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The map label for this gene is nadB1 [H]

Identifier: 71907649

GI number: 71907649

Start: 2173910

End: 2175487

Strand: Reverse

Name: nadB1 [H]

Synonym: Daro_2021

Alternate gene names: 71907649

Gene position: 2175487-2173910 (Counterclockwise)

Preceding gene: 71907663

Following gene: 71907639

Centisome position: 48.33

GC content: 54.12

Gene sequence:

>1578_bases
GTGCAGAAATTTGATGTCCTGATCATCGGTAGCGGGCTTGCTGGCCAGTCTGCCGCATTGAGACTCGCCCCTCATTGCCG
AGTGGTACTCGTCAGCAAGCGTAGCCTTGAAGACTCCGCATCCGGCTGGGCTCAAGGGGGGATTGCTGCGGTACTGGACA
GCCAGGATTCCATCGAAGCGCATATTCGGGATACGCTGATTGCCGGCGCTTGGTTGAACGACGAAAAAGCTACCCGCCAT
GTCGTTGAAAACGGGCGCCGAGTTATCGAGTGGCTGATTGAACAAGGCGTCCCTTTCACCAAAGACGACTCTGGCTACCA
CCTTACCCGCGAAGGAGGCCACAGTGCTCGCCGTGTTATCCACGTTGCTGACGCGACTGGTCTTGCCGTACAGGACACGT
TAACCAAGAAAGTTCGCGCCAATCCAAACATTACCGTTCTGGAAGATCACATCGCGATCGACCTGATCACGGGAGACAAG
CTCGGTCAAAACGATAAGCGCTGCTATGGCGCCTACATTCTGAATAATCGTAATGGTGAAGTGATCACCATTGGCGCCCA
GAACACCCTTATCGCCACAGGCGGTGCCGGCAAGGTTTATCTCTATACGACCAACCCCGATACCTCCACAGGTGATGGCA
TAGCCATGGCTTATCGTGCGGGTTGCCGGGTATCGAACATGGAATTTATCCAGTTTCACCCGACCTGTCTCTATCACCCC
CAGGCTAAATCATTCCTTATATCTGAAGCAGTACGTGGCGAAGGCGGGCTACTCCGCCTGCCGGACGGAACTCGCTTCAT
GCCTGAGCACGATGACCGCGCAGAACTGGCACCGCGTGACATCGTCGCTCGTGCCATCGACTTCGAAATGAAGAAACGCG
GCCTCGATTGTGTCTTCCTCGATATTTCACACAAGGATGAAGCGTTCATTCGCGGTCATTTCCCGAATATTTACGCTCGC
TGCCTGGAACTGGGTATTGATATCACCCAGGAAGCGATTCCTGTCGTGCCTGCTGCCCACTACACCTGCGGCGGTATTGT
CAGCGATCTTCACGGCCGCACCGATGTGTCAGGACTGTACGTCGCCGGTGAAGCCTCCTGCACCGGACTGCACGGTGCCA
ACCGCCTTGCTTCCAACTCATTGCTTGAATGCCTAGTGTTTGCCGAAGCAGCGGTTAACGACATCTTGAGCAAGAAATCC
GAAAAAATCCCCACATTGCCGCGCTGGGATGAAAGCCGGGTGACTGATGCCGATGAAGAAGTGGTCATATCCCATAACTG
GGATGAGCTCCGTCGCTTCATGTGGGATTACGTCGGTATTGTCCGAACGACCAAACGACTGAAACGGGCAAAACATCGCA
TTGGTTTGTTGATGCGGGAAATTGACGAGTTTTATGCCAATTTCCGGGTTAGCCATGACCTTATTGAGTTACGCAATTTG
GTAGTAACCGCGGACTTGATCGTGCGCTGTGCCATGTTGCGCAAAGAAAGCCGGGGACTACATTTTTCCCGAGATTTTCC
TGATATGGCCAGCAAGCCGAAGAACACGGTCCTCAAGCGTCGCCGACAAGCGGGCTGA

Upstream 100 bases:

>100_bases
GAAGATAGGTAGTTATCCTTAATTTGTGACTATCTGTAACGGGATGAATCGTTTTCTGCGTGCTATATTTCGTTCAAAAC
TATTCATATAGAGAACAGCC

Downstream 100 bases:

>100_bases
ATTTCGCTCGCCAACGGAGAAATACGCGCAGGCGCCTGAAATCGTCAGTTTTCATGCTATCCGCAGCCACAACAAGTACG
CATTTTTTGCCGTTCAGTGC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MQKFDVLIIGSGLAGQSAALRLAPHCRVVLVSKRSLEDSASGWAQGGIAAVLDSQDSIEAHIRDTLIAGAWLNDEKATRH
VVENGRRVIEWLIEQGVPFTKDDSGYHLTREGGHSARRVIHVADATGLAVQDTLTKKVRANPNITVLEDHIAIDLITGDK
LGQNDKRCYGAYILNNRNGEVITIGAQNTLIATGGAGKVYLYTTNPDTSTGDGIAMAYRAGCRVSNMEFIQFHPTCLYHP
QAKSFLISEAVRGEGGLLRLPDGTRFMPEHDDRAELAPRDIVARAIDFEMKKRGLDCVFLDISHKDEAFIRGHFPNIYAR
CLELGIDITQEAIPVVPAAHYTCGGIVSDLHGRTDVSGLYVAGEASCTGLHGANRLASNSLLECLVFAEAAVNDILSKKS
EKIPTLPRWDESRVTDADEEVVISHNWDELRRFMWDYVGIVRTTKRLKRAKHRIGLLMREIDEFYANFRVSHDLIELRNL
VVTADLIVRCAMLRKESRGLHFSRDFPDMASKPKNTVLKRRRQAG

Sequences:

>Translated_525_residues
MQKFDVLIIGSGLAGQSAALRLAPHCRVVLVSKRSLEDSASGWAQGGIAAVLDSQDSIEAHIRDTLIAGAWLNDEKATRH
VVENGRRVIEWLIEQGVPFTKDDSGYHLTREGGHSARRVIHVADATGLAVQDTLTKKVRANPNITVLEDHIAIDLITGDK
LGQNDKRCYGAYILNNRNGEVITIGAQNTLIATGGAGKVYLYTTNPDTSTGDGIAMAYRAGCRVSNMEFIQFHPTCLYHP
QAKSFLISEAVRGEGGLLRLPDGTRFMPEHDDRAELAPRDIVARAIDFEMKKRGLDCVFLDISHKDEAFIRGHFPNIYAR
CLELGIDITQEAIPVVPAAHYTCGGIVSDLHGRTDVSGLYVAGEASCTGLHGANRLASNSLLECLVFAEAAVNDILSKKS
EKIPTLPRWDESRVTDADEEVVISHNWDELRRFMWDYVGIVRTTKRLKRAKHRIGLLMREIDEFYANFRVSHDLIELRNL
VVTADLIVRCAMLRKESRGLHFSRDFPDMASKPKNTVLKRRRQAG
>Mature_525_residues
MQKFDVLIIGSGLAGQSAALRLAPHCRVVLVSKRSLEDSASGWAQGGIAAVLDSQDSIEAHIRDTLIAGAWLNDEKATRH
VVENGRRVIEWLIEQGVPFTKDDSGYHLTREGGHSARRVIHVADATGLAVQDTLTKKVRANPNITVLEDHIAIDLITGDK
LGQNDKRCYGAYILNNRNGEVITIGAQNTLIATGGAGKVYLYTTNPDTSTGDGIAMAYRAGCRVSNMEFIQFHPTCLYHP
QAKSFLISEAVRGEGGLLRLPDGTRFMPEHDDRAELAPRDIVARAIDFEMKKRGLDCVFLDISHKDEAFIRGHFPNIYAR
CLELGIDITQEAIPVVPAAHYTCGGIVSDLHGRTDVSGLYVAGEASCTGLHGANRLASNSLLECLVFAEAAVNDILSKKS
EKIPTLPRWDESRVTDADEEVVISHNWDELRRFMWDYVGIVRTTKRLKRAKHRIGLLMREIDEFYANFRVSHDLIELRNL
VVTADLIVRCAMLRKESRGLHFSRDFPDMASKPKNTVLKRRRQAG

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=506, Percent_Identity=33.201581027668, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1788928, Length=523, Percent_Identity=60.9942638623327, Blast_Score=645, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=521, Percent_Identity=32.2456813819578, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=32.5581395348837, Blast_Score=202, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17550100, Length=514, Percent_Identity=33.0739299610895, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17505833, Length=519, Percent_Identity=32.5626204238921, Blast_Score=221, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI71986328, Length=455, Percent_Identity=28.7912087912088, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322416, Length=511, Percent_Identity=33.0724070450098, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6322701, Length=526, Percent_Identity=31.1787072243346, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322511, Length=484, Percent_Identity=26.4462809917355, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=478, Percent_Identity=27.1966527196653, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17137288, Length=527, Percent_Identity=32.258064516129, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24655642, Length=527, Percent_Identity=32.258064516129, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24655647, Length=527, Percent_Identity=32.258064516129, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24663005, Length=550, Percent_Identity=32.1818181818182, Blast_Score=219, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 58212; Mature: 58212

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFDVLIIGSGLAGQSAALRLAPHCRVVLVSKRSLEDSASGWAQGGIAAVLDSQDSIEA
CCCEEEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCCCCHHCCCEEEEECCCCHHHH
HIRDTLIAGAWLNDEKATRHVVENGRRVIEWLIEQGVPFTKDDSGYHLTREGGHSARRVI
HHHHHHEEECEECCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEE
HVADATGLAVQDTLTKKVRANPNITVLEDHIAIDLITGDKLGQNDKRCYGAYILNNRNGE
EEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCCCCCCEEEEEEEEECCCCC
VITIGAQNTLIATGGAGKVYLYTTNPDTSTGDGIAMAYRAGCRVSNMEFIQFHPTCLYHP
EEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCEEEECC
QAKSFLISEAVRGEGGLLRLPDGTRFMPEHDDRAELAPRDIVARAIDFEMKKRGLDCVFL
CHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
DISHKDEAFIRGHFPNIYARCLELGIDITQEAIPVVPAAHYTCGGIVSDLHGRTDVSGLY
EECCCCCEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEE
VAGEASCTGLHGANRLASNSLLECLVFAEAAVNDILSKKSEKIPTLPRWDESRVTDADEE
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VVISHNWDELRRFMWDYVGIVRTTKRLKRAKHRIGLLMREIDEFYANFRVSHDLIELRNL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VVTADLIVRCAMLRKESRGLHFSRDFPDMASKPKNTVLKRRRQAG
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQKFDVLIIGSGLAGQSAALRLAPHCRVVLVSKRSLEDSASGWAQGGIAAVLDSQDSIEA
CCCEEEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCCCCHHCCCEEEEECCCCHHHH
HIRDTLIAGAWLNDEKATRHVVENGRRVIEWLIEQGVPFTKDDSGYHLTREGGHSARRVI
HHHHHHEEECEECCHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCEEEE
HVADATGLAVQDTLTKKVRANPNITVLEDHIAIDLITGDKLGQNDKRCYGAYILNNRNGE
EEECCCCCCHHHHHHHHHCCCCCEEEEECCEEEEEEECCCCCCCCCEEEEEEEEECCCCC
VITIGAQNTLIATGGAGKVYLYTTNPDTSTGDGIAMAYRAGCRVSNMEFIQFHPTCLYHP
EEEEECCCEEEEECCCCEEEEEECCCCCCCCCCEEEEECCCCCCCCEEEEEECCEEEECC
QAKSFLISEAVRGEGGLLRLPDGTRFMPEHDDRAELAPRDIVARAIDFEMKKRGLDCVFL
CHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
DISHKDEAFIRGHFPNIYARCLELGIDITQEAIPVVPAAHYTCGGIVSDLHGRTDVSGLY
EECCCCCEEEECCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEE
VAGEASCTGLHGANRLASNSLLECLVFAEAAVNDILSKKSEKIPTLPRWDESRVTDADEE
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VVISHNWDELRRFMWDYVGIVRTTKRLKRAKHRIGLLMREIDEFYANFRVSHDLIELRNL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VVTADLIVRCAMLRKESRGLHFSRDFPDMASKPKNTVLKRRRQAG
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]