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The map label for this gene is ahcY [H]

Identifier: 71905828

GI number: 71905828

Start: 203478

End: 204890

Strand: Reverse

Name: ahcY [H]

Synonym: Daro_0186

Alternate gene names: 71905828

Gene position: 204890-203478 (Counterclockwise)

Preceding gene: 71905829

Following gene: 71905827

Centisome position: 4.55

GC content: 61.22

Gene sequence:

>1413_bases
GTGGCTGAATTCAAAGACTACGTTATCGCCGATCTTTCCCTTGCCGACTGGGGTCGCAAGGAAATCCTCATTGCCGAAAC
CGAAATGCCGGGCCTGATGGCCATTCGCGAAGAGTTCGCGAAGACCCAGCCGCTCAAGGGCGCCCGCATCACCGGTTCGC
TGCACATGACCATCCAGACCGCCGTGCTGATCGAGACGCTGACCGCGCTCGGCGCCGAAGTCCGCTGGGCCTCGTGCAAC
ATCTTCTCGACCCAGGACCACGCAGCCGCCGCCATCGCCGCGCAGAACATCCCGGTCTTCGCCGTCAAGGGCGAAACTCT
GGTCGATTACTGGGATTACACCCACCGCATCTTCGAATGGGCTGACGGCGGTTATTCGAACATGATTCTCGACGACGGCG
GCGATGCCACCCTGCTGCTGCACCTCGGCGCCCGTGCCGAAAAGGACATCTCCCTGCTGGCCAAGCCGGGCTCCGAAGAA
GAAACCATCCTCTTCGCCGCCATCAAGGCCAAGCTGGCCGTCGATCCGACCTGGTACTCCGTGCGCCTGGCCCAGATCAA
GGGCGTCACCGAGGAAACCACCACCGGCGTGCATCGCCTGTACCAGATGCATCAGCGTGGCGAGCTCAAGTTCCCGGGCA
TCAACGTTAACGATTCCGTCACCAAGTCCAAATTCGACAACCTTTACGGCTGCCGCGAATCGCTGGTCGATGGCATTAAG
CGCGCCACCGACGTGATGATCGCCGGCAAGGTTGCCGTCATCGCCGGTTACGGCGACGTGGGCAAGGGTTCGGCCCAAGC
CATGCGCGCCCTGTCGGCACAAGTCTGGGTCACCGAAATCGACCCGATCTGCGCCCTGCAGGCCGCGATGGAAGGCTATC
GCGTCGTCACCATGGAATACGCCGCCGACAAGGCCGACATCTTCGTCACCACGACCGGCAACTTCCACGTCATCACCCAT
GACCACATGGCTGCGATGAAGAACAACGCCATCGTCTGCAACATCGGTCACTTCGACAACGAAATCGACGTCGCCTCGAT
CGAGAAGTACCAGTGGGAAGAGATCAAGCCGCAAGTCGATCACGTCATCTTCCCGGACGGCAAGCGCATCATCCTGCTCG
CCAAGGGCCGTCTGGTGAACCTCGGCTGCGGCACGGGCCACCCGTCCTACGTGATGTCGTCGTCCTTCGCCAACCAGACC
ATCGCCCAGATCGAGCTGTGGACGGAGGCAGTCAAGGGTTCCAACAAGTACCCGGTCGGCGTCTACACGCTTCCCAAGCA
CCTGGACGAAAAGGTAGCCCGTCTGCAACTGAAGACGCTGAACGCCCAATTGTCCGAGCTGACCGACGAACAGGCCGCCT
ACATCAGCGTGCCGAAGGAAGGCCCGTACAAGGCCGACCACTACCGCTACTAA

Upstream 100 bases:

>100_bases
AAAACGGCGCTCACTGATCAACCCTGCCGGGCGCAGGGGGCCGCCGGTGAGCAACAACGCCGTTATTCCCCTCCCCGTCA
CAGTTATTTAGGAGCTTACT

Downstream 100 bases:

>100_bases
GCGATCACCATGCTGAACCTGCTCGCTGTCTGGATCGTCAATGCGCTAGCCCTGCTGGCGCTACCCTATGTCGTTCCGTC
GGTCCAGATAGCCGGGTTTG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAEFKDYVIADLSLADWGRKEILIAETEMPGLMAIREEFAKTQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWASCN
IFSTQDHAAAAIAAQNIPVFAVKGETLVDYWDYTHRIFEWADGGYSNMILDDGGDATLLLHLGARAEKDISLLAKPGSEE
ETILFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHQRGELKFPGINVNDSVTKSKFDNLYGCRESLVDGIK
RATDVMIAGKVAVIAGYGDVGKGSAQAMRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTTTGNFHVITH
DHMAAMKNNAIVCNIGHFDNEIDVASIEKYQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQT
IAQIELWTEAVKGSNKYPVGVYTLPKHLDEKVARLQLKTLNAQLSELTDEQAAYISVPKEGPYKADHYRY

Sequences:

>Translated_470_residues
MAEFKDYVIADLSLADWGRKEILIAETEMPGLMAIREEFAKTQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWASCN
IFSTQDHAAAAIAAQNIPVFAVKGETLVDYWDYTHRIFEWADGGYSNMILDDGGDATLLLHLGARAEKDISLLAKPGSEE
ETILFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHQRGELKFPGINVNDSVTKSKFDNLYGCRESLVDGIK
RATDVMIAGKVAVIAGYGDVGKGSAQAMRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTTTGNFHVITH
DHMAAMKNNAIVCNIGHFDNEIDVASIEKYQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQT
IAQIELWTEAVKGSNKYPVGVYTLPKHLDEKVARLQLKTLNAQLSELTDEQAAYISVPKEGPYKADHYRY
>Mature_469_residues
AEFKDYVIADLSLADWGRKEILIAETEMPGLMAIREEFAKTQPLKGARITGSLHMTIQTAVLIETLTALGAEVRWASCNI
FSTQDHAAAAIAAQNIPVFAVKGETLVDYWDYTHRIFEWADGGYSNMILDDGGDATLLLHLGARAEKDISLLAKPGSEEE
TILFAAIKAKLAVDPTWYSVRLAQIKGVTEETTTGVHRLYQMHQRGELKFPGINVNDSVTKSKFDNLYGCRESLVDGIKR
ATDVMIAGKVAVIAGYGDVGKGSAQAMRALSAQVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTTTGNFHVITHD
HMAAMKNNAIVCNIGHFDNEIDVASIEKYQWEEIKPQVDHVIFPDGKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQTI
AQIELWTEAVKGSNKYPVGVYTLPKHLDEKVARLQLKTLNAQLSELTDEQAAYISVPKEGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=472, Percent_Identity=58.2627118644068, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI239937451, Length=444, Percent_Identity=58.7837837837838, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI298286489, Length=467, Percent_Identity=48.8222698072805, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539337, Length=467, Percent_Identity=48.8222698072805, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI24308043, Length=467, Percent_Identity=48.8222698072805, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI195539349, Length=467, Percent_Identity=48.8222698072805, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI21361647, Length=467, Percent_Identity=47.3233404710921, Blast_Score=429, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=473, Percent_Identity=58.7737843551797, Blast_Score=534, Evalue=1e-152,
Organism=Saccharomyces cerevisiae, GI6320882, Length=482, Percent_Identity=57.2614107883817, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24642172, Length=466, Percent_Identity=58.7982832618026, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24656245, Length=456, Percent_Identity=49.1228070175439, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=467, Percent_Identity=47.7516059957173, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=466, Percent_Identity=47.6394849785408, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51790; Mature: 51659

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFKDYVIADLSLADWGRKEILIAETEMPGLMAIREEFAKTQPLKGARITGSLHMTIQT
CCCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEEHH
AVLIETLTALGAEVRWASCNIFSTQDHAAAAIAAQNIPVFAVKGETLVDYWDYTHRIFEW
HHHHHHHHHCCCEEEEEEEEEECCCCCHHEEEEECCCEEEEEECCEEEEHHHHHHHHHHH
ADGGYSNMILDDGGDATLLLHLGARAEKDISLLAKPGSEEETILFAAIKAKLAVDPTWYS
CCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCEEE
VRLAQIKGVTEETTTGVHRLYQMHQRGELKFPGINVNDSVTKSKFDNLYGCRESLVDGIK
EEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RATDVMIAGKVAVIAGYGDVGKGSAQAMRALSAQVWVTEIDPICALQAAMEGYRVVTMEY
HHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCEEEEEEEE
AADKADIFVTTTGNFHVITHDHMAAMKNNAIVCNIGHFDNEIDVASIEKYQWEEIKPQVD
CCCCCCEEEEECCCEEEEECCHHHHHCCCEEEEEECCCCCCCCEECCCCCCHHHCCCCCC
HVIFPDGKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQTIAQIELWTEAVKGSNKYPVG
EEECCCCCEEEEEECCCEEEEECCCCCCCHHHCCHHCCCHHHHHHHHHHHHCCCCCCCEE
VYTLPKHLDEKVARLQLKTLNAQLSELTDEQAAYISVPKEGPYKADHYRY
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
AEFKDYVIADLSLADWGRKEILIAETEMPGLMAIREEFAKTQPLKGARITGSLHMTIQT
CCCCCEEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEEHH
AVLIETLTALGAEVRWASCNIFSTQDHAAAAIAAQNIPVFAVKGETLVDYWDYTHRIFEW
HHHHHHHHHCCCEEEEEEEEEECCCCCHHEEEEECCCEEEEEECCEEEEHHHHHHHHHHH
ADGGYSNMILDDGGDATLLLHLGARAEKDISLLAKPGSEEETILFAAIKAKLAVDPTWYS
CCCCCCEEEEECCCCEEEEEEECCCCCCCEEEEECCCCCCCEEEEEEEEEEEEECCCEEE
VRLAQIKGVTEETTTGVHRLYQMHQRGELKFPGINVNDSVTKSKFDNLYGCRESLVDGIK
EEEEECCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RATDVMIAGKVAVIAGYGDVGKGSAQAMRALSAQVWVTEIDPICALQAAMEGYRVVTMEY
HHHHEEEECCEEEEEECCCCCCCHHHHHHHHHHEEEEEECCHHHHHHHHHCCEEEEEEEE
AADKADIFVTTTGNFHVITHDHMAAMKNNAIVCNIGHFDNEIDVASIEKYQWEEIKPQVD
CCCCCCEEEEECCCEEEEECCHHHHHCCCEEEEEECCCCCCCCEECCCCCCHHHCCCCCC
HVIFPDGKRIILLAKGRLVNLGCGTGHPSYVMSSSFANQTIAQIELWTEAVKGSNKYPVG
EEECCCCCEEEEEECCCEEEEECCCCCCCHHHCCHHCCCHHHHHHHHHHHHCCCCCCCEE
VYTLPKHLDEKVARLQLKTLNAQLSELTDEQAAYISVPKEGPYKADHYRY
EEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA