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The map label for this gene is fadD6 [H]

Identifier: 68537009

GI number: 68537009

Start: 2230931

End: 2232664

Strand: Direct

Name: fadD6 [H]

Synonym: jk1915

Alternate gene names: 68537009

Gene position: 2230931-2232664 (Clockwise)

Preceding gene: 68537003

Following gene: 68537010

Centisome position: 90.6

GC content: 62.75

Gene sequence:

>1734_bases
ATGACTGACACCGAGCGCCCAGAGGGAACGGCCTGGAAGGACAAGCCTTACCTGAAGTACTACGCGGAGTGGACTCCGCA
CAGCCTGGAGTACCAAGACGACACCATGGCTAAGCTTCTCGACCGTACTGTCGCCGAACACTCGAGCGCCGACATCCTGG
ACTTCTTCGGCCAGACGATGACTTACGGAGATTTCCTTAAGCAGGTCAAGAGCGTGGCCGCTGGCCTGCGCGAGCTGGGC
GTGCGCCCCGGCGACCGCGTGGCAGTAACCCTGCCGAACTGCCCGCAGCACCTGATTACGATCTTCGCCGCCCACAAGCT
GGGCGCCGTAGTGGCAGAGCACAACCCTCTGTACACCGCCCGCGAGCTGGAAGGCCCCTGCAAGGACCACGGCGCGAAGG
TTGCGGTGGTCTGGGACAAGATCGCCCCGATGTTCCAGGAGCTTTCACGCACCACGCCGCTGGAGAAGATCGTCAGTGTG
AACATGATCGACGCGATGCCGCTGGTGAAGCGTCTGGCTCTGAAGCTGCCGATCAAGTCGATCAAGGAAAAGCGCGACCA
GCTGCACGGTGAGGCACCGGGCACCATCCCGTTCTCCCAGCTGCAGAGCGCCAAGTTTGGTGGCGACGGATCGGACATCG
AAAACTCCCCGGAGACGACACAGGACTCCCCTGCGTTTATCCTCTTCACTTCCGGCACGACCGGTAAGCCCAAGGGCGCG
CAGCTGACGCACGGCAACGTCATGTCCAACGTCGTCCAGGGACTGTCCTGGATCAGCGGCATCGGCGAGCGTGGCCAGGA
GAAGTTCCTAGCCGCCTTGCCACTGTTCCATATTTACGGCCTGACCCTGACCGCCGCGTTGGCCGTATCCACCGGCGGCA
AGCTGCTACTACTGCCGAAGCCGGAGATTCCGCTGATCGTGGACCAGCTTAAGCGCGAAACCCCCACCTACATGCCGGGC
GTACCGACCCTGTACGACAAGATCCTGGCCGCCGCCGAAGAGCACAACCTGGACCTGCGCGGAATCGCCAACGCCCTGTC
CGGCGCAGCGCCGCTGCCGGTGCACACCACCCTGGAGTGGGAGAAGAAGACCGGCGGCAAGATCGTGGAGGGCTACGGCC
TGACCGAATCCAGCCCGATCCTCGTAGCCAACCCCGTTACCTCGGAGCGCCGCGCAGGCTACATCGGCATCCCGTTCCCG
GATACGGAAATGCGCGTGGCCGACCCGAACGACTTCAGCAAGACCATGCCGGACGGCGAGCCGGGTGAACTACTGGCCCG
CGGCCGCCAGGTTTTCCACGGGTACATCAACATCCCGGATGAGGATCAGCCGTTCCACGAGGATTGGTTCTGCACTGGTG
ACATGGCTGTGATGGAGCCGGACGGCTTCATCAAGATCGTCTCCCGCATTAAGGAAATGATCATCACCGGCGGGTTTAAC
GTTTACCCCGCCGAGGTGGAGGAGTTCCTGGAGGAGCACGAGCAGATCCAGAAGGCCGGCGTGGTTGGCCTGCCGCAGGA
CGACGGCTCGGAAGAGGTTGTCGCCGCAGTTGTTCTGGCGGACGGTGTCAGCGAGGCTGACTTCGACAAGGAAGCCATCC
GGGAGTGGGCTCGCGAAGGTCTGACCCGCTACAAGGTTCCCCGCCGCTTCTTCGTCGTCGACGAGATGCCGGCTGATCTG
ATCGGCAAGATCCGCCGCCGTGAGGTTAAGGACCTGATCATGACGATGCTGTAG

