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The map label for this gene is ubiB [H]

Identifier: 71906769

GI number: 71906769

Start: 1237096

End: 1238436

Strand: Reverse

Name: ubiB [H]

Synonym: Daro_1130

Alternate gene names: 71906769

Gene position: 1238436-1237096 (Counterclockwise)

Preceding gene: 71906770

Following gene: 71906763

Centisome position: 27.51

GC content: 61.97

Gene sequence:

>1341_bases
ATGTCCGATGATTCTCAGGGAACCCCGGAGGAAAATTCCGCCCCGGTTCCCCACGGACGCTGGTCGCGCCTGGCCCGTCT
GGGCTCATTGGCCGGCGGCGTGGCCGGCAATATGCTGGCCGAGGGCGCCCGCCAGTTTGCACAAGGCAAGCGGCCAAAAA
TCCAGCAACTACTGCTGACGCCGGCCAATGCCCGCCGGGTGGCCGATCAACTGGCGCAACTACGCGGTGCGGCCATGAAA
GTGGGGCAGCTGCTATCGATGGATGCCGGCGAACTGCTGCCGCCCGAACTGGCCGACATTCTTGCCCGACTGCGCGCCGA
CGCCATCCCGATGCCGATGAGCCAGGTGGTCAAGGTGCTCAATACCAACTGGGGCGAAGGCTGGGATCGCCATTTCGAGC
GTTTCTCCTTCACCCCGATGGCAGCAGCCTCGATCGGCCAGGTGCATTTCGGGCAAAGGAAAGATGGCCGCCACTTGGCG
ATCAAGATCCAGTACCCCGGCGTTCGCCAGAGCATCGACAGCGATGTCGACAATGTGGCCACCCTGCTCCGTGTTTCCGG
CCTGCTGCCCAAAACGCTGGACGTCAAACCACTACTGGAAGAAGCCAAAAAGCAATTGCATGACGAAGCCGATTACCGTC
GAGAGGGCGCCTGCATGATGCAGTTTGCCGGCCTGCTGGCCGATGCCGACGAGTTCATGGTGCCGGAAATGCACGACGAT
CTGACCACGGAAAACATCCTGGCGATGACCCGCCTGGATGGCGTGGCCGTCGAGTCCCTGAGCCATGCCCCGCAGGCGGA
GCGGGACCGCATCATCAGCCAGTTATTCAGGCTGCTGTTTCGCGAGATTTTCGAATTCCGGCTAATCCAGACTGACCCGA
ACTTCGCCAATTACCGATACGCCGCCGCGTCACAGCAGCTCATGCTGCTCGACTTCGGCGCTACCCGGGTGTACCCCGCG
GCCATGATCGACAGCTATCGCCACCTGATGCTCAGCGCCATTGCCGATGATCGTTCGGCGATGAACCAGGCGGCCCAGGC
GATCGGCTATTTTCAGAGCGATATTAAGGAGGGGCAGCGCCAGGCTGTGCTGGATATTTTCGCGCTGGCCTGCGAGCCGC
TGCGACAGGCAGGAGAATACGATTTCGGCAGTTCCGATCTGGCGCTGCGAATTCGTGACGCGAGCATGGTACTCGGCATG
GATCGGGATTTCTGGCACACCCCACCGGCGGATGCGCTCTTTCTGCATCGCAAGCTGGGCGGCCTGTATCTGCTGGCAGC
AAGGCTCAAGGCGCGGGCGAACTTGCATGAAATCGCTGCCCGCCACTTGCTGGCCGGCTAG

Upstream 100 bases:

>100_bases
GCCTTCATCATCATGCTGATGAAAGGCCCGGCCTACGTCGCCGATGCCTACCCGCTCGATGAGGACGAAAGTCTGGAACC
CAGGCCGGAACGGGATCGTC

Downstream 100 bases:

>100_bases
CTGGCGGCGCGGATCCCCCCCGTGAGAACGAAGATCTGAATCACACCGGCCTGACTCAGCCAGCGCTCAATTGGTCAGGA
TGCGAACCTTGACCGTCTTG

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSDDSQGTPEENSAPVPHGRWSRLARLGSLAGGVAGNMLAEGARQFAQGKRPKIQQLLLTPANARRVADQLAQLRGAAMK
VGQLLSMDAGELLPPELADILARLRADAIPMPMSQVVKVLNTNWGEGWDRHFERFSFTPMAAASIGQVHFGQRKDGRHLA
IKIQYPGVRQSIDSDVDNVATLLRVSGLLPKTLDVKPLLEEAKKQLHDEADYRREGACMMQFAGLLADADEFMVPEMHDD
LTTENILAMTRLDGVAVESLSHAPQAERDRIISQLFRLLFREIFEFRLIQTDPNFANYRYAAASQQLMLLDFGATRVYPA
AMIDSYRHLMLSAIADDRSAMNQAAQAIGYFQSDIKEGQRQAVLDIFALACEPLRQAGEYDFGSSDLALRIRDASMVLGM
DRDFWHTPPADALFLHRKLGGLYLLAARLKARANLHEIAARHLLAG

Sequences:

>Translated_446_residues
MSDDSQGTPEENSAPVPHGRWSRLARLGSLAGGVAGNMLAEGARQFAQGKRPKIQQLLLTPANARRVADQLAQLRGAAMK
VGQLLSMDAGELLPPELADILARLRADAIPMPMSQVVKVLNTNWGEGWDRHFERFSFTPMAAASIGQVHFGQRKDGRHLA
IKIQYPGVRQSIDSDVDNVATLLRVSGLLPKTLDVKPLLEEAKKQLHDEADYRREGACMMQFAGLLADADEFMVPEMHDD
LTTENILAMTRLDGVAVESLSHAPQAERDRIISQLFRLLFREIFEFRLIQTDPNFANYRYAAASQQLMLLDFGATRVYPA
AMIDSYRHLMLSAIADDRSAMNQAAQAIGYFQSDIKEGQRQAVLDIFALACEPLRQAGEYDFGSSDLALRIRDASMVLGM
DRDFWHTPPADALFLHRKLGGLYLLAARLKARANLHEIAARHLLAG
>Mature_445_residues
SDDSQGTPEENSAPVPHGRWSRLARLGSLAGGVAGNMLAEGARQFAQGKRPKIQQLLLTPANARRVADQLAQLRGAAMKV
GQLLSMDAGELLPPELADILARLRADAIPMPMSQVVKVLNTNWGEGWDRHFERFSFTPMAAASIGQVHFGQRKDGRHLAI
KIQYPGVRQSIDSDVDNVATLLRVSGLLPKTLDVKPLLEEAKKQLHDEADYRREGACMMQFAGLLADADEFMVPEMHDDL
TTENILAMTRLDGVAVESLSHAPQAERDRIISQLFRLLFREIFEFRLIQTDPNFANYRYAAASQQLMLLDFGATRVYPAA
MIDSYRHLMLSAIADDRSAMNQAAQAIGYFQSDIKEGQRQAVLDIFALACEPLRQAGEYDFGSSDLALRIRDASMVLGMD
RDFWHTPPADALFLHRKLGGLYLLAARLKARANLHEIAARHLLAG

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=423, Percent_Identity=36.1702127659575, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI27363457, Length=436, Percent_Identity=38.7614678899083, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI217416386, Length=367, Percent_Identity=38.1471389645777, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI40254938, Length=298, Percent_Identity=30.8724832214765, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=31.140350877193, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI41393593, Length=308, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI2367309, Length=199, Percent_Identity=30.6532663316583, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32565180, Length=447, Percent_Identity=36.241610738255, Blast_Score=284, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17559152, Length=295, Percent_Identity=24.7457627118644, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321319, Length=421, Percent_Identity=37.7672209026128, Blast_Score=295, Evalue=1e-80,
Organism=Drosophila melanogaster, GI18859849, Length=399, Percent_Identity=37.34335839599, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI22024280, Length=296, Percent_Identity=27.7027027027027, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24662575, Length=299, Percent_Identity=23.4113712374582, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 49454; Mature: 49323

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDSQGTPEENSAPVPHGRWSRLARLGSLAGGVAGNMLAEGARQFAQGKRPKIQQLLLT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHC
PANARRVADQLAQLRGAAMKVGQLLSMDAGELLPPELADILARLRADAIPMPMSQVVKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
NTNWGEGWDRHFERFSFTPMAAASIGQVHFGQRKDGRHLAIKIQYPGVRQSIDSDVDNVA
HCCCCCHHHHHHHHCCCCCHHHHHHCHHCCCCCCCCCEEEEEEECCCHHHHHHCCHHHHH
TLLRVSGLLPKTLDVKPLLEEAKKQLHDEADYRREGACMMQFAGLLADADEFMVPEMHDD
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCHHHC
LTTENILAMTRLDGVAVESLSHAPQAERDRIISQLFRLLFREIFEFRLIQTDPNFANYRY
CCHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEE
AAASQQLMLLDFGATRVYPAAMIDSYRHLMLSAIADDRSAMNQAAQAIGYFQSDIKEGQR
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVLDIFALACEPLRQAGEYDFGSSDLALRIRDASMVLGMDRDFWHTPPADALFLHRKLG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHH
GLYLLAARLKARANLHEIAARHLLAG
HHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDDSQGTPEENSAPVPHGRWSRLARLGSLAGGVAGNMLAEGARQFAQGKRPKIQQLLLT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHC
PANARRVADQLAQLRGAAMKVGQLLSMDAGELLPPELADILARLRADAIPMPMSQVVKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
NTNWGEGWDRHFERFSFTPMAAASIGQVHFGQRKDGRHLAIKIQYPGVRQSIDSDVDNVA
HCCCCCHHHHHHHHCCCCCHHHHHHCHHCCCCCCCCCEEEEEEECCCHHHHHHCCHHHHH
TLLRVSGLLPKTLDVKPLLEEAKKQLHDEADYRREGACMMQFAGLLADADEFMVPEMHDD
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCHHHC
LTTENILAMTRLDGVAVESLSHAPQAERDRIISQLFRLLFREIFEFRLIQTDPNFANYRY
CCHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEE
AAASQQLMLLDFGATRVYPAAMIDSYRHLMLSAIADDRSAMNQAAQAIGYFQSDIKEGQR
HHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVLDIFALACEPLRQAGEYDFGSSDLALRIRDASMVLGMDRDFWHTPPADALFLHRKLG
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHH
GLYLLAARLKARANLHEIAARHLLAG
HHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]