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The map label for this gene is tsaA [H]

Identifier: 71906203

GI number: 71906203

Start: 626526

End: 627191

Strand: Reverse

Name: tsaA [H]

Synonym: Daro_0563

Alternate gene names: 71906203

Gene position: 627191-626526 (Counterclockwise)

Preceding gene: 71906210

Following gene: 71906202

Centisome position: 13.93

GC content: 56.91

Gene sequence:

>666_bases
ATGGCTGCTTGGTTAAATTGCATGTTTCCCCCCAACCTCAAAACCGATCACGATAAGGAGTTCCCCATGGCCGTTCTCGT
TGGCAAGCAAGCCCCGGATTTCACCGCCACCGCCGTTTATGGCAACAACGAAATCAAGGAACTGAAGCTGTCCTCCTTCA
AGGGCAAGCCTGTCGTTCTCTTTTTCTACCCGCTCGATTTCACCTTCGTCTGCCCGTCCGAACTGATCGCTTTCGATCAC
CGCCTGGAAGAATTCAAGCAGCGCGGCGTTGAAGTGATCGGCGTCTCCATCGATTCCCAGTTCACCCATCTGGCCTGGAA
GAACACCGCCGTCAAGGAAGGCGGCATTGGCCCGGTTGGCTATCCGCTGGTTGCCGACGTCAAGCATGAAATCTGCCGCG
CCTACGACGTCGAACTCGAAGCTGCCGGTGTCGCCCTGCGCGGTTCCTTCCTGATTGATAAAAATGGCACCGTCATGCAC
CAGGTCGTCAACATGCTGCCGCTCGGCCGCAACATCGACGAAATGCTGCGCATGGTCGATGCCCTGCAGTTCTTCGAAGA
AAACGGCGAAGTTTGTCCGGCCGGCTGGAACAAGGGCAAGCCGGGCATGGTCGCCTCCACGGAAGGTGTCGCTGCTTACC
TGGCCAAGAACGCCAAGAAGCTGTAA

Upstream 100 bases:

>100_bases
TTATTTTCATACTGGGATTATGCCAGCGTACAGCACTTTCCAGACACGCCTTGCCAAAGCCAATGCAGCCGTATGAGCTG
GAATGCTGGTTTGACACGAC

Downstream 100 bases:

>100_bases
CACTCGCCGTTTCCAGCCCACGCTGTGGGCTGGCCAGAAGAAAAACCCCGGTCGCATTTCTGCCGGGGTTTTTTTCCATT
GTTATTTTCCTGAATAACAG

Product: Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MAAWLNCMFPPNLKTDHDKEFPMAVLVGKQAPDFTATAVYGNNEIKELKLSSFKGKPVVLFFYPLDFTFVCPSELIAFDH
RLEEFKQRGVEVIGVSIDSQFTHLAWKNTAVKEGGIGPVGYPLVADVKHEICRAYDVELEAAGVALRGSFLIDKNGTVMH
QVVNMLPLGRNIDEMLRMVDALQFFEENGEVCPAGWNKGKPGMVASTEGVAAYLAKNAKKL

Sequences:

>Translated_221_residues
MAAWLNCMFPPNLKTDHDKEFPMAVLVGKQAPDFTATAVYGNNEIKELKLSSFKGKPVVLFFYPLDFTFVCPSELIAFDH
RLEEFKQRGVEVIGVSIDSQFTHLAWKNTAVKEGGIGPVGYPLVADVKHEICRAYDVELEAAGVALRGSFLIDKNGTVMH
QVVNMLPLGRNIDEMLRMVDALQFFEENGEVCPAGWNKGKPGMVASTEGVAAYLAKNAKKL
>Mature_220_residues
AAWLNCMFPPNLKTDHDKEFPMAVLVGKQAPDFTATAVYGNNEIKELKLSSFKGKPVVLFFYPLDFTFVCPSELIAFDHR
LEEFKQRGVEVIGVSIDSQFTHLAWKNTAVKEGGIGPVGYPLVADVKHEICRAYDVELEAAGVALRGSFLIDKNGTVMHQ
VVNMLPLGRNIDEMLRMVDALQFFEENGEVCPAGWNKGKPGMVASTEGVAAYLAKNAKKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=191, Percent_Identity=53.9267015706806, Blast_Score=214, Evalue=6e-56,
Organism=Homo sapiens, GI5453549, Length=190, Percent_Identity=50, Blast_Score=204, Evalue=4e-53,
Organism=Homo sapiens, GI4505591, Length=191, Percent_Identity=49.738219895288, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI32455266, Length=191, Percent_Identity=49.738219895288, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI32455264, Length=191, Percent_Identity=49.738219895288, Blast_Score=203, Evalue=8e-53,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=50, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI32483377, Length=188, Percent_Identity=50.531914893617, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI33188454, Length=80, Percent_Identity=68.75, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4758638, Length=197, Percent_Identity=29.4416243654822, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1786822, Length=168, Percent_Identity=35.1190476190476, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=187, Percent_Identity=50.8021390374332, Blast_Score=190, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI32565831, Length=187, Percent_Identity=50.8021390374332, Blast_Score=190, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17554494, Length=181, Percent_Identity=47.5138121546961, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25153706, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323613, Length=192, Percent_Identity=45.8333333333333, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320661, Length=190, Percent_Identity=44.2105263157895, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319407, Length=200, Percent_Identity=28.5, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24656348, Length=211, Percent_Identity=51.6587677725119, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17864676, Length=211, Percent_Identity=51.6587677725119, Blast_Score=219, Evalue=1e-57,
Organism=Drosophila melanogaster, GI17738015, Length=174, Percent_Identity=51.7241379310345, Blast_Score=201, Evalue=3e-52,
Organism=Drosophila melanogaster, GI17157991, Length=190, Percent_Identity=48.9473684210526, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24641739, Length=190, Percent_Identity=48.9473684210526, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21357347, Length=188, Percent_Identity=43.6170212765958, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24581278, Length=190, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17975518, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652434, Length=191, Percent_Identity=29.3193717277487, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=29.2553191489362, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24398; Mature: 24266

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAWLNCMFPPNLKTDHDKEFPMAVLVGKQAPDFTATAVYGNNEIKELKLSSFKGKPVVL
CCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHCCCCCCEEEE
FFYPLDFTFVCPSELIAFDHRLEEFKQRGVEVIGVSIDSQFTHLAWKNTAVKEGGIGPVG
EEECCCEEEECHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
YPLVADVKHEICRAYDVELEAAGVALRGSFLIDKNGTVMHQVVNMLPLGRNIDEMLRMVD
CCHHHHHHHHHHHHHCCEEEECCEEEECEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
ALQFFEENGEVCPAGWNKGKPGMVASTEGVAAYLAKNAKKL
HHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AAWLNCMFPPNLKTDHDKEFPMAVLVGKQAPDFTATAVYGNNEIKELKLSSFKGKPVVL
CCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHCCCCCCEEEE
FFYPLDFTFVCPSELIAFDHRLEEFKQRGVEVIGVSIDSQFTHLAWKNTAVKEGGIGPVG
EEECCCEEEECHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
YPLVADVKHEICRAYDVELEAAGVALRGSFLIDKNGTVMHQVVNMLPLGRNIDEMLRMVD
CCHHHHHHHHHHHHHCCEEEECCEEEECEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
ALQFFEENGEVCPAGWNKGKPGMVASTEGVAAYLAKNAKKL
HHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]