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The map label for this gene is glmU

Identifier: 71891803

GI number: 71891803

Start: 9294

End: 10682

Strand: Direct

Name: glmU

Synonym: BPEN_010

Alternate gene names: 71891803

Gene position: 9294-10682 (Clockwise)

Preceding gene: 71891802

Following gene: 71891808

Centisome position: 1.17

GC content: 32.97

Gene sequence:

>1389_bases
ATGTCGTATATTAATTTCAGCGCGATTATCCTTGCTGCCGGTAGAGGTAATAGAATGTTGTCTGATACACCAAAGGTGTT
GTACCAAATTGGTGGTAAGTTTATGTTACAACATTTGATTGATTCTGTAATGCAGGTAGGTGTGAGCTCCATATATGTAG
TGCATGGATACAAAGGAGAAATGATAATAAAAGAAATTAATACGAATCAATACAAAATTCCTGTATATTGGATATTGCAA
CATGATCTTACTGGGACTGGAGATGCTGTTCAGAGAGTGTTACCTTTCATCAGTGATGACGAAGAAGTTCTTGTTTTATA
TGGTGATGTTCCTTTTGTTTCTTATAAAACATTACAACGATTGCATGTCATTAAATCCCAATGTGATATAAGTATGTTAA
CTGCTACACTACCTAATCCAAAAGGATATGGGCGTATTGTTCGGAACCAGGAAGGGAGTGTTGTTAGTATCATAGAACAT
GATGACATCATTAATGATGATCAAAAAAAAATTAAAGAAGTTAGTACTGGTATTTTTATTGCTATTTCTAATCATTTAAA
GTGTTGGTTAAGCACATTAACAACTCATAAGTCAAAAAATGAATTTTATTTAACAGATATAATTCAGATAGCTCATCAAT
CAGGTTACAGTATACATACCATGTGTCCTGATGATACATTTGAGATCATGGGAGTAAATAGTAAATCAGATTTCGTTGAT
TTAGATAAACAATATCAACAAAGAAAAGTACAATGTTTATTATCATCAGGGTTGATGATTATTGATCCAAATAGGTTTGA
TTTAAGAGGAACGTTAGTACATGGGAAGGATGTGTACATTGATATAAATGTGATCATTGAGGGGCATGTTTCTTTGGGGA
ATAGAGTTAAAATAGGAGCAAGTTGTATATTGAAAGATACGATAGTTGCCGATGATGTAGAGATATACCCATTTTCAATA
ATTGAAAATACAACAATAGGTTTCCAAAGCAAAGTTGGACCATTTGTTCGGTTGAGACCAGGAACTGAATTAAAAGAAAA
AAGTCATGTGGGAAATTTTGTAGAAATAAAAAATACCCGATTGGGAGAGCAATCCAAGGTTAAACACCTTAGTTATTTAG
GTGATGCAGAAATTGGTAATCAAGTAAATATCGGAGCTGGCACTATTATTTGCAATTATGATGGCATGATGAAACATCAA
ACTATTATTGGTGATGACGTTTTTATTGGAGCTGATAGTCAGCTGGTAGCTCCAATCACTATTGGAAAAAATGTAACTAT
TGGAGCTGGAACTACAGTAACTCGAGATGTGGCAGCTAATGAAACTATTATTAGTAGAATACGACAATTTTCCATTTTAA
ATTGGAAGCGATTAAAAAACAAAAAATAA

Upstream 100 bases:

>100_bases
TAATTTTTCTGTTTATGTATATGTAGTTATATGTTTAATGTAATAAAAATAGTTTATAACCAAAAATAAGAATCACAAAA
AATATATAAAGATAAAGATT

Downstream 100 bases:

>100_bases
AATTATTTTTTGTTTAAGAATTATTCGCCAATCAAACATTATATAAACATAGCTTATTCAGAAATTATTTCTTTCTATAT
CTTTATCAAAGTGTATATGT

Product: N-acetyl glucosamine-1-phosphate uridyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSYINFSAIILAAGRGNRMLSDTPKVLYQIGGKFMLQHLIDSVMQVGVSSIYVVHGYKGEMIIKEINTNQYKIPVYWILQ
HDLTGTGDAVQRVLPFISDDEEVLVLYGDVPFVSYKTLQRLHVIKSQCDISMLTATLPNPKGYGRIVRNQEGSVVSIIEH
DDIINDDQKKIKEVSTGIFIAISNHLKCWLSTLTTHKSKNEFYLTDIIQIAHQSGYSIHTMCPDDTFEIMGVNSKSDFVD
LDKQYQQRKVQCLLSSGLMIIDPNRFDLRGTLVHGKDVYIDINVIIEGHVSLGNRVKIGASCILKDTIVADDVEIYPFSI
IENTTIGFQSKVGPFVRLRPGTELKEKSHVGNFVEIKNTRLGEQSKVKHLSYLGDAEIGNQVNIGAGTIICNYDGMMKHQ
TIIGDDVFIGADSQLVAPITIGKNVTIGAGTTVTRDVAANETIISRIRQFSILNWKRLKNKK

Sequences:

>Translated_462_residues
MSYINFSAIILAAGRGNRMLSDTPKVLYQIGGKFMLQHLIDSVMQVGVSSIYVVHGYKGEMIIKEINTNQYKIPVYWILQ
HDLTGTGDAVQRVLPFISDDEEVLVLYGDVPFVSYKTLQRLHVIKSQCDISMLTATLPNPKGYGRIVRNQEGSVVSIIEH
DDIINDDQKKIKEVSTGIFIAISNHLKCWLSTLTTHKSKNEFYLTDIIQIAHQSGYSIHTMCPDDTFEIMGVNSKSDFVD
LDKQYQQRKVQCLLSSGLMIIDPNRFDLRGTLVHGKDVYIDINVIIEGHVSLGNRVKIGASCILKDTIVADDVEIYPFSI
IENTTIGFQSKVGPFVRLRPGTELKEKSHVGNFVEIKNTRLGEQSKVKHLSYLGDAEIGNQVNIGAGTIICNYDGMMKHQ
TIIGDDVFIGADSQLVAPITIGKNVTIGAGTTVTRDVAANETIISRIRQFSILNWKRLKNKK
>Mature_461_residues
SYINFSAIILAAGRGNRMLSDTPKVLYQIGGKFMLQHLIDSVMQVGVSSIYVVHGYKGEMIIKEINTNQYKIPVYWILQH
DLTGTGDAVQRVLPFISDDEEVLVLYGDVPFVSYKTLQRLHVIKSQCDISMLTATLPNPKGYGRIVRNQEGSVVSIIEHD
DIINDDQKKIKEVSTGIFIAISNHLKCWLSTLTTHKSKNEFYLTDIIQIAHQSGYSIHTMCPDDTFEIMGVNSKSDFVDL
DKQYQQRKVQCLLSSGLMIIDPNRFDLRGTLVHGKDVYIDINVIIEGHVSLGNRVKIGASCILKDTIVADDVEIYPFSII
ENTTIGFQSKVGPFVRLRPGTELKEKSHVGNFVEIKNTRLGEQSKVKHLSYLGDAEIGNQVNIGAGTIICNYDGMMKHQT
IIGDDVFIGADSQLVAPITIGKNVTIGAGTTVTRDVAANETIISRIRQFSILNWKRLKNKK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=460, Percent_Identity=50.6521739130435, Blast_Score=489, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_BLOPB (Q494C1)

Other databases:

- EMBL:   CP000016
- RefSeq:   YP_277532.1
- ProteinModelPortal:   Q494C1
- SMR:   Q494C1
- STRING:   Q494C1
- GeneID:   3562625
- GenomeReviews:   CP000016_GR
- KEGG:   bpn:BPEN_010
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   CLSK492480
- BioCyc:   CBLO291272:BPEN_010-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 51551; Mature: 51420

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 369-369 BINDING 80-80 BINDING 144-144 BINDING 159-159 BINDING 393-393 BINDING 429-429 BINDING 446-446

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYINFSAIILAAGRGNRMLSDTPKVLYQIGGKFMLQHLIDSVMQVGVSSIYVVHGYKGE
CCEEEEEEEEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
MIIKEINTNQYKIPVYWILQHDLTGTGDAVQRVLPFISDDEEVLVLYGDVPFVSYKTLQR
EEEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
LHVIKSQCDISMLTATLPNPKGYGRIVRNQEGSVVSIIEHDDIINDDQKKIKEVSTGIFI
HHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCEEE
AISNHLKCWLSTLTTHKSKNEFYLTDIIQIAHQSGYSIHTMCPDDTFEIMGVNSKSDFVD
EECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCH
LDKQYQQRKVQCLLSSGLMIIDPNRFDLRGTLVHGKDVYIDINVIIEGHVSLGNRVKIGA
HHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCEEEEEEEEEEEEEECCCCEEEECC
SCILKDTIVADDVEIYPFSIIENTTIGFQSKVGPFVRLRPGTELKEKSHVGNFVEIKNTR
EEEEECCEEECCCEEEEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHCCCCEEEEECCC
LGEQSKVKHLSYLGDAEIGNQVNIGAGTIICNYDGMMKHQTIIGDDVFIGADSQLVAPIT
CCCHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCEECEEEECCEEEECCCCCEEEEEE
IGKNVTIGAGTTVTRDVAANETIISRIRQFSILNWKRLKNKK
ECCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
SYINFSAIILAAGRGNRMLSDTPKVLYQIGGKFMLQHLIDSVMQVGVSSIYVVHGYKGE
CEEEEEEEEEEECCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEECCCCC
MIIKEINTNQYKIPVYWILQHDLTGTGDAVQRVLPFISDDEEVLVLYGDVPFVSYKTLQR
EEEEEECCCEEEEEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHH
LHVIKSQCDISMLTATLPNPKGYGRIVRNQEGSVVSIIEHDDIINDDQKKIKEVSTGIFI
HHHHHHCCCEEEEEEECCCCCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHCCEEE
AISNHLKCWLSTLTTHKSKNEFYLTDIIQIAHQSGYSIHTMCPDDTFEIMGVNSKSDFVD
EECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCH
LDKQYQQRKVQCLLSSGLMIIDPNRFDLRGTLVHGKDVYIDINVIIEGHVSLGNRVKIGA
HHHHHHHHHHHHHHHCCEEEECCCCEEEEEEEEECCEEEEEEEEEEEEEECCCCEEEECC
SCILKDTIVADDVEIYPFSIIENTTIGFQSKVGPFVRLRPGTELKEKSHVGNFVEIKNTR
EEEEECCEEECCCEEEEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHCCCCEEEEECCC
LGEQSKVKHLSYLGDAEIGNQVNIGAGTIICNYDGMMKHQTIIGDDVFIGADSQLVAPIT
CCCHHHHHHHHHCCCCCCCCEEECCCCEEEECCCCCEECEEEECCEEEECCCCCEEEEEE
IGKNVTIGAGTTVTRDVAANETIISRIRQFSILNWKRLKNKK
ECCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA