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The map label for this gene is pat

Identifier: 68537125

GI number: 68537125

Start: 2374538

End: 2375659

Strand: Direct

Name: pat

Synonym: jk2030

Alternate gene names: 68537125

Gene position: 2374538-2375659 (Clockwise)

Preceding gene: 68537124

Following gene: 68537126

Centisome position: 96.43

GC content: 66.58

Gene sequence:

>1122_bases
ATGATTCGCCCTGATCTTTCCTCCCTGCCCGCATACGTCCCCGGCTCCACCCAGCCGGGCGCGCTGAAGTTGGCTTCCAA
CGAGTCTTCGCTGTCGCCGTTGCCTTCTGTTAGTGCTGTTATTAATGACGCCACCTCGAACCTCAACCGCTACCCCGACA
TGGCTTCGGGCGCGTTGCGTGGGAAGCTCGCGCAGTGGTTGGGCGTGGACCTCGACAACGTCGCCGTAGGTAATGGCAGT
TCCGCCCTATGCCAGCAGCTGGTGCAGGCCACATGCAAGGACGGCGATGAGGTTGTGTACGCCTGGCGGTCGTTCGAGGC
ATATCCGATCCTGTGCAAGATCGCCGGTGCGGTTGGGGTGGGTGTGCCGCTGAAGAGTGGGCGTCATGACCTAAAGGCAA
TGAGTGAGGCGATCGGCGAGCGTACGCGTTTGGTGTTTGTGTGCAACCCGAATAATCCGACGGGCACGACGGTGAGCCGC
GACGAGTTCCGTGAGTTCATGGGGCGCGTGCCTGCGGATGTGACGGTCGTGCTGGATGAGGCCTATGTGGAGTACAACCG
GGATGCGGAGTCTCCGGTGGCGTTGGAGGAGCTGCAGCGCTACCCGAACCTGGCGGTGTGCCGGACGTTCTCGAAGGCGT
ATGGGCTGGCGGGGCTGCGGCTGGGGTACCTGGTCGGGCCGGCCGAGCTGGTGGAGGCCGTGAATAAGGTGGGGATTCCT
TTCGGCGTGAACGCGCTGGCCCAGGCGGCGGGGATCGCGAGCGTGGAGGCGCAGGGCGAGCTGGCCGAGCGCGTGGACGC
GACGGTGGCCGAGCGCGAGCGGGTGGAGGCGTACCTGGCGGGGGTTGCTCCGGCTGGGGCTGACGAACCGCTGACGTACC
CGTCGCAGGCGAACTTTGTGTGGCTGAACGCGGGCGAGCGCGCGGAGGCGCTGGATGAGGCGCTGAAGCGCGAGGGTGTC
ATCGCGCGGTGCTTCGCGGGCGAGGGCGTGCGCGTGACGGTGACGACGGCGGAGGAGACGGATGTGCTGCTCCGCGCACT
GGAGCGTGCGCTGCCTGCCGTTGGGCTGGTTGAGGCTGGCGCTGAGTCGGCTGGCCTGCAGGCCTCCCCGCAGGCTGATT
AG

Upstream 100 bases:

>100_bases
CGAACTTAGCCTACACAACCTGCCCATCTTCCCCAAATTCCCACCCACTCCCCGCCCACTCCCCGAAGCCCTGTCCCCAG
CGCCCACTACACTGTGCAGT

Downstream 100 bases:

>100_bases
CGCCGTGCATCCGGAGGATCCGACGCGCATCCCCGCCGTGGTGGAGCGCCTGCGCGCGGCGTGGGAGGCTCAGCCTTCGG
TGCCGTTTGCGCAGTTGTGG

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MIRPDLSSLPAYVPGSTQPGALKLASNESSLSPLPSVSAVINDATSNLNRYPDMASGALRGKLAQWLGVDLDNVAVGNGS
SALCQQLVQATCKDGDEVVYAWRSFEAYPILCKIAGAVGVGVPLKSGRHDLKAMSEAIGERTRLVFVCNPNNPTGTTVSR
DEFREFMGRVPADVTVVLDEAYVEYNRDAESPVALEELQRYPNLAVCRTFSKAYGLAGLRLGYLVGPAELVEAVNKVGIP
FGVNALAQAAGIASVEAQGELAERVDATVAERERVEAYLAGVAPAGADEPLTYPSQANFVWLNAGERAEALDEALKREGV
IARCFAGEGVRVTVTTAEETDVLLRALERALPAVGLVEAGAESAGLQASPQAD

Sequences:

