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The map label for this gene is zraS [C]

Identifier: 71906606

GI number: 71906606

Start: 1052120

End: 1053325

Strand: Reverse

Name: zraS [C]

Synonym: Daro_0967

Alternate gene names: 71906606

Gene position: 1053325-1052120 (Counterclockwise)

Preceding gene: 71906607

Following gene: 71906605

Centisome position: 23.4

GC content: 62.69

Gene sequence:

>1206_bases
ATGAGCGAGCTTGCCTTCGACCGCGAATGGAGCCTGGCCGAATTGCTCGAACCAGCCATACTCGAGCGCATTGGCCCCTT
ACTGGCGCAACTGCTCGGTGGCGATGCCGCTATCGTCGATGCGCTCGGAAAAACTTTCTGGGGCGTTGTCGATAGCAAGG
CGGGCCGCGAAGCCCTGACCCTGGAACTGGAGCCCATCGGCTACCTGGCCAGCACGACAGCGGCGCCCGGCACGCTGCAA
GCCGGTGCCGGCTTCCTGACCCAGTTGCTGCGCATCCAGGTCCGCTTCAGGATGGCTTCAAGCCTGCATCTGGAAGCGGT
AGCCGAGGATTTCGAGACCCTGAAGCGCGAACATGCCCGCCTGCTCGAATCGGAGACCCGCTACAAGACATTGGCCGGCG
AACTGGAGAGCCGCGTCAAGGCGCAGGTCGCCCAGCTCGACGAACGCCAGCAGATGCTCTACCAGGCCGAGAAGCTCGCC
TCGGTCGGCCAGCTGGCGGCTGGCATGGCGCACGAGATCAACAATCCGCTCGGTTTCGCCCGCAGCAACTTGAGTACCTT
TAGCCTCTACCTGAAAAAGCTGGCGACCCTGAAAACCAGATTGGACGATGTCGAGACCGCCTGGCGCGAACTCGACATGG
ATTTCGTGCTCGAAGATGGCCTCGACCTGCTCGGCGAGACGGCCGTGGGGCTGGAACGGATCGCCCGCATCGTGGCCGAC
CTCAAGAGTTTCTCCAATGTCGATCGCGCCACTGAAGAGCTGGCTGACCTCAACGACAGCATCCGCCATGCGATCAGCGT
CATCGAGCGGCAGTTGCCGCCCGGGGTCAGCCTGCAGGTCGAGTTGGGCGATCTACCGGCCATCGTTTGCCTGCCCGGCC
ATCTCAACCAGCTTTTCTACAATCTGATCCACAACGCGGTACAGGCCATCCAGGATGCCGGCCACTCCGGTGTCGTGCGC
ATTTCCAGCCGCCTCACCCCTCAGGAAGTTGCCATCAGCATCTCCGATAACGGCATCGGCATGGGTGCCGAGCAGCGCGA
ACGTGCTTTCGAGCCCTTCTTCACCACTCGCCCGGTCGGCAGCGGTGCCGGACTGGGCCTGAGCACTGCTCGCAACATCG
TCCTCGCCCATAGCGGCCATCTCACGATTGCCAGCGAACCGGGGCAAGGCACCACGATCAACCTCAGTTTTCCGACACCA
CCATGA

Upstream 100 bases:

>100_bases
TGCTCACCGCGCTTTATCGCCGCCACGCCGATAACCTGGCGCTGGCCAGCGAGCACGGCCTGGACGAAGCCGCATTCGTC
GCGGGCGCACTGGGACGAGC

Downstream 100 bases:

>100_bases
CTGACTATTCGGCACTCTTCACCGGCCAGACCAGCACGCCGCAAGCGCCGGCCAGTCACCTGACGCCGCCGAAATACCGC
CTGCTGATCGTCGATGACGA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MSELAFDREWSLAELLEPAILERIGPLLAQLLGGDAAIVDALGKTFWGVVDSKAGREALTLELEPIGYLASTTAAPGTLQ
AGAGFLTQLLRIQVRFRMASSLHLEAVAEDFETLKREHARLLESETRYKTLAGELESRVKAQVAQLDERQQMLYQAEKLA
SVGQLAAGMAHEINNPLGFARSNLSTFSLYLKKLATLKTRLDDVETAWRELDMDFVLEDGLDLLGETAVGLERIARIVAD
LKSFSNVDRATEELADLNDSIRHAISVIERQLPPGVSLQVELGDLPAIVCLPGHLNQLFYNLIHNAVQAIQDAGHSGVVR
ISSRLTPQEVAISISDNGIGMGAEQRERAFEPFFTTRPVGSGAGLGLSTARNIVLAHSGHLTIASEPGQGTTINLSFPTP
P

Sequences:

>Translated_401_residues
MSELAFDREWSLAELLEPAILERIGPLLAQLLGGDAAIVDALGKTFWGVVDSKAGREALTLELEPIGYLASTTAAPGTLQ
AGAGFLTQLLRIQVRFRMASSLHLEAVAEDFETLKREHARLLESETRYKTLAGELESRVKAQVAQLDERQQMLYQAEKLA
SVGQLAAGMAHEINNPLGFARSNLSTFSLYLKKLATLKTRLDDVETAWRELDMDFVLEDGLDLLGETAVGLERIARIVAD
LKSFSNVDRATEELADLNDSIRHAISVIERQLPPGVSLQVELGDLPAIVCLPGHLNQLFYNLIHNAVQAIQDAGHSGVVR
ISSRLTPQEVAISISDNGIGMGAEQRERAFEPFFTTRPVGSGAGLGLSTARNIVLAHSGHLTIASEPGQGTTINLSFPTP
P
>Mature_400_residues
SELAFDREWSLAELLEPAILERIGPLLAQLLGGDAAIVDALGKTFWGVVDSKAGREALTLELEPIGYLASTTAAPGTLQA
GAGFLTQLLRIQVRFRMASSLHLEAVAEDFETLKREHARLLESETRYKTLAGELESRVKAQVAQLDERQQMLYQAEKLAS
VGQLAAGMAHEINNPLGFARSNLSTFSLYLKKLATLKTRLDDVETAWRELDMDFVLEDGLDLLGETAVGLERIARIVADL
KSFSNVDRATEELADLNDSIRHAISVIERQLPPGVSLQVELGDLPAIVCLPGHLNQLFYNLIHNAVQAIQDAGHSGVVRI
SSRLTPQEVAISISDNGIGMGAEQRERAFEPFFTTRPVGSGAGLGLSTARNIVLAHSGHLTIASEPGQGTTINLSFPTPP

Specific function: Member Of The Two-Component Regulatory System Zras/Zrar. May Function As A Membrane-Associated Protein Kinase That Phosphorylates Zrar In Response To High Concentrations Of Zinc Or Lead In The Medium. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=252, Percent_Identity=30.952380952381, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788549, Length=260, Percent_Identity=30.3846153846154, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1790300, Length=259, Percent_Identity=27.7992277992278, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788393, Length=134, Percent_Identity=32.089552238806, Blast_Score=62, Evalue=9e-11,
Organism=Escherichia coli, GI145693157, Length=178, Percent_Identity=26.4044943820225, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43432; Mature: 43301

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELAFDREWSLAELLEPAILERIGPLLAQLLGGDAAIVDALGKTFWGVVDSKAGREALT
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEE
LELEPIGYLASTTAAPGTLQAGAGFLTQLLRIQVRFRMASSLHLEAVAEDFETLKREHAR
EEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLESETRYKTLAGELESRVKAQVAQLDERQQMLYQAEKLASVGQLAAGMAHEINNPLGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RSNLSTFSLYLKKLATLKTRLDDVETAWRELDMDFVLEDGLDLLGETAVGLERIARIVAD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKSFSNVDRATEELADLNDSIRHAISVIERQLPPGVSLQVELGDLPAIVCLPGHLNQLFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHH
NLIHNAVQAIQDAGHSGVVRISSRLTPQEVAISISDNGIGMGAEQRERAFEPFFTTRPVG
HHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEECCCCCCCCHHHHHHHCCCCCCCCCCC
SGAGLGLSTARNIVLAHSGHLTIASEPGQGTTINLSFPTPP
CCCCCCHHHHCCEEEEECCCEEEECCCCCCCEEEEECCCCC
>Mature Secondary Structure 
SELAFDREWSLAELLEPAILERIGPLLAQLLGGDAAIVDALGKTFWGVVDSKAGREALT
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEE
LELEPIGYLASTTAAPGTLQAGAGFLTQLLRIQVRFRMASSLHLEAVAEDFETLKREHAR
EEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLESETRYKTLAGELESRVKAQVAQLDERQQMLYQAEKLASVGQLAAGMAHEINNPLGFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RSNLSTFSLYLKKLATLKTRLDDVETAWRELDMDFVLEDGLDLLGETAVGLERIARIVAD
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKSFSNVDRATEELADLNDSIRHAISVIERQLPPGVSLQVELGDLPAIVCLPGHLNQLFY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCHHHHHHH
NLIHNAVQAIQDAGHSGVVRISSRLTPQEVAISISDNGIGMGAEQRERAFEPFFTTRPVG
HHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEECCCCCCCCHHHHHHHCCCCCCCCCCC
SGAGLGLSTARNIVLAHSGHLTIASEPGQGTTINLSFPTPP
CCCCCCHHHHCCEEEEECCCEEEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1333793 [H]