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The map label for this gene is srpG [H]

Identifier: 71907762

GI number: 71907762

Start: 2305885

End: 2306859

Strand: Reverse

Name: srpG [H]

Synonym: Daro_2138

Alternate gene names: 71907762

Gene position: 2306859-2305885 (Counterclockwise)

Preceding gene: 71907763

Following gene: 71907761

Centisome position: 51.25

GC content: 62.77

Gene sequence:

>975_bases
ATGTCCAAATGGTTTGCAGATAATTCACAGTCGATCGGCCGCACGCCGCTGATCAAGCTCAACCGTGTCATCGACGGCGC
CAAGGCTACCGTGCTCGCCAAGATCGAAGGTCGCAACCCGGCCTATTCGGTCAAGTGCCGGATCGGCGCCGCCCTGATCA
ATGATGCCGAGAAGCGTGGCCTGCTCGGTCCGGGCAAGGAGCTGGTCGAGCCGACTTCCGGCAACACCGGCATCGCGCTG
GCTTTCGTCGCCGCCGCCAAGGGTATTCCGCTGACGCTGACCATGCCCGAAACGATGAGTATCGAACGGCGCAAGCTGCT
GACGGCTTTTGGTGCCAAGCTGGTGCTGACCGAAGGCGCCAAGGGCATGTCCGGCGCCATCGCCAAGGCCGAGGAAATTG
CCGCTTCCGATGCCAAGTACGTGTTGTTGCAGCAGTTCAAGAACCCGGCCAATCCGGCCATCCACGAACTGACCACCGGT
CCGGAAATCTGGGACGACACCGATGGCGCCATCGACATTCTGGTGTCCGGGGTCGGCACTGGCGGCACGATCACCGGTGT
TTCGCGTTACATCAAGAACACCAAGGGCAAGGCGATCCAGTCGGTCGCCGTCGAGCCGACCGCCAGCCCGGTGCTGACCC
AGGCTCGTGCCGGCGAGCCAATCAAGCCCGGTCCGCACAAGATTCAGGGGATTGGCGCCGGTTTCGTGCCGGCCGTGCTC
GATCTGTCGCTGCTCGATGCCGTTGAGCAAGTGTCTAATGAGGATGCCGTGCTTTACGCCCGCCGCCTGGCCAAGGAAGA
GGGCATCATCTCCGGGATTTCCAGCGGTGCTGCGGTTGCGGCGGCCGCTCGTCTGGCCCGGATACCGGAAAATGCCGGCA
AGACCATTGTCGCCATCCTGCCTGACTCCGGCGAGCGTTACCTCAGCTCCATCCTGTTCGAAGGCTTGTTCAACGAAGCC
GGGCTGGCCGCATGA

Upstream 100 bases:

>100_bases
TCTCGACGAACAGCAGCGGCGTGGTTCCTTCAATGGCTGGCGTAGCGCCGGCCTGCCGTGGATTCAGGACTGATTCAAAC
ATTTTCAGGGAGAAAACAGC

Downstream 100 bases:

>100_bases
GACACCCCGTTGCCAACTCATCCCTGGCCTACGAGCAGGTGGGTGGCTGGGGCGTCAAAGGGATCGTTGCCGAACTGCAT
TCGGCACGAGATCGCTGGCG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MSKWFADNSQSIGRTPLIKLNRVIDGAKATVLAKIEGRNPAYSVKCRIGAALINDAEKRGLLGPGKELVEPTSGNTGIAL
AFVAAAKGIPLTLTMPETMSIERRKLLTAFGAKLVLTEGAKGMSGAIAKAEEIAASDAKYVLLQQFKNPANPAIHELTTG
PEIWDDTDGAIDILVSGVGTGGTITGVSRYIKNTKGKAIQSVAVEPTASPVLTQARAGEPIKPGPHKIQGIGAGFVPAVL
DLSLLDAVEQVSNEDAVLYARRLAKEEGIISGISSGAAVAAAARLARIPENAGKTIVAILPDSGERYLSSILFEGLFNEA
GLAA

Sequences:

>Translated_324_residues
MSKWFADNSQSIGRTPLIKLNRVIDGAKATVLAKIEGRNPAYSVKCRIGAALINDAEKRGLLGPGKELVEPTSGNTGIAL
AFVAAAKGIPLTLTMPETMSIERRKLLTAFGAKLVLTEGAKGMSGAIAKAEEIAASDAKYVLLQQFKNPANPAIHELTTG
PEIWDDTDGAIDILVSGVGTGGTITGVSRYIKNTKGKAIQSVAVEPTASPVLTQARAGEPIKPGPHKIQGIGAGFVPAVL
DLSLLDAVEQVSNEDAVLYARRLAKEEGIISGISSGAAVAAAARLARIPENAGKTIVAILPDSGERYLSSILFEGLFNEA
GLAA
>Mature_323_residues
SKWFADNSQSIGRTPLIKLNRVIDGAKATVLAKIEGRNPAYSVKCRIGAALINDAEKRGLLGPGKELVEPTSGNTGIALA
FVAAAKGIPLTLTMPETMSIERRKLLTAFGAKLVLTEGAKGMSGAIAKAEEIAASDAKYVLLQQFKNPANPAIHELTTGP
EIWDDTDGAIDILVSGVGTGGTITGVSRYIKNTKGKAIQSVAVEPTASPVLTQARAGEPIKPGPHKIQGIGAGFVPAVLD
LSLLDAVEQVSNEDAVLYARRLAKEEGIISGISSGAAVAAAARLARIPENAGKTIVAILPDSGERYLSSILFEGLFNEAG
LAA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=331, Percent_Identity=36.8580060422961, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI295821200, Length=331, Percent_Identity=36.8580060422961, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI4557415, Length=331, Percent_Identity=36.8580060422961, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1788754, Length=324, Percent_Identity=70.0617283950617, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI2367138, Length=304, Percent_Identity=44.4078947368421, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=310, Percent_Identity=49.3548387096774, Blast_Score=281, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI115535073, Length=303, Percent_Identity=53.7953795379538, Blast_Score=274, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=314, Percent_Identity=47.1337579617834, Blast_Score=268, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI32566674, Length=303, Percent_Identity=48.1848184818482, Blast_Score=261, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI17561720, Length=314, Percent_Identity=47.7707006369427, Blast_Score=244, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=48.4444444444444, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=326, Percent_Identity=38.3435582822086, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=322, Percent_Identity=35.0931677018634, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17561716, Length=131, Percent_Identity=48.0916030534351, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=36.9426751592357, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=31.1926605504587, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24643623, Length=311, Percent_Identity=36.9774919614148, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129101, Length=311, Percent_Identity=36.9774919614148, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33586; Mature: 33455

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKWFADNSQSIGRTPLIKLNRVIDGAKATVLAKIEGRNPAYSVKCRIGAALINDAEKRG
CCCCCCCCCCCCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEEEEECHHHHCCHHHCC
LLGPGKELVEPTSGNTGIALAFVAAAKGIPLTLTMPETMSIERRKLLTAFGAKLVLTEGA
CCCCCHHHCCCCCCCCCEEEEEEHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCC
KGMSGAIAKAEEIAASDAKYVLLQQFKNPANPAIHELTTGPEIWDDTDGAIDILVSGVGT
CCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCC
GGTITGVSRYIKNTKGKAIQSVAVEPTASPVLTQARAGEPIKPGPHKIQGIGAGFVPAVL
CCHHHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
DLSLLDAVEQVSNEDAVLYARRLAKEEGIISGISSGAAVAAAARLARIPENAGKTIVAIL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEE
PDSGERYLSSILFEGLFNEAGLAA
CCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKWFADNSQSIGRTPLIKLNRVIDGAKATVLAKIEGRNPAYSVKCRIGAALINDAEKRG
CCCCCCCCCCCCCCCCEEHHHHHCCCCEEEEEEEECCCCCEEEEEEECHHHHCCHHHCC
LLGPGKELVEPTSGNTGIALAFVAAAKGIPLTLTMPETMSIERRKLLTAFGAKLVLTEGA
CCCCCHHHCCCCCCCCCEEEEEEHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCC
KGMSGAIAKAEEIAASDAKYVLLQQFKNPANPAIHELTTGPEIWDDTDGAIDILVSGVGT
CCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCEEEEEEECCCC
GGTITGVSRYIKNTKGKAIQSVAVEPTASPVLTQARAGEPIKPGPHKIQGIGAGFVPAVL
CCHHHHHHHHHHCCCCCHHHEEECCCCCCHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
DLSLLDAVEQVSNEDAVLYARRLAKEEGIISGISSGAAVAAAARLARIPENAGKTIVAIL
HHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEE
PDSGERYLSSILFEGLFNEAGLAA
CCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]