Click here to switch to the map view.

The map label for this gene is czcC [H]

Identifier: 71908241

GI number: 71908241

Start: 2828159

End: 2829457

Strand: Reverse

Name: czcC [H]

Synonym: Daro_2628

Alternate gene names: 71908241

Gene position: 2829457-2828159 (Counterclockwise)

Preceding gene: 71908242

Following gene: 71908240

Centisome position: 62.86

GC content: 65.05

Gene sequence:

>1299_bases
ATGTTGTTCGACACCCCTGCCGGGGAGCGCGCTTGGTCGCGTCGTCTCGGCATTCTGGCGGGCCTTGTCCTTGCCACTGG
CAGCGCCTTTGCGGCTGCTCCATTGACGCTGGACGAGGCTTGGCGCTTGGCAGAGAGCGCCAATCCGACGCTACGCGCCG
CTCGTGCCAATCTCGACGCCGCCGAAGGCCAACTGCGGGACAGCTCCGGCCTGCTCTACAACAATCCGCAGCTCTCGACA
GACCAGACCCGCCGTCGCGTTCCACAAGCGGGCCAGTCGGATAACCGTTTCCATGAACAGACGGTCGGTATCTCGCAGAC
CTTCGAGATCGCCGGTCAGGCCGGTTACCGGCGCGAAGCTGCCGTCCGCGAGCTCGCCGCCGTCACGGAAAGCATCGACG
AAGTCCGCCGCCAGGTACGCGCCGAAGTCGAGCAGCGTTTCTACCGGGTACTGATCCTGCAACGGCGCATCGAGACCGAG
CGTGAGGCTCTGAGCGCCGTCAACGACGCCGCTTCGGCGGTCAAGAAACGGGTGGCGGCGGGCGAGGATAGCCGCCTCGA
CGGCAACCTGGCGGCGGTGGAAGCCGAGCGCGGCCACAACCAGCTTGCCGTGCTCGACGAACAACTCCTGCAGGCCCGCG
CTGAGCTGGCGACGGCGCTGCAACTACCCGCCACTACCTTGCCGGAAACAGTTGGTGAATTGCGGGCGATGCCGATGGCT
GCCACCCTGGAAACATTGCAGGCAGCAGCCCGCGAACGGCCCCTGCTGCGTTCATTGGAACACCGGGAACTGGCTGCCCG
CAATCGACTCGGCCTGGAACGCTCGGCCGCCTATCCCGATATCACGGTGGGCCTGAGCACGGGCCGGGAAGGCCCCTACG
ACACCCGCGAACAGTTCACCCGTCTGACGCTCTCCGTTCCATTGCCGCTGTTCCGCCGCAATGGCGCCGGAATTGGCAAG
GCGATGACAGAACTGACCCAGGCGGAAATTGAGCGACAAAGCACCGAGCGAGAAGTCACGGCCCAGGTGAATGCCCTCTG
GCAACGGCTGAGCAGCCTGCAAGGCCGCGTCAAACGGCTGGGCGAGTCCGTCTTGCCGGCCCTCGACGAGAACCGGCACC
TGTCGTCTACCGCCTATCGGGCAGGCGAAATCGGCCTGCTGCAACTGCTGCTGGTCAATCGTCAGTTGCTGGACGCCCGT
CGCGACTATCTTGATGCCCTCGGCGACTTCATCCAGACCCGCATTGCCCTGGAACAGACCGCCGGCTGGCCCAACTTTGC
CCACGAGAAGAACAAATGA

Upstream 100 bases:

>100_bases
TTCCGTCCGCCCCGAAGCGCCTTTCAAGCCTAGACCGACCTAGTTCCTCAGCGGATGCCGTAGCGCATTCTGCTTCTTCA
TCGCTTGAAAGGTTTCTCCC

Downstream 100 bases:

>100_bases
TGACCCGTACCCTGACCGCCGCCGCCCTGGTGCTTTTGCTGACGCTGGCCGCCTGCGGCCGCAATGCCCCCGAGGCCAAG
CCGGCAACCGAAAGCCAAAC

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLFDTPAGERAWSRRLGILAGLVLATGSAFAAAPLTLDEAWRLAESANPTLRAARANLDAAEGQLRDSSGLLYNNPQLST
DQTRRRVPQAGQSDNRFHEQTVGISQTFEIAGQAGYRREAAVRELAAVTESIDEVRRQVRAEVEQRFYRVLILQRRIETE
REALSAVNDAASAVKKRVAAGEDSRLDGNLAAVEAERGHNQLAVLDEQLLQARAELATALQLPATTLPETVGELRAMPMA
ATLETLQAAARERPLLRSLEHRELAARNRLGLERSAAYPDITVGLSTGREGPYDTREQFTRLTLSVPLPLFRRNGAGIGK
AMTELTQAEIERQSTEREVTAQVNALWQRLSSLQGRVKRLGESVLPALDENRHLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPNFAHEKNK

Sequences:

>Translated_432_residues
MLFDTPAGERAWSRRLGILAGLVLATGSAFAAAPLTLDEAWRLAESANPTLRAARANLDAAEGQLRDSSGLLYNNPQLST
DQTRRRVPQAGQSDNRFHEQTVGISQTFEIAGQAGYRREAAVRELAAVTESIDEVRRQVRAEVEQRFYRVLILQRRIETE
REALSAVNDAASAVKKRVAAGEDSRLDGNLAAVEAERGHNQLAVLDEQLLQARAELATALQLPATTLPETVGELRAMPMA
ATLETLQAAARERPLLRSLEHRELAARNRLGLERSAAYPDITVGLSTGREGPYDTREQFTRLTLSVPLPLFRRNGAGIGK
AMTELTQAEIERQSTEREVTAQVNALWQRLSSLQGRVKRLGESVLPALDENRHLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPNFAHEKNK
>Mature_432_residues
MLFDTPAGERAWSRRLGILAGLVLATGSAFAAAPLTLDEAWRLAESANPTLRAARANLDAAEGQLRDSSGLLYNNPQLST
DQTRRRVPQAGQSDNRFHEQTVGISQTFEIAGQAGYRREAAVRELAAVTESIDEVRRQVRAEVEQRFYRVLILQRRIETE
REALSAVNDAASAVKKRVAAGEDSRLDGNLAAVEAERGHNQLAVLDEQLLQARAELATALQLPATTLPETVGELRAMPMA
ATLETLQAAARERPLLRSLEHRELAARNRLGLERSAAYPDITVGLSTGREGPYDTREQFTRLTLSVPLPLFRRNGAGIGK
AMTELTQAEIERQSTEREVTAQVNALWQRLSSLQGRVKRLGESVLPALDENRHLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPNFAHEKNK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47719; Mature: 47719

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDTPAGERAWSRRLGILAGLVLATGSAFAAAPLTLDEAWRLAESANPTLRAARANLDA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHCCCCH
AEGQLRDSSGLLYNNPQLSTDQTRRRVPQAGQSDNRFHEQTVGISQTFEIAGQAGYRREA
HCCCCCCCCCCEECCCCCCHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHH
AVRELAAVTESIDEVRRQVRAEVEQRFYRVLILQRRIETEREALSAVNDAASAVKKRVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEDSRLDGNLAAVEAERGHNQLAVLDEQLLQARAELATALQLPATTLPETVGELRAMPMA
CCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
ATLETLQAAARERPLLRSLEHRELAARNRLGLERSAAYPDITVGLSTGREGPYDTREQFT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCCCHHHHHH
RLTLSVPLPLFRRNGAGIGKAMTELTQAEIERQSTEREVTAQVNALWQRLSSLQGRVKRL
HHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GESVLPALDENRHLSSTAYRAGEIGLLQLLLVNRQLLDARRDYLDALGDFIQTRIALEQT
HHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPNFAHEKNK
CCCCCCCCCCCC
>Mature Secondary Structure
MLFDTPAGERAWSRRLGILAGLVLATGSAFAAAPLTLDEAWRLAESANPTLRAARANLDA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHCCCCCHHHHHHHHHCCCCHHHHHHCCCCH
AEGQLRDSSGLLYNNPQLSTDQTRRRVPQAGQSDNRFHEQTVGISQTFEIAGQAGYRREA
HCCCCCCCCCCEECCCCCCHHHHHHHCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHH
AVRELAAVTESIDEVRRQVRAEVEQRFYRVLILQRRIETEREALSAVNDAASAVKKRVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEDSRLDGNLAAVEAERGHNQLAVLDEQLLQARAELATALQLPATTLPETVGELRAMPMA
CCCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHH
ATLETLQAAARERPLLRSLEHRELAARNRLGLERSAAYPDITVGLSTGREGPYDTREQFT
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCCCHHHHHH
RLTLSVPLPLFRRNGAGIGKAMTELTQAEIERQSTEREVTAQVNALWQRLSSLQGRVKRL
HHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GESVLPALDENRHLSSTAYRAGEIGLLQLLLVNRQLLDARRDYLDALGDFIQTRIALEQT
HHHHHHHCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPNFAHEKNK
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]