>Translated_373_residues
MIRPDLSSLPAYVPGSTQPGALKLASNESSLSPLPSVSAVINDATSNLNRYPDMASGALRGKLAQWLGVDLDNVAVGNGS
SALCQQLVQATCKDGDEVVYAWRSFEAYPILCKIAGAVGVGVPLKSGRHDLKAMSEAIGERTRLVFVCNPNNPTGTTVSR
DEFREFMGRVPADVTVVLDEAYVEYNRDAESPVALEELQRYPNLAVCRTFSKAYGLAGLRLGYLVGPAELVEAVNKVGIP
FGVNALAQAAGIASVEAQGELAERVDATVAERERVEAYLAGVAPAGADEPLTYPSQANFVWLNAGERAEALDEALKREGV
IARCFAGEGVRVTVTTAEETDVLLRALERALPAVGLVEAGAESAGLQASPQAD
>Mature_373_residues
MIRPDLSSLPAYVPGSTQPGALKLASNESSLSPLPSVSAVINDATSNLNRYPDMASGALRGKLAQWLGVDLDNVAVGNGS
SALCQQLVQATCKDGDEVVYAWRSFEAYPILCKIAGAVGVGVPLKSGRHDLKAMSEAIGERTRLVFVCNPNNPTGTTVSR
DEFREFMGRVPADVTVVLDEAYVEYNRDAESPVALEELQRYPNLAVCRTFSKAYGLAGLRLGYLVGPAELVEAVNKVGIP
FGVNALAQAAGIASVEAQGELAERVDATVAERERVEAYLAGVAPAGADEPLTYPSQANFVWLNAGERAEALDEALKREGV
IARCFAGEGVRVTVTTAEETDVLLRALERALPAVGLVEAGAESAGLQASPQAD

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=312, Percent_Identity=30.7692307692308, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786816, Length=227, Percent_Identity=26.8722466960352, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788722, Length=257, Percent_Identity=26.8482490272374, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=383, Percent_Identity=25.3263707571802, Blast_Score=102, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_CORJK (Q4JSJ5)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_251830.1
- ProteinModelPortal:   Q4JSJ5
- SMR:   Q4JSJ5
- STRING:   Q4JSJ5
- GeneID:   3432859
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk2030
- NMPDR:   fig|306537.3.peg.920
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   TTIVWIC
- ProtClustDB:   PRK03321
- BioCyc:   CJEI306537:JK2030-MONOMER
- HAMAP:   MF_01513
- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 39305; Mature: 39305

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRPDLSSLPAYVPGSTQPGALKLASNESSLSPLPSVSAVINDATSNLNRYPDMASGALR
CCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
GKLAQWLGVDLDNVAVGNGSSALCQQLVQATCKDGDEVVYAWRSFEAYPILCKIAGAVGV
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHEEEHHHHCC
GVPLKSGRHDLKAMSEAIGERTRLVFVCNPNNPTGTTVSRDEFREFMGRVPADVTVVLDE
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEH
AYVEYNRDAESPVALEELQRYPNLAVCRTFSKAYGLAGLRLGYLVGPAELVEAVNKVGIP
HHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHCCCC
FGVNALAQAAGIASVEAQGELAERVDATVAERERVEAYLAGVAPAGADEPLTYPSQANFV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
WLNAGERAEALDEALKREGVIARCFAGEGVRVTVTTAEETDVLLRALERALPAVGLVEAG
EEECCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHCC
AESAGLQASPQAD
CCCCCCCCCCCCC
>Mature Secondary Structure
MIRPDLSSLPAYVPGSTQPGALKLASNESSLSPLPSVSAVINDATSNLNRYPDMASGALR
CCCCCHHHCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
GKLAQWLGVDLDNVAVGNGSSALCQQLVQATCKDGDEVVYAWRSFEAYPILCKIAGAVGV
HHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHEEEHHHHCC
GVPLKSGRHDLKAMSEAIGERTRLVFVCNPNNPTGTTVSRDEFREFMGRVPADVTVVLDE
CCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEH
AYVEYNRDAESPVALEELQRYPNLAVCRTFSKAYGLAGLRLGYLVGPAELVEAVNKVGIP
HHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHEECHHHHHHHHHHCCCC
FGVNALAQAAGIASVEAQGELAERVDATVAERERVEAYLAGVAPAGADEPLTYPSQANFV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEE
WLNAGERAEALDEALKREGVIARCFAGEGVRVTVTTAEETDVLLRALERALPAVGLVEAG
EEECCCHHHHHHHHHHHCCCEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHCC
AESAGLQASPQAD
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA