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The map label for this gene is gltP [H]

Identifier: 71891822

GI number: 71891822

Start: 37404

End: 38693

Strand: Direct

Name: gltP [H]

Synonym: BPEN_030

Alternate gene names: 71891822

Gene position: 37404-38693 (Clockwise)

Preceding gene: 71891821

Following gene: 71891828

Centisome position: 4.72

GC content: 33.1

Gene sequence:

>1290_bases
ATGATGATTAGAAAGTTTAAAATTACCCTTGCTTGGAAAATTTTTTTTGCTTTAAACTTGGGTATTGTTTTAGGAATTGT
ATTGCATAATCAAACAGAATTAAAAGATTGGATGATCACGACATTTCTTTCTCCAGCTGGAGAAATTTTTATTCGTATGA
TAAAAATGATCGTGGTTCCCATTGTAATGGCTACATTGGTGGTTGGAATCGCTGGTATTGGAGATGCAAGAAAATTGGGA
AGTATTGGTTTAAAGACTATTATTTATTTCGAGATTATTACAACACTTGCTATAGTACTTGGTGTAGCTTTTGCTAATTT
GTTGCATCCTGGTTATGGAATTGACATGTCTCTTCTTTCGAAAACGGATATTTCAATGTACGAGCAAACTACATCTGAAA
TACAGTCAAATTTGGTAAATACTATGTTATCGTTGATTCCTTCGAATATTATTAATTCTATGGCTAAAGGAGATATGTTA
CCAGTTATTTTTTTCTCGGTAATTTTTGGACTTGGATTAGCTACATTGCCAGAAAAAACTAAAACTCCATTATTGGACAT
TTTTAATTCTGTAGCGGATACTATGTTCGAAGTAACACATATAGTGATGCGTTATGCTCCTATTGGGGTGTTTGCTTTAA
TTTCAGTTACAGTTGCGACTTTTGGATTCAGCTCTTTGTTGCCTCTTACTAAACTTGTATTATTAGTTTATGGTGCTATT
GTTTTTTTTGCATTAGTAGTATTAGGTATAGTGGCACGCATATGCAATCTTAGAATTTGGAAATTAATTTGTATTTTAAA
AGAAGAACTGATTTTATCTTTTTCTACTGCTAGTTCAGAAACTGTATTACCACGTATTATAGAAAAAATGGAAGCTTATG
GAGCTCCATCAACTATCACTGGATTTGTAGTGCCTACTGGTTATTCTTTTAATTTAGATGGATCAACTTTATATCAAAGT
ATTGCTGCTATTTTCATTGCACAATTATATGGTATTGAATTATCTTTAAGTCAGGAAATTATTTTAGTATTGACTTTAAT
GATCACTTCTAAAGGTATCGCTGGTGTTCCAGGAGTTTCCTTTGTAGTATTGTTAGCTACATTAGGTAGCGTAGGTATTC
CATTGGAAGGGTTGGCGTTTATAGCAGGTGTGGATAGGGTTTTAGACATGGGTCGTACAGCGTTAAATGTTATAGGCAAT
GCTTTAGCGGTGTTAGTAATTGCAAAGTGGGAGAATCAGTATGATACAGAACAAGCTCTGATATATGAATCAGAGATGCT
ATCTAAATGA

Upstream 100 bases:

>100_bases
TTAATGGGGATTTTTTGGAAGAGAATTTAAATCAGTTGATATAATTAATTCCGGATTGATGTGAAATAAAAAAATAACTC
ATTTTAATTAAGGGGTAACT

Downstream 100 bases:

>100_bases
ATAATATGTTTATTATTCGTAATTATTGCAAGAATAAGATTAGATTATACAGTATTTGGTATTATCAGATCTTTCTTTTT
GAAAGAAAGAATGTATGCAA

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MMIRKFKITLAWKIFFALNLGIVLGIVLHNQTELKDWMITTFLSPAGEIFIRMIKMIVVPIVMATLVVGIAGIGDARKLG
SIGLKTIIYFEIITTLAIVLGVAFANLLHPGYGIDMSLLSKTDISMYEQTTSEIQSNLVNTMLSLIPSNIINSMAKGDML
PVIFFSVIFGLGLATLPEKTKTPLLDIFNSVADTMFEVTHIVMRYAPIGVFALISVTVATFGFSSLLPLTKLVLLVYGAI
VFFALVVLGIVARICNLRIWKLICILKEELILSFSTASSETVLPRIIEKMEAYGAPSTITGFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIELSLSQEIILVLTLMITSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVLDMGRTALNVIGN
ALAVLVIAKWENQYDTEQALIYESEMLSK

Sequences:

>Translated_429_residues
MMIRKFKITLAWKIFFALNLGIVLGIVLHNQTELKDWMITTFLSPAGEIFIRMIKMIVVPIVMATLVVGIAGIGDARKLG
SIGLKTIIYFEIITTLAIVLGVAFANLLHPGYGIDMSLLSKTDISMYEQTTSEIQSNLVNTMLSLIPSNIINSMAKGDML
PVIFFSVIFGLGLATLPEKTKTPLLDIFNSVADTMFEVTHIVMRYAPIGVFALISVTVATFGFSSLLPLTKLVLLVYGAI
VFFALVVLGIVARICNLRIWKLICILKEELILSFSTASSETVLPRIIEKMEAYGAPSTITGFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIELSLSQEIILVLTLMITSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVLDMGRTALNVIGN
ALAVLVIAKWENQYDTEQALIYESEMLSK
>Mature_429_residues
MMIRKFKITLAWKIFFALNLGIVLGIVLHNQTELKDWMITTFLSPAGEIFIRMIKMIVVPIVMATLVVGIAGIGDARKLG
SIGLKTIIYFEIITTLAIVLGVAFANLLHPGYGIDMSLLSKTDISMYEQTTSEIQSNLVNTMLSLIPSNIINSMAKGDML
PVIFFSVIFGLGLATLPEKTKTPLLDIFNSVADTMFEVTHIVMRYAPIGVFALISVTVATFGFSSLLPLTKLVLLVYGAI
VFFALVVLGIVARICNLRIWKLICILKEELILSFSTASSETVLPRIIEKMEAYGAPSTITGFVVPTGYSFNLDGSTLYQS
IAAIFIAQLYGIELSLSQEIILVLTLMITSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRVLDMGRTALNVIGN
ALAVLVIAKWENQYDTEQALIYESEMLSK

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=447, Percent_Identity=26.6219239373602, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI66773030, Length=463, Percent_Identity=26.7818574514039, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI40254478, Length=492, Percent_Identity=26.0162601626016, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=26.056338028169, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI194239697, Length=485, Percent_Identity=25.5670103092783, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI4827012, Length=315, Percent_Identity=30.7936507936508, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI262359914, Length=394, Percent_Identity=24.6192893401015, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI5032093, Length=427, Percent_Identity=26.463700234192, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI223468566, Length=312, Percent_Identity=28.2051282051282, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI223468564, Length=279, Percent_Identity=28.3154121863799, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI301601644, Length=137, Percent_Identity=33.5766423357664, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1790514, Length=430, Percent_Identity=71.1627906976744, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=35.5769230769231, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI1788024, Length=448, Percent_Identity=25.8928571428571, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789473, Length=394, Percent_Identity=26.3959390862944, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537407, Length=427, Percent_Identity=26.463700234192, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71983106, Length=416, Percent_Identity=25.9615384615385, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983099, Length=416, Percent_Identity=25.9615384615385, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71996953, Length=444, Percent_Identity=25.2252252252252, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=466, Percent_Identity=27.6824034334764, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=446, Percent_Identity=25.7847533632287, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17541374, Length=412, Percent_Identity=25.7281553398058, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24583025, Length=431, Percent_Identity=26.6821345707657, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI17137668, Length=431, Percent_Identity=26.6821345707657, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24583023, Length=431, Percent_Identity=26.6821345707657, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI281360481, Length=451, Percent_Identity=24.8337028824834, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI281360483, Length=455, Percent_Identity=24.6153846153846, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137666, Length=455, Percent_Identity=24.6153846153846, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46564; Mature: 46564

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCC
>Mature Secondary Structure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HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]