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The map label for this gene is arpR [H]

Identifier: 71907782

GI number: 71907782

Start: 2329233

End: 2329850

Strand: Reverse

Name: arpR [H]

Synonym: Daro_2159

Alternate gene names: 71907782

Gene position: 2329850-2329233 (Counterclockwise)

Preceding gene: 71907786

Following gene: 71907776

Centisome position: 51.76

GC content: 58.41

Gene sequence:

>618_bases
GTGGTACGCAAAACCAAGGAAGAAGCAGAGCAGACGCGGAAGCACCTGATCGACGCGGCGCGCACTGTGTTCCATGAGTG
TGGCGTCAGCCGTTCGACGCTGGAAAAAATTGCCAAGGCGGCTGGCGTGACACGCGGCGCCGTTTATTGGCATTTCAAGG
ACAAGGCCGAGTTGTTCTTCGCCATGCGCGAAGATGTTTTTGCCCCGATGGTCGAACGGACCGATGCTTTATTGCTGTCG
GATCAATTTGCCAATCCGCTCGACGCCATCGAAGCCTCGATCAAGGAGTTCTTCCGAGTCCTTGATGACTGCTCGGTCGT
TCGTGAAGTGTTCGAGATCATGATTTCGCGCTGCGAGTATGTCGACGAGTTTGCCGCGGTACAGGAAGAAGTCGGCCGGC
CGGCCCAGACCTTTCTGGCCAAGATTGAGCGCGTTTATCTACAGGCCGCCGAGCGGGGCACCTTGCGTCAGGGGCTTGAT
CCACACGCCACGGCCAAGGATACTTGGGCGTTTACCACAGGGTTGGTGCATCTGCTGCTCGGTTGCCAGAAGGGTTCGGA
TCTGCCGTCACGGGTGCCGGAAATGATTTCCGCCCACATGGCCTTGCGGCGGGCCTGA

Upstream 100 bases:

>100_bases
TTATAAACATTCATGAATGTATGTAAATACGAATTTGTAACTAACCGTTATCAAGCATTTTAGGACGCATAAATTAACGG
AAGTTCGTTCAGGAGAGAAA

Downstream 100 bases:

>100_bases
GCCGCAAGGCGTTCTTGATTATTTACTGCAGGCAGCGCGGATGATGCGCTCGGTCTTGGCTTCATCGAGTTCGGCGTGAC
CACCTAGTGCCGCATTGCCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 205; Mature: 205

Protein sequence:

>205_residues
MVRKTKEEAEQTRKHLIDAARTVFHECGVSRSTLEKIAKAAGVTRGAVYWHFKDKAELFFAMREDVFAPMVERTDALLLS
DQFANPLDAIEASIKEFFRVLDDCSVVREVFEIMISRCEYVDEFAAVQEEVGRPAQTFLAKIERVYLQAAERGTLRQGLD
PHATAKDTWAFTTGLVHLLLGCQKGSDLPSRVPEMISAHMALRRA

Sequences:

>Translated_205_residues
MVRKTKEEAEQTRKHLIDAARTVFHECGVSRSTLEKIAKAAGVTRGAVYWHFKDKAELFFAMREDVFAPMVERTDALLLS
DQFANPLDAIEASIKEFFRVLDDCSVVREVFEIMISRCEYVDEFAAVQEEVGRPAQTFLAKIERVYLQAAERGTLRQGLD
PHATAKDTWAFTTGLVHLLLGCQKGSDLPSRVPEMISAHMALRRA
>Mature_205_residues
MVRKTKEEAEQTRKHLIDAARTVFHECGVSRSTLEKIAKAAGVTRGAVYWHFKDKAELFFAMREDVFAPMVERTDALLLS
DQFANPLDAIEASIKEFFRVLDDCSVVREVFEIMISRCEYVDEFAAVQEEVGRPAQTFLAKIERVYLQAAERGTLRQGLD
PHATAKDTWAFTTGLVHLLLGCQKGSDLPSRVPEMISAHMALRRA

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=132, Percent_Identity=40.9090909090909, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=30.5418719211823, Blast_Score=83, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23148; Mature: 23148

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKTKEEAEQTRKHLIDAARTVFHECGVSRSTLEKIAKAAGVTRGAVYWHFKDKAELFF
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHH
AMREDVFAPMVERTDALLLSDQFANPLDAIEASIKEFFRVLDDCSVVREVFEIMISRCEY
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDEFAAVQEEVGRPAQTFLAKIERVYLQAAERGTLRQGLDPHATAKDTWAFTTGLVHLLL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GCQKGSDLPSRVPEMISAHMALRRA
HCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVRKTKEEAEQTRKHLIDAARTVFHECGVSRSTLEKIAKAAGVTRGAVYWHFKDKAELFF
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEECHHHHHHH
AMREDVFAPMVERTDALLLSDQFANPLDAIEASIKEFFRVLDDCSVVREVFEIMISRCEY
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDEFAAVQEEVGRPAQTFLAKIERVYLQAAERGTLRQGLDPHATAKDTWAFTTGLVHLLL
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GCQKGSDLPSRVPEMISAHMALRRA
HCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]