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The map label for this gene is lysR [H]

Identifier: 71907275

GI number: 71907275

Start: 1768791

End: 1769699

Strand: Reverse

Name: lysR [H]

Synonym: Daro_1644

Alternate gene names: 71907275

Gene position: 1769699-1768791 (Counterclockwise)

Preceding gene: 71907277

Following gene: 71907274

Centisome position: 39.32

GC content: 58.86

Gene sequence:

>909_bases
ATGAATTTAACTCATCGCCAGCTGACGATTTTTCGCGCCATCATGCTGCACGGCAACTTGGGGCGTGCGGCTGCCGCGTG
CGCGTCAAGCCAGCCCACTTTGAGTCGCGAGCTGGGTCGTCTGGAGCAGTTACTGGGGTTTAACCTTTTTGACCGGGTGC
GGGGCCGATTACGACCTACCGTGCGGGCACTTGCGCTGATGCAGGAAGTAGAACGCTCGTTTATAGGCTTGGAACAGATC
GCAGCGCGCGCCAGCGAATTGCGCACGCAAGCGACAGGTCACTTGCGCATTGCGTGTTTGCCGGCATTGGCCCATGCCTT
GGTACCCCGCGCACTGGTATATCTCTCACATGCACATCCTGAACTAGGAGTCAGCGTGCATCCCTTAGAGTCGCCCTGGC
TGGAGCAAGCCATGAGTGAACAGCGTTTTGACCTGGGACTGAGTGAAACCCAAGAGGCACCTGCTGGAGTTGCCTTGCAG
CCCTTACTGAAAGTCAATGAAGTGGCTGTTTTGCCACGTGATCACAGCCTGTGCCGCAAGGCGCGACTGCAACCACGCGA
CTTTACAGGCGAGCGCTTCATCAGTCTCGCGGTTGGCGACCCGTATCGAACCGCCATTGATGCGATGTTCGAGGACGCTA
AAGTACATCGCGCAACCCTGCTTGAAACCACGAGCGCAGTGGCCGTCTGCGCCATGGTGCGTCAGGGCCTGGGCGTTGCC
ATCGTAAACCCGCTCACCGCACTGGAACTCAGCGGACCGGACCTAGTAGTGCGGCCGCTTACCGTTGCCATCGGTTACCA
GGTGAATATGCTTCTTCCGGACATCGCAGCTCCGCACCCCTTGCAGGGCGTTCTCGCAGACGCCGTACGCAAGGCCTGTG
CCGCCTTGAACAAGCATCACTCGCTATGA

Upstream 100 bases:

>100_bases
GAGCGATGGTAGCGGGAGTAAAAGGGTTCATGGGTGGATGATCCCCTTCATATTTAATTCAATCAATGCTATTACTGTTA
TGTAGCTATTCAATATTGAT

Downstream 100 bases:

>100_bases
GTTCCATAGCTGCCGGCCAAGCTGCAAATCTGAGCACCCTCAGGTCTATGACCGCTTCCGAGCGAGCGTGAAAATGAATG
GCCGGAATGAAGAAATATCC

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MNLTHRQLTIFRAIMLHGNLGRAAAACASSQPTLSRELGRLEQLLGFNLFDRVRGRLRPTVRALALMQEVERSFIGLEQI
AARASELRTQATGHLRIACLPALAHALVPRALVYLSHAHPELGVSVHPLESPWLEQAMSEQRFDLGLSETQEAPAGVALQ
PLLKVNEVAVLPRDHSLCRKARLQPRDFTGERFISLAVGDPYRTAIDAMFEDAKVHRATLLETTSAVAVCAMVRQGLGVA
IVNPLTALELSGPDLVVRPLTVAIGYQVNMLLPDIAAPHPLQGVLADAVRKACAALNKHHSL

Sequences:

>Translated_302_residues
MNLTHRQLTIFRAIMLHGNLGRAAAACASSQPTLSRELGRLEQLLGFNLFDRVRGRLRPTVRALALMQEVERSFIGLEQI
AARASELRTQATGHLRIACLPALAHALVPRALVYLSHAHPELGVSVHPLESPWLEQAMSEQRFDLGLSETQEAPAGVALQ
PLLKVNEVAVLPRDHSLCRKARLQPRDFTGERFISLAVGDPYRTAIDAMFEDAKVHRATLLETTSAVAVCAMVRQGLGVA
IVNPLTALELSGPDLVVRPLTVAIGYQVNMLLPDIAAPHPLQGVLADAVRKACAALNKHHSL
>Mature_302_residues
MNLTHRQLTIFRAIMLHGNLGRAAAACASSQPTLSRELGRLEQLLGFNLFDRVRGRLRPTVRALALMQEVERSFIGLEQI
AARASELRTQATGHLRIACLPALAHALVPRALVYLSHAHPELGVSVHPLESPWLEQAMSEQRFDLGLSETQEAPAGVALQ
PLLKVNEVAVLPRDHSLCRKARLQPRDFTGERFISLAVGDPYRTAIDAMFEDAKVHRATLLETTSAVAVCAMVRQGLGVA
IVNPLTALELSGPDLVVRPLTVAIGYQVNMLLPDIAAPHPLQGVLADAVRKACAALNKHHSL

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=268, Percent_Identity=45.8955223880597, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=26.3829787234043, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790399, Length=248, Percent_Identity=26.6129032258064, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=254, Percent_Identity=22.4409448818898, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1788481, Length=250, Percent_Identity=24.4, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32846; Mature: 32846

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS50931 HTH_LYSR ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTHRQLTIFRAIMLHGNLGRAAAACASSQPTLSRELGRLEQLLGFNLFDRVRGRLRPT
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VRALALMQEVERSFIGLEQIAARASELRTQATGHLRIACLPALAHALVPRALVYLSHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
ELGVSVHPLESPWLEQAMSEQRFDLGLSETQEAPAGVALQPLLKVNEVAVLPRDHSLCRK
CCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHH
ARLQPRDFTGERFISLAVGDPYRTAIDAMFEDAKVHRATLLETTSAVAVCAMVRQGLGVA
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IVNPLTALELSGPDLVVRPLTVAIGYQVNMLLPDIAAPHPLQGVLADAVRKACAALNKHH
EECCHHEEEECCCCEEEEHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SL
CC
>Mature Secondary Structure
MNLTHRQLTIFRAIMLHGNLGRAAAACASSQPTLSRELGRLEQLLGFNLFDRVRGRLRPT
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VRALALMQEVERSFIGLEQIAARASELRTQATGHLRIACLPALAHALVPRALVYLSHAHP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHCCC
ELGVSVHPLESPWLEQAMSEQRFDLGLSETQEAPAGVALQPLLKVNEVAVLPRDHSLCRK
CCCCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEECCCCHHHHHH
ARLQPRDFTGERFISLAVGDPYRTAIDAMFEDAKVHRATLLETTSAVAVCAMVRQGLGVA
HCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IVNPLTALELSGPDLVVRPLTVAIGYQVNMLLPDIAAPHPLQGVLADAVRKACAALNKHH
EECCHHEEEECCCCEEEEHHHHEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
SL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]