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The map label for this gene is glpK [H]

Identifier: 68536761

GI number: 68536761

Start: 1949404

End: 1950990

Strand: Direct

Name: glpK [H]

Synonym: jk1671

Alternate gene names: 68536761

Gene position: 1949404-1950990 (Clockwise)

Preceding gene: 68536760

Following gene: 68536762

Centisome position: 79.16

GC content: 65.22

Gene sequence:

>1587_bases
GTGGTAGAAAACTTTACAAACCAGCTGACCGGGACCTTGGCTAAGTGGAAAAGCTCCAAGAGGGGCTACGTATTGGCGCT
CGACCAGGGGACGACGTCTACCCGCTGCATCATTTTTGATGCTCACGGCAAGATCATCAGCTCCAGCCACATGGAGCACC
GGCAGATCTTCCCGCGCCCCGGTTGGGTGGAGCACGACCCGGAGGAGATCCGGCGCAACACCCGGCGCGTGATGGCGGAC
GCAGCAGCCTCCCGCGACATTCCGGTCGAGGAGTTCGCAGCGGTGGGCATCACCAACCAGCGCGAAACCACCGTCGTATG
GGACCGCGCCACTGGCAAGCCCATCTACAACGCCATCGTGTGGCAGGACACGCGCACCGATAAGATCGTGAGCTCTCTGA
GCGAAGAACAGAAGACCATGATCTTCGAGCGCACCGGGCTGAACGCCTCCACCTACTTCGCCGGGCCGAAGATCCAGTGG
ATCCTGGACAACGTCGAAGGCGCCCGCGAGAAGGCGGAGCGTGGGGAGCTGGCCTTCGGAACCATCGATACGTGGCTGAT
CTGGGAACTCACGCGCCGTTCGCGCAAGAAGTCGAAGGCGAGCCGCAGCGATCACGCCCGGCACGTCACGGACGTCACCA
ATGCCTCGCGCACCATGCTGATGGACCTGCGGACACAGACTTGGGATCCAGAGCTGTGCGAGCTGTTCGGCGTGCCGGAA
TCCATGCTGCCGGAGATCGTCAGCTCTTCCGAGGTCGTCGGGAAGGTCCGCCGCAGCGGGCCGGTGCAAGGCGTGCCGAT
CGCTGGCTTCCTGGGCGACCAGCAGGCCGCAGCCTTCGGCCAGGTGTGCTTTAACCAGGGCGAGGCGAAGAACACCTACG
GCACTGGCAACTTCCTGCTGATGAACACCGGCACCGAGCCGCAGTGGTCCGAGCACGGGCTGATCACCACCGTCGCCTAC
CGGCTGGGCAACCAGCCCGCCGTGTACGCGCTGGAGGGCTCCATCGCCGTCACCGGCTCCCTGGTGCAGTGGCTGCGCGA
CAACCTGGGGTTCTTCGATACCGCCGACGACATCGAGCCGCTGGCTCGCAGCGTGGACGATAACGGCGGCTGCTACATCG
TGCCGGCCTTCAGCGGGCTGCTGGCGCCACATTGGCGCCCCGAGGCCCGCGGCATCATCGCGGGGCTGACCCGTTATGTG
ACGAAGGCGCACATCGCCCGCGCCGCACTGGAAGCCACGGCCTTCCAGACCCGCGAGGTGGTCGAGGCCATGAATGCGGA
CTCGCAGGTGGATCTGAAGAACCTGCGCGTCGACGGTGGCATGGTGGTCAACTCGCTGCTGATGCAGTTCCAGGCCGACC
AGCTGGAGGTGCCAGTGACGGTGCCGGAGGTCTCGGAGACCACCGCCCTCGGAGCGGCCTACGCCGCCGGCCTGGCCGTG
GGCTTCTACCGGGACCTCGACGAGCTGGTTTCCCTCTGGCAGGAGGAAAAGACCTACTTCCCCAAGGGCGACCCGGAGGA
GCGCAAGATCGCCTACGACAAGTGGAAGCGCGCCGTGGAGCGGACGTTCGGTTGGACCGACGATTAG

Upstream 100 bases:

>100_bases
CAATAGCGCAGCGGACGCAGCGGACACAGCGGACACAGCGGACACAGAAGAAGCAGTGGACACCGAGCACAGCAACGACA
GCGACGACAGTGACGACTGA

Downstream 100 bases:

>100_bases
GCGTCCACTGCTACCTTAGAAGTATGAACGAACCGTCCCGCCGTGAAATCCGCATCTCCGATGTCGACCGTAGCGACGCT
ATCAGCGCGCTTGGCGAGCA

Product: putative glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MVENFTNQLTGTLAKWKSSKRGYVLALDQGTTSTRCIIFDAHGKIISSSHMEHRQIFPRPGWVEHDPEEIRRNTRRVMAD
AAASRDIPVEEFAAVGITNQRETTVVWDRATGKPIYNAIVWQDTRTDKIVSSLSEEQKTMIFERTGLNASTYFAGPKIQW
ILDNVEGAREKAERGELAFGTIDTWLIWELTRRSRKKSKASRSDHARHVTDVTNASRTMLMDLRTQTWDPELCELFGVPE
SMLPEIVSSSEVVGKVRRSGPVQGVPIAGFLGDQQAAAFGQVCFNQGEAKNTYGTGNFLLMNTGTEPQWSEHGLITTVAY
RLGNQPAVYALEGSIAVTGSLVQWLRDNLGFFDTADDIEPLARSVDDNGGCYIVPAFSGLLAPHWRPEARGIIAGLTRYV
TKAHIARAALEATAFQTREVVEAMNADSQVDLKNLRVDGGMVVNSLLMQFQADQLEVPVTVPEVSETTALGAAYAAGLAV
GFYRDLDELVSLWQEEKTYFPKGDPEERKIAYDKWKRAVERTFGWTDD

Sequences:

>Translated_528_residues
MVENFTNQLTGTLAKWKSSKRGYVLALDQGTTSTRCIIFDAHGKIISSSHMEHRQIFPRPGWVEHDPEEIRRNTRRVMAD
AAASRDIPVEEFAAVGITNQRETTVVWDRATGKPIYNAIVWQDTRTDKIVSSLSEEQKTMIFERTGLNASTYFAGPKIQW
ILDNVEGAREKAERGELAFGTIDTWLIWELTRRSRKKSKASRSDHARHVTDVTNASRTMLMDLRTQTWDPELCELFGVPE
SMLPEIVSSSEVVGKVRRSGPVQGVPIAGFLGDQQAAAFGQVCFNQGEAKNTYGTGNFLLMNTGTEPQWSEHGLITTVAY
RLGNQPAVYALEGSIAVTGSLVQWLRDNLGFFDTADDIEPLARSVDDNGGCYIVPAFSGLLAPHWRPEARGIIAGLTRYV
TKAHIARAALEATAFQTREVVEAMNADSQVDLKNLRVDGGMVVNSLLMQFQADQLEVPVTVPEVSETTALGAAYAAGLAV
GFYRDLDELVSLWQEEKTYFPKGDPEERKIAYDKWKRAVERTFGWTDD
>Mature_528_residues
MVENFTNQLTGTLAKWKSSKRGYVLALDQGTTSTRCIIFDAHGKIISSSHMEHRQIFPRPGWVEHDPEEIRRNTRRVMAD
AAASRDIPVEEFAAVGITNQRETTVVWDRATGKPIYNAIVWQDTRTDKIVSSLSEEQKTMIFERTGLNASTYFAGPKIQW
ILDNVEGAREKAERGELAFGTIDTWLIWELTRRSRKKSKASRSDHARHVTDVTNASRTMLMDLRTQTWDPELCELFGVPE
SMLPEIVSSSEVVGKVRRSGPVQGVPIAGFLGDQQAAAFGQVCFNQGEAKNTYGTGNFLLMNTGTEPQWSEHGLITTVAY
RLGNQPAVYALEGSIAVTGSLVQWLRDNLGFFDTADDIEPLARSVDDNGGCYIVPAFSGLLAPHWRPEARGIIAGLTRYV
TKAHIARAALEATAFQTREVVEAMNADSQVDLKNLRVDGGMVVNSLLMQFQADQLEVPVTVPEVSETTALGAAYAAGLAV
GFYRDLDELVSLWQEEKTYFPKGDPEERKIAYDKWKRAVERTFGWTDD

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=512, Percent_Identity=49.0234375, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI4504007, Length=511, Percent_Identity=49.119373776908, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI42794763, Length=516, Percent_Identity=48.6434108527132, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI41393575, Length=510, Percent_Identity=48.0392156862745, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI88196792, Length=523, Percent_Identity=31.7399617590822, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1790361, Length=512, Percent_Identity=50.9765625, Blast_Score=502, Evalue=1e-143,
Organism=Escherichia coli, GI1787789, Length=543, Percent_Identity=26.1510128913444, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790005, Length=475, Percent_Identity=24.6315789473684, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789987, Length=514, Percent_Identity=22.1789883268482, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789168, Length=510, Percent_Identity=22.5490196078431, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1789138, Length=479, Percent_Identity=22.1294363256785, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=511, Percent_Identity=43.2485322896282, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI71986140, Length=537, Percent_Identity=26.0707635009311, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71986147, Length=305, Percent_Identity=30.4918032786885, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321755, Length=573, Percent_Identity=38.5689354275742, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI17864214, Length=514, Percent_Identity=43.7743190661479, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24655555, Length=517, Percent_Identity=42.7466150870406, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655560, Length=517, Percent_Identity=42.7466150870406, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655570, Length=517, Percent_Identity=42.7466150870406, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655574, Length=517, Percent_Identity=42.7466150870406, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655565, Length=517, Percent_Identity=42.7466150870406, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24654573, Length=444, Percent_Identity=45.4954954954955, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19922058, Length=543, Percent_Identity=33.7016574585635, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI24652871, Length=510, Percent_Identity=34.3137254901961, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24656367, Length=525, Percent_Identity=31.6190476190476, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI21357867, Length=540, Percent_Identity=30.7407407407407, Blast_Score=231, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24656372, Length=371, Percent_Identity=33.4231805929919, Blast_Score=181, Evalue=2e-45,
Organism=Drosophila melanogaster, GI45552909, Length=314, Percent_Identity=31.2101910828025, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 58789; Mature: 58789

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVENFTNQLTGTLAKWKSSKRGYVLALDQGTTSTRCIIFDAHGKIISSSHMEHRQIFPRP
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCEECCCCCHHHHCCCCC
GWVEHDPEEIRRNTRRVMADAAASRDIPVEEFAAVGITNQRETTVVWDRATGKPIYNAIV
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCHHEEEE
WQDTRTDKIVSSLSEEQKTMIFERTGLNASTYFAGPKIQWILDNVEGAREKAERGELAFG
ECCCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCEEEEEECCHHHHHHHHHCCCEEEE
TIDTWLIWELTRRSRKKSKASRSDHARHVTDVTNASRTMLMDLRTQTWDPELCELFGVPE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCHHHHHHHCCCH
SMLPEIVSSSEVVGKVRRSGPVQGVPIAGFLGDQQAAAFGQVCFNQGEAKNTYGTGNFLL
HHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEE
MNTGTEPQWSEHGLITTVAYRLGNQPAVYALEGSIAVTGSLVQWLRDNLGFFDTADDIEP
EECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHCCCCCCCHHHHHH
LARSVDDNGGCYIVPAFSGLLAPHWRPEARGIIAGLTRYVTKAHIARAALEATAFQTREV
HHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAMNADSQVDLKNLRVDGGMVVNSLLMQFQADQLEVPVTVPEVSETTALGAAYAAGLAV
HHHHCCCCCCCHHHEEECCHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHH
GFYRDLDELVSLWQEEKTYFPKGDPEERKIAYDKWKRAVERTFGWTDD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVENFTNQLTGTLAKWKSSKRGYVLALDQGTTSTRCIIFDAHGKIISSSHMEHRQIFPRP
CCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCEECCCCCHHHHCCCCC
GWVEHDPEEIRRNTRRVMADAAASRDIPVEEFAAVGITNQRETTVVWDRATGKPIYNAIV
CCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCHHEEEE
WQDTRTDKIVSSLSEEQKTMIFERTGLNASTYFAGPKIQWILDNVEGAREKAERGELAFG
ECCCCHHHHHHHHHHHHHHEEEEECCCCCEEEECCCEEEEEECCHHHHHHHHHCCCEEEE
TIDTWLIWELTRRSRKKSKASRSDHARHVTDVTNASRTMLMDLRTQTWDPELCELFGVPE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEHHCCCCCHHHHHHHCCCH
SMLPEIVSSSEVVGKVRRSGPVQGVPIAGFLGDQQAAAFGQVCFNQGEAKNTYGTGNFLL
HHHHHHHCCHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCEEE
MNTGTEPQWSEHGLITTVAYRLGNQPAVYALEGSIAVTGSLVQWLRDNLGFFDTADDIEP
EECCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHHCCCCCCCHHHHHH
LARSVDDNGGCYIVPAFSGLLAPHWRPEARGIIAGLTRYVTKAHIARAALEATAFQTREV
HHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAMNADSQVDLKNLRVDGGMVVNSLLMQFQADQLEVPVTVPEVSETTALGAAYAAGLAV
HHHHCCCCCCCHHHEEECCHHHHHHHHHHHCCCCEECCEECCCCCHHHHHHHHHHHHHHH
GFYRDLDELVSLWQEEKTYFPKGDPEERKIAYDKWKRAVERTFGWTDD
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA