATTGGTCGTGGGCACAATGCGCGTGAAGAGAGTAACCAAG
CCATTATGCACGCTGAAATGATGGCTATTAACGAGGCTAACGCTCATGAAGGCAACTGGCGTTTATTAGATACCACACTC
TTTGTGACCATCGAGCCTTGTGTGATGTGTAGTGGTGCCATTGGGCTAGCAAGGATTCCGCATGTTATTTATGGAGCCAG
CAATCAAAAATTTGGTGGAGTAGACAGCCTTTACCAGATTTTGACAGATGAGCGCTTAAACCATCGCGTGCAAGTTGAAC
GAGGCCTGCTAGCAGCAGACTGTGCTAACATCATGCAAACCTTTTTCCGCCAAGGGCGAGAGCGCAAAAAAATAGCTAAG
CATTTGATCAAGGAACAGTCAGATCCCTTTGACTAG

Upstream 100 bases:

>100_bases
ATTTAGAAGTGTTGAGGCAAGAAACACAGGCCTATGCAGGTAATATTCCTGTTGACCTTGCCTTACCACACAAATCTTGG
AACTTGGGGAGTCTTTCTTG

Downstream 100 bases:

>100_bases
AGTTTTAAGGAGTTTGTTATCACATGCATTTTTGGTGAAGGGTAGCCTGTCAAAATACTGAGTGAAACGTTAGACCATTT
TTCCAATGGTTGTTAGATTC

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTL
FVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAK
HLIKEQSDPFD

Sequences:

>Translated_171_residues
MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTL
FVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAK
HLIKEQSDPFD
>Mature_170_residues
PYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTLF
VTIEPCVMCSGAIGLARIPHVIYGASNQKFGGVDSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAKH
LIKEQSDPFD

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family

Homologues:

Organism=Homo sapiens, GI124107608, Length=156, Percent_Identity=33.974358974359, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI145693172, Length=151, Percent_Identity=39.7350993377483, Blast_Score=126, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17541138, Length=148, Percent_Identity=35.8108108108108, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17554608, Length=100, Percent_Identity=39, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322425, Length=118, Percent_Identity=32.2033898305085, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325319, Length=96, Percent_Identity=37.5, Blast_Score=71, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355527, Length=148, Percent_Identity=32.4324324324324, Blast_Score=86, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TADA_STRP1 (P68999)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   YP_281543.1
- ProteinModelPortal:   P68999
- SMR:   P68999
- EnsemblBacteria:   EBSTRT00000001125
- EnsemblBacteria:   EBSTRT00000029058
- GeneID:   3572724
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spz:M5005_Spy_0179
- GeneTree:   EBGT00050000027322
- HOGENOM:   HBG741046
- OMA:   IMHAEIM
- ProtClustDB:   CLSK811608
- BioCyc:   SPYO293653:M5005_SPY0179-MONOMER
- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193

Pfam domain/function: PF00383 dCMP_cyt_deam_1; SSF53927 Cytidine_deaminase-like

EC number: NA

Molecular weight: Translated: 19289; Mature: 19158

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: ACT_SITE 59-59

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEM
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHH
MAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGVDSLYQI
HHHCCCCCCCCCEEEEEEEEEEEECHHHHHCCCHHHHHHCHHEECCCCCCCCCHHHHHHH
LTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAKHLIKEQSDPFD
HHHHHHCCHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEM
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEECCCCCCHHHHHHHHHHHH
MAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGVDSLYQI
HHHCCCCCCCCCEEEEEEEEEEEECHHHHHCCCHHHHHHCHHEECCCCCCCCCHHHHHHH
LTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKIAKHLIKEQSDPFD
HHHHHHCCHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296