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The map label for this gene is guaD [H]

Identifier: 71907361

GI number: 71907361

Start: 1858714

End: 1859187

Strand: Reverse

Name: guaD [H]

Synonym: Daro_1731

Alternate gene names: 71907361

Gene position: 1859187-1858714 (Counterclockwise)

Preceding gene: 71907369

Following gene: 71907360

Centisome position: 41.31

GC content: 63.71

Gene sequence:

>474_bases
ATGAACCCGGATGACCAGTTTCTCGCCCGTGCCATCGAACTGGCGCGGCAAGGCAGTGAAAGCGGCGAAGGCGGACCGTT
CGGCGCCGTAATCGTCCGCGATGGCCGGATCATCGCCGAAGGCTGGAACCGTGTCGTCGCCAGCCACGATCCGACCGCCC
ACGCCGAAATTGGCGCCATCCGCACTGCCTGTGCCGGGCAAGACCACTTTCACCTGCACGGCTGCACCCTCTACGCTTCC
AGCGAACCCTGCCCGATGTGCCTGTCGGCTGCCTACTGGGCGCGTATCGAACGCATCGTCTTCGCCAACAGCCGGGCCGA
AGCGGCTGCCATCGGCTTTTGCGACGACGAGTTGTACAGCGAACTGAATCGCCATTTTTCGGCCCGCAGCATTGTCATGG
AACATCACCCCATGCCCGGCGCGCTTGAGCCGTTGGAAAGCTGGGCCGCCAACCCCGGTCGAATCCCCTATTGA

Upstream 100 bases:

>100_bases
GCCTGATTGTGGCGGGACAAATGCCCCTGCCATGTTGGGGGCCGTATAATAGCATCGACCTATTTGATCGACCCCGCAGT
ACCGAGGAAGGATCGGCCAG

Downstream 100 bases:

>100_bases
TCCGCCGACCGTAAGCCATGCTTCCCACCTCGATCCCCCAGCGTGCCGAAACGCTGCAGGTGCTTCGCCTGATCAGTGAG
TTCGAACCGATCCTGATGCT

Product: cytidine/deoxycytidylate deaminase, zinc-binding region

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MNPDDQFLARAIELARQGSESGEGGPFGAVIVRDGRIIAEGWNRVVASHDPTAHAEIGAIRTACAGQDHFHLHGCTLYAS
SEPCPMCLSAAYWARIERIVFANSRAEAAAIGFCDDELYSELNRHFSARSIVMEHHPMPGALEPLESWAANPGRIPY

Sequences:

>Translated_157_residues
MNPDDQFLARAIELARQGSESGEGGPFGAVIVRDGRIIAEGWNRVVASHDPTAHAEIGAIRTACAGQDHFHLHGCTLYAS
SEPCPMCLSAAYWARIERIVFANSRAEAAAIGFCDDELYSELNRHFSARSIVMEHHPMPGALEPLESWAANPGRIPY
>Mature_157_residues
MNPDDQFLARAIELARQGSESGEGGPFGAVIVRDGRIIAEGWNRVVASHDPTAHAEIGAIRTACAGQDHFHLHGCTLYAS
SEPCPMCLSAAYWARIERIVFANSRAEAAAIGFCDDELYSELNRHFSARSIVMEHHPMPGALEPLESWAANPGRIPY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=115, Percent_Identity=40.8695652173913, Blast_Score=88, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17554608, Length=152, Percent_Identity=44.078947368421, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17555996, Length=153, Percent_Identity=38.562091503268, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17101; Mature: 17101

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPDDQFLARAIELARQGSESGEGGPFGAVIVRDGRIIAEGWNRVVASHDPTAHAEIGAI
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCHHHEECCCCCCCHHHHHHH
RTACAGQDHFHLHGCTLYASSEPCPMCLSAAYWARIERIVFANSRAEAAAIGFCDDELYS
HHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCHHHHH
ELNRHFSARSIVMEHHPMPGALEPLESWAANPGRIPY
HHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNPDDQFLARAIELARQGSESGEGGPFGAVIVRDGRIIAEGWNRVVASHDPTAHAEIGAI
CCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCEEEECCHHHEECCCCCCCHHHHHHH
RTACAGQDHFHLHGCTLYASSEPCPMCLSAAYWARIERIVFANSRAEAAAIGFCDDELYS
HHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEECCCHHHHH
ELNRHFSARSIVMEHHPMPGALEPLESWAANPGRIPY
HHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]