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The map label for this gene is menB [H]

Identifier: 68536963

GI number: 68536963

Start: 2183206

End: 2184168

Strand: Direct

Name: menB [H]

Synonym: jk1870

Alternate gene names: 68536963

Gene position: 2183206-2184168 (Clockwise)

Preceding gene: 68536957

Following gene: 68536968

Centisome position: 88.66

GC content: 65.11

Gene sequence:

>963_bases
ATGACTGATTCCAGCAACAACCCCTTCAAACCCGAGCTGTGGCGCCCGGTAGATGCGCCGGGTGTAAACAACTTCACGGA
CATCACCTACCACCGTCACGTCGGCGAAGGCCGCGCCAACGGCATCGTCCGCATCGCCTTTGACCGCCCCGAGGTCCGCA
ACGCCTTCCGCCCGCACACCGTCGACGAGCTGTACCGGGCGCTGGATCACGCGCGCCGCACCCCGGACGTGGGCACCATC
CTGTTGACCGGTAACGGGCCGTCCCCGAAGGACGGCGGCTGGGCGTTTTGCTCCGGCGGCGACCAGCGCATTCGTGGCCG
TTCCGGTTATCAGTACGCCACCAGCCACGATTCGGACGTCGCCGCCGCTGGCGCCGATGGGGTGGACGAGGCCCGCGCGA
AGGTGGAGGGCGGCCGCCTGCACATCCTGGAGGTGCAGCGCCTGATCCGCACGATGCCGAAAGTTGTGATCTGCCTGGTC
AACGGCTGGGCCGCTGGCGGCGGGCACAGCCTGCACGTGGTGTGCGACCTGACCCTGGCCTCCCGCGAGCACGCTAAGTT
CAAGCAGACGGACGCCGACGTCGGCTCCTTCGACGCAGGCTATGGCTCCGCCTACCTGGCCAAGCAGGTGGGCCAGAAGT
TTGCCCGCGAAATCTTCTTCCTCGGCGAGGCCATCGACGCTGAAACGATGCACCAGATGGGAGCCGTCAACCGGGTGGTG
GATCACGCGGATCTGGAGGACACCGCCATCGAATGGGGCCGCAAGATCAACACCAAATCCCCCACCGCACAGCGCATGCT
GAAGTTCGCCTTCAACCTAACCGACGATGGGTTGATGGGCCAGCAGGTCTTCGCGGGTGAGGCTACGCGCCTGGCCTACA
TGACCGACGAGGCCGTAGAAGGCAAGGATGCCTTCCTAGAAAAGCGCGAGCCGAACTGGGACGACTTCCCGTACTACTAC
TAA

Upstream 100 bases:

>100_bases
TCGGCGAGCGACGGCAGCGGAAAAGACAGGTGGGAAGATGCGGCGGAATGGTTCATGCTTCCTACCTTGCCAAAAGCGGC
TGGCCGATAGAATGGCGGGC

Downstream 100 bases:

>100_bases
CTAAGACAGTCCGGGGCTCTCTAAGACAAGTCTTCTTTGACAATTCTGCGCCCTTGGCGAAGCCCGCCTGTCGTCCAATG
ACTCAGGACGCACAGCACCA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTDSSNNPFKPELWRPVDAPGVNNFTDITYHRHVGEGRANGIVRIAFDRPEVRNAFRPHTVDELYRALDHARRTPDVGTI
LLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYATSHDSDVAAAGADGVDEARAKVEGGRLHILEVQRLIRTMPKVVICLV
NGWAAGGGHSLHVVCDLTLASREHAKFKQTDADVGSFDAGYGSAYLAKQVGQKFAREIFFLGEAIDAETMHQMGAVNRVV
DHADLEDTAIEWGRKINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKDAFLEKREPNWDDFPYYY

Sequences:

>Translated_320_residues
MTDSSNNPFKPELWRPVDAPGVNNFTDITYHRHVGEGRANGIVRIAFDRPEVRNAFRPHTVDELYRALDHARRTPDVGTI
LLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYATSHDSDVAAAGADGVDEARAKVEGGRLHILEVQRLIRTMPKVVICLV
NGWAAGGGHSLHVVCDLTLASREHAKFKQTDADVGSFDAGYGSAYLAKQVGQKFAREIFFLGEAIDAETMHQMGAVNRVV
DHADLEDTAIEWGRKINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKDAFLEKREPNWDDFPYYY
>Mature_319_residues
TDSSNNPFKPELWRPVDAPGVNNFTDITYHRHVGEGRANGIVRIAFDRPEVRNAFRPHTVDELYRALDHARRTPDVGTIL
LTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYATSHDSDVAAAGADGVDEARAKVEGGRLHILEVQRLIRTMPKVVICLVN
GWAAGGGHSLHVVCDLTLASREHAKFKQTDADVGSFDAGYGSAYLAKQVGQKFAREIFFLGEAIDAETMHQMGAVNRVVD
HADLEDTAIEWGRKINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVEGKDAFLEKREPNWDDFPYYY

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=314, Percent_Identity=29.2993630573248, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI31542718, Length=291, Percent_Identity=28.1786941580756, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788597, Length=310, Percent_Identity=44.1935483870968, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI221142681, Length=281, Percent_Identity=25.9786476868327, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082183, Length=286, Percent_Identity=25.8741258741259, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787660, Length=275, Percent_Identity=29.4545454545455, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787659, Length=282, Percent_Identity=24.822695035461, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=280, Percent_Identity=26.0714285714286, Blast_Score=94, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=237, Percent_Identity=27.4261603375527, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI25145438, Length=292, Percent_Identity=27.3972602739726, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129971, Length=308, Percent_Identity=26.2987012987013, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653477, Length=308, Percent_Identity=26.2987012987013, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653139, Length=296, Percent_Identity=24.3243243243243, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 35364; Mature: 35233

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSSNNPFKPELWRPVDAPGVNNFTDITYHRHVGEGRANGIVRIAFDRPEVRNAFRPHT
CCCCCCCCCCCHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHCCCCCC
VDELYRALDHARRTPDVGTILLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYATSHDSDV
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEECCCCCCCC
AAAGADGVDEARAKVEGGRLHILEVQRLIRTMPKVVICLVNGWAAGGGHSLHVVCDLTLA
CCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEEEC
SREHAKFKQTDADVGSFDAGYGSAYLAKQVGQKFAREIFFLGEAIDAETMHQMGAVNRVV
CCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DHADLEDTAIEWGRKINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVE
HHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCHHCC
GKDAFLEKREPNWDDFPYYY
CHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDSSNNPFKPELWRPVDAPGVNNFTDITYHRHVGEGRANGIVRIAFDRPEVRNAFRPHT
CCCCCCCCCCHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCHHHHHCCCCCC
VDELYRALDHARRTPDVGTILLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYATSHDSDV
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEECCCCCCCC
AAAGADGVDEARAKVEGGRLHILEVQRLIRTMPKVVICLVNGWAAGGGHSLHVVCDLTLA
CCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEEEEC
SREHAKFKQTDADVGSFDAGYGSAYLAKQVGQKFAREIFFLGEAIDAETMHQMGAVNRVV
CCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
DHADLEDTAIEWGRKINTKSPTAQRMLKFAFNLTDDGLMGQQVFAGEATRLAYMTDEAVE
HHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCHHCC
GKDAFLEKREPNWDDFPYYY
CHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA