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The map label for this gene is guaB [H]

Identifier: 71907957

GI number: 71907957

Start: 2520335

End: 2521798

Strand: Reverse

Name: guaB [H]

Synonym: Daro_2338

Alternate gene names: 71907957

Gene position: 2521798-2520335 (Counterclockwise)

Preceding gene: 71907959

Following gene: 71907956

Centisome position: 56.03

GC content: 57.86

Gene sequence:

>1464_bases
ATGCGACTGCTGCAAAAAGCCCTGACATTCGACGACGTTCTGCTCGTCCCCGCACACTCTCAGATTCTGCCCCGTGACGT
AAGCTTGGCAACCAGGCTTACGCGCAACATTACCCTGAACCTGCCGTTGCTTTCCGCTGCCATGGATACCGTGACGGAAG
GGCGCCTTGCGATTGCAATGGCCCAGGAGGGTGGTATCGGCATCATTCACAAGAATCTGTCACCGAAGGCACAAGCTGCC
GAAGTGGCCAAGGTAAAGCGTTTCGAATCCGGTATTCTGAAGGATCCGATCACGGTTTCTCCGTTGATGACTGTGCGTGA
TGTGATTGAAATCACCCGTCAATACAAGATTTCCGGGCTGCCGGTGATCGACAAGTCTGGCAAGGTCGTCGGTATAGTCA
CCAATCGCGACATGCGCTTCGAGACCAATCTAGATCAACCGGTCAAGGCGATCATGACACCGCGCAAGCGTCTCGTCACG
GTCAAGGAAGGCGCCAGCGTCGAGGATGCCAAGGAACTGATCCGCAGGCATCGCCTGGAGCGCGTGCTGGTCATCGACGA
TGAGTGGCACATGCGCGGCCTGATCACCGTCAAGGATATTCTGAAATCCACTGAGCATCCGCTGGCCAACAAGGATTCCT
CTGGTCGCCTGCGCGCTGGCGCGGCAGTTGGCGTTGGTGCCGGCACCGAGGAACGTGTTGAATTGCTGGCCGAAGCTGGT
GTTGATGTGATTGTCGTCGATACCGCCCACGGCCACTCGCAAGGCGTGCTCGACCGCGTCCAGTGGGTCAAGAAGAATTT
CCCGCAGATCGAAGTTATCGGCGGCAACATCGCTACGGCTGATGCCGCTCGGGCGTTGGTTGATATGGGGGCCGATGGCG
TCAAGGTTGGTATTGGTCCTGGTTCCATCTGTACGACGCGCATCGTCGCCGGTGTTGGCGTGCCACAGATCACGGCCATC
CAGAATGTATCCGATTCGCTCAAGGGTACTGGCGTACCGATGATTGCCGATGGCGGCATCCGTTACTCCGGCGACATCGC
CAAGGCCATCGCGGCTGGTGCCGATACCGTCATGCTTGGCGGCCTGTTTGCCGGTACGGAAGAGGCTCCGGGCGAAGTTG
AACTGTTCCAGGGGCGTTCCTACAAGTCATACCGTGGTATGGGGTCGTTGGGCGCCATGCAGGCCGGTTCGTCGGATCGC
TATTTTCAGGAAACGACATCCAATGTCGACAAGTTCGTACCGGAAGGCATTGAAGGACGTGTTCCCTACAAGGGTTCCGT
GCTTGCCGTGATCCACCAGTTGATGGGCGGCCTGCGCTCGTCGATGGGTTACCTCGGCAGCCCGACCATCGACCACATGC
ACGATAACGCCTGTTTCGTCGAAATCACTTCAGCCGGTATCCGTGAGTCGCATGTCCACGACGTGCAGATCACCAAGGAA
GCACCGAACTACCATCTCGACTGA

Upstream 100 bases:

>100_bases
AAACAAGGGCAAAAACGAGAGAGGATTTCGTGGTCATCTGGGTTTCCTTGGCTTTTCTGTATAATACGATTTTGTGACCT
TGGATTAAAGGCTAAAGGCC

Downstream 100 bases:

>100_bases
TCGTTCCTGTGTCCCAGAGGGGCGGCTCCGGTAGCCGCCCTTTTCATTCAAGGTCTTGAATATGTCTCACCAGAAAATCC
TCATCCTCGATTTCGGTTCC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 487; Mature: 487

Protein sequence:

>487_residues
MRLLQKALTFDDVLLVPAHSQILPRDVSLATRLTRNITLNLPLLSAAMDTVTEGRLAIAMAQEGGIGIIHKNLSPKAQAA
EVAKVKRFESGILKDPITVSPLMTVRDVIEITRQYKISGLPVIDKSGKVVGIVTNRDMRFETNLDQPVKAIMTPRKRLVT
VKEGASVEDAKELIRRHRLERVLVIDDEWHMRGLITVKDILKSTEHPLANKDSSGRLRAGAAVGVGAGTEERVELLAEAG
VDVIVVDTAHGHSQGVLDRVQWVKKNFPQIEVIGGNIATADAARALVDMGADGVKVGIGPGSICTTRIVAGVGVPQITAI
QNVSDSLKGTGVPMIADGGIRYSGDIAKAIAAGADTVMLGGLFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQAGSSDR
YFQETTSNVDKFVPEGIEGRVPYKGSVLAVIHQLMGGLRSSMGYLGSPTIDHMHDNACFVEITSAGIRESHVHDVQITKE
APNYHLD

Sequences:

>Translated_487_residues
MRLLQKALTFDDVLLVPAHSQILPRDVSLATRLTRNITLNLPLLSAAMDTVTEGRLAIAMAQEGGIGIIHKNLSPKAQAA
EVAKVKRFESGILKDPITVSPLMTVRDVIEITRQYKISGLPVIDKSGKVVGIVTNRDMRFETNLDQPVKAIMTPRKRLVT
VKEGASVEDAKELIRRHRLERVLVIDDEWHMRGLITVKDILKSTEHPLANKDSSGRLRAGAAVGVGAGTEERVELLAEAG
VDVIVVDTAHGHSQGVLDRVQWVKKNFPQIEVIGGNIATADAARALVDMGADGVKVGIGPGSICTTRIVAGVGVPQITAI
QNVSDSLKGTGVPMIADGGIRYSGDIAKAIAAGADTVMLGGLFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQAGSSDR
YFQETTSNVDKFVPEGIEGRVPYKGSVLAVIHQLMGGLRSSMGYLGSPTIDHMHDNACFVEITSAGIRESHVHDVQITKE
APNYHLD
>Mature_487_residues
MRLLQKALTFDDVLLVPAHSQILPRDVSLATRLTRNITLNLPLLSAAMDTVTEGRLAIAMAQEGGIGIIHKNLSPKAQAA
EVAKVKRFESGILKDPITVSPLMTVRDVIEITRQYKISGLPVIDKSGKVVGIVTNRDMRFETNLDQPVKAIMTPRKRLVT
VKEGASVEDAKELIRRHRLERVLVIDDEWHMRGLITVKDILKSTEHPLANKDSSGRLRAGAAVGVGAGTEERVELLAEAG
VDVIVVDTAHGHSQGVLDRVQWVKKNFPQIEVIGGNIATADAARALVDMGADGVKVGIGPGSICTTRIVAGVGVPQITAI
QNVSDSLKGTGVPMIADGGIRYSGDIAKAIAAGADTVMLGGLFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQAGSSDR
YFQETTSNVDKFVPEGIEGRVPYKGSVLAVIHQLMGGLRSSMGYLGSPTIDHMHDNACFVEITSAGIRESHVHDVQITKE
APNYHLD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=451, Percent_Identity=42.350332594235, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=42.350332594235, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=42.350332594235, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI34328930, Length=451, Percent_Identity=42.350332594235, Blast_Score=351, Evalue=1e-96,
Organism=Homo sapiens, GI66933016, Length=451, Percent_Identity=41.4634146341463, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI217035152, Length=447, Percent_Identity=42.2818791946309, Blast_Score=345, Evalue=7e-95,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=41.4634146341463, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=39.0243902439024, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=38.8663967611336, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=38.8663967611336, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=38.8663967611336, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=38.8663967611336, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI156104880, Length=269, Percent_Identity=37.9182156133829, Blast_Score=165, Evalue=1e-40,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=61.522633744856, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=33.7837837837838, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71994385, Length=472, Percent_Identity=38.5593220338983, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=428, Percent_Identity=40.4205607476636, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=34.7280334728033, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.8760330578512, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6322012, Length=459, Percent_Identity=39.8692810457516, Blast_Score=348, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6323464, Length=459, Percent_Identity=40.0871459694989, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.4615384615385, Blast_Score=263, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=41.025641025641, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=39.7515527950311, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=39.7515527950311, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=40.3628117913832, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52151; Mature: 52151

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLQKALTFDDVLLVPAHSQILPRDVSLATRLTRNITLNLPLLSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCEEEECHHHHHHHHHHCCCCEEEEE
AQEGGIGIIHKNLSPKAQAAEVAKVKRFESGILKDPITVSPLMTVRDVIEITRQYKISGL
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVIDKSGKVVGIVTNRDMRFETNLDQPVKAIMTPRKRLVTVKEGASVEDAKELIRRHRLE
CEECCCCCEEEEEECCCEEEECCCCHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCC
RVLVIDDEWHMRGLITVKDILKSTEHPLANKDSSGRLRAGAAVGVGAGTEERVELLAEAG
EEEEECCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHCC
VDVIVVDTAHGHSQGVLDRVQWVKKNFPQIEVIGGNIATADAARALVDMGADGVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEHHHHHHHHHHCCCCCEEEECCC
GSICTTRIVAGVGVPQITAIQNVSDSLKGTGVPMIADGGIRYSGDIAKAIAAGADTVMLG
CCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEEC
GLFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQAGSSDRYFQETTSNVDKFVPEGIEGR
EEEECCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VPYKGSVLAVIHQLMGGLRSSMGYLGSPTIDHMHDNACFVEITSAGIRESHVHDVQITKE
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCEEEEEEEC
APNYHLD
CCCCCCC
>Mature Secondary Structure
MRLLQKALTFDDVLLVPAHSQILPRDVSLATRLTRNITLNLPLLSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCEEEECHHHHHHHHHHCCCCEEEEE
AQEGGIGIIHKNLSPKAQAAEVAKVKRFESGILKDPITVSPLMTVRDVIEITRQYKISGL
ECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
PVIDKSGKVVGIVTNRDMRFETNLDQPVKAIMTPRKRLVTVKEGASVEDAKELIRRHRLE
CEECCCCCEEEEEECCCEEEECCCCHHHHHHHCCCHHEEEEECCCCHHHHHHHHHHHCCC
RVLVIDDEWHMRGLITVKDILKSTEHPLANKDSSGRLRAGAAVGVGAGTEERVELLAEAG
EEEEECCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCEEECCEEECCCCCHHHHHHHHHCC
VDVIVVDTAHGHSQGVLDRVQWVKKNFPQIEVIGGNIATADAARALVDMGADGVKVGIGP
CCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCEEHHHHHHHHHHCCCCCEEEECCC
GSICTTRIVAGVGVPQITAIQNVSDSLKGTGVPMIADGGIRYSGDIAKAIAAGADTVMLG
CCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCCEEEEC
GLFAGTEEAPGEVELFQGRSYKSYRGMGSLGAMQAGSSDRYFQETTSNVDKFVPEGIEGR
EEEECCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCC
VPYKGSVLAVIHQLMGGLRSSMGYLGSPTIDHMHDNACFVEITSAGIRESHVHDVQITKE
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEEECCCCCCCCCEEEEEEEC
APNYHLD
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA