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The map label for this gene is gcvH [H]

Identifier: 71907438

GI number: 71907438

Start: 1944465

End: 1944908

Strand: Reverse

Name: gcvH [H]

Synonym: Daro_1809

Alternate gene names: 71907438

Gene position: 1944908-1944465 (Counterclockwise)

Preceding gene: 71907439

Following gene: 71907437

Centisome position: 43.21

GC content: 62.61

Gene sequence:

>444_bases
ATGGCCCACACCCCTTTCACCGGCAGCATCCCCGACGACCGCCTCTACAGCCCCCACTACGACATGTGGGTGCAGCCCGG
CGACAACGGTGAAGTCCTGATCGGCGCCACCAGTTTCGGCATTTTTCTGGCCGGCGAAATCATCGCCTTCACCGCCAAGC
CCAACGGCGCCGAAATCGAAATCGGCCGCGGCATGGGCACCATCGAATCTCGCAAGACCGTGCTCGCCGTCCACGCCCCG
ATTTCCTTCGTCCTGCTCGAAGGCAACGAAACCGCTGAAGAGCGTCCGACCGTGGTCAACAAGGCACCCTACGACGCCGG
CTGGATGGCCCGCGCCAGACCAACCAACTGGCCGGAAGATTCAGCCACGCTGGTCGATGCCAAAGCCTACCGCGCCCACA
TCCTGAAAATCGAACCCGAGGCCAGCTTCGATGAGCCGCAATAA

Upstream 100 bases:

>100_bases
TTCCCCGGTGGGACGGCCGGTCTTCAAAACCGGCAGGGCCTGTCAAACAGGCTTGGGTAGGTTCGACTCCTGCTCTCTTC
CGCCATTTTTCCTCTGCTAA

Downstream 100 bases:

>100_bases
ACCGCCCGCCCCGGAAAACCTCGCCTTCCTGATCTGGGCCGCCACCCCGGACCACCCGGAACTGATCACCACCCCGCTCG
TCCACGCTCTCGCCGCCCGC

Product: glycine cleavage H-protein

Products: Proton; NADH; NH3; CO2; 5,10-methylene-THF [C]

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MAHTPFTGSIPDDRLYSPHYDMWVQPGDNGEVLIGATSFGIFLAGEIIAFTAKPNGAEIEIGRGMGTIESRKTVLAVHAP
ISFVLLEGNETAEERPTVVNKAPYDAGWMARARPTNWPEDSATLVDAKAYRAHILKIEPEASFDEPQ

Sequences:

>Translated_147_residues
MAHTPFTGSIPDDRLYSPHYDMWVQPGDNGEVLIGATSFGIFLAGEIIAFTAKPNGAEIEIGRGMGTIESRKTVLAVHAP
ISFVLLEGNETAEERPTVVNKAPYDAGWMARARPTNWPEDSATLVDAKAYRAHILKIEPEASFDEPQ
>Mature_146_residues
AHTPFTGSIPDDRLYSPHYDMWVQPGDNGEVLIGATSFGIFLAGEIIAFTAKPNGAEIEIGRGMGTIESRKTVLAVHAPI
SFVLLEGNETAEERPTVVNKAPYDAGWMARARPTNWPEDSATLVDAKAYRAHILKIEPEASFDEPQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein [H]

COG id: COG0509

COG function: function code E; Glycine cleavage system H protein (lipoate-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR002930
- InterPro:   IPR017453
- InterPro:   IPR011053 [H]

Pfam domain/function: PF01597 GCV_H [H]

EC number: NA

Molecular weight: Translated: 16039; Mature: 15908

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHTPFTGSIPDDRLYSPHYDMWVQPGDNGEVLIGATSFGIFLAGEIIAFTAKPNGAEIE
CCCCCCCCCCCCCCEECCCCCEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCCCEEE
IGRGMGTIESRKTVLAVHAPISFVLLEGNETAEERPTVVNKAPYDAGWMARARPTNWPED
ECCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCEEECCCCCCCCEECCCCCCCCCC
SATLVDAKAYRAHILKIEPEASFDEPQ
CCEEEECCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
AHTPFTGSIPDDRLYSPHYDMWVQPGDNGEVLIGATSFGIFLAGEIIAFTAKPNGAEIE
CCCCCCCCCCCCCEECCCCCEEEEECCCCCEEEEEECCCEEEEEEEEEEEECCCCCEEE
IGRGMGTIESRKTVLAVHAPISFVLLEGNETAEERPTVVNKAPYDAGWMARARPTNWPED
ECCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCEEECCCCCCCCEECCCCCCCCCC
SATLVDAKAYRAHILKIEPEASFDEPQ
CCEEEECCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Lipoyl Cofactor. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NAD; L-glycine; THF [C]

Specific reaction: NAD + L-glycine + THF = Proton + NADH + NH3 + CO2 + 5,10-methylene-THF [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA