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The map label for this gene is ntpA [H]

Identifier: 71906271

GI number: 71906271

Start: 695011

End: 695463

Strand: Reverse

Name: ntpA [H]

Synonym: Daro_0631

Alternate gene names: 71906271

Gene position: 695463-695011 (Counterclockwise)

Preceding gene: 71906272

Following gene: 71906270

Centisome position: 15.45

GC content: 58.5

Gene sequence:

>453_bases
ATGACCGGGACCAAGCAGCCGGTCTCGGTTCTGGTTGTAATCCACACGCCGGCACTCGACATACTCGTCCTCGAAAGAGC
TGCCCATCCCGGGTTCTGGCAATCAGTGACCGGTAGCCGGGAAGAAAACGAGCAACTGATTGACACTGCCCGTCGCGAAG
TCCTTGAGGAAACGGGGATCGAGGCAACCAGAGAGTCTTTCGTCGACTGGTCGATGACCAACACCTACGAGATATTCAGC
GAGTGGCGGCACCGCTACGCACCTGGCATCACTCATAACACCGAACACGTCTTTAGCCTGCAGGTGCCGCAACGAATCGA
CATTACCACCGCCCCGGATGAGCACCGAAGCTGGCGATGGCTTCCCAGGCAGCAAGCCGCCGACCTGTGCTTCTCATGGA
GCAATCGGGACGCCATCCTGATGCTGCAGCAGCGACTCGATTCGAGGACTTGA

Upstream 100 bases:

>100_bases
CAGTTCTACAGGCGGCGGCGGAAATTCGTCGCGACTCGCACAGCCCCTTCTGGATACTCATTGACACCCCGGCGCGCGAC
ATTCCTGTGCTTGCCGAGGC

Downstream 100 bases:

>100_bases
AACCCCAAAAAAGCCTCCTATATTGGTATCAGGAAAGTTTGATCAACCAAGGAGGCAAGCATGGCAAACATCACTCGACT
CGATCCATTCGACGATCTTT

Product: dATP pyrophosphohydrolase

Products: AMP; diphosphate

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTGTKQPVSVLVVIHTPALDILVLERAAHPGFWQSVTGSREENEQLIDTARREVLEETGIEATRESFVDWSMTNTYEIFS
EWRHRYAPGITHNTEHVFSLQVPQRIDITTAPDEHRSWRWLPRQQAADLCFSWSNRDAILMLQQRLDSRT

Sequences:

>Translated_150_residues
MTGTKQPVSVLVVIHTPALDILVLERAAHPGFWQSVTGSREENEQLIDTARREVLEETGIEATRESFVDWSMTNTYEIFS
EWRHRYAPGITHNTEHVFSLQVPQRIDITTAPDEHRSWRWLPRQQAADLCFSWSNRDAILMLQQRLDSRT
>Mature_149_residues
TGTKQPVSVLVVIHTPALDILVLERAAHPGFWQSVTGSREENEQLIDTARREVLEETGIEATRESFVDWSMTNTYEIFSE
WRHRYAPGITHNTEHVFSLQVPQRIDITTAPDEHRSWRWLPRQQAADLCFSWSNRDAILMLQQRLDSRT

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=138, Percent_Identity=47.8260869565217, Blast_Score=110, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.8

Molecular weight: Translated: 17458; Mature: 17327

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGTKQPVSVLVVIHTPALDILVLERAAHPGFWQSVTGSREENEQLIDTARREVLEETGI
CCCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
EATRESFVDWSMTNTYEIFSEWRHRYAPGITHNTEHVFSLQVPQRIDITTAPDEHRSWRW
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCC
LPRQQAADLCFSWSNRDAILMLQQRLDSRT
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TGTKQPVSVLVVIHTPALDILVLERAAHPGFWQSVTGSREENEQLIDTARREVLEETGI
CCCCCCEEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
EATRESFVDWSMTNTYEIFSEWRHRYAPGITHNTEHVFSLQVPQRIDITTAPDEHRSWRW
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCCC
LPRQQAADLCFSWSNRDAILMLQQRLDSRT
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O

Specific reaction: ATP + H2O = AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]