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The map label for this gene is yngE [H]

Identifier: 71905734

GI number: 71905734

Start: 108638

End: 110245

Strand: Reverse

Name: yngE [H]

Synonym: Daro_0092

Alternate gene names: 71905734

Gene position: 110245-108638 (Counterclockwise)

Preceding gene: 71905735

Following gene: 71905733

Centisome position: 2.45

GC content: 63.5

Gene sequence:

>1608_bases
ATGACCGTACTGAAAACCCAACTCAACCCGCGCTCAGCCGATTTTCAGGCCAACGCGGACGCCATGCGGACGGTGGTTGC
CGACCTGCATGAAAAGGTCGACAAGATCGCCCTCGGTGGTCCGGAAGCTGCCCGCCAAAAACACCTGGCGCGCGGCAAGT
TGCTGCCCCGCGAACGGGTCAGCGGCCTGCTCGATCCCGGCACGCCCTTCCTCGAAATCGGCCAGTTCGCTGCCTACGGC
ATGTACGGTGGCGATGTGCCGGCCGCCTCGGTGATCGCCGGCATTGGCCGCGTGCATGGGGTCGAATGCATGGTCGTCGC
CAACGATGCGACCGTGAAGGGTGGCACCTACTATCCGCTGACGGTGAAAAAGCACTTGCGGGCGCAGGAAATTGCGCTCG
AAAACCACCTGCCCTGCGTCTATCTGGTCGATTCCGGCGGTGCCTTCCTGCCGATGCAGGACGAGGTCTTCCCGGACAAG
GAGCACTTCGGCCGCATCTTCTTCAACCAGGCCAATTTGTCGGCCAAGGGCATCCCGCAGATCGCCGCAGTGATGGGTTC
CTGCACCGCCGGTGGCGCCTACGTGCCGGCCATGTGCGACGAGTCGATCATCGTCAAGAACCAGGGCACGATCTTTTTGG
GCGGCCCGCCGCTAGTGAAGGCTGCGACCGGCGAAGTAGTGTCGGCCGAAGACCTCGGCGGCGCTGACGTGCATACGCGC
ATTTCCGGCGTCGTCGACCATCTGGCCGAGAACGATGCCCATGCGCTGGCCATCGCCCGCCGCATCATCAAGGACCTGAA
CTGGAAGAAGCAGCCACCAGTCACCCTGACCGCACCGGCCGAGCCGCTCTATTCGGCCGAGGAACTGTACGGCGTAATCC
CGACCGACAGCAAGAAGCCTTTCGACGTGCGCGAAATCATCGGTCGCATCGTCGATGGCTCCGATTTCGACGAATTCAAG
GCCCGTTACGGCACGACCTTGGTCTGCGGCTTTGCCCGCATCTACGGCTATCCGGTCGGCATCGTCGCCAACAACGGCAT
CCTGTTCAGCGAATCCGCCCTCAAAGGCGCGCATTTCATTGAACTCTGCGCTCAGCGCGGCATTCCGCTCGTTTTCCTGC
AGAACATCACCGGTTTCATGGTTGGCCGCAAGTACGAAAATGGCGGCATCGCCCGTGACGGCGCCAAGATGGTGACGGCC
GTCGCCACCGCCAAGGTGCCGAAATTCACCGTCGTCATCGGCGGCTCGTTCGGCGCCGGCAACTACGGCATGTGCGGCCG
CGCCTACTCGCCGCGCTTTTTGTGGATGTGGCCGAACGCCCGCATCTCGGTGATGGGCGGCGAACAGGCGGCCGGCGTGC
TGGCCACCGTCAAGCGCGACGGCATGGAAGCGACCGGCAAGACCTGGAGCGCCGAGGAAGAGGCCGCCTTCAAGGCACCG
ATCCGCGAACAGTACGAGACGCAGGGCCACCCCTACTACGCCTCGGCCCGCCTGTGGGACGACGGCATCATCGATCCGGC
CGATACCCGCCGGGTGCTTGGCCTCGGTCTTTCCGCCTCGATGAATGCGCCAGCCGAAGAAACGAAGTTCGGCATTTTCC
GGATGTAA

Upstream 100 bases:

>100_bases
CGGAGCCAGTCAGCAAATGGCTCAAAGAGGAAAAGCAGTTGTAGCGCTTTTCAGGAATTCAGAAATTCAGGCAAACGGAA
ACAAATAAAAGCGAGGAGAC

Downstream 100 bases:

>100_bases
GCGATGTACCTGCCCAAGCACTTCGCGGAAACCGACATTGGCACCCTGCACGCGCTGATGCGCGAGTATCCGCTCGCCAC
GCTGGTCAGTCATGGCCCGG

Product: carboxyl transferase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MTVLKTQLNPRSADFQANADAMRTVVADLHEKVDKIALGGPEAARQKHLARGKLLPRERVSGLLDPGTPFLEIGQFAAYG
MYGGDVPAASVIAGIGRVHGVECMVVANDATVKGGTYYPLTVKKHLRAQEIALENHLPCVYLVDSGGAFLPMQDEVFPDK
EHFGRIFFNQANLSAKGIPQIAAVMGSCTAGGAYVPAMCDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGADVHTR
ISGVVDHLAENDAHALAIARRIIKDLNWKKQPPVTLTAPAEPLYSAEELYGVIPTDSKKPFDVREIIGRIVDGSDFDEFK
ARYGTTLVCGFARIYGYPVGIVANNGILFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYENGGIARDGAKMVTA
VATAKVPKFTVVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAGVLATVKRDGMEATGKTWSAEEEAAFKAP
IREQYETQGHPYYASARLWDDGIIDPADTRRVLGLGLSASMNAPAEETKFGIFRM

Sequences:

>Translated_535_residues
MTVLKTQLNPRSADFQANADAMRTVVADLHEKVDKIALGGPEAARQKHLARGKLLPRERVSGLLDPGTPFLEIGQFAAYG
MYGGDVPAASVIAGIGRVHGVECMVVANDATVKGGTYYPLTVKKHLRAQEIALENHLPCVYLVDSGGAFLPMQDEVFPDK
EHFGRIFFNQANLSAKGIPQIAAVMGSCTAGGAYVPAMCDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGADVHTR
ISGVVDHLAENDAHALAIARRIIKDLNWKKQPPVTLTAPAEPLYSAEELYGVIPTDSKKPFDVREIIGRIVDGSDFDEFK
ARYGTTLVCGFARIYGYPVGIVANNGILFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYENGGIARDGAKMVTA
VATAKVPKFTVVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAGVLATVKRDGMEATGKTWSAEEEAAFKAP
IREQYETQGHPYYASARLWDDGIIDPADTRRVLGLGLSASMNAPAEETKFGIFRM
>Mature_534_residues
TVLKTQLNPRSADFQANADAMRTVVADLHEKVDKIALGGPEAARQKHLARGKLLPRERVSGLLDPGTPFLEIGQFAAYGM
YGGDVPAASVIAGIGRVHGVECMVVANDATVKGGTYYPLTVKKHLRAQEIALENHLPCVYLVDSGGAFLPMQDEVFPDKE
HFGRIFFNQANLSAKGIPQIAAVMGSCTAGGAYVPAMCDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGADVHTRI
SGVVDHLAENDAHALAIARRIIKDLNWKKQPPVTLTAPAEPLYSAEELYGVIPTDSKKPFDVREIIGRIVDGSDFDEFKA
RYGTTLVCGFARIYGYPVGIVANNGILFSESALKGAHFIELCAQRGIPLVFLQNITGFMVGRKYENGGIARDGAKMVTAV
ATAKVPKFTVVIGGSFGAGNYGMCGRAYSPRFLWMWPNARISVMGGEQAAGVLATVKRDGMEATGKTWSAEEEAAFKAPI
REQYETQGHPYYASARLWDDGIIDPADTRRVLGLGLSASMNAPAEETKFGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=533, Percent_Identity=67.1669793621013, Blast_Score=747, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=487, Percent_Identity=34.2915811088296, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI295821216, Length=507, Percent_Identity=32.9388560157791, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI310133460, Length=143, Percent_Identity=60.1398601398601, Blast_Score=169, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17552936, Length=538, Percent_Identity=62.267657992565, Blast_Score=703, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147362, Length=500, Percent_Identity=34, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI25147359, Length=500, Percent_Identity=34, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586065, Length=551, Percent_Identity=63.8838475499093, Blast_Score=732, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 57384; Mature: 57253

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLKTQLNPRSADFQANADAMRTVVADLHEKVDKIALGGPEAARQKHLARGKLLPRERV
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHH
SGLLDPGTPFLEIGQFAAYGMYGGDVPAASVIAGIGRVHGVECMVVANDATVKGGTYYPL
CCCCCCCCCHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQEIALENHLPCVYLVDSGGAFLPMQDEVFPDKEHFGRIFFNQANLSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCCHHHCCEEEEEECCCCCCCCHH
IAAVMGSCTAGGAYVPAMCDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGADVHTR
HHHHHHCCCCCCEEEHHHCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
ISGVVDHLAENDAHALAIARRIIKDLNWKKQPPVTLTAPAEPLYSAEELYGVIPTDSKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHEEECCCCCCCC
FDVREIIGRIVDGSDFDEFKARYGTTLVCGFARIYGYPVGIVANNGILFSESALKGAHFI
CCHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHCCEEEEEECCCEEEECHHHCCHHHH
ELCAQRGIPLVFLQNITGFMVGRKYENGGIARDGAKMVTAVATAKVPKFTVVIGGSFGAG
HHHHHCCCCEEEECCCCHHEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAAGVLATVKRDGMEATGKTWSAEEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHEEHHHCCCCCCCCCCCCCHHHHHHCC
IREQYETQGHPYYASARLWDDGIIDPADTRRVLGLGLSASMNAPAEETKFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCEECC
>Mature Secondary Structure 
TVLKTQLNPRSADFQANADAMRTVVADLHEKVDKIALGGPEAARQKHLARGKLLPRERV
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCHHHH
SGLLDPGTPFLEIGQFAAYGMYGGDVPAASVIAGIGRVHGVECMVVANDATVKGGTYYPL
CCCCCCCCCHHHHCCHHEECCCCCCCCHHHHHHHHHHHCCEEEEEEECCCEECCCEEEEE
TVKKHLRAQEIALENHLPCVYLVDSGGAFLPMQDEVFPDKEHFGRIFFNQANLSAKGIPQ
EHHHHHHHHHHHHHCCCCEEEEECCCCEECCCCCCCCCCHHHCCEEEEEECCCCCCCCHH
IAAVMGSCTAGGAYVPAMCDESIIVKNQGTIFLGGPPLVKAATGEVVSAEDLGGADVHTR
HHHHHHCCCCCCEEEHHHCCCEEEEECCCEEEECCCCEEEECCCCEEECCCCCCCHHHHH
ISGVVDHLAENDAHALAIARRIIKDLNWKKQPPVTLTAPAEPLYSAEELYGVIPTDSKKP
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHEEECCCCCCCC
FDVREIIGRIVDGSDFDEFKARYGTTLVCGFARIYGYPVGIVANNGILFSESALKGAHFI
CCHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHCCEEEEEECCCEEEECHHHCCHHHH
ELCAQRGIPLVFLQNITGFMVGRKYENGGIARDGAKMVTAVATAKVPKFTVVIGGSFGAG
HHHHHCCCCEEEECCCCHHEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCC
NYGMCGRAYSPRFLWMWPNARISVMGGEQAAGVLATVKRDGMEATGKTWSAEEEAAFKAP
CCCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHEEHHHCCCCCCCCCCCCCHHHHHHCC
IREQYETQGHPYYASARLWDDGIIDPADTRRVLGLGLSASMNAPAEETKFGIFRM
HHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]