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The map label for this gene is adk

Identifier: 71892084

GI number: 71892084

Start: 367270

End: 367923

Strand: Direct

Name: adk

Synonym: BPEN_310

Alternate gene names: 71892084

Gene position: 367270-367923 (Clockwise)

Preceding gene: 71892083

Following gene: 71892086

Centisome position: 46.39

GC content: 30.89

Gene sequence:

>654_bases
TTGATACGTATTATATTTTTAGGTCCTCCTGGATCCGGAAAAGGAACACAAGCTCATCTTATTGCAAATAAGTATAACAT
TCCAAATATTTCTACAGGCACGATGTTGCGTCAAGCACTAACTAGAAGTACACATAAGTCCTATGAACTTCACAAAAATA
TTATGCATACTGGTGATTTAGTAAATGATGAATTTATGGTGCAATTAATTAGCACACGTATTAATCAAAATGACTGTCGT
AATGGATTTTTATTGGATGGTTTTCCTAGAACAATTTTGCAAGCAAAATCTATGAAACAATGTAAAATTTTTGTAAATTA
CATCATAGAATTTTTTGCATCAGATTCTGTGATTATTGATCGTATTGCAGGCCGAAGAATACATGTAGGCTCTGGTAGAA
CTTATCATATTAAATTCAATCCGCCGAGAAATTATGGATTAGATGATATTACCGGAGAAATTTTGACTACTCGAAAAGAT
GACCACGAAGAAGCTATACGTAAACGATTAAGTAATTACTACCAACACACTGAACCAGTGTTAGATTATTATCGAGAAGA
ATCGAAATATAAAAAAATGAAATATTTTTCTGTTGATGGAAATCGTGATATTTCTAAAATCTATAAAGAGTTAATTAATA
TCATTAGTTCATGA

Upstream 100 bases:

>100_bases
ATAAAAGGCTGTTATTTATATCTAAGTATTAAGTAGATAATGTTTTAACATATCATAAGCATCGTTTACTAAATTTTTAT
AATTTTATTGAGAATTAAAT

Downstream 100 bases:

>100_bases
TACTTGTTATCATTTTTCATTTCGGTTCCTATTTATGAATATCAATATCATTATAGATAATAACAGCGTATAAAATCGTT
CGTTATCTCATCAAAATTAT

Product: ATP-AMP transphosphorylase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MIRIIFLGPPGSGKGTQAHLIANKYNIPNISTGTMLRQALTRSTHKSYELHKNIMHTGDLVNDEFMVQLISTRINQNDCR
NGFLLDGFPRTILQAKSMKQCKIFVNYIIEFFASDSVIIDRIAGRRIHVGSGRTYHIKFNPPRNYGLDDITGEILTTRKD
DHEEAIRKRLSNYYQHTEPVLDYYREESKYKKMKYFSVDGNRDISKIYKELINIISS

Sequences:

>Translated_217_residues
MIRIIFLGPPGSGKGTQAHLIANKYNIPNISTGTMLRQALTRSTHKSYELHKNIMHTGDLVNDEFMVQLISTRINQNDCR
NGFLLDGFPRTILQAKSMKQCKIFVNYIIEFFASDSVIIDRIAGRRIHVGSGRTYHIKFNPPRNYGLDDITGEILTTRKD
DHEEAIRKRLSNYYQHTEPVLDYYREESKYKKMKYFSVDGNRDISKIYKELINIISS
>Mature_217_residues
MIRIIFLGPPGSGKGTQAHLIANKYNIPNISTGTMLRQALTRSTHKSYELHKNIMHTGDLVNDEFMVQLISTRINQNDCR
NGFLLDGFPRTILQAKSMKQCKIFVNYIIEFFASDSVIIDRIAGRRIHVGSGRTYHIKFNPPRNYGLDDITGEILTTRKD
DHEEAIRKRLSNYYQHTEPVLDYYREESKYKKMKYFSVDGNRDISKIYKELINIISS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=219, Percent_Identity=41.0958904109589, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI4502013, Length=219, Percent_Identity=41.0958904109589, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI19923437, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI310110345, Length=186, Percent_Identity=37.6344086021505, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832003, Length=186, Percent_Identity=37.6344086021505, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI8051579, Length=186, Percent_Identity=37.6344086021505, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI53832001, Length=186, Percent_Identity=37.6344086021505, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI22749187, Length=176, Percent_Identity=30.1136363636364, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI7706497, Length=219, Percent_Identity=28.310502283105, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI28144899, Length=206, Percent_Identity=26.2135922330097, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI28144897, Length=206, Percent_Identity=26.2135922330097, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=53.4883720930233, Blast_Score=249, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17552384, Length=189, Percent_Identity=44.4444444444444, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17537943, Length=192, Percent_Identity=32.8125, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17567503, Length=191, Percent_Identity=27.2251308900524, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=219, Percent_Identity=26.4840182648402, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533833, Length=195, Percent_Identity=28.2051282051282, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=217, Percent_Identity=39.63133640553, Blast_Score=178, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321018, Length=187, Percent_Identity=40.1069518716578, Blast_Score=134, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=217, Percent_Identity=27.6497695852535, Blast_Score=90, Evalue=3e-19,
Organism=Drosophila melanogaster, GI22026816, Length=217, Percent_Identity=41.9354838709677, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=37.2340425531915, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=37.2340425531915, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI221459597, Length=218, Percent_Identity=24.3119266055046, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356893, Length=218, Percent_Identity=24.3119266055046, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BLOPB (Q493A3)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277814.1
- HSSP:   P69441
- ProteinModelPortal:   Q493A3
- SMR:   Q493A3
- STRING:   Q493A3
- GeneID:   3562587
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_310
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- BioCyc:   CBLO291272:BPEN_310-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 25153; Mature: 25153

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRIIFLGPPGSGKGTQAHLIANKYNIPNISTGTMLRQALTRSTHKSYELHKNIMHTGDL
CEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNDEFMVQLISTRINQNDCRNGFLLDGFPRTILQAKSMKQCKIFVNYIIEFFASDSVIID
CCHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEH
RIAGRRIHVGSGRTYHIKFNPPRNYGLDDITGEILTTRKDDHEEAIRKRLSNYYQHTEPV
HHCCCEEEECCCEEEEEEECCCCCCCCCHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LDYYREESKYKKMKYFSVDGNRDISKIYKELINIISS
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIRIIFLGPPGSGKGTQAHLIANKYNIPNISTGTMLRQALTRSTHKSYELHKNIMHTGDL
CEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNDEFMVQLISTRINQNDCRNGFLLDGFPRTILQAKSMKQCKIFVNYIIEFFASDSVIID
CCHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEH
RIAGRRIHVGSGRTYHIKFNPPRNYGLDDITGEILTTRKDDHEEAIRKRLSNYYQHTEPV
HHCCCEEEECCCEEEEEEECCCCCCCCCHHCCHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LDYYREESKYKKMKYFSVDGNRDISKIYKELINIISS
HHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA