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The map label for this gene is accA1 [H]

Identifier: 71905731

GI number: 71905731

Start: 105215

End: 107215

Strand: Reverse

Name: accA1 [H]

Synonym: Daro_0089

Alternate gene names: 71905731

Gene position: 107215-105215 (Counterclockwise)

Preceding gene: 71905732

Following gene: 71905730

Centisome position: 2.38

GC content: 64.72

Gene sequence:

>2001_bases
ATGTTCACCAAGATTCTGATCGCCAACCGCGGGGAAATCGCCTGCCGCGTCATCAAGACCGCCCACCGCATGGGCATCCG
CACCGTCGCCGTCTATTCCGAAGCCGATGCCAATGCCCGCCACGTCCGCCTCGCTGACGAAGCTGTGCTGCTCGGCCCGG
CCGCTGCCCGCGAGTCCTACCTCGTGGCCGACAAGATCATCGACGCCTGCAAGCGCACTGGTGCCCAGGCCGTGCATCCG
GGTTACGGCTTCCTGTCCGAAAATGCCGACTTTGCCGATGCGCTGGCTGCCAGCGGCATCGCCTTCATCGGCCCGCCGGC
TTCGGCCATCCGCGCCATGGGCTCCAAGTCAGAAGCCAAGAAACTGATGGGCAGTGCCGCCGTGCCGCTGACGCCGGGCT
ATCACGGCGATGATCAAACCCCCGCCCTGCTCCACAAGGAAGCCGACGCCATCGGCTACCCGGTGCTGATCAAGGCGGCC
GCCGGCGGTGGCGGCAAGGGCATGCGCCTGGTCGAGAAATCGGAAGATTTCCCCGATGCGCTGGCCTCCTGCAAGCGCGA
GGCGATTTCCAGCTTCGGCGACGACCATGTGCTGATCGAGAAGTACATCACCAAGCCGCGCCACATCGAAATCCAGGTCT
TCGCCGACACGCTGGGTAACTGTGTTTACCTGTTTGAGCGCGACTGCTCGGTGCAGCGCCGTCACCAGAAGGTGTTGGAA
GAAGCCCCAGCCCCGGGTATGCCGGAAGAACGCCGCCGCCAGATGGGCGAAGCCGCGGTCGCCGCAGCCAAGGCGGTCGG
TTACGTTGGTGCCGGTACAGTCGAGTTCATTGCCAACCAGGATGGCTCGTTCTATTTCATGGAAATGAACACCCGCCTGC
AGGTCGAACACCCGGTCACCGAAATGATCACCGGGCAGGATCTGGTCGAATGGCAGTTGCGCGTCGCTTCGGGCGAGCCG
CTGCCGCTGCGCCAGGAACAACTGCAGATTCGCGGCCATGCGCTGGAAGCACGTATCTACGCCGAAGACGCCAGCAAGGG
TTTCCTGCCCGCTACCGGCAAGCTGGTTCGCCTTGCCCCACCGGCCGAATCGCTGAATGTCCGCGTCGACACCGGCGTCG
AAGAGGACGACGAGATCACGCCCTTCTACGACCCGATGATCGCCAAGCTGATCGTCTGGGACGAGCATCGCGACGCCGCG
CTGGCCCGCATGCGCAAGGCGCTGGCCGACTATCAGGTGGCCGGCGTCACGACCAATATCGATTTCCTGTCTCGCCTTGT
CGCCTGCCCGGCCTTCGCTGGCGCGGACCTCGATACCGGCCTGATCGAGCGCCAGAAGGAATTCCTCTTCCCCGAAACGC
AAGCCGTGCCACGCGATGTGCTACTGGTCGCCACGGTCGGCGAACTGCTCTGGGAACAGCACGAGGCCAAGCAGGCCGCC
AGAGCCAACGGCGATCCCTATTCCCCGTGGCATGCCCGTGACGGCTGGCGAATGAACCTGTCTTCAGCCCGCACCATCAG
CTTCCGGGATGGCGAAGCGCTGGTCGACACCCAGGTCCGCTATCAGCGCGACCAGTGGCAGATCACGCTGAATGGCGAAA
CCACCCTGGCCCGCGGCAAGAAGCTCGACGGCGACCGCTTTGCCGTCGAATTCGACGACCGCCGCCTGATCGCCAGCGTC
GTGGCTGTCGCCGACAAGCGCAGCATCTTCCTGCAAGGCACCACCTTCACGTTGCTTCGCGACGATCCGCTGCATCGCGT
CGATGCCGGCGACAGCCATGGTGGCGGCCTGACCGCACCGATGCCCGGCAAGGTCGTCGCGATGCTCGCCCAGCCCGGCC
AGAAGGTCGAAAAAGGCACGCCACTGCTGATCCTCGAAGCGATGAAGATGGAGCACACCATCACGGCACCGGCTGCCGGC
ACCGTCAAGGCCTTCTGCTACGCGGCCGGCGAACAGGTGACCGACGGCGCCGCGCTGGTCGAGTTCGAAAGCGAGGCATA
A

Upstream 100 bases:

>100_bases
CGCCCACCGCATCGCCCACCTGCGCGCCACGCCGGAAGCCCGCGAAGGCATCGCCGCCTTCCTCGACAAACGTCAGCCCA
ACTGGATTGGGGAATAAGCC

Downstream 100 bases:

>100_bases
TGACCCACGCTTACCGACCTCTCTCGCCAGCCTGACCATGAACGATCTGCGCAGAAAACTGATTCTTGTCGGCGGCATGG
CCGCGATCCCGATGGCGACC

Product: 3-methylcrotonoyl-CoA carboxylase, alpha subunit

Products: NA

Alternate protein names: Biotin carboxylase; Biotin carboxyl carrier protein; BCCP [H]

Number of amino acids: Translated: 666; Mature: 666

Protein sequence:

>666_residues
MFTKILIANRGEIACRVIKTAHRMGIRTVAVYSEADANARHVRLADEAVLLGPAAARESYLVADKIIDACKRTGAQAVHP
GYGFLSENADFADALAASGIAFIGPPASAIRAMGSKSEAKKLMGSAAVPLTPGYHGDDQTPALLHKEADAIGYPVLIKAA
AGGGGKGMRLVEKSEDFPDALASCKREAISSFGDDHVLIEKYITKPRHIEIQVFADTLGNCVYLFERDCSVQRRHQKVLE
EAPAPGMPEERRRQMGEAAVAAAKAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGQDLVEWQLRVASGEP
LPLRQEQLQIRGHALEARIYAEDASKGFLPATGKLVRLAPPAESLNVRVDTGVEEDDEITPFYDPMIAKLIVWDEHRDAA
LARMRKALADYQVAGVTTNIDFLSRLVACPAFAGADLDTGLIERQKEFLFPETQAVPRDVLLVATVGELLWEQHEAKQAA
RANGDPYSPWHARDGWRMNLSSARTISFRDGEALVDTQVRYQRDQWQITLNGETTLARGKKLDGDRFAVEFDDRRLIASV
VAVADKRSIFLQGTTFTLLRDDPLHRVDAGDSHGGGLTAPMPGKVVAMLAQPGQKVEKGTPLLILEAMKMEHTITAPAAG
TVKAFCYAAGEQVTDGAALVEFESEA

Sequences:

>Translated_666_residues
MFTKILIANRGEIACRVIKTAHRMGIRTVAVYSEADANARHVRLADEAVLLGPAAARESYLVADKIIDACKRTGAQAVHP
GYGFLSENADFADALAASGIAFIGPPASAIRAMGSKSEAKKLMGSAAVPLTPGYHGDDQTPALLHKEADAIGYPVLIKAA
AGGGGKGMRLVEKSEDFPDALASCKREAISSFGDDHVLIEKYITKPRHIEIQVFADTLGNCVYLFERDCSVQRRHQKVLE
EAPAPGMPEERRRQMGEAAVAAAKAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGQDLVEWQLRVASGEP
LPLRQEQLQIRGHALEARIYAEDASKGFLPATGKLVRLAPPAESLNVRVDTGVEEDDEITPFYDPMIAKLIVWDEHRDAA
LARMRKALADYQVAGVTTNIDFLSRLVACPAFAGADLDTGLIERQKEFLFPETQAVPRDVLLVATVGELLWEQHEAKQAA
RANGDPYSPWHARDGWRMNLSSARTISFRDGEALVDTQVRYQRDQWQITLNGETTLARGKKLDGDRFAVEFDDRRLIASV
VAVADKRSIFLQGTTFTLLRDDPLHRVDAGDSHGGGLTAPMPGKVVAMLAQPGQKVEKGTPLLILEAMKMEHTITAPAAG
TVKAFCYAAGEQVTDGAALVEFESEA
>Mature_666_residues
MFTKILIANRGEIACRVIKTAHRMGIRTVAVYSEADANARHVRLADEAVLLGPAAARESYLVADKIIDACKRTGAQAVHP
GYGFLSENADFADALAASGIAFIGPPASAIRAMGSKSEAKKLMGSAAVPLTPGYHGDDQTPALLHKEADAIGYPVLIKAA
AGGGGKGMRLVEKSEDFPDALASCKREAISSFGDDHVLIEKYITKPRHIEIQVFADTLGNCVYLFERDCSVQRRHQKVLE
EAPAPGMPEERRRQMGEAAVAAAKAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVTEMITGQDLVEWQLRVASGEP
LPLRQEQLQIRGHALEARIYAEDASKGFLPATGKLVRLAPPAESLNVRVDTGVEEDDEITPFYDPMIAKLIVWDEHRDAA
LARMRKALADYQVAGVTTNIDFLSRLVACPAFAGADLDTGLIERQKEFLFPETQAVPRDVLLVATVGELLWEQHEAKQAA
RANGDPYSPWHARDGWRMNLSSARTISFRDGEALVDTQVRYQRDQWQITLNGETTLARGKKLDGDRFAVEFDDRRLIASV
VAVADKRSIFLQGTTFTLLRDDPLHRVDAGDSHGGGLTAPMPGKVVAMLAQPGQKVEKGTPLLILEAMKMEHTITAPAAG
TVKAFCYAAGEQVTDGAALVEFESEA

Specific function: This protein carries two functions:biotin carboxyl carrier protein and biotin carboxyltransferase [H]

COG id: COG4770

COG function: function code I; Acetyl/propionyl-CoA carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=676, Percent_Identity=49.2603550295858, Blast_Score=646, Evalue=0.0,
Organism=Homo sapiens, GI65506442, Length=685, Percent_Identity=42.7737226277372, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI189095269, Length=685, Percent_Identity=42.7737226277372, Blast_Score=480, Evalue=1e-135,
Organism=Homo sapiens, GI295821183, Length=673, Percent_Identity=42.6448736998514, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI106049528, Length=491, Percent_Identity=41.1405295315682, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI106049295, Length=491, Percent_Identity=41.1405295315682, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI106049292, Length=491, Percent_Identity=41.1405295315682, Blast_Score=358, Evalue=8e-99,
Organism=Homo sapiens, GI38679960, Length=708, Percent_Identity=29.3785310734463, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI38679974, Length=708, Percent_Identity=29.3785310734463, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI38679971, Length=708, Percent_Identity=29.3785310734463, Blast_Score=280, Evalue=3e-75,
Organism=Homo sapiens, GI38679977, Length=708, Percent_Identity=29.3785310734463, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI38679967, Length=708, Percent_Identity=29.3785310734463, Blast_Score=280, Evalue=4e-75,
Organism=Homo sapiens, GI134142062, Length=712, Percent_Identity=29.9157303370786, Blast_Score=268, Evalue=1e-71,
Organism=Escherichia coli, GI1789654, Length=450, Percent_Identity=49.3333333333333, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI71987519, Length=671, Percent_Identity=46.4977645305514, Blast_Score=556, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17567343, Length=677, Percent_Identity=42.5406203840473, Blast_Score=499, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17562816, Length=462, Percent_Identity=43.0735930735931, Blast_Score=347, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI71997168, Length=697, Percent_Identity=25.3945480631277, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI71997163, Length=697, Percent_Identity=25.3945480631277, Blast_Score=196, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.2433537832311, Blast_Score=194, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6319685, Length=451, Percent_Identity=44.5676274944568, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=42.6339285714286, Blast_Score=332, Evalue=9e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=42.6339285714286, Blast_Score=324, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6324343, Length=724, Percent_Identity=29.2817679558011, Blast_Score=264, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=33.6206896551724, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24651757, Length=672, Percent_Identity=49.702380952381, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651759, Length=633, Percent_Identity=48.9731437598736, Blast_Score=591, Evalue=1e-169,
Organism=Drosophila melanogaster, GI281363050, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652224, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652222, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652220, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652218, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=9e-97,
Organism=Drosophila melanogaster, GI24652212, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652210, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652214, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI19921944, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24652216, Length=471, Percent_Identity=43.312101910828, Blast_Score=351, Evalue=1e-96,
Organism=Drosophila melanogaster, GI161076407, Length=728, Percent_Identity=28.1593406593407, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24586460, Length=728, Percent_Identity=28.1593406593407, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI161076409, Length=728, Percent_Identity=28.1593406593407, Blast_Score=260, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24586458, Length=728, Percent_Identity=28.1593406593407, Blast_Score=260, Evalue=2e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR001882
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14 [H]

Molecular weight: Translated: 72399; Mature: 72399

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTKILIANRGEIACRVIKTAHRMGIRTVAVYSEADANARHVRLADEAVLLGPAAARESY
CCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCHHHCCCH
LVADKIIDACKRTGAQAVHPGYGFLSENADFADALAASGIAFIGPPASAIRAMGSKSEAK
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
KLMGSAAVPLTPGYHGDDQTPALLHKEADAIGYPVLIKAAAGGGGKGMRLVEKSEDFPDA
HHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCEEECCCCCCHHH
LASCKREAISSFGDDHVLIEKYITKPRHIEIQVFADTLGNCVYLFERDCSVQRRHQKVLE
HHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMPEERRRQMGEAAVAAAKAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEECCCHH
EMITGQDLVEWQLRVASGEPLPLRQEQLQIRGHALEARIYAEDASKGFLPATGKLVRLAP
HHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEEECC
PAESLNVRVDTGVEEDDEITPFYDPMIAKLIVWDEHRDAALARMRKALADYQVAGVTTNI
CCCCCEEEEECCCCCCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHCCEEEEEEECH
DFLSRLVACPAFAGADLDTGLIERQKEFLFPETQAVPRDVLLVATVGELLWEQHEAKQAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RANGDPYSPWHARDGWRMNLSSARTISFRDGEALVDTQVRYQRDQWQITLNGETTLARGK
HCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEECCHHEEECCEEEEEECCCEEECCCC
KLDGDRFAVEFDDRRLIASVVAVADKRSIFLQGTTFTLLRDDPLHRVDAGDSHGGGLTAP
CCCCCEEEEEECCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCC
MPGKVVAMLAQPGQKVEKGTPLLILEAMKMEHTITAPAAGTVKAFCYAAGEQVTDGAALV
CCCCEEEEECCCCCHHHCCCCEEEEEEHHHCCEECCCCCCHHHHHHHHCCCCCCCCEEEE
EFESEA
EECCCC
>Mature Secondary Structure
MFTKILIANRGEIACRVIKTAHRMGIRTVAVYSEADANARHVRLADEAVLLGPAAARESY
CCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCHHHCCCH
LVADKIIDACKRTGAQAVHPGYGFLSENADFADALAASGIAFIGPPASAIRAMGSKSEAK
HHHHHHHHHHHHCCCCEECCCCCCCCCCCCHHHHHHHCCEEEECCCHHHHHHHCCHHHHH
KLMGSAAVPLTPGYHGDDQTPALLHKEADAIGYPVLIKAAAGGGGKGMRLVEKSEDFPDA
HHHCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCCCEEECCCCCCHHH
LASCKREAISSFGDDHVLIEKYITKPRHIEIQVFADTLGNCVYLFERDCSVQRRHQKVLE
HHHHHHHHHHHCCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCHHHHHHHHHHH
EAPAPGMPEERRRQMGEAAVAAAKAVGYVGAGTVEFIANQDGSFYFMEMNTRLQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCEEEECCCHH
EMITGQDLVEWQLRVASGEPLPLRQEQLQIRGHALEARIYAEDASKGFLPATGKLVRLAP
HHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCEEEEEEEEECCCCCCCCCCCCCEEEECC
PAESLNVRVDTGVEEDDEITPFYDPMIAKLIVWDEHRDAALARMRKALADYQVAGVTTNI
CCCCCEEEEECCCCCCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHCCEEEEEEECH
DFLSRLVACPAFAGADLDTGLIERQKEFLFPETQAVPRDVLLVATVGELLWEQHEAKQAA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
RANGDPYSPWHARDGWRMNLSSARTISFRDGEALVDTQVRYQRDQWQITLNGETTLARGK
HCCCCCCCCCCCCCCCEEECCCCEEEEECCCCEEECCHHEEECCEEEEEECCCEEECCCC
KLDGDRFAVEFDDRRLIASVVAVADKRSIFLQGTTFTLLRDDPLHRVDAGDSHGGGLTAP
CCCCCEEEEEECCHHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCCCCCCCCCCCCCCC
MPGKVVAMLAQPGQKVEKGTPLLILEAMKMEHTITAPAAGTVKAFCYAAGEQVTDGAALV
CCCCEEEEECCCCCHHHCCCCEEEEEEHHHCCEECCCCCCHHHHHHHHCCCCCCCCEEEE
EFESEA
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]