Upstream 100 bases:

>100_bases
ATTGCTTAATTCCACCAAAGAAAACGAGAAAGTTAGATAGGGTGCCAAAGTAACGTGCATCACGTTTTGAAGACTGTTTC
TTTAGACCTAAGGGATCTAC

Downstream 100 bases:

>100_bases
GCGGACGCTTCCCCTCTTCTAGCTCTTCCCGAGTTCGGCGAATACGCCGGGCTCGGGTTTCTGCTTTCTTGGCTCCCTAA
GCGCCGAATGTCGCTAGAAC

Product: long-chain-fatty-acid--CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTDTERPEGTAWKDKPYLKYYAEWTPHSLEYQDDTMAKLLDRTVAEHSSADILDFFGQTMTYGDFLKQVKSVAAGLRELG
VRPGDRVAVTLPNCPQHLITIFAAHKLGAVVAEHNPLYTARELEGPCKDHGAKVAVVWDKIAPMFQELSRTTPLEKIVSV
NMIDAMPLVKRLALKLPIKSIKEKRDQLHGEAPGTIPFSQLQSAKFGGDGSDIENSPETTQDSPAFILFTSGTTGKPKGA
QLTHGNVMSNVVQGLSWISGIGERGQEKFLAALPLFHIYGLTLTAALAVSTGGKLLLLPKPEIPLIVDQLKRETPTYMPG
VPTLYDKILAAAEEHNLDLRGIANALSGAAPLPVHTTLEWEKKTGGKIVEGYGLTESSPILVANPVTSERRAGYIGIPFP
DTEMRVADPNDFSKTMPDGEPGELLARGRQVFHGYINIPDEDQPFHEDWFCTGDMAVMEPDGFIKIVSRIKEMIITGGFN
VYPAEVEEFLEEHEQIQKAGVVGLPQDDGSEEVVAAVVLADGVSEADFDKEAIREWAREGLTRYKVPRRFFVVDEMPADL
IGKIRRREVKDLIMTML

Sequences:

>Translated_577_residues
MTDTERPEGTAWKDKPYLKYYAEWTPHSLEYQDDTMAKLLDRTVAEHSSADILDFFGQTMTYGDFLKQVKSVAAGLRELG
VRPGDRVAVTLPNCPQHLITIFAAHKLGAVVAEHNPLYTARELEGPCKDHGAKVAVVWDKIAPMFQELSRTTPLEKIVSV
NMIDAMPLVKRLALKLPIKSIKEKRDQLHGEAPGTIPFSQLQSAKFGGDGSDIENSPETTQDSPAFILFTSGTTGKPKGA
QLTHGNVMSNVVQGLSWISGIGERGQEKFLAALPLFHIYGLTLTAALAVSTGGKLLLLPKPEIPLIVDQLKRETPTYMPG
VPTLYDKILAAAEEHNLDLRGIANALSGAAPLPVHTTLEWEKKTGGKIVEGYGLTESSPILVANPVTSERRAGYIGIPFP
DTEMRVADPNDFSKTMPDGEPGELLARGRQVFHGYINIPDEDQPFHEDWFCTGDMAVMEPDGFIKIVSRIKEMIITGGFN
VYPAEVEEFLEEHEQIQKAGVVGLPQDDGSEEVVAAVVLADGVSEADFDKEAIREWAREGLTRYKVPRRFFVVDEMPADL
IGKIRRREVKDLIMTML
>Mature_576_residues
TDTERPEGTAWKDKPYLKYYAEWTPHSLEYQDDTMAKLLDRTVAEHSSADILDFFGQTMTYGDFLKQVKSVAAGLRELGV
RPGDRVAVTLPNCPQHLITIFAAHKLGAVVAEHNPLYTARELEGPCKDHGAKVAVVWDKIAPMFQELSRTTPLEKIVSVN
MIDAMPLVKRLALKLPIKSIKEKRDQLHGEAPGTIPFSQLQSAKFGGDGSDIENSPETTQDSPAFILFTSGTTGKPKGAQ
LTHGNVMSNVVQGLSWISGIGERGQEKFLAALPLFHIYGLTLTAALAVSTGGKLLLLPKPEIPLIVDQLKRETPTYMPGV
PTLYDKILAAAEEHNLDLRGIANALSGAAPLPVHTTLEWEKKTGGKIVEGYGLTESSPILVANPVTSERRAGYIGIPFPD
TEMRVADPNDFSKTMPDGEPGELLARGRQVFHGYINIPDEDQPFHEDWFCTGDMAVMEPDGFIKIVSRIKEMIITGGFNV
YPAEVEEFLEEHEQIQKAGVVGLPQDDGSEEVVAAVVLADGVSEADFDKEAIREWAREGLTRYKVPRRFFVVDEMPADLI
GKIRRREVKDLIMTML

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=531, Percent_Identity=29.5668549905838, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI187761345, Length=413, Percent_Identity=30.5084745762712, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI187761343, Length=413, Percent_Identity=30.5084745762712, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI38505220, Length=514, Percent_Identity=25.0972762645914, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI42544132, Length=508, Percent_Identity=23.8188976377953, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI122937307, Length=508, Percent_Identity=24.8031496062992, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=23.1968810916179, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=23.1968810916179, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=23.1968810916179, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI115511026, Length=516, Percent_Identity=22.8682170542636, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI28416953, Length=555, Percent_Identity=22.7027027027027, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI40807491, Length=366, Percent_Identity=25.9562841530055, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI13325057, Length=363, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1788107, Length=540, Percent_Identity=34.4444444444444, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI145693145, Length=533, Percent_Identity=28.1425891181989, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI221142682, Length=545, Percent_Identity=25.1376146788991, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1790505, Length=576, Percent_Identity=22.7430555555556, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789201, Length=361, Percent_Identity=28.2548476454294, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786810, Length=362, Percent_Identity=24.3093922651934, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786801, Length=504, Percent_Identity=23.4126984126984, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786529, Length=553, Percent_Identity=22.4231464737794, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=517, Percent_Identity=29.9806576402321, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI32563687, Length=521, Percent_Identity=28.7907869481766, Blast_Score=206, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17560308, Length=540, Percent_Identity=29.8148148148148, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI71994703, Length=537, Percent_Identity=27.1880819366853, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71994694, Length=537, Percent_Identity=27.1880819366853, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71994690, Length=537, Percent_Identity=27.1880819366853, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17557194, Length=529, Percent_Identity=24.5746691871456, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=531, Percent_Identity=25.4237288135593, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17538037, Length=534, Percent_Identity=23.9700374531835, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI71985884, Length=570, Percent_Identity=24.9122807017544, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531443, Length=523, Percent_Identity=23.9005736137667, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=558, Percent_Identity=24.0143369175627, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17556552, Length=601, Percent_Identity=26.4559068219634, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17510401, Length=495, Percent_Identity=23.030303030303, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=522, Percent_Identity=21.264367816092, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319699, Length=494, Percent_Identity=25.7085020242915, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6323182, Length=554, Percent_Identity=23.4657039711191, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319264, Length=544, Percent_Identity=23.5294117647059, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24581924, Length=527, Percent_Identity=29.2220113851992, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI18859661, Length=539, Percent_Identity=29.4990723562152, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21355181, Length=510, Percent_Identity=27.2549019607843, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI19921316, Length=502, Percent_Identity=24.9003984063745, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24666501, Length=540, Percent_Identity=23.8888888888889, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24666497, Length=540, Percent_Identity=23.8888888888889, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI281366413, Length=540, Percent_Identity=23.8888888888889, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922652, Length=542, Percent_Identity=22.5092250922509, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17933690, Length=502, Percent_Identity=24.1035856573705, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24656500, Length=530, Percent_Identity=21.6981132075472, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653035, Length=370, Percent_Identity=23.7837837837838, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648260, Length=567, Percent_Identity=22.5749559082892, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21356947, Length=373, Percent_Identity=23.0563002680965, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356441, Length=308, Percent_Identity=23.0519480519481, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076582, Length=295, Percent_Identity=23.728813559322, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63582; Mature: 63451

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTERPEGTAWKDKPYLKYYAEWTPHSLEYQDDTMAKLLDRTVAEHSSADILDFFGQTM
CCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TYGDFLKQVKSVAAGLRELGVRPGDRVAVTLPNCPQHLITIFAAHKLGAVVAEHNPLYTA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEH
RELEGPCKDHGAKVAVVWDKIAPMFQELSRTTPLEKIVSVNMIDAMPLVKRLALKLPIKS
HHCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
IKEKRDQLHGEAPGTIPFSQLQSAKFGGDGSDIENSPETTQDSPAFILFTSGTTGKPKGA
HHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
QLTHGNVMSNVVQGLSWISGIGERGQEKFLAALPLFHIYGLTLTAALAVSTGGKLLLLPK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
PEIPLIVDQLKRETPTYMPGVPTLYDKILAAAEEHNLDLRGIANALSGAAPLPVHTTLEW
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEE
EKKTGGKIVEGYGLTESSPILVANPVTSERRAGYIGIPFPDTEMRVADPNDFSKTMPDGE
CCCCCCEEEECCCCCCCCCEEEECCCCHHHCCCEEECCCCCCCEEECCCCCHHHCCCCCC
PGELLARGRQVFHGYINIPDEDQPFHEDWFCTGDMAVMEPDGFIKIVSRIKEMIITGGFN
HHHHHHHHHHHHEEEECCCCCCCCCCCCCEECCCEEEECCCHHHHHHHHHHHHHHHCCCC
VYPAEVEEFLEEHEQIQKAGVVGLPQDDGSEEVVAAVVLADGVSEADFDKEAIREWAREG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LTRYKVPRRFFVVDEMPADLIGKIRRREVKDLIMTML
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TDTERPEGTAWKDKPYLKYYAEWTPHSLEYQDDTMAKLLDRTVAEHSSADILDFFGQTM
CCCCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHH
TYGDFLKQVKSVAAGLRELGVRPGDRVAVTLPNCPQHLITIFAAHKLGAVVAEHNPLYTA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEH
RELEGPCKDHGAKVAVVWDKIAPMFQELSRTTPLEKIVSVNMIDAMPLVKRLALKLPIKS
HHCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
IKEKRDQLHGEAPGTIPFSQLQSAKFGGDGSDIENSPETTQDSPAFILFTSGTTGKPKGA
HHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
QLTHGNVMSNVVQGLSWISGIGERGQEKFLAALPLFHIYGLTLTAALAVSTGGKLLLLPK
EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
PEIPLIVDQLKRETPTYMPGVPTLYDKILAAAEEHNLDLRGIANALSGAAPLPVHTTLEW
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEEEEE
EKKTGGKIVEGYGLTESSPILVANPVTSERRAGYIGIPFPDTEMRVADPNDFSKTMPDGE
CCCCCCEEEECCCCCCCCCEEEECCCCHHHCCCEEECCCCCCCEEECCCCCHHHCCCCCC
PGELLARGRQVFHGYINIPDEDQPFHEDWFCTGDMAVMEPDGFIKIVSRIKEMIITGGFN
HHHHHHHHHHHHEEEECCCCCCCCCCCCCEECCCEEEECCCHHHHHHHHHHHHHHHCCCC
VYPAEVEEFLEEHEQIQKAGVVGLPQDDGSEEVVAAVVLADGVSEADFDKEAIREWAREG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
LTRYKVPRRFFVVDEMPADLIGKIRRREVKDLIMTML
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]