| Definition | Streptococcus pyogenes MGAS5005 chromosome, complete genome. |
|---|---|
| Accession | NC_007297 |
| Length | 1,838,554 |
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The map label for this gene is adh2 [H]
Identifier: 71909853
GI number: 71909853
Start: 58509
End: 61151
Strand: Direct
Name: adh2 [H]
Synonym: M5005_Spy_0039
Alternate gene names: 71909853
Gene position: 58509-61151 (Clockwise)
Preceding gene: 71909852
Following gene: 161936128
Centisome position: 3.18
GC content: 40.26
Gene sequence:
>2643_bases ATGACTGAAGGACATAATACTGTTGAAACAACCTCTGTTTCTGTGACAATTGATGCTCTTGTTCAAAAAGGTTTAGCTGC TCTTGAAGAGATGCGTAAGCTTGACCAAGAACAAGTTGATTATATCGTAGCCAAAGCTTCTGTTGCTGCTTTGGATGCTC ACGGTGAACTTGCTAAACATGCTTATGAAGAAACAGGTCGCGGTGTCTTTGAAGATAAAGCAACAAAAAATCTATTTGCT TGTGAGCATGTGGTTAATAACATGCGCCATCAAAAAACAGTAGGAATTATTGAAGAAGATGATGTGACAGGTTTGACATT AATTGCTGAGCCGGTGGGTGTTATCTGTGGGATTACACCAACAACTAACCCAACTTCAACAGCTATCTTTAAATCTTTGA TTTCGTTAAAAACACGTAATCCAATTATTTTTGCCTTTCACCCATCAGCACAAGAATCATCAGCACATGCCGCTCGTATT GTTCGTGATGCTGCTATTGCCGCTGGTGCTCCTGAAAATTGTGTGCAGTGGGTTGAAACACCATCACTTGAAGCAACAAA TGCTTTGATGAATCATGACGGCATTGCCACTATCCTTGCGACAGGTGGAAATGCGATGGTTAAAGCGGCATACTCATGTG GGAAACCTGCCCTTGGGGTAGGTGCTGGTAACGTTCCAGCTTATGTTGAAAAATCAGCTAATATCCGTCAAGCCGCTCAT GATATTGTGATGTCTAAATCATTTGATAATGGTATGGTCTGTGCCTCTGAACAAGCTGTTATCATCGATAAAGAAATCTA TGACGATTTTGTAGCAGAATTCAAATCTTACCATACTTATTTTGTAAATAAAAAAGAAAAAGCCCTTCTTGAAGAATTCT GTTTTGGTGCCAAAGCAAATAGCAAAAACTGTGCTGGTGCAAAATTAAATCCAAATATTGTAGGAAAACCAGCTACTTGG ATTGCAGAACAAGCTGGATTTACTGTTCCAGAAGGAACCAATATTCTTGCTGCAGAATGTAAAGAAGTTTCAGAAAATGA GCCTTTAACACGTGAAAAATTATCTCCAGTCATTGCTGTTTTAAAATCTGAATCACGTGAAGACGGTGTTGAAAAAGCTC GTCAAATGGTTGAATTTAATGGACTCGGTCACTCAGCTGCCATTCATACAGCAGATGCAGAATTGGCAAAAGAATTTGGA ACTAGAATCCGTGCTATCCGCGTCATCTGGAATTCACCTTCTACATTTGGTGGTATCGGGGATGTTTACAATGCTTTCTT ACCATCATTGACTCTTGGTTGTGGTTCGTATGGACGTAACGCAGTTGGTGATAACGTTAGTGCTATAAATCTCTTGAACA TCAAAAAAGTAGGAAGACGTAGAAATAATATGCAATGGTTTAAAGTTCCTTCAAAAACATACTTCGAACGTGATTCAATT CAATATTTGCAAAAATGTCGTGACGTTGAACGTGTCATGATTGTTACAGATCACGCTATGGTTGAGCTTGGTTTCTTGGA TCGTATCATTGAACAACTTGATCTTCGTCGCAATAAAGTTGTTTATCAGATCTTTGCTGAAGTAGAACCAGATCCAGACA TTACAACTGTTATGAAAGGTACTGAATTAATGCGTACCTTCAAACCAGACACCATTATTGCCCTTGGCGGGGGATCCCCT ATGGATGCAGCCAAAGTTATGTGGCTCTTCTACGAGCAACCAGAAGTTGATTTCCATGACCTCGTTCAAAAATTCATGGA TATCCGCAAACGTGCGTTCAAATTCCCAGAACTTGGTAAGAAAACAAAATTTGTTGCTATCCCAACAACTTCTGGAACAG GTTCAGAGGTGACACCATTTGCCGTTATCTCTGACAAAGCAAATAATCGTAAATATCCAATCGCTGATTACTCATTAACA CCAACTGTAGCCATTGTTGACCCAGCTTTGGTATTGACTGTTCCAGGCTTTATTGCTGCTGATACTGGTATGGACGTTTT GACACACGCAACCGAAGCTTACGTGTCACAAATGGCCAATGACTTTACGGATGGTTTAGCTCTTCAAGCCATTAAAATTG TTTTTGATAATCTTGAAAAATCAGTTAAAACAGCCGATTTTGAAGCACGTGAAAAGATGCATAATGCGTCAACTATGGCA GGTATGGCTTTCGCCAATGCATTCTTAGGTATTTCTCACTCAATGGCGCATAAAATTGGCGCACAATTCCATACCGTACA CGGACGTACAAATGCAATTCTTTTGCCGTATGTTATCCGCTATAATGGGACTCGTCCAGCTAAAACGGCGACATGGCCTA AGTATAATTACTACCGTGCGGATGAAAAATACCAAGACATTGCGAAATTGTTAGGGCTTCCAGCTTCTACACCAGAAGAA GCAGTGGAATCTTATGCGAAAGCTGTTTATGATCTGGGTTGCCGAGTTGGTATTCAAATGAACTTCAAAGCTCAAGGTAT CGACGAAAACGAATGGAAAGAACATTCTCGTGAATTGGCTTACCTTGCTTATGAAGACCAATGTTCACCTGCTAACCCAC GTCTTCCAATGGTTGATCACATGCAAGAAATTATTGAAGATGCTTACTATGGTTATGCTGAACGTCCAGGACGACGTAAG TGA
Upstream 100 bases:
>100_bases TCACAAATTTATTGTGAAATGATTTACAAAATTTCAAAAAGTGCTATAATAATTTTGTAAACAAAATTGTGAAACTTTTA ACAATATAAAGGAGTCTCAA
Downstream 100 bases:
>100_bases TTTTTAATGTTGATACCAGGAAATGATTTCTTATGATTAAAGTCATAAGAAATCATTTTATTTTCTAAATATATCATTTA TATCCAGTGTCAGAAAATGT
Product: bifunctional acetaldehyde-CoA/alcohol dehydrogenase
Products: NA
Alternate protein names: Alcohol dehydrogenase; ADH; Acetaldehyde dehydrogenase [acetylating]; ACDH; Pyruvate-formate-lyase deactivase; PFL deactivase [H]
Number of amino acids: Translated: 880; Mature: 879
Protein sequence:
>880_residues MTEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATW IAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFG TRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEE AVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK
Sequences:
>Translated_880_residues MTEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFA CEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARI VRDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH DIVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATW IAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFG TRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSP MDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLT PTVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEE AVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK >Mature_879_residues TEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVAKASVAALDAHGELAKHAYEETGRGVFEDKATKNLFAC EHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIV RDAAIAAGAPENCVQWVETPSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAHD IVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKPATWI AEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAVLKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGT RIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSIQ YLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTELMRTFKPDTIIALGGGSPM DAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTP TVAIVDPALVLTVPGFIAADTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMAG MAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPASTPEEA VESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELAYLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK
Specific function: This enzyme has three activities:ADH, ACDH, and PFL- deactivase. In aerobic conditions it acts as a hydrogen peroxide scavenger. The PFL deactivase activity catalyzes the quenching of the pyruvate-formate-lyase catalyst in an iron, NAD, and CoA dependent
COG id: COG1012
COG function: function code C; NAD-dependent aldehyde dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the iron- containing alcohol dehydrogenase family [H]
Homologues:
Organism=Homo sapiens, GI133922590, Length=270, Percent_Identity=30, Blast_Score=102, Evalue=2e-21, Organism=Escherichia coli, GI1787493, Length=867, Percent_Identity=47.7508650519031, Blast_Score=775, Evalue=0.0, Organism=Escherichia coli, GI1789163, Length=401, Percent_Identity=33.9152119700748, Blast_Score=209, Evalue=8e-55, Organism=Escherichia coli, GI87082107, Length=415, Percent_Identity=32.7710843373494, Blast_Score=189, Evalue=7e-49, Organism=Escherichia coli, GI48994951, Length=398, Percent_Identity=32.9145728643216, Blast_Score=180, Evalue=3e-46, Organism=Escherichia coli, GI1788797, Length=385, Percent_Identity=30.6493506493506, Blast_Score=155, Evalue=1e-38, Organism=Escherichia coli, GI1789386, Length=334, Percent_Identity=25.748502994012, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17537053, Length=255, Percent_Identity=29.0196078431373, Blast_Score=114, Evalue=3e-25, Organism=Saccharomyces cerevisiae, GI6321181, Length=418, Percent_Identity=31.3397129186603, Blast_Score=187, Evalue=9e-48, Organism=Saccharomyces cerevisiae, GI6324950, Length=323, Percent_Identity=23.8390092879257, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24657991, Length=378, Percent_Identity=28.3068783068783, Blast_Score=102, Evalue=2e-21,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001670 - InterPro: IPR018211 - InterPro: IPR016161 - InterPro: IPR016163 - InterPro: IPR016162 - InterPro: IPR015590 - InterPro: IPR012079 [H]
Pfam domain/function: PF00171 Aldedh; PF00465 Fe-ADH [H]
EC number: =1.1.1.1; =1.2.1.10 [H]
Molecular weight: Translated: 96738; Mature: 96607
Theoretical pI: Translated: 6.22; Mature: 6.22
Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVAKASVAALDAHGELAKH CCCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCHHEEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWVET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPATWIAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGTRIRAIRVIWNSPSTFGGIG HHCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEC DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLPASTPEEAVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHCCEE YLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC >Mature Secondary Structure TEGHNTVETTSVSVTIDALVQKGLAALEEMRKLDQEQVDYIVAKASVAALDAHGELAKH CCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHH AYEETGRGVFEDKATKNLFACEHVVNNMRHQKTVGIIEEDDVTGLTLIAEPVGVICGITP HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCHHEEEECCC TTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWVET CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCC PSLEATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAH CCCHHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCHHHHHHH DIVMSKSFDNGMVCASEQAVIIDKEIYDDFVAEFKSYHTYFVNKKEKALLEEFCFGAKAN HHHHHCCCCCCCEEECCCEEEEEHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHCCCCCC SKNCAGAKLNPNIVGKPATWIAEQAGFTVPEGTNILAAECKEVSENEPLTREKLSPVIAV CCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH LKSESREDGVEKARQMVEFNGLGHSAAIHTADAELAKEFGTRIRAIRVIWNSPSTFGGIG HHCCCHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCEEEEEEEECCCCCCCCHH DVYNAFLPSLTLGCGSYGRNAVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSI HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCEEEECCCHHHHCHHHH QYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKG HHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHH TELMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGK HHHHHHCCCCEEEEECCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC KTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVLTVPGFIAA CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCEEC DTGMDVLTHATEAYVSQMANDFTDGLALQAIKIVFDNLEKSVKTADFEAREKMHNASTMA CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH GMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRA HHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEC DEKYQDIAKLLGLPASTPEEAVESYAKAVYDLGCRVGIQMNFKAQGIDENEWKEHSRELA CHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHCCEE YLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYAERPGRRK EEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]