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The map label for this gene is merA [H]

Identifier: 68536528

GI number: 68536528

Start: 1699014

End: 1700435

Strand: Direct

Name: merA [H]

Synonym: jk1442

Alternate gene names: 68536528

Gene position: 1699014-1700435 (Clockwise)

Preceding gene: 68536526

Following gene: 68536529

Centisome position: 69.0

GC content: 71.52

Gene sequence:

>1422_bases
ATGCCTACGAAGTACGATCTCGCCATCATCGGATCGGGAGGCGGCGCGTTCGCCGCTGCGATCCGCGCCAGCACGCTCGG
GAAGTCGGTGGTGATGATCGAGCGCGGGACGCTCGGCGGCACCTGCGTGAACACGGGCTGCGTCCCGTCGAAGGCGCTCA
TTGCCGCGGCCGGCGCGCGGCACGTCGCGGTCGACGCCGCAACCCGGTTCCCCGGGATCGCGACGACGGCGGATCCCGTC
GACATGCCCGCGCTGATCGCTGGGAAGCAAGCGTTGGTGGAGTCGCTGCGCGGCGAGAAGTACGCCGACGTCGCCGACTC
CTACGGCTGGCAGGTCCTCCGCGGCGACGCCTCGTTCGTGGGCACCCCTGATGCGCCGGTTCTCGATGTTGCCGGATCCG
ACGGAAGCGTCGAGACCATCGAGGCCCACCACTACCTGGTCGCGACTGGTTCTCGCCCGTGGGCACCGCCGATCGACGGC
CTGGAGGAGACCGGATACCTGACCTCGACCACGGCGATGGAGCTGACGGAGGTCCCCGAGTCGCTGCTGGTGCTCGGCGG
CGGCTACGTCGCCCTGGAGCAGGCGCAGCTGTTCGCCCGCCTCGGCTCGCAGGTCACGCTGCTCGTGCGGTCCCGGCTCG
CCTCGAAGGAGGAGCCGGAGGTGTCGAAGGCGCTCCAGGAGGTGTTCGCCGACGAGGGCATCCGCGTCGTCAGCCGCGCA
GTGCCCACCCGGGTCTCCCGCGGCACGGGAGGCGAGGCCGTCGTGACCGCCGCCTTGTCCGGCGGCTCGCAGGAGTTCCG
CGCCGACCAGGTCCTGGTCGCCCTCGGACGCCGTCCCGTCACCGATGGCCTGAACCTCGATGCGGTCGGGGTGAATACCG
GAGACTCCGGCGAGGTGGTCGTCTCCGACCGGCTGCAGTCCTCGAACCCGCGGGTCTGGGCCGCGGGCGACGTGACCGGG
CACCCCGAGTTCGTCTACGTCGCCGCCCACCACGGCACCCTCGTCGCCGAGAACGCGTTCGCCGACGCCGACCGGTCCGT
CGACTACGCCCGCCTGCCGCGGGTGACGTTCACCGGGACCGCGATCGGCGCGGTCGGGATGACCGAGAAGGACGTCCTCG
CCGCGGGGATCCGCTGCGACTGCCGCGTCCTGCCCCTGCACCACGTGCCCCGCGCCTTGGTGAACCGCGACACCCGCGGG
TTCATCAAGATCGTCGTGAACGCCGAGACGAAAGAGATCCTCGGCCTGACCGCCGTCGCCAAGGACGCCGGGGAGCTCGC
CGCCGCAGGCGTCCACGTGCTCGGCAGGACCGTCGCCGAGGTCGCCAACGCCTGGGCCCCCTACCTGACCATGGCCGAGG
GCATCCGGATCGCCGCGAAGGCCTTCACCACCGACCCGTCGCTGCTGTCGTGCTGCGCATGA

Upstream 100 bases:

>100_bases
ATTGCTGTCTCCCTCCGTGGCCGCGCTTGACCTTCCCCTGCACTGGAAGGTCCAGTATGGCTGAGACAGAGCAGAAAGCC
AAGAGTTGACAGGAGTAGCG

Downstream 100 bases:

>100_bases
ACGGCAACGCAGGCAATCGGGGAGATCTCATCCTGAAGCAGACGATGAGCGCCGATCAGGACCGCGACGAATGGCGCGCC
GGTCCCGTCGTCGCTGCAGT

Product: putative mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPV
DMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGSDGSVETIEAHHYLVATGSRPWAPPIDG
LEETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
VPTRVSRGTGGEAVVTAALSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVNTGDSGEVVVSDRLQSSNPRVWAAGDVTG
HPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGTAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRG
FIKIVVNAETKEILGLTAVAKDAGELAAAGVHVLGRTVAEVANAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

Sequences:

>Translated_473_residues
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPV
DMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGSDGSVETIEAHHYLVATGSRPWAPPIDG
LEETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
VPTRVSRGTGGEAVVTAALSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVNTGDSGEVVVSDRLQSSNPRVWAAGDVTG
HPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGTAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRG
FIKIVVNAETKEILGLTAVAKDAGELAAAGVHVLGRTVAEVANAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
>Mature_472_residues
PTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGARHVAVDAATRFPGIATTADPVD
MPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFVGTPDAPVLDVAGSDGSVETIEAHHYLVATGSRPWAPPIDGL
EETGYLTSTTAMELTEVPESLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRAV
PTRVSRGTGGEAVVTAALSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVNTGDSGEVVVSDRLQSSNPRVWAAGDVTGH
PEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGTAIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGF
IKIVVNAETKEILGLTAVAKDAGELAAAGVHVLGRTVAEVANAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=481, Percent_Identity=29.9376299376299, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI22035672, Length=491, Percent_Identity=30.7535641547862, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI50301238, Length=426, Percent_Identity=28.8732394366197, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI148277065, Length=431, Percent_Identity=27.6102088167053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519430, Length=431, Percent_Identity=27.6102088167053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519428, Length=431, Percent_Identity=27.6102088167053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI33519426, Length=431, Percent_Identity=27.6102088167053, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI148277071, Length=431, Percent_Identity=27.6102088167053, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI291045266, Length=449, Percent_Identity=27.6169265033408, Blast_Score=129, Evalue=9e-30,
Organism=Homo sapiens, GI291045268, Length=438, Percent_Identity=28.5388127853881, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=30.1927194860814, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1789915, Length=372, Percent_Identity=36.5591397849462, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=29.0393013100437, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI87082354, Length=479, Percent_Identity=28.8100208768267, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32565766, Length=461, Percent_Identity=32.9718004338395, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17557007, Length=500, Percent_Identity=27.4, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=361, Percent_Identity=29.3628808864266, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71983429, Length=361, Percent_Identity=29.3628808864266, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71982272, Length=458, Percent_Identity=27.7292576419214, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6321091, Length=478, Percent_Identity=29.9163179916318, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=476, Percent_Identity=26.4705882352941, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=481, Percent_Identity=27.2349272349272, Blast_Score=122, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=32.4731182795699, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17737741, Length=491, Percent_Identity=28.7169042769857, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24640549, Length=501, Percent_Identity=27.3453093812375, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24640553, Length=501, Percent_Identity=27.3453093812375, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24640551, Length=501, Percent_Identity=26.7465069860279, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 49003; Mature: 48872

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGAR
CCCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCCCHHHHHHCCCC
HVAVDAATRFPGIATTADPVDMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFV
EEEEEHHHCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCC
GTPDAPVLDVAGSDGSVETIEAHHYLVATGSRPWAPPIDGLEETGYLTSTTAMELTEVPE
CCCCCCEEEECCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
SLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
EEEEECCCEEEHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
VPTRVSRGTGGEAVVTAALSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVNTGDSGEVV
HCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEE
VSDRLQSSNPRVWAAGDVTGHPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGT
EECCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHCCCEEEECC
AIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGFIKIVVNAETKEILGLTAVA
EEEECCCCCHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
KDAGELAAAGVHVLGRTVAEVANAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCC
>Mature Secondary Structure 
PTKYDLAIIGSGGGAFAAAIRASTLGKSVVMIERGTLGGTCVNTGCVPSKALIAAAGAR
CCCEEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCEEECCCCCCHHHHHHCCCC
HVAVDAATRFPGIATTADPVDMPALIAGKQALVESLRGEKYADVADSYGWQVLRGDASFV
EEEEEHHHCCCCCCCCCCCCCCCHHHHCHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCC
GTPDAPVLDVAGSDGSVETIEAHHYLVATGSRPWAPPIDGLEETGYLTSTTAMELTEVPE
CCCCCCEEEECCCCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCCEEEEHHHHHHHHCCC
SLLVLGGGYVALEQAQLFARLGSQVTLLVRSRLASKEEPEVSKALQEVFADEGIRVVSRA
EEEEECCCEEEHHHHHHHHHCCCCEEEHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHH
VPTRVSRGTGGEAVVTAALSGGSQEFRADQVLVALGRRPVTDGLNLDAVGVNTGDSGEVV
HCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCEE
VSDRLQSSNPRVWAAGDVTGHPEFVYVAAHHGTLVAENAFADADRSVDYARLPRVTFTGT
EECCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCHHHCCCEEEECC
AIGAVGMTEKDVLAAGIRCDCRVLPLHHVPRALVNRDTRGFIKIVVNAETKEILGLTAVA
EEEECCCCCHHHHHCCCCCCEEEECHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHH
KDAGELAAAGVHVLGRTVAEVANAWAPYLTMAEGIRIAAKAFTTDPSLLSCCA
HCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1494353 [H]