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The map label for this gene is tadA [H]

Identifier: 71907824

GI number: 71907824

Start: 2376705

End: 2377145

Strand: Reverse

Name: tadA [H]

Synonym: Daro_2202

Alternate gene names: 71907824

Gene position: 2377145-2376705 (Counterclockwise)

Preceding gene: 71907825

Following gene: 71907823

Centisome position: 52.81

GC content: 59.86

Gene sequence:

>441_bases
ATGCGCGAGGCTATTTCGCTAGCCCGCGCAGCCGAGTGCCTCGGCGAGGTGCCGGTTGGTGCTGTCGTCGTCCTGAATGG
CGAGATTGTAGGGCGTGGATTCAATTCGCCGATCGGTGAAAGCGATCCGACAGCTCACGCCGAAATTGCAGCATTGCGCG
ATGCCGCGAGGGTTTTGGGCAATTACCGCCTGCCGGGGTGCGAGTTGTTCGTGACTCTGGAGCCCTGTGCCATGTGTGCC
GGGGCGATCATGCATTCCCGGATCAGCCGTGTCATTTACGGAGCGCGTGATCCGAAGACAGGGGTGCATGGGAGTGTCGT
CGATCTGTTCGGCGTTGAACGCCTGAATCATCACGCCACTGTTGAAGGCGGGGTGCTTGCGGAGGAGTGCAGCACGTTGT
TGTCGGGCTTCTTCGCCAGTCGTCGCAAAAAATCGCAATGA

Upstream 100 bases:

>100_bases
ATGGCATAACATCTTGTTAGAAAAAGACAAAACTTGTCCTGTTGACGATCGAGTGGGAATAATCGAGGAAACCGTCGCCG
GACTCGGCGATGAATTTTTC

Downstream 100 bases:

>100_bases
AGCTTCAGGTATCCGTCGCCCGGCAGCTGATGAGTGTCATCGACGACGCTGGTACTACGCTCCACGAGTATCCTGTATCG
ACAGCGCTGGCTGGTGTGGG

Product: tRNA-adenosine deaminase

Products: uridine; NH3

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MREAISLARAAECLGEVPVGAVVVLNGEIVGRGFNSPIGESDPTAHAEIAALRDAARVLGNYRLPGCELFVTLEPCAMCA
GAIMHSRISRVIYGARDPKTGVHGSVVDLFGVERLNHHATVEGGVLAEECSTLLSGFFASRRKKSQ

Sequences:

>Translated_146_residues
MREAISLARAAECLGEVPVGAVVVLNGEIVGRGFNSPIGESDPTAHAEIAALRDAARVLGNYRLPGCELFVTLEPCAMCA
GAIMHSRISRVIYGARDPKTGVHGSVVDLFGVERLNHHATVEGGVLAEECSTLLSGFFASRRKKSQ
>Mature_146_residues
MREAISLARAAECLGEVPVGAVVVLNGEIVGRGFNSPIGESDPTAHAEIAALRDAARVLGNYRLPGCELFVTLEPCAMCA
GAIMHSRISRVIYGARDPKTGVHGSVVDLFGVERLNHHATVEGGVLAEECSTLLSGFFASRRKKSQ

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=146, Percent_Identity=34.9315068493151, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI145693172, Length=144, Percent_Identity=54.8611111111111, Blast_Score=165, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17554608, Length=96, Percent_Identity=40.625, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17541138, Length=145, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17555996, Length=97, Percent_Identity=41.2371134020619, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355527, Length=144, Percent_Identity=36.1111111111111, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.5

Molecular weight: Translated: 15430; Mature: 15430

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREAISLARAAECLGEVPVGAVVVLNGEIVGRGFNSPIGESDPTAHAEIAALRDAARVLG
CCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
NYRLPGCELFVTLEPCAMCAGAIMHSRISRVIYGARDPKTGVHGSVVDLFGVERLNHHAT
CCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
VEGGVLAEECSTLLSGFFASRRKKSQ
CCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MREAISLARAAECLGEVPVGAVVVLNGEIVGRGFNSPIGESDPTAHAEIAALRDAARVLG
CCHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
NYRLPGCELFVTLEPCAMCAGAIMHSRISRVIYGARDPKTGVHGSVVDLFGVERLNHHAT
CCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
VEGGVLAEECSTLLSGFFASRRKKSQ
CCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cytidine; H2O

Specific reaction: cytidine + H2O = uridine + